NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6

Mucosal Immunology

Volumn 7, Issue 6, 2014, Pages 1312-1325

  Watanabe, T ^a,b   Asano, N ^b,c   Meng, G ^b   Yamashita, K ^a   Arai, Y ^a   Sakurai, T ^d   Kudo, M ^d   Fuss, I J ^b   Kitani, A ^b   Shimosegawa, T ^c   Chiba, T ^a   Strober, W ^b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 4; LYSINE; MURAMYL DIPEPTIDE; MYELOID DIFFERENTIATION FACTOR 88; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; VIRUS VECTOR; CARD15 PROTEIN, MOUSE; INTERFERON REGULATORY FACTOR; INTERFERON REGULATORY FACTOR-4; NOD2 PROTEIN, HUMAN; RIPK2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; DOWN REGULATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IMMUNOREGULATION; INHIBITION KINETICS; INNATE IMMUNITY; INTESTINE FLORA; LAMINA PROPRIA; MONONUCLEAR CELL; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; UBIQUITINATION; ANIMAL; COLON; DENDRITIC CELL; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; INFLAMMATION; PATHOLOGY;

ANIMALS; COLON; CROHN DISEASE; DENDRITIC CELLS; DOWN-REGULATION; HEK293 CELLS; HUMANS; INFLAMMATION; INTERFERON REGULATORY FACTORS; MICE; NOD2 SIGNALING ADAPTOR PROTEIN; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION;

EID: 84906790709     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2014.19     Document Type: Article

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