A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading

Biochemistry

Volumn 48, Issue 27, 2009, Pages 6288-6290

  Wang, Meng ^a,b   Zhou, Hui ^c   Wirz, Monica ^a   Tang, Yi ^c   Boddy, Christopher N ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b SYRACUSE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSS-COUPLING; IN-VITRO; KINETIC CHARACTERIZATION; MACRO-CYCLIZATION; MACROCYCLIC; PING-PONG BI-BI MECHANISM; POLYKETIDE; POLYKETIDE SYNTHASE; SUBSTRATE SPECIFICITY; THIOESTER; THIOESTERASE; ZEARALENONE;

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY;

AMINES;

ALCOHOL DERIVATIVE; AMINE; FUNGAL ENZYME; POLYKETIDE SYNTHASE; POLYKETIDE SYNTHASE 13; RESORCINOL DERIVATIVE; THIOESTER; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG; ZEARALENONE;

ARTICLE; BIOSYNTHESIS; CHEMICAL REACTION KINETICS; CROSS COUPLING REACTION; CYCLIZATION; ENZYME MECHANISM; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROCYCLIZATION; PRIORITY JOURNAL; REACTION ANALYSIS;

BIOCATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIZATION; ESTERASES; GIBBERELLA; KINETICS; POLYKETIDE SYNTHASES; SUBSTRATE SPECIFICITY;

ZEA;

EID: 67650066485     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9009049     Document Type: Article

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