Biomedical engineering strategies for peripheral nerve repair: Surgical applications, state of the art, and future challenges

Critical Reviews in Biomedical Engineering

Volumn 39, Issue 2, 2011, Pages 81-124

  Pfister, Bryan J ^a   Gordon, Tessa ^b   Loverde, Joseph R ^a   Kochar, Arshneel S ^d   Mackinnon, Susan E ^c   Kacy Cullen, D ^d  

^a NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

DTI; MRI; Nerve conduit; Nerve injury; Neurography; Peripheral nerve; Regeneration; Schwann cell; Tissue engineering

Indexed keywords

BIOMEDICAL ENGINEERING; BIOPHYSICS; CELL ENGINEERING; DECISION MAKING; GRAFTS; MAGNETIC RESONANCE IMAGING; NEURONS; RECOVERY; REPAIR; SURGERY; TISSUE; TISSUE ENGINEERING;

NERVE CONDUITS; NERVE INJURIES; NEUROGRAPHY; PERIPHERAL NERVES; REGENERATION; SCHWANN CELLS;

TISSUE REGENERATION;

BRAIN DERIVED NEUROTROPHIC FACTOR; CHEMOKINE RECEPTOR CXCR4; CILIARY NEUROTROPHIC FACTOR; COLLAGEN; CYCLIC AMP; EARLY GROWTH RESPONSE FACTOR 1; FIBRIN; GELATIN; HEPARIN; HYDROXYMETHYLCELLULOSE; KERATIN; LAMININ; LAMININ ALPHA2; LAMININ GAMMA1; METHYLCELLULOSE; N ACETYLASPARTIC ACID; NERVE GROWTH FACTOR RECEPTOR; NEURITE PROMOTING FACTOR; NEUROTROPHIN 3; PLATELET DERIVED GROWTH FACTOR BB; POLYCAPROLACTONE; POLYGLACTIN; POLYGLYCOLIC ACID; SILICONE; STROMAL CELL DERIVED FACTOR 1; STROMAL CELL DERIVED FACTOR 1ALPHA; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VASCULOTROPIN;

BIOMEDICAL ENGINEERING; COMORBIDITY; DECISION MAKING; DIFFUSION TENSOR IMAGING; DIFFUSION WEIGHTED IMAGING; DISEASE CLASSIFICATION; DONOR; ELECTROMYOGRAPHY; FRACTIONAL ANISOTROPY; HUMAN; NERVE DEGENERATION; NERVE FIBER REGENERATION; NERVE FUNCTION; NERVE GRAFT; NERVE REGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REINNERVATION; REVIEW; SCHWANN CELL; TREATMENT OUTCOME;

EID: 79960032608     PISSN: 0278940X     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevBiomedEng.v39.i2.20     Document Type: Review

References (259)

1. Robinson LR. Traumatic injury to peripheral nerves. Muscle Nerve. 2000;23(6):863-73.
2. Evans GR. Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat Rec. 2001;263(4):396-404.
3. Siemionow M, Brzezicki G. Chapter 8: Current techniques and concepts in peripheral nerve repair. Int Rev Neurobiol. 2009;87:141-72.
4. Scholz T, Krichevsky A, Sumarto A, Jaffurs D, Wirth GA, Paydar K, Evans G. Peripheral nerve injuries: an international survey of current treatments and future perspectives. J Reconstr Microsurg. 2009;25(6):339-44.
5. Brushart TM, editor. The mechanical and humoral control of specificity in nerve repair. Philadelphia: JB Lippincott; 1991.
6. Mackinnon SE, Dellon AL. Surgery of the peripheral nerve. New York: Thieme Medical Publishers; 1988.
7. Battiston B, Raimondo S, Tos P, Gaidano V, Audisio C, Scevola A, Perroteau I, Geuna S. Chapter 11: Tissue engineering of peripheral nerves. Int Rev Neurobiol. 2009;87:227-49.
8. Schmidt CE, Leach JB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng. 2003;5:293-347.
9. Moore AM, Kasukurthi R, Magill CK, Farhadi HF, Borschel GH, Mackinnon SE. Limitations of conduits in peripheral nerve repairs. Hand (NY). 2009;4(2):180-6.
10. Assaf Y, Pasternak O. Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci. 2008;34(1):51-61.
11. Hiltunen J, Suortti T, Arvela S, Seppa M, Joensuu R, Hari R. Diffusion tensor imaging and tractography of distal peripheral nerves at 3 T. Clin Neurophysiol. 2005;116(10):2315-23.
12. Khalil C, Budzik JF, Kermarrec E, Balbi V, Le Thuc V, Cotten A. Tractography of peripheral nerves and skeletal muscles. Eur J Radiol. 2010;76(3):391-7.
13. Lehmann HC, Zhang J, Mori S, Sheikh KA. Diffusion tensor imaging to assess axonal regeneration in peripheral nerves. Exp Neurol. 2010;223(1):238-44.
14. Vargas MI, Viallon M, Nguyen D, Delavelle J, Becker M. Diffusion tensor imaging (DTI) and tractography of the brachial plexus: feasibility and initial experience in neoplastic conditions. Neuroradiology. 2010;52(3):237-45.
15. Belkas JS, Shoichet MS, Midha R. Peripheral nerve regeneration through guidance tubes. Neurol Res. 2004;26(2):151-60.
16. Smith JW. Factors influencing nerve repair. II. Collateral circulation of peripheral nerves. Arch Surg. 1966;93(3):433-7.
17. Smith JW. Factors influencing nerve repair. I. Blood supply of peripheral nerves. Arch Surg. 1966;93(2):335-41.
18. Seddon HJ. Surgical disorders of the peripheral nerves. Second ed. New York: Churchill Livingstone; 1975.
19. Sunderland S. Nerves and nerve injuries. Second ed. New York: Churchill Livingstone; 1978.
20. Ray WZ, Mackinnon SE. Management of nerve gaps: autografts, allografts, nerve transfers, and end-to-side neurorrhaphy. Exp Neurol. 2010;223(1):77-85.
21. Prasad AR, Steck JK, Dellon AL. Zone of traction injury of the common peroneal nerve. Ann Plast Surg. 2007;59(3):302-6.
22. Lundborg G, Rydevik B. Effects of stretching the tibial nerve of the rabbit. A preliminary study of the intraneural circulation and the barrier function of the perineurium. J Bone Joint Surg Br. 1973;55(2):390-401.
23. Millesi H, Meissl G, Berger A. The interfascicular nerve-grafting of the median and ulnar nerves. J Bone Joint Surg Am. 1972;54(4):727-50.
24. Kline DG, Hudson AR. Nerve injuries: operative results for major nerve injuries, entrapments and tumors. Philadelphia: W.B. Saunders; 1995.
25. Nichols CM, Brenner MJ, Fox IK, Tung TH, Hunter DA, Rickman SR, Mackinnon SE. Effects of motor versus sensory nerve grafts on peripheral nerve regeneration. Exp Neurol. 2004;190(2):347-55.
26. Brenner MJ, Dvali L, Hunter DA, Myckatyn TM, Mackinnon SE. Motor neuron regeneration through end-to-side repairs is a function of donor nerve axotomy. Plast Reconstr Surg. 2007;120(1):215-23.
