Bis-quaternary gemini surfactants as components of nonviral gene delivery systems: A comprehensive study from physicochemical properties to membrane interactions

International Journal of Pharmaceutics

Volumn 474, Issue 1-2, 2014, Pages 57-69

  Cardoso, Ana M ^a,b   Morais, Catarina M ^a,b   Silva, Sandra G ^c   Marques, Eduardo F ^c   De Lima, Maria C Pedroso ^a,b   Jurado, Maria Amália S ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Bis quaternary gemini surfactant; Cell membrane interactions; Complex preparation; Physico chemical characterization; Transfection efficiency

Indexed keywords

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; AMPHOPHILE; CHOLESTEROL; DIOLEOYLPHOSPHATIDYLCHOLINE; GEMINI SURFACTANT; GLYCEROPHOSPHOETHANOLAMINE; SURFACTANT; UNCLASSIFIED DRUG; DNA; LIPID;

ARTICLE; CELL VIABILITY; CHEMICAL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA VECTOR; FEMALE; GENE DELIVERY SYSTEM; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; HELA CELL LINE; HETEROZYGOTE; HUMAN; HUMAN CELL; INTERNALIZATION; LIPID BILAYER; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PINOCYTOSIS; PRIORITY JOURNAL; ZETA POTENTIAL; CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY; DEVICES; PLASMID; DIFFERENTIAL SCANNING CALORIMETRY; MOLECULAR INTERACTION;

CELL MEMBRANE; CELL SURVIVAL; CHEMISTRY, PHYSICAL; DNA; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; PLASMIDS; SURFACE-ACTIVE AGENTS;

EID: 84906267891     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.08.011     Document Type: Article

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