-
1
-
-
84890137047
-
Druggable protein-protein interactions-From hot spots to hot segments
-
London, N., Raveh, B., and Schueler-Furman, O. (2013) Druggable protein-protein interactions-From hot spots to hot segments Curr. Opin. Chem. Biol. 17, 952-959
-
(2013)
Curr. Opin. Chem. Biol.
, vol.17
, pp. 952-959
-
-
London, N.1
Raveh, B.2
Schueler-Furman, O.3
-
2
-
-
23044496736
-
Protein-protein interactions in human disease
-
Ryan, D. P. and Matthews, J. M. (2005) Protein-protein interactions in human disease Curr. Opin. Struct. Biol. 15, 441-446
-
(2005)
Curr. Opin. Struct. Biol.
, vol.15
, pp. 441-446
-
-
Ryan, D.P.1
Matthews, J.M.2
-
3
-
-
76149109071
-
Targeting protein-protein interactions for therapeutic intervention: A challenge for the future
-
Zinzalla, G. and Thurston, D. E. (2009) Targeting protein-protein interactions for therapeutic intervention: A challenge for the future Future Med. Chem. 1, 65-93
-
(2009)
Future Med. Chem.
, vol.1
, pp. 65-93
-
-
Zinzalla, G.1
Thurston, D.E.2
-
4
-
-
84875436143
-
Inhibition of α-helix-mediated protein-protein interactions using designed molecules
-
Azzarito, V., Long, K., Murphy, N. S., and Wilson, A. J. (2013) Inhibition of α-helix-mediated protein-protein interactions using designed molecules Nat. Chem. 5, 161-173
-
(2013)
Nat. Chem.
, vol.5
, pp. 161-173
-
-
Azzarito, V.1
Long, K.2
Murphy, N.S.3
Wilson, A.J.4
-
5
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin, M. R. and Wells, J. A. (2004) Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream Nat. Rev. Drug. Discovery 3, 301-317
-
(2004)
Nat. Rev. Drug. Discovery
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
6
-
-
84884603669
-
Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes
-
Cesa, L. C., Patury, S., Komiyama, T., Ahmad, A., Zuiderweg, E. R. P., and Gestwicki, J. E. (2013) Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes ACS Chem. Biol. 8, 1988-1997
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 1988-1997
-
-
Cesa, L.C.1
Patury, S.2
Komiyama, T.3
Ahmad, A.4
Zuiderweg, E.R.P.5
Gestwicki, J.E.6
-
7
-
-
84865203739
-
Fine-tuning multiprotein complexes using small molecules
-
Thompson, A. D., Dugan, A., Gestwicki, J. E., and Mapp, A. K. (2012) Fine-tuning multiprotein complexes using small molecules ACS Chem. Biol. 7, 1311-1320
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1311-1320
-
-
Thompson, A.D.1
Dugan, A.2
Gestwicki, J.E.3
Mapp, A.K.4
-
8
-
-
84879020527
-
Plucking the high hanging fruit: A systematic approach for targeting protein-protein interactions
-
Raj, M., Bullock, B. N., and Arora, P. S. (2013) Plucking the high hanging fruit: A systematic approach for targeting protein-protein interactions Bioorg. Med. Chem. 21, 4051-4057
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 4051-4057
-
-
Raj, M.1
Bullock, B.N.2
Arora, P.S.3
-
9
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells, J. A. and McClendon, C. L. (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces Nature 450, 1001-1009
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
10
-
-
84855584802
-
Stapled peptides for intracellular drug targets
-
Verdine, G. L. and Hilinski, G. J. (2012) Stapled peptides for intracellular drug targets Methods Enzymol. 503, 3-33
-
(2012)
Methods Enzymol.
, vol.503
, pp. 3-33
-
-
Verdine, G.L.1
Hilinski, G.J.2
-
11
-
-
77955369875
-
Downsizing human, bacterial, and viral proteins to short water-stable α-helices that maintain biological potency
-
Harrison, R. S., Shepherd, N. E., Hoang, H. N., Ruiz-Gomez, G., Hill, T. A., Driver, R. W., Desai, V. S., Young, P. R., Abbenante, G., and Fairlie, D. P. (2010) Downsizing human, bacterial, and viral proteins to short water-stable α-helices that maintain biological potency Proc. Natl. Acad. Sci. U.S.A. 107, 11686-11691
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 11686-11691
-
-
Harrison, R.S.1
Shepherd, N.E.2
Hoang, H.N.3
Ruiz-Gomez, G.4
Hill, T.A.5
Driver, R.W.6
Desai, V.S.7
Young, P.R.8
Abbenante, G.9
Fairlie, D.P.10
-
12
-
-
84884640689
-
Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling
-
Kushal, S., Lao, B. B., Henchey, L. K., Dubey, R., Mesallati, H., Traaseth, N. J., Olenyuk, B. Z., and Arora, P. S. (2013) Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling Proc. Natl. Acad. Sci. U.S.A. 110, 15602-15607
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 15602-15607
-
-
Kushal, S.1
Lao, B.B.2
Henchey, L.K.3
Dubey, R.4
Mesallati, H.5
Traaseth, N.J.6
Olenyuk, B.Z.7
Arora, P.S.8
-
13
-
-
84863393294
-
Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: Analogues of the Bim BH3 domain
-
Boersma, M. D., Haase, H. S., Peterson-Kaufman, K. J., Lee, E. F., Clarke, O. B., Colman, P. M., Smith, B. J., Horne, W. S., Fairlie, W. D., and Gellman, S. H. (2012) Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: Analogues of the Bim BH3 domain J. Am. Chem. Soc. 134, 315-323
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 315-323
-
-
Boersma, M.D.1
Haase, H.S.2
Peterson-Kaufman, K.J.3
Lee, E.F.4
Clarke, O.B.5
Colman, P.M.6
Smith, B.J.7
Horne, W.S.8
Fairlie, W.D.9
Gellman, S.H.10
-
14
-
-
68949119587
-
Assessment of helical interfaces in protein-protein interactions
-
Jochim, A. L. and Arora, P. S. (2009) Assessment of helical interfaces in protein-protein interactions Mol. BioSyst. 5, 924-926
-
(2009)
Mol. BioSyst.