27. Brenner MJ, Hess JR, Myckatyn TM, Hayashi A, Hunter DA, Mackinnon SE. Repair of motor nerve gaps with sensory nerve inhibits regeneration in rats. Laryngoscope. 2006;116(9):1685-92.
28. Hess JR, Brenner MJ, Fox IK, Nichols CM, Myckatyn TM, Hunter DA, Rickman SR, Mackinnon SE. Use of cold-preserved allografts seeded with autologous Schwann cells in the treatment of a long-gap peripheral nerve injury. Plast Reconstr Surg. 2007;119(1):246-59.
29. Meek MF, Coert JH. Clinical use of nerve conduits in peripheral-nerve repair: review of the literature. J Reconstr Microsurg. 2002;18(2):97-109.
30. Chiu DT, Strauch B. A prospective clinical evaluation of autogenous vein grafts used as a nerve conduit for distal sensory nerve defects of 3 cm or less. Plast Reconstr Surg. 1990;86(5):928-34.
31. Mackinnon SE, Dellon AL. A study of nerve regeneration across synthetic (Maxon) and biologic (collagen) nerve conduits for nerve gaps up to 5 cm in the primate. J Reconstr Microsurg. 1990;6(2):117-21.
32. Hayashi A, Pannucci C, Moradzadeh A, Kawamura D, Magill C, Hunter DA, Tong AY, Parsadanian A, Mackinnon SE, Myckatyn TM. Axotomy or compression is required for axonal sprouting following end-to-side neurorrhaphy. Exp Neurol. 2008;211(2):539-50.
33. Pannucci C, Myckatyn TM, Mackinnon SE, Hayashi A. End-to-side nerve repair: review of the literature. Restor Neurol Neurosci. 2007;25(1):45-63.
34. Burnett MG, Zager EL. Pathophysiology of peripheral nerve injury: a brief review. Neurosurg Focus. 2004;16(5):E1.
35. Fu SY, Gordon T. The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol. 1997;14(1-2):67-116.
36. Gordon T. Dependence of peripheral nerves on their target organs. In: Burnstock G, O'Brien R, Vrbove G, editors. Somatic and autonomic nerve-muscle interactions. Amsterdam: Elsevier; 1983. p. 289-316
37. Fu SY, Gordon T. Contributing factors to poor functional recovery after delayed nerve repair: prolonged denervation. J Neurosci. 1995;15(5 Pt 2):3886-95.
38. Fu SY, Gordon T. Contributing factors to poor functional recovery after delayed nerve repair: prolonged axotomy. J Neurosci. 1995;15(5 Pt 2):3876-85.
39. Sulaiman OA, Gordon T. Effects of short-and long-term Schwann cell denervation on peripheral nerve regeneration, myelination, and size. Glia. 2000;32(3):234-46.
40. Boyd JG, Gordon T. A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor. Eur J Neurosci. 2002;15(4):613-26.
41. Al-Majed AA, Brushart TM, Gordon T. Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci. 2000;12(12):4381-90.
42. Eberhardt KA, Irintchev A, Al-Majed AA, Simova O, Brushart TM, Gordon T, Schachner M. BDNF/TrkB signaling regulates HNK-1 carbohydrate expression in regenerating motor nerves and promotes functional recovery after peripheral nerve repair. Exp Neurol. 2006;198(2):500-10.
43. Al-Majed AA, Neumann CM, Brushart TM, Gordon T. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci. 2000;20(7):2602-8.
44. Brushart TM, Hoffman PN, Royall RM, Murinson BB, Witzel C, Gordon T. Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. J Neurosci. 2002;22(15):6631-8.
45. Brushart TM, Jari R, Verge V, Rohde C, Gordon T. Electrical stimulation restores the specificity of sensory axon regeneration. Exp Neurol. 2005;194(1):221-9.
46. Geremia NM, Gordon T, Brushart TM, Al-Majed AA, Verge VM. Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression. Exp Neurol. 2007;205(2):347-59.
47. Boyd JG, Gordon T. Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Exp Neurol. 2003;183(2):610-9.
48. Boyd JG, Gordon T. Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol. 2003;27(3):277-324.
49. Sulaiman OA, Voda J, Gold BG, Gordon T. FK506 increases peripheral nerve regeneration after chronic axotomy but not after chronic Schwann cell denervation. Exp Neurol. 2002;175(1):127-37.
50. Midha R, Munro CA, Chan S, Nitising A, Xu QG, Gordon T. Regeneration into protected and chronically denervated peripheral nerve stumps. Neurosurgery. 2005;57(6):1289-99; discussion-99.
51. Walsh SK, Gordon T, Addas BM, Kemp SW, Midha R. Skin-derived precursor cells enhance peripheral nerve regeneration following chronic denervation. Exp Neurol. 2010;223(1):221-8.
52. Gordon T, Brushart TM, Amirjani N, Chan KM. The potential of electrical stimulation to promote functional recovery after peripheral nerve injury-comparisons between rats and humans. Acta Neurochir Suppl. 2007;100:3-11.
53. Gordon T, Brushart TM, Chan KM. Augmenting nerve regeneration with electrical stimulation. Neurol Res. 2008;30(10):1012-22.
54. Gordon T, Amirjani N, Edwards DC, Chan KM. Brief post-surgical electrical stimulation accelerates axon regeneration and muscle reinnervation without affecting the functional measures in carpal tunnel syndrome patients. Exp Neurol. 2010;223(1):192-202.
55. Whitlock EL, Tuffaha SH, Luciano JP, Yan Y, Hunter DA, Magill CK, Moore AM, Tong AY, Mackinnon SE, Borschel GH. Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle Nerve. 2009;39(6):787-99.
56. Maeda T, Mackinnon SE, Best TJ, Evans PJ, Hunter DA, Midha RT. Regeneration across 'stepping-stone' nerve grafts. Brain Res. 1993;618(2):196-202.
57. Hoke A, Redett R, Hameed H, Jari R, Zhou C, Li ZB, Griffin JW, Brushart TM. Schwann cells express motor and sensory phenotypes that regulate axon regeneration. J Neurosci. 2006;26(38):9646-55.
58. Williams LR, Longo FM, Powell HC, Lundborg G, Varon S. Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol. 1983;218(4):460-70.
59. Williams LR, Danielsen N, Muller H, Varon S. Exogenous matrix precursors promote functional nerve regeneration across a 15-mm gap within a silicone chamber in the rat. J Comp Neurol. 1987;264(2):284-90.
60. Varon S, Williams LR, Gage FH. Exogenous administration of neuronotrophic factors in vivo protects central nervous system neurons against axotomy induced degeneration. Prog Brain Res. 1987;71:191-201.
61. Dodla MC, Bellamkonda RV. Differences between the effect of anisotropic and isotropic laminin and nerve growth factor presenting scaffolds on nerve regeneration across long peripheral nerve gaps. Biomaterials. 2008;29(1):33-46.
62. Bellamkonda RV. Peripheral nerve regeneration: an opinion on channels, scaffolds and anisotropy. Biomaterials. 2006;27(19):3515-8.
