Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis

Cancer Research

Volumn 66, Issue 6, 2006, Pages 2923-2927

  Ma, Xinrong ^a   Kundu, Namita ^a   Rifat, Salah ^a   Walser, Tonya ^a   Fulton, Amy M ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 2 (8 CHLORO 10,11 DIHYDRODIBENZ[B,F][1,4]OXAZEPINE 10 CARBONYL)HYDRAZINE; 6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; 7 [5 (4 BIPHENYLYLMETHOXY) 2 MORPHOLINO 3 OXOCYCLOPENTYL] 4 HEPTENOIC ACID; BUTAPROST; CYCLIC AMP; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; G PROTEIN COUPLED RECEPTOR; INDOMETACIN; ONO AE3 208; ONO AE3 240; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E1; PROSTAGLANDIN E2; PROSTAGLANDIN EP4 RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CHEMOTAXIS; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROSTAGLANDIN SYNTHESIS; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION;

ANIMALS; BIPHENYL COMPOUNDS; CYCLOOXYGENASE 2 INHIBITORS; FEMALE; INDOMETHACIN; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NAPHTHALENES; NEOPLASM METASTASIS; PHENYLBUTYRATES; PROTEIN ISOFORMS; RECEPTORS, PROSTAGLANDIN E;

EID: 33645527575     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4348     Document Type: Article

References (20)

1. Ristimaki A, Sivula A, Lundin M, et al. Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer. Cancer Res 2002;62:632-5.
2. Harris RE, Chlebowski RT, Jackson RD, et al. Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. Cancer Res 2003;63:6096-101.
3. Taketo MM. Cyclooxygenase-2 inhibitors in tumorigenesis (part I). J Natl Cancer Inst 1998;90: 1529-36.
4. Fulton AM, Heppner GH. Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas. Cancer Res 1985;45:4779-84.
5. Kundu N, Fulton AM. Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. Cancer Res 2002; 62:2343-6.
6. Kundu N, Walser TC, Ma X Fulton AM. Cyclooxygenase inhibitors modulate NK activities that control metastatic disease. Cancer Immunol Immunother 2005;54:981-7.
7. Wang D, Wang M, Cheng Y, Fitzgerald GA. Cardiovascular hazard and nonsteroidal anti-inflammatory drugs. Curr Opin Pharmacol 2005;2:204-10.
8. Narumiya S, Sugimoto Y, Ushikubi F. Prostanoid receptors: structures properties and functions. Physiol Rev 1999;79:1193-226.
9. 2 receptor in mammary tumor metastasis. Cancer Res 1991;51:2047-50.
10. Watanabe T, Satoh H, Togoh M, Taniguchi S, Hashimoto Y, Kurokawa K. Positive and negative regulation of cell proliferation through prostaglandin receptors in NIH-3T3 cells. J Cell Physiol 1996;69:401-9.
11. Mutoh M, Watanabe K, Kitamura T, et al. Involvement of prostaglandin E receptor subtype EP4 in colon carcinogenesis. Cancer Res 2002;62:28-32.
12. Sonoshita M, Takaku K, Sasaki N, et al. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Δ 716) knockout mice. Nat Med 2001;9:1048-51.
13. Watanabe K, Kawamori T, Nakatsugi S, et al. Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res 1999;59:5093-6.
14. Kawamori T, Uchiya N, Nakatsugi S, et al. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on breast cancer development. Carcinogenesis 2001;22:2001-4.
15. 2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. J Clin Endocrinol Metab 2003;88:2810-6.
16. 2-dependent angiogenic switch in cyclooxygenase-2-induced breast cancer progression. Proc Natl Acad Sci U S A 2004;101:591-6.
17. 2 receptor EP2 is required for cyclooxygenase-2-mediated mammary hyperplasia. Cancer Res 2005;65:4496-9.
18. 2 receptors in migration of murine and human breast cancer cells. Exp Cell Res 2003;289:265-74.
19. 2 regulates cell migration via the intracellular activation of the epidermal growth factor receptor. J Biol Chem 2003;278:35451-7.
20. Coker SJ, Parratt JR. AH23848, a thromboxane antagonist, suppresses ischaemia and reperfusion-induced arrhythmias in anaesthetized greyhounds. Br J Pharmacol 1985;86:259-64.