Evaluation of cellular uptake and intracellular trafficking as determining factors of gene expression for amino acid-substituted gemini surfactant-based DNA nanoparticles

Journal of Nanobiotechnology

Volumn 10, Issue , 2012, Pages

  Singh, Jagbir ^a   Michel, Deborah ^a   Chitanda, Jackson M ^a   Verrall, Ronald E ^a   Badea, Ildiko ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Caveolae mediated endocytosis; Cellular uptake; Clathrin mediated endocytosis; Endosomal escape; Non viral gene delivery

Indexed keywords

CAVEOLAE-MEDIATED ENDOCYTOSIS; CELLULAR UPTAKE; CLATHRIN-MEDIATED ENDOCYTOSIS; ENDOSOMAL ESCAPE; NON-VIRAL GENE DELIVERY;

AMINO ACIDS; BINDING ENERGY; CONFOCAL MICROSCOPY; GENE EXPRESSION; GENE TRANSFER; NANOCAPSULES; NANOPARTICLES; SURFACE ACTIVE AGENTS; TRANSMISSION ELECTRON MICROSCOPY;

MOLECULAR BIOLOGY;

CAVEOLIN; CLATHRIN; GENISTEIN; NANOPARTICLE; SURFACTANT; 1,25 DIHYDROXY 21 (3 HYDROXY 3 METHYLBUTYL)VITAMIN D(3); 1,25-DIHYDROXY-21-(3-HYDROXY-3-METHYLBUTYL)VITAMIN D(3); AMINO ACID; BETA CYCLODEXTRIN DERIVATIVE; CALCITRIOL; CHLORPROMAZINE; DNA; DRUG DERIVATIVE; GAMMA INTERFERON; LIPID; METHYL BETA CYCLODEXTRIN; METHYL-BETA-CYCLODEXTRIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONFOCAL LASER MICROSCOPY; DNA BINDING; ENDOSOME; GENE EXPRESSION; NONVIRAL GENE THERAPY; PARTICLE SIZE; PH; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; CAVEOLA; CELL CULTURE; CHEMISTRY; EVALUATION; GENE TRANSFER; GENETIC TRANSFECTION; GENETICS; METABOLISM; RABBIT; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACIDS; ANIMALS; BETA-CYCLODEXTRINS; BIOLOGICAL TRANSPORT; CALCITRIOL; CAVEOLAE; CELLS, CULTURED; CHLORPROMAZINE; CLATHRIN; DNA; ENDOSOMES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HYDROGEN-ION CONCENTRATION; INTERFERON-GAMMA; LIPIDS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; RABBITS; SURFACE-ACTIVE AGENTS; TRANSFECTION;

EID: 84856382927     PISSN: None     EISSN: 14773155     Source Type: Journal    
DOI: 10.1186/1477-3155-10-7     Document Type: Article

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