63. Yan H, Zhang F, Chen MB, Lineaweaver WC. Chapter 10: Conduit luminal additives for peripheral nerve repair. Int Rev Neurobiol. 2009;87:199-225.
64. Dubey N, Letourneau PC, Tranquillo RT. Guided neurite elongation and Schwann cell invasion into magnetically aligned collagen in simulated peripheral nerve regeneration. Exp Neurol. 1999;158(2):338-50.
65. Rosner BI, Siegel RA, Grosberg A, Tranquillo RT. Rational design of contact guiding, neurotrophic matrices for peripheral nerve regeneration. Ann Biomed Eng. 2003;31(11):1383-401.
66. Hudson TW, Evans GR, Schmidt CE. Engineering strategies for peripheral nerve repair. Clin Plast Surg. 1999;26(4):617-28, ix.
67. de Ruiter GC, Malessy MJ, Yaszemski MJ, Windebank AJ, Spinner RJ. Designing ideal conduits for peripheral nerve repair. Neurosurg Focus. 2009;26(2):E5.
68. Kemp SW, Walsh SK, Midha R. Growth factor and stem cell enhanced conduits in peripheral nerve regeneration and repair. Neurol Res. 2008;30(10):1030-8.
69. Hall S. Nerve repair: a neurobiologist's view. J Hand Surg [Br]. 2001;26(2):129-36.
70. Vrbova G, Mehra N, Shanmuganathan H, Tyreman N, Schachner M, Gordon T. Chemical communication between regenerating motor axons and Schwann cells in the growth pathway. Eur J Neurosci. 2009;30(3):366-75.
71. Bunge RP. The role of the Schwann cell in trophic support and regeneration. J Neurol. 1994;242(1 Suppl 1):S19-21.
72. Bunge MB, Bunge RP, Kleitman N, Dean AC. Role of peripheral nerve extracellular matrix in Schwann cell function and in neurite regeneration. Dev Neurosci. 1989;11(4-5):348-60.
73. Bunge RP. Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr Opin Neurobiol. 1993;3(5):805-9.
74. Morrissey TK, Kleitman N, Bunge RP. Isolation and functional characterization of Schwann cells derived from adult peripheral nerve. J Neurosci. 1991;11(8):2433-42.
75. Giger RJ, Hollis ER, 2nd, Tuszynski MH. Guidance molecules in axon regeneration. Cold Spring Harb Perspect Biol. 2010;2(7):a001867.
76. Dickson BJ. Molecular mechanisms of axon guidance. Science. 2002;298(5600):1959-64.
77. Yu TW, Bargmann CI. Dynamic regulation of axon guidance. Nat Neurosci. 2001;4 Suppl:1169-76.
78. Franz CK, Quach ET, Krudy CA, Federici T, Kliem MA, Snyder BR, Raore B, Boulis NM. A conditioning lesion provides selective protection in a rat model of Amyotrophic Lateral Sclerosis. PLoS One. 2009;4(10):e7357.
79. O'Donnell M, Chance RK, Bashaw GJ. Axon growth and guidance: receptor regulation and signal transduction. Annu Rev Neurosci. 2009;32:383-412.
80. Willis D, Li KW, Zheng JQ, Chang JH, Smit A, Kelly T, Merianda TT, Sylvester J, van Minnen J, Twiss JL. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. J Neurosci. 2005;25(4):778-91.
81. Dahlin L, Johansson F, Lindwall C, Kanje M. Chapter 28: Future perspective in peripheral nerve reconstruction. Int Rev Neurobiol. 2009;87:507-30.
82. Nomura H, Tator CH, Shoichet MS. Bioengineered strategies for spinal cord repair. J Neurotrauma. 2006;23(3-4):496-507.
83. Willerth SM, Sakiyama-Elbert SE. Approaches to neural tissue engineering using scaffolds for drug delivery. Adv Drug Deliv Rev. 2007;59(4-5):325-38.
84. Pfister LA, Papaloizos M, Merkle HP, Gander B. Nerve conduits and growth factor delivery in peripheral nerve repair. J Peripher Nerv Syst. 2007;12(2):65-82.
85. Yu LM, Wosnick JH, Shoichet MS. Miniaturized system of neurotrophin patterning for guided regeneration. J Neurosci Methods. 2008;171(2):253-63.
86. Geuna S, Nicolino S, Raimondo S, Gambarotta G, Battiston B, Tos P, Perroteau I. Nerve regeneration along bioengineered scaffolds. Microsurgery. 2007;27(5):429-38.
87. Piotrowicz A, Shoichet MS. Nerve guidance channels as drug delivery vehicles. Biomaterials. 2005;26 (29): 5872-78.
88. Lloyd BM, Luginbuhl RD, Brenner MJ, Rocque BG, Tung TH, Myckatyn TM, Hunter DA, Mackinnon SE, Borschel GH. Use of motor nerve material in peripheral nerve repair with conduits. Microsurgery. 2007;27(2):138-45.
89. Huang JH, Cullen DK, Browne KD, Groff R, Zhang J, Pfister BJ, Zager EL, Smith DH. Longterm survival and integration of transplanted engineered nervous tissue constructs promotes peripheral nerve regeneration. Tissue Eng Part A. 2009;15(7):1677-85.
90. Pfister BJ, Bonislawski DP, Smith DH, Cohen AS. Stretch-grown axons retain the ability to transmit active electrical signals. FEBS Lett. 2006;580(14):3525-31.
91. Pfister BJ, Iwata A, Meaney DF, Smith DH. Extreme stretch growth of integrated axons. J Neurosci. 2004;24(36):7978-83.
92. Pfister BJ, Iwata A, Taylor AG, Wolf JA, Meaney DF, Smith DH. Development of transplantable nervous tissue constructs comprised of stretch-grown axons. J Neurosci Methods. 2006;153(1):95-103.
93. Lexell J, Downham D, Sjostrom M. Distribution of different fibre types in human skeletal muscles. A statistical and computational model for the study of fibre type grouping and early diagnosis of skeletal muscle fibre denervation and reinnervation. J Neurol Sci. 1983;61(3):301-14.
94. Tyler MJ, Cameron DA. Cellular pattern formation during retinal regeneration: a role for homotypic control of cell fate acquisition. Vision Res. 2007;47(4):501-11.
95. Sakumura Y, Tsukada Y, Yamamoto N, Ishii S. A molecular model for axon guidance based on cross talk between rho GTPases. Biophys J. 2005;89(2):812-22.
96. Lagerlund TD, Low PA. Mathematical modeling of time-dependent oxygen transport in rat peripheral nerve. Comput Biol Med. 1993;23(1):29-47.
97. Lagerlund TD, Low PA. Axial diffusion and Michaelis-Menten kinetics in oxygen delivery in rat peripheral nerve. Am J Physiol. 1991;260(2 Pt 2):R430-40.
98. Sharma GC, Jain M. A computational solution of mathematical model for oxygen transport in peripheral nerve. Comput Biol Med. 2004;34(7):633-45.
99. Lundborg G. Nerve injury and repair: regeneration, reconstruction, and cortical remodeling, 2nd ed. Philadelphia: Elsevier Science Health Science Div.; 2005.
