Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer

Cancer Chemotherapy and Pharmacology

Volumn 68, Issue 3, 2011, Pages 619-629

  Yu, Wei ^a   Chen, Li ^a   Yang, Yu Qing ^b   Falck, John R ^c   Guo, Austin M ^d   Li, Ying ^a   Yang, Jing ^a  

^a WUHAN UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d HENRY FORD HEALTH SYSTEM   (United States)

Author keywords

20 HETE; Angiogenesis; Cytochrome P450; Metastasis; NSCLC

Indexed keywords

20 HYDROXYEICOSA 5,14 DIENOIC ACID; 20 HYDROXYEICOSA 6,15 DIENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; ALKANE 1 MONOOXYGENASE; ARACHIDONIC ACID; CYTOCHROME P450; CYTOCHROME P450 4A11; ENZYME INHIBITOR; GELATINASE B; MATRIX METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOTROPIN B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INVASION; CANCER MODEL; CANCER SIZE; CAPILLARY DENSITY; CONTROLLED STUDY; ENZYME INDUCTION; EXPRESSION VECTOR; FATTY ACID SYNTHESIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROXYLATION; IN VIVO STUDY; LUNG METASTASIS; LUNG NON SMALL CELL CANCER; METASTASIS; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; ONCOGENE PROTEIN V-AKT; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80054697990     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-010-1521-8     Document Type: Article

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