Synthesis of atypical bile acids for use as investigative tools for the genetic defect of 3β-hydroxy-Δ5-C27-steroid oxidoreductase deficiency

Journal of Steroid Biochemistry and Molecular Biology

Volumn 144, Issue PART B, 2014, Pages 348-360

  Gioiello, Antimo ^a   Cerra, Bruno ^a   Zhang, Wujuan ^b   Vallerini, Gian Paolo ^c   Costantino, Gabriele ^c   Franco, Francesca De ^d   Passeri, Daniela ^d   Pellicciari, Roberto ^a,d   Setchell, Kenneth D R ^b  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PARMA   (Italy)

^d TES Pharma   (Italy)

Author keywords

3 Hydroxy 5 C27 steroid oxidoreductase; Bile acids; Biomarkers; Diagnosis; Gene expression; Inborn errors; Mass spectrometry; Nuclear receptors; Synthesis

Indexed keywords

BILE ACID; CELL RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR; PREGNANE X RECEPTOR; STEROID RECEPTOR; 3BETA HYDROXY DELTA5 C27 STEROID OXIDOREDUCTASE; 3BETA HYDROXY DELTA5 CHOLENOIC ACID; CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

CONGENITAL ADRENAL HYPERPLASIA; GENETICS; HEPG2 CELL LINE; HUMAN; METABOLISM; SYNTHESIS; ARTICLE; BILE ACID SYNTHESIS; DETOXIFICATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC DISORDER; HOMEOSTASIS; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADRENAL HYPERPLASIA, CONGENITAL; BILE ACIDS AND SALTS; HEP G2 CELLS; HUMANS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID;

EID: 84906833004     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.06.008     Document Type: Article

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