100. Gordon T, Sulaiman O, Midha R. Pathophysiology of surgical nerve disorders. In: Winn HR, Youmans JR, editors. Neurological Surgery, 6th ed. Philadelphia: W.B. Saunders Company; 2010.
101. Filler AG, Kline DG. General principles in evaluating and treating peripheral nerve pathology, injuries, and entrapments and their historical content. In: Winn HR, Youmans JR, editors. Neurological Surgery, 6th ed. Philadelphia: W.B. Saunders Company; 2010.
102. Bendszus M, Stoll G. Technology insight: visualizing peripheral nerve injury using MRI. Nat Clin Pract Neurol. 2005;1(1):45-53.
103. Jambawalikar S, Baum J, Button T, Li H, Geronimo V, Gould ES. Diffusion tensor imaging of peripheral nerves. Skeletal Radiol. 2010;39(11):1073-9.
104. Khachi G, Skirgaudes M, Lee WP, Wollstein R. The clinical applications of peripheral nerve imaging in the upper extremity. J Hand Surg Am. 2007;32(10):1600-4.
105. Koltzenburg M, Bendszus M. Imaging of peripheral nerve lesions. Curr Opin Neurol. 2004;17(5):621-6.
106. Sheikh KA. Non-invasive imaging of nerve regeneration. Exp Neurol. 2010;223(1):72-6.
107. Howe FA, Filler AG, Bell BA, Griffiths JR. Magnetic resonance neurography. Magn Reson Med. 1992;28(2):328-38.
108. Takagi T, Nakamura M, Yamada M, Hikishima K, Momoshima S, Fujiyoshi K, Shibata S, Okano HJ, Toyama Y, Okano H. Visualization of peripheral nerve degeneration and regeneration: monitoring with diffusion tensor tractography. Neuroimage. 2009;44(3):884-92.
109. Huang H. Delineating neural structures of developmental human brains with diffusion tensor imaging. ScientificWorld J. 2010;10:135-44.
110. Aagaard BD, Lazar DA, Lankerovich L, Andrus K, Hayes CE, Maravilla K, Kliot M. High-resolution magnetic resonance imaging is a noninvasive method of observing injury and recovery in the peripheral nervous system. Neurosurgery. 2003;53(1):199-203; discussion-4.
111. Behr B, Schnabel R, Mirastschijski U, Ibrahim B, Angenstein F, Schneider W. Magnetic resonance imaging monitoring of peripheral nerve regeneration following neurotmesis at 4.7 Tesla. Plast Reconstr Surg. 2009;123(6):1778-88.
112. Bendszus M, Wessig C, Solymosi L, Reiners K, Koltzenburg M. MRI of peripheral nerve degeneration and regeneration: correlation with electrophysiology and histology. Exp Neurol. 2004;188(1):171-7.
113. Cudlip SA, Howe FA, Griffiths JR, Bell BA. Magnetic resonance neurography of peripheral nerve following experimental crush injury, and correlation with functional deficit. J Neurosurg. 2002;96(4):755-9.
114. Dailey AT, Tsuruda JS, Filler AG, Maravilla KR, Goodkin R, Kliot M. Magnetic resonance neurography of peripheral nerve degeneration and regeneration. Lancet. 1997;350(9086):1221-2.
115. Does MD, Snyder RE. Multiexponential T2 relaxation in degenerating peripheral nerve. Magn Reson Med. 1996;35(2):207-13.
116. Lacour-Petit MC, Lozeron P, Ducreux D. MRI of peripheral nerve lesions of the lower limbs. Neuroradiology. 2003;45(3):166-70.
117. Li X, Shen J, Chen J, Wang X, Liu Q, Liang B. Magnetic resonance imaging evaluation of acute crush injury of rabbit sciatic nerve: correlation with histology. Can Assoc Radiol J. 2008;59(3):123-30.
118. Stanisz GJ, Midha R, Munro CA, Henkelman RM. MR properties of rat sciatic nerve following trauma. Magn Reson Med. 2001;45(3):415-20.
119. Swanger RS, Maldjian C, Buckley K. MRI appearance of nerve regeneration in a surgically repaired ulnar nerve. Eur J Trauma Emerg Surg. 2010;36(1):73-5.
120. Bendszus M, Wessig C, Schutz A, Horn T, Kleinschnitz C, Sommer C, Misselwitz B, Stoll G. Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging. Ann Neurol. 2005;57(3):388-95.
121. Matsuda K, Wang HX, Suo C, McCombe D, Horne MK, Morrison WA, Egan GF. Retrograde axonal tracing using manganese enhanced magnetic resonance imaging. Neuroimage. 2010;50(2):366-74.
122. Wessig C, Bendszus M, Stoll G. In vivo visualization of focal demyelination in peripheral nerves by gadofluorine M-enhanced magnetic resonance imaging. Exp Neurol. 2007;204(1):14-9.
123. Ellegood J, McKay RT, Hanstock CC, Beaulieu C. Anisotropic diffusion of metabolites in peripheral nerve using diffusion weighted magnetic resonance spectroscopy at ultra-high field. J Magn Reson. 2007;184(1):20-8.
124. Holl N, Echaniz-Laguna A, Bierry G, Mohr M, Loeffler JP, Moser T, Dietemann JL, Kremer S. Diffusion-weighted MRI of denervated muscle: a clinical and experimental study. Skeletal Radiol. 2008;37(12):1111-7.
125. Bromberg MB. Motor unit number estimation: new techniques and new uses. Suppl Clin Neurophysiol. 2004;57:120-36.
126. Gordon T. The physiology of neural injury and regeneration: The role of neurotrophic factors. J Commun Disord. 2010;43(4):265-73.
127. Gordon T, Sulaiman O, Boyd JG. Experimental strategies to promote functional recovery after peripheral nerve injuries. J Peripher Nerv Syst. 2003;8(4):236-50.
128. Galtrey CM, Fawcett JW. Characterization of tests of functional recovery after median and ulnar nerve injury and repair in the rat forelimb. J Peripher Nerv Syst. 2007;12(1):11-27.
129. Karabeg R, Jakirlic M, Dujso V. Sensory recovery after forearm median and ulnar nerve grafting. Med Arh. 2009;63(2):97-9.
130. Ronchi G, Nicolino S, Raimondo S, Tos P, Battiston B, Papalia I, Varejão AS, Giacobini-Robecchi MG, Perroteau I, Geuna S. Functional and morphological assessment of a standardized crush injury of the rat median nerve. J Neurosci Methods. 2009;179(1):51-7.
131. Wang H, Spinner RJ, Sorenson EJ, Windebank AJ. Measurement of forelimb function by digital video motion analysis in rat nerve transection models. J Peripher Nerv Syst. 2008;13(1):92-102.
132. Sinis N, Schaller HE, Becker ST, Lanaras T, Schulte-Eversum C, Müller HW, Vonthein R, Rösner H, Haerle M. Cross-chest median nerve transfer: a new model for the evaluation of nerve regeneration across a 40 mm gap in the rat. J Neurosci Methods. 2006;156(1-2):166-72.