, vol.5
, pp. 924-926
-
-
Jochim, A.L.1
Arora, P.S.2
-
15
-
-
77958105231
-
Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors
-
Jochim, A. L. and Arora, P. S. (2010) Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors ACS Chem. Biol. 5, 919-923
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 919-923
-
-
Jochim, A.L.1
Arora, P.S.2
-
16
-
-
80052566586
-
Assessing helical protein interfaces for inhibitor design
-
Bullock, B. N., Jochim, A. L., and Arora, P. S. (2011) Assessing helical protein interfaces for inhibitor design J. Am. Chem. Soc. 133, 14220-14223
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 14220-14223
-
-
Bullock, B.N.1
Jochim, A.L.2
Arora, P.S.3
-
17
-
-
84885995896
-
HippDB: A database of readily targeted helical protein-protein interactions
-
Bergey, C. M., Watkins, A. M., and Arora, P. S. (2013) HippDB: A database of readily targeted helical protein-protein interactions Bioinformatics 29, 2806-2807
-
(2013)
Bioinformatics
, vol.29
, pp. 2806-2807
-
-
Bergey, C.M.1
Watkins, A.M.2
Arora, P.S.3
-
18
-
-
0028916599
-
A hot-spot of binding-energy in a hormone-receptor interface
-
Clackson, T. and Wells, J. A. (1995) A hot-spot of binding-energy in a hormone-receptor interface Science 267, 383-386
-
(1995)
Science
, vol.267
, pp. 383-386
-
-
Clackson, T.1
Wells, J.A.2
-
19
-
-
0024403619
-
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis
-
Cunningham, B. C. and Wells, J. A. (1989) High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis Science 244, 1081-1085
-
(1989)
Science
, vol.244
, pp. 1081-1085
-
-
Cunningham, B.C.1
Wells, J.A.2
-
20
-
-
3242879771
-
Computational alanine scanning of protein-protein interfaces
-
Kortemme, T., Kim, D. E., and Baker, D. (2004) Computational alanine scanning of protein-protein interfaces Sci. STKE 2004, pl2
-
(2004)
Sci. STKE
, vol.2004
, pp. 2
-
-
Kortemme, T.1
Kim, D.E.2
Baker, D.3
-
21
-
-
8844277625
-
ICBS: A database of interactions between protein chains mediated by β-sheet formation
-
Dou, Y., Baisnee, P. F., Pollastri, G., Pecout, Y., Nowick, J., and Baldi, P. (2004) ICBS: A database of interactions between protein chains mediated by β-sheet formation Bioinformatics 20, 2767-2777
-
(2004)
Bioinformatics
, vol.20
, pp. 2767-2777
-
-
Dou, Y.1
Baisnee, P.F.2
Pollastri, G.3
Pecout, Y.4
Nowick, J.5
Baldi, P.6
-
22
-
-
84876492200
-
The supramolecular chemistry of β-sheets
-
Cheng, P. N., Pham, J. D., and Nowick, J. S. (2013) The supramolecular chemistry of β-sheets J. Am. Chem. Soc. 135, 5477-5492
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 5477-5492
-
-
Cheng, P.N.1
Pham, J.D.2
Nowick, J.S.3
-
23
-
-
17244364283
-
Proteases universally recognize β-strands in their active sites
-
Tyndall, J. D., Nall, T., and Fairlie, D. P. (2005) Proteases universally recognize β-strands in their active sites Chem. Rev. 105, 973-999
-
(2005)
Chem. Rev.
, vol.105
, pp. 973-999
-
-
Tyndall, J.D.1
Nall, T.2
Fairlie, D.P.3
-
24
-
-
11144306533
-
β-Strand mimetics
-
Loughlin, W. A., Tyndall, J. D. A., Glenn, M. P., and Fairlie, D. P. (2004) β-Strand mimetics Chem. Rev. 104, 6085-6117
-
(2004)
Chem. Rev.
