A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF

Experimental Neurology

Volumn 261, Issue , 2014, Pages 578-593

  Hoyng, Stefan A ^a,b   De Winter, Fred ^a,b   Gnavi, Sara ^a,c   de Boer, Ralph ^b   Boon, Lennard I ^a   Korvers, Laura M ^a   Tannemaat, Martijn R ^a,b   Malessy, Martijn J A ^a,b   Verhaagen, Joost ^a,d  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TURIN   (Italy)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Gene therapy; Neurotrophic factor; Peripheral nerve repair; Schwann cell; Viral vector

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; LENTIVIRUS VECTOR; NERVE GROWTH FACTOR; NEURITE PROMOTING FACTOR; NEUROTROPHIN 3; VASCULOTROPIN; VIRUS VECTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOGRAFT; BIOASSAY; BRAIN ELECTROPHYSIOLOGY; BRAIN FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MODIFICATION; ELECTROMYOGRAPHY; GENE OVEREXPRESSION; GENE THERAPY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MORPHOMETRICS; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NOCICEPTIVE STIMULATION; NONHUMAN; NONVIRAL GENE THERAPY; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REINNERVATION; SCHWANN CELL; SCIATIC NERVE INJURY; TRANSGENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; COMPARATIVE STUDY; FEMALE; HISTOLOGY; NERVE FUNCTION; NERVE SURGERY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; VASCULARIZATION; ANIMAL; ANKLE; AUTOTRANSPLANTATION; BIOSYNTHESIS; DRUG EFFECTS; EVOKED MUSCLE RESPONSE; GENE VECTOR; GENETICS; INNERVATION; METABOLISM; MOTION; NERVE REGENERATION; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSIOLOGY; SKELETAL MUSCLE; TIME; WISTAR RAT;

ANIMALS; ANKLE; AUTOGRAFTS; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; MOTION; MUSCLE, SKELETAL; NERVE GROWTH FACTOR; NERVE REGENERATION; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; SCHWANN CELLS; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS;

EID: 84906739381     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.08.002     Document Type: Article

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