133. Ichihara S, Inada Y, Nakada A, Endo K, Azuma T, Nakai R, Tsutsumi S, Kurosawa H, Nakamura T. Development of new nerve guide tube for repair of long nerve defects. Tissue Eng Part C Methods. 2009;15(3):387-402.
134. Suzuki K, Kawauchi A, Nakamura T, Itoi S, Ito T, So J, Ukimura O, Hagiwara A, Yamagishi H, Miki T. Histologic and electrophysiological study of nerve regeneration using a polyglycolic acidcollagen nerve conduit filled with collagen sponge in canine model. Urology. 2009;74(4):958-63.
135. Young RC, Wiberg M, Terenghi G. Poly-3-hydroxybutyrate (PHB): a resorbable conduit for long-gap repair in peripheral nerves. Br J Plast Surg. 2002;55(3):235-40.
136. Tung WL, Zhao C, Yoshii Y, Su FC, An KN, Amadio PC. Comparative study of carpal tunnel compliance in the human, dog, rabbit, and rat. J Orthop Res. 2010;28(5):652-6.
137. Mligiliche N, Tabata Y, Endoh K, Ide C. Peripheral nerve regeneration through a long detergent-denatured muscle autografts in rabbits. Neuroreport. 2001;12(8):1719-22.
138. Archibald SJ, Krarup C, Shefner J, Li ST, Madison RD. A collagen-based nerve guide conduit for peripheral nerve repair: an electrophysiological study of nerve regeneration in rodents and nonhuman primates. J Comp Neurol. 1991;306(4):685-96.
139. Zhang P, Zhang C, Kou Y, Yin X, Zhang H, Jiang B. The histological analysis of biological conduit sleeve bridging rhesus monkey median nerve injury with small gap. Artif Cells Blood Substit Immobil Biotechnol. 2009;37(2):101-4.
140. Mackinnon SE, Dellon AL, Lundborg G, Hudson AR, Hunter DA. A study of neurotrophism in a primate model. J Hand Surg Am. 1986;11(6):888-94.
141. Krarup C, Archibald SJ, Madison RD. Factors that influence peripheral nerve regeneration: an electrophysiological study of the monkey median nerve. Ann Neurol. 2002;51(1):69-81.
142. Tos P, Ronchi G, Nicolino S, Audisio C, Raimondo S, Fornaro M, Battiston B, Graziani A, Perroteau I, Geuna S. Employment of the mouse median nerve model for the experimental assessment of peripheral nerve regeneration. J Neurosci Methods. 2008;169(1):119-27.
143. Tos P, Ronchi G, Papalia I, Sallen V, Legagneux J, Geuna S, Giacobini-Robecchi MG. Chapter 4: Methods and protocols in peripheral nerve regeneration experimental research: part I-experimental models. Int Rev Neurobiol. 2009;87:47-79.
144. Crawford AT, Desai D, Gokina P, Basak S, Kim HA. E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase a pathway. Glia. 2008;56(15):1637-47.
145. Yang DP, Zhang DP, Mak KS, Bonder DE, Pomeroy SL, Kim HA. Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Mol Cell Neurosci. 2008;38(1):80-8.
146. Tresco PA. Tissue engineering strategies for nervous system repair. Prog Brain Res. 2000;128:349-63.
147. Wen X, Tresco PA. Effect of filament diameter and extracellular matrix molecule precoating on neurite outgrowth and Schwann cell behavior on multifilament entubulation bridging device in vitro. J Biomed Mater Res A. 2006;76(3):626-37.
148. Seidlits SK, Lee JY, Schmidt CE. Nanostructured scaffolds for neural applications. Nanomedicine (London). 2008;3(2):183-99.
149. Yoo S, van Niekerk EA, Merianda TT, Twiss JL. Dynamics of axonal mRNA transport and implications for peripheral nerve regeneration. Exp Neurol. 2010;223(1):19-27.
150. Pfister BJ, Huang JH, Kameswaran N, Zager EL, Smith DH. Neural engineering to produce in vitro nerve constructs and neurointerface. Neu-rosurgery. 2007;60(1):137-41; discussion 41-2.
151. Vyas A, Li Z, Aspalter M, Feiner J, Hoke A, Zhou C, O'Daly A, Abdullah M, Rohde C, Brushart TM. An in vitro model of adult mammalian nerve repair. Exp Neurol. 2010;223(1):112-8.
152. Stecker MM, Baylor K, Stevenson M. In-vitro stability of peripheral nerve preparations: relation to ischemic responses. Brain Res. 2010;1337:1-7.
153. Yu Z, Graudejus O, Lacour SP, Wagner S, Morrison B, 3rd. Neural sensing of electrical activity with stretchable microelectrode arrays. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:4210-3.
154. Cullen DK, A RP, Doorish JF, Smith DH, Pfister BJ. Developing a tissue-engineered neuralelectrical relay using encapsulated neuronal constructs on conducting polymer fibers. J Neural Eng. 2008;5(4):374-84.
155. Ansselin AD, Fink T, Davey DF. Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells. Neuropathol Appl Neurobiol. 1997;23(5):387-98.
156. Apel PJ, Garrett JP, Sierpinski P, Ma J, Atala A, Smith TL, Koman LA, Van Dyke ME. Peripheral nerve regeneration using a keratin-based scaffold: long-term functional and histological outcomes in a mouse model. J Hand Surg Am. 2008;33(9):1541-7.
157. Arai T, Lundborg G, Dahlin LB. Bioartificial nerve graft for bridging extended nerve defects in rat sciatic nerve based on resorbable guiding filaments. Scand J Plast Reconstr Surg Hand Surg. 2000;34(2):101-8.
158. Ashley WW, Jr., Weatherly T, Park TS. Collagen nerve guides for surgical repair of brachial plexus birth injury. J Neurosurg. 2006;105(6 Suppl):452-6.
159. Barras FM, Pasche P, Bouche N, Aebischer P, Zurn AD. Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat. J Neurosci Res. 2002;70(6):746-55.
160. Borgens RB, Shi R, Bohnert D. Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol. J Exp Biol. 2002;205(Pt 1):1-12.
161. Braga-Silva J. The use of silicone tubing in the late repair of the median and ulnar nerves in the forearm. J Hand Surg Br. 1999;24(6):703-6.
162. Bunting S, Di Silvio L, Deb S, Hall S. Bioresorbable glass fibres facilitate peripheral nerve regeneration. J Hand Surg Br. 2005;30(3):242-7.
163. Cai J, Peng X, Nelson KD, Eberhart R, Smith GM. Permeable guidance channels containing microfilament scaffolds enhance axon growth and maturation. J Biomed Mater Res A. 2005;75(2):374-86.
164. Casanas J, Serra J, Orduna M, Garcia-Portabella M, Mir X. Repair of digital sensory nerves of the hand using polyglycolic acid conduits. J Hand Surg Br. 2000;25(44).
165. Ceballos D, Navarro X, Dubey N, Wendelschafer-Crabb G, Kennedy WR, Tranquillo RT. Magnetically aligned collagen gel filling a collagen nerve guide improves peripheral nerve regeneration. Exp Neurol. 1999;158(2):290-300.
166. Chang CJ, Hsu SH. The effect of high outflow permeability in asymmetric poly(DL-lactic acidco-glycolic acid) conduits for peripheral nerve regeneration. Biomaterials. 2006;27(7):1035-42.