, vol.104
, pp. 6085-6117
-
-
Loughlin, W.A.1
Tyndall, J.D.A.2
Glenn, M.P.3
Fairlie, D.P.4
-
26
-
-
38949203748
-
Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance
-
Ghosh, A. K., Chapsal, B. D., Weber, I. T., and Mitsuya, H. (2007) Design of HIV protease inhibitors targeting protein backbone: An effective strategy for combating drug resistance Acc. Chem. Res. 41, 78-86
-
(2007)
Acc. Chem. Res.
, vol.41
, pp. 78-86
-
-
Ghosh, A.K.1
Chapsal, B.D.2
Weber, I.T.3
Mitsuya, H.4
-
27
-
-
0028882977
-
Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport
-
Smith, A. B., Hirschmann, R., Pasternak, A., Guzman, M. C., Yokoyama, A., Sprengeler, P. A., Darke, P. L., Emini, E. A., and Schleif, W. A. (1995) Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport J. Am. Chem. Soc. 117, 11113-11123
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 11113-11123
-
-
Smith, A.B.1
Hirschmann, R.2
Pasternak, A.3
Guzman, M.C.4
Yokoyama, A.5
Sprengeler, P.A.6
Darke, P.L.7
Emini, E.A.8
Schleif, W.A.9
-
28
-
-
84867878408
-
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
-
Cheng, P.-N., Liu, C., Zhao, M., Eisenberg, D., and Nowick, J. S. (2012) Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity Nat. Chem. 4, 927-933
-
(2012)
Nat. Chem.
, vol.4
, pp. 927-933
-
-
Cheng, P.-N.1
Liu, C.2
Zhao, M.3
Eisenberg, D.4
Nowick, J.S.5
-
29
-
-
84869233037
-
Toward a Hepatitis C Virus Vaccine: The Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody
-
Potter, J. A., Owsianka, A. M., Jeffery, N., Matthews, D. J., Keck, Z.-Y., Lau, P., Foung, S. K. H., Taylor, G. L., and Patel, A. H. (2012) Toward a Hepatitis C Virus Vaccine: the Structural Basis of Hepatitis C Virus Neutralization by AP33, a Broadly Neutralizing Antibody J. Virol. 86, 12923-12932
-
(2012)
J. Virol.
, vol.86
, pp. 12923-12932
-
-
Potter, J.A.1
Owsianka, A.M.2
Jeffery, N.3
Matthews, D.J.4
Keck, Z.-Y.5
Lau, P.6
Foung, S.K.H.7
Taylor, G.L.8
Patel, A.H.9
-
30
-
-
1842605531
-
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
-
Franklin, M. C., Carey, K. D., Vajdos, F. F., Leahy, D. J., de Vos, A. M., and Sliwkowski, M. X. (2004) Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex Cancer Cell 5, 317-328
-
(2004)
Cancer Cell
, vol.5
, pp. 317-328
-
-
Franklin, M.C.1
Carey, K.D.2
Vajdos, F.F.3
Leahy, D.J.4
De Vos, A.M.5
Sliwkowski, M.X.6
-
31
-
-
17444403242
-
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
-
Li, S., Schmitz, K. R., Jeffrey, P. D., Wiltzius, J. J. W., Kussie, P., and Ferguson, K. M. (2005) Structural basis for inhibition of the epidermal growth factor receptor by cetuximab Cancer Cell 7, 301-311
-
(2005)
Cancer Cell
, vol.7
, pp. 301-311
-
-
Li, S.1
Schmitz, K.R.2
Jeffrey, P.D.3
Wiltzius, J.J.W.4
Kussie, P.5
Ferguson, K.M.6
-
32
-
-
0035939298
-
Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor
-
Gao, Y., Voigt, J., Wu, J. X., Yang, D. J., and Burke, T. R. (2001) Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor Bioorg. Med. Chem. Lett. 11, 1889-1892
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 1889-1892
-
-
Gao, Y.1
Voigt, J.2
Wu, J.X.3
Yang, D.J.4
Burke, T.R.5
-
33
-
-
25144517155
-
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
-
Phan, J., Shi, Z. D., Burke, T. R., Jr., and Waugh, D. S. (2005) Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain J. Mol. Biol. 353, 104-115
-
(2005)
J. Mol. Biol.
, vol.353
, pp. 104-115
-
-
Phan, J.1
Shi, Z.D.2
Burke Jr., T.R.3
Waugh, D.S.4
-
34
-
-
84555190565
-
Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library
-
Yamagishi, Y., Shoji, I., Miyagawa, S., Kawakami, T., Katoh, T., Goto, Y., and Suga, H. (2011) Natural product-like macrocyclic N-methyl-peptide inhibitors against a ubiquitin ligase uncovered from a ribosome-expressed de novo library Chem. Biol. 18, 1562-1570
-
(2011)
Chem. Biol.
, vol.18
, pp. 