167. Chang CJ, Hsu SH, Yen HJ, Chang H, Hsu SK. Effects of unidirectional permeability in asymmetric poly(DL-lactic acid-co-glycolic acid) conduits on peripheral nerve regeneration: an in vitro and in vivo study. J Biomed Mater Res B Appl Biomater. 2007;83(1):206-15.
168. Chen CJ, Ou YC, Liao SL, Chen WY, Chen SY, Wu CW, Wang CC, Wang WY, Huang YS, Hsu SH. Transplantation of bone marrow stromal cells for peripheral nerve repair. Exp Neurol. 2007;204(1):443-53.
169. Chen YS, Hsieh CL, Tsai CC, Chen TH, Cheng WC, Hu CL, Yao CH. Peripheral nerve regeneration using silicone rubber chambers filled with collagen, laminin and fibronectin. Biomaterials. 2000;21(15):1541-7.
170. Cheng B, Chen Z. Fabricating autologous tissue to engineer artificial nerve. Microsurgery. 2002;22(4):133-7.
171. Chew SY, Mi R, Hoke A, Leong KW. Aligned protein-polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform. Adv Funct Mater. 2007;17(8):1288-96.
172. Cui L, Jiang J, Wei L, Zhou X, Fraser JL, Snider BJ, Yu SP. Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. Stem Cells. 2008;26(5):1356-65.
173. Evans GR, Brandt K, Katz S, Chauvin P, Otto L, Bogle M, Wang B, Meszlenyi RK, Lu L, Mikos AG, Patrick CW Jr. Bioactive poly(Llactic acid) conduits seeded with Schwann cells for peripheral nerve regeneration. Biomaterials. 2002;23(3):841-8.
174. Fine EG, Decosterd I, Papaloizos M, Zurn AD, Aebischer P. GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. Eur J Neurosci. 2002;15(4):589-601.
175. Francel PC, Francel TJ, Mackinnon SE, Hertl C. Enhancing nerve regeneration across a silicone tube conduit by using interposed short-segment nerve grafts. J Neurosurg. 1997;87(6):887-92.
176. Gamez E, Goto Y, Nagata K, Iwaki T, Sasaki T, Matsuda T. Photofabricated gelatin-based nerve conduits: nerve tissue regeneration potentials. Cell Transplant. 2004;13(5):549-64.
177. Garrity R. The use of plastic and rubber tubing in the management of irreparable nerve injuries. Surg Forum. 1955;6:517-20.
178. Gilchrist T, Glasby MA, Healy DM, Kelly G, Lenihan DV, McDowall KL, Miller IA, Myles LM. In vitro nerve repair-in vivo. The reconstruction of peripheral nerves by entubulation with biodegradeable glass tubes-a preliminary report. Br J Plast Surg. 1998;51(3):231-7.
179. Guenard V, Kleitman N, Morrissey TK, Bunge RP, Aebischer P. Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. J Neurosci. 1992;12(9):3310-20.
180. Hadlock T, Sundback C, Hunter D, Cheney M, Vacanti JP. A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration. Tissue Eng. 2000;6(2):119-27.
181. Hagiwara A, Nakashima S, Itoh T, Sakakura C, Otsuji E, Yamagishi H, Okajima S, Kusuzaki K, Hase H, Kubo S, Soh J, Miki T, Toba T, Nakamura T, Shimizu Y. [Clinical application of PGA-tube for regeneration of intrapelvic nerves during extended surgery for intrapelvic recurrent rectal cancer]. Gan To Kagaku Ryoho. 2002;29(12):2202-4.
182. Hashimoto T, Suzuki Y, Kitada M, Kataoka K, Wu S, Suzuki K, Endo K, Nishimura Y, Ide C. Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Exp Brain Res. 2002;146(3):356-68.
183. He C, Chen Z. Enhancement of motor nerve regeneration by nerve growth factor. Microsurgery. 1992;13(3):151-4.
184. Hobson MI, Green CJ, Terenghi G. VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy. J Anat. 2000;197 Pt 4:591-605.
185. Hu W, Gu J, Deng A, Gu X. Polyglycolic acid filaments guide Schwann cell migration in vitro and in vivo. Biotechnol Lett. 2008;30(11):1937-42.
186. Inada Y, Morimoto S, Moroi K, Endo K, Nakamura T. Surgical relief of causalgia with an artificial nerve guide tube: Successful surgical treatment of causalgia (Complex Regional Pain Syndrome Type II) by in situ tissue engineering with a polyglycolic acid-collagen tube. Pain. 2005;117(3):251-8.
187. Itoh S, Takakuda K, Ichinose S, Kikuchi M, Schinomiya K. A study of induction of nerve regeneration using bioabsorbable tubes. J Reconstr Microsurg. 2001;17(2):115-23.
188. Jiang X, Lim SH, Mao HQ, Chew SY. Current applications and future perspectives of artificial nerve conduits. Exp Neurol. 2010;223(1):86-101.
189. Kalbermatten DF, Kingham PJ, Mahay D, Mantovani C, Pettersson J, Raffoul W, Balcin H, Pierer G, Terenghi G. Fibrin matrix for suspension of regenerative cells in an artificial nerve conduit. J Plast Reconstr Aesthet Surg. 2008;61(6):669-75.
190. Kauppila T, Jyvasjarvi E, Huopaniemi T, Hujanen E, Liesi P. A laminin graft replaces neurorrhaphy in the restorative surgery of the rat sciatic nerve. Exp Neurol. 1993;123(2):181-91.
191. Kim YT, Haftel VK, Kumar S, Bellamkonda RV. The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. Biomaterials. 2008;29(21):3117-27.
192. Lee AC, Yu VM, Lowe JB 3rd, Brenner MJ, Hunter DA, Mackinnon SE, Sakiyama-Elbert SE. Controlled release of nerve growth factor enhances sciatic nerve regeneration. Exp Neurol. 2003;184(1):295-303.
193. Li ST, Archibald SJ, Krarup C, Madison RD. Peripheral nerve repair with collagen conduits. Clin Mater. 1992;9(3-4):195-200.
194. Lohmeyer J, Zimmermann S, Sommer B, Machens HG, Lange T, Mailander P. [Bridging peripheral nerve defects by means of nerve conduits]. Chirurg. 2007;78(2):142-7.
195. Lundborg G, Dahlin L, Dohi D, Kanje M, Terada N. A new type of «bioartificial» nerve graft for bridging extended defects in nerves. J Hand Surg Br. 1997;22(3):299-303.
196. Lundborg G, Dahlin LB, Danielsen N. Ulnar nerve repair by the silicone chamber technique. Case report. Scand J Plast Reconstr Surg Hand Surg. 1991;25(1):79-82.
197. Lundborg G, Rosen B, Abrahamson SO, Dahlin L, Danielsen N. Tubular repair of the median nerve in the human forearm. Preliminary findings. J Hand Surg Br. 1994;19(3):273-6.
198. Lundborg G, Rosen B, Dahlin L, Danielsen N, Holmberg J. Tubular versus conventional repair of median and ulnar nerves in the human forearm: early results from a prospective, randomized, clinical study. J Hand Surg Am. 1997;22(1):99-106.
199. Mackinnon SE, Dellon AL. Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube. Plast Reconstr Surg. 1990;85(3):419-24.
200. Madison R, da Silva CF, Dikkes P, Chiu TH, Sidman RL. Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel. Exp Neurol. 1985;88(3):767-72.
201. Madison RD, da Silva C, Dikkes P, Sidman RL, Chiu TH. Peripheral nerve regeneration with entubulation repair: comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel. Exp Neurol. 1987;95(2):378-90.
202. Madison RD, Da Silva CF, Dikkes P. Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses. Brain Res. 1988;447(2):325-34.
203. Matsumoto K, Ohnishi K, Kiyotani T, Sekine T, Ueda H, Nakamura T, Endo K, Shimizu Y. Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves. Brain Res. 2000;868(2):315-28.
204. McKay Hart A, Wiberg M, Terenghi G. Exogenous leukaemia inhibitory factor enhances nerve regeneration after late secondary repair using a bioartificial nerve conduit. Br J Plast Surg. 2003;56(5):444-50.
205. Meek MF, Coert JH. US Food and Drug Administration/ Conformit Europe-approved absorbable nerve conduits for clinical repair of peripheral and cranial nerves. Ann Plast Surg. 2008;60(4):466-72.
206. Meek MF, Jansen K, Steendam R, van Oeveren W, van Wachem PB, van Luyn MJ. In vitro degradation and biocompatibility of poly(DLlactide-epsilon-caprolactone) nerve guides. J Biomed Mater Res A. 2004;68(1):43-51.
207. Merle M, Dellon AL, Campbell JN, Chang PS. Complications from silicon-polymer intubulation of nerves. Microsurgery. 1989;10(2):130-3.
208. Midha R, Munro CA, Dalton PD, Tator CH, Shoichet MS. Growth factor enhancement of peripheral nerve regeneration through a novel synthetic hydrogel tube. J Neurosurg. 2003;99(3):555-65.
209. Mohammad JA, Warnke PH, Pan YC, Shenaq S. Increased axonal regeneration through a biodegradable amnionic tube nerve conduit: effect of local delivery and incorporation of nerve growth factor/hyaluronic acid media. Ann Plast Surg. 2000;44(1):59-64.
210. Mohanna PN, Terenghi G, Wiberg M. Composite PHB-GGF conduit for long nerve gap repair: a long-term evaluation. Scand J Plast Reconstr Surg Hand Surg. 2005;39(3):129-37.
211. Mosahebi A, Fuller P, Wiberg M, Terenghi G. Effect of allogeneic Schwann cell transplantation on peripheral nerve regeneration. Exp Neurol. 2002;173(2):213-23.
212. Mosahebi A, Wiberg M, Terenghi G. Addition of fibronectin to alginate matrix improves peripheral nerve regeneration in tissue-engineered conduits. Tissue Eng. 2003;9(2):209-18.
213. Mosahebi A, Woodward B, Wiberg M, Martin R, Terenghi G. Retroviral labeling of Schwann cells: in vitro characterization and in vivo transplantation to improve peripheral nerve regeneration. Glia. 2001;34(1):8-17.
214. Nakayama K, Takakuda K, Koyama Y, Itoh S, Wang W, Mukai T, Shirahama N. Enhancement of peripheral nerve regeneration using bioabsorbable polymer tubes packed with fibrin gel. Artif Organs. 2007;31(7):500-8.
215. Nicoli Aldini N, Fini M, Rocca M, Giavaresi G, Giardino R. Guided regeneration with resorbable conduits in experimental peripheral nerve injuries. Int Orthop. 2000;24(3):121-5.
216. Nie X, Zhang YJ, Tian WD, Jiang M, Dong R, Chen JW, Jin Y. Improvement of peripheral nerve regeneration by a tissue-engineered nerve filled with ectomesenchymal stem cells. Int J Oral Maxillofac Surg. 2007;36(1):32-8.
217. Nilsson A, Dahlin L, Lundborg G, Kanje M. Graft repair of a peripheral nerve without the sacrifice of a healthy donor nerve by the use of acutely dissociated autologous Schwann cells. Scand J Plast Reconstr Surg Hand Surg. 2005;39(1):1-6.
218. Ohta M, Suzuki Y, Chou H, Ishikawa N, Suzuki S, Tanihara M, Suzuki Y, Mizushima Y, Dezawa M, Ide C. Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. J Biomed Mater Res A. 2004;71(4):661-8.
219. Phillips JB, Bunting SC, Hall SM, Brown RA. Neural tissue engineering: a self-organizing collagen guidance conduit. Tissue Eng. 2005;11(9-10):1611-7.
220. Pogrel MA, McDonald AR, Kaban LB. Gore-Tex tubing as a conduit for repair of lingual and inferior alveolar nerve continuity defects: a preliminary report. J Oral Maxillofac Surg. 1998;56(3):319-21; discussion 21-2.
221. Rich KM, Alexander TD, Pryor JC, Hollowell JP. Nerve growth factor enhances regeneration through silicone chambers. Exp Neurol. 1989;105(2):162-70.
222. Rodriguez FJ, Verdu E, Ceballos D, Navarro X. Nerve guides seeded with autologous schwann cells improve nerve regeneration. Exp Neurol. 2000;161(2):571-84.
223. Rosen JM, Padilla JA, Nguyen KD, Padilla MA, Sabelman EE, Pham HN. Artificial nerve graft using collagen as an extracellular matrix for nerve repair compared with sutured autograft in a rat model. Ann Plast Surg. 1990;25(5):375-87.
224. Rosen JM, Padilla JA, Nguyen KD, Siedman J, Pham HN. Artificial nerve graft using glycolide trimethylene carbonate as a nerve conduit filled with collagen compared to sutured autograft in a rat model. J Rehabil Res Dev. 1992;29(2):1-12.
225. Rutkowski GE, Miller CA, Jeftinija S, Mallapragada SK. Synergistic effects of micropatterned biodegradable conduits and Schwann cells on sciatic nerve regeneration. J Neural Eng. 2004;1(3):151-7.
226. Satou T, Nishida S, Hiruma S, Tanji K, Takahashi M, Fujita S, Mizuhara Y, Akai F, Hashimoto S. A morphological study on the effects of collagen gel matrix on regeneration of severed rat sciatic nerve in silicone tubes. Acta Pathol Jpn. 1986;36(2):199-208.
227. Seckel BR, Jones D, Hekimian KJ, Wang KK, Chakalis DP, Costas PD. Hyaluronic acid through a new injectable nerve guide delivery system enhances peripheral nerve regeneration in the rat. J Neurosci Res. 1995;40(3):318-24.
228. Sierpinski P, Garrett J, Ma J, Apel P, Klorig D, Smith T, Koman LA, Atala A, Van Dyke M. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves. Biomaterials. 2008;29(1):118-28.
229. Sinis N, Schaller HE, Schulte-Eversum C, Schlosshauer B, Doser M, Dietz K, Rösner H, Müller HW, Haerle M. Nerve regeneration across a 2-cm gap in the rat median nerve using a resorbable nerve conduit filled with Schwann cells. J Neurosurg. 2005;103(6):1067-76.
230. Stanec S, Stanec Z. Ulnar nerve reconstruction with an expanded polytetrafluoroethylene conduit. Br J Plast Surg. 1998;51(8):637-9.
231. Stanec S, Stanec Z. Reconstruction of upper-extremity peripheral-nerve injuries with ePTFE conduits. J Reconstr Microsurg. 1998;14(4):227-32.
232. Stang F, Fansa H, Wolf G, Reppin M, Keilhoff G. Structural parameters of collagen nerve grafts influence peripheral nerve regeneration. Biomaterials. 2005;26(16):3083-91.
233. Sterne GD, Brown RA, Green CJ, Terenghi G. Neurotrophin-3 delivered locally via fibronectin mats enhances peripheral nerve regeneration. Eur J Neurosci. 1997;9(7):1388-96.
234. Toba T, Nakamura T, Lynn AK, Matsumoto K, Fukuda S, Yoshitani M, Hori Y, Shimizu Y. Evaluation of peripheral nerve regeneration across an 80-mm gap using a polyglycolic acid (PGA)-collagen nerve conduit filled with laminin-soaked collagen sponge in dogs. Int J Artif Organs. 2002;25(3):230-7.
235. Toba T, Nakamura T, Shimizu Y, Matsumoto K, Ohnishi K, Fukuda S, Yoshitani M, Ueda H, Hori Y, Endo K. Regeneration of canine peroneal nerve with the use of a polyglycolic acid-collagen tube filled with laminin-soaked collagen sponge: a comparative study of collagen sponge and collagen fibers as filling materials for nerve conduits. J Biomed Mater Res. 2001;58(6):622-30.
236. Unezaki S, Yoshii S, Mabuchi T, Saito A, Ito S. Effects of neurotrophic factors on nerve regeneration monitored by in vivo imaging in thy1-YFP transgenic mice. J Neurosci Methods. 2009;178(2):308-15.
237. Varejao AS, Cabrita AM, Meek MF, Fornaro M, Geuna S. Nerve regeneration inside fresh skeletal muscle-enriched synthetic tubes: a laser confocal microscope study in the rat sciatic nerve model. Ital J Anat Embryol. 2003;108(2):77-82.
238. Verdu E, Labrador RO, Rodriguez FJ, Ceballos D, Fores J, Navarro X. Alignment of collagen and laminin-containing gels improve nerve regeneration within silicone tubes. Restor Neurol Neurosci. 2002;20(5):169-79.
239. Vleggeert-Lankamp CL, de Ruiter GC, Wolfs JF, Pego AP, van den Berg RJ, Feirabend HK, Malessy MJ, Lakke EA. Pores in synthetic nerve conduits are beneficial to regeneration. J Biomed Mater Res A. 2007;80(4):965-82.
240. Walter MA, Kurouglu R, Caulfield JB, Vasconez LO, Thompson JA. Enhanced peripheral nerve regeneration by acidic fibroblast growth factor. Lymphokine Cytokine Res. 1993;12(3):135-41.
241. Wang S, Cai Q, Hou J, Bei J, Zhang T, Yang J, Wan Y. Acceleration effect of basic fibroblast growth factor on the regeneration of peripheral nerve through a 15-mm gap. J Biomed Mater Res A. 2003;66(3):522-31.
242. Wang S, Wan AC, Xu X, Gao S, Mao HQ, Leong KW, Yu H. A new nerve guide conduit material composed of a biodegradable poly(phosphoester). Biomaterials. 2001;22(10):1157-69.
243. Weber RA, Breidenbach WC, Brown RE, Jabaley ME, Mass DP. A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr Surg. 2000;106(5):1036-45; discussion 46-8.
244. Wells MR, Kraus K, Batter DK, Blunt DG, Weremowitz J, Lynch SE, Antoniades HN, Hansson HA. Gel matrix vehicles for growth factor application in nerve gap injuries repaired with tubes: a comparison of biomatrix, collagen, and methylcellulose. Exp Neurol. 1997;146(2):395-402.
245. Whitworth IH, Brown RA, Dore C, Green CJ, Terenghi G. Orientated mats of fibronectin as a conduit material for use in peripheral nerve repair. J Hand Surg Br. 1995;20(4):429-36.
246. Williams LR. Exogenous fibrin matrix precursors stimulate the temporal progress of nerve regeneration within a silicone chamber. Neurochem Res. 1987;12(10):851-60.
247. Woerly S, Pinet E, de Robertis L, Van Diep D, Bousmina M. Spinal cord repair with PHPMA hydrogel containing RGD peptides (NeuroGel). Biomaterials. 2001;22(10):1095-111.
248. Wood MD, Moore AM, Hunter DA, Tuffaha S, Borschel GH, Mackinnon SE, Sakiyama-Elbert SE. Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration. Acta Biomater. 2009;5(4):959-68.
249. Wu F, Xing D, Peng Z, Rao T. Enhanced rat sciatic nerve regeneration through silicon tubes implanted with valproic acid. J Reconstr Microsurg. 2008;24(4):267-76.
250. Xu X, Yee WC, Hwang PY, Yu H, Wan AC, Gao S, Boon KL, Mao HQ, Leong KW, Wang S. Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. Biomaterials. 2003;24(13):2405-12.
251. Yang Y, Ding F, Wu J, Hu W, Liu W, Liu J, Gu X. Development and evaluation of silk fibroinbased nerve grafts used for peripheral nerve regeneration. Biomaterials. 2007;28(36):5526-35.
252. Yoshii S, Oka M. Peripheral nerve regeneration along collagen filaments. Brain Res. 2001;888(1):158-62.
253. Yoshii S, Oka M, Shima M, Taniguchi A, Akagi M. 30 mm regeneration of rat sciatic nerve along collagen filaments. Brain Res. 2002;949(1-2):202-8.
254. Yoshii S, Oka M, Shima M, Taniguchi A, Akagi M. Bridging a 30-mm nerve defect using collagen filaments. J Biomed Mater Res A. 2003;67(2):467-74.
255. Yu X, Bellamkonda RV. Tissue-engineered scaffolds are effective alternatives to autografts for bridging peripheral nerve gaps. Tissue Eng. 2003;9(3):421-30.
256. Yuen D, Jensen JR, Rodriguez G, and Li ST. A semipermeable, kink resistant type I collagenbased nerve guide for PNS repair. Trans Soc Biomaterials. 2003:p. 228.
257. Zhang J, Lineaweaver WC, Oswald T, Chen Z, Zhang F. Ciliary neurotrophic factor for acceleration of peripheral nerve regeneration: an experimental study. J Reconstr Microsurg. 2004;20(4):323-7.
258. Zhang P, He X, Zhao F, Zhang D, Fu Z, Jiang B. Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured schwann and bone marrow stromal cells in rats. J Reconstr Microsurg. 2005;21(8):565-71.
259. Zhang P, Xue F, Kou Y, Fu Z, Zhang D, Zhang H, Jiang B. The experimental study of absorbable chitin conduit for bridging peripheral nerve defect with nerve fasciculu in rats. Artif Cells Blood Substit Immobil Biotechnol. 2008;36(4):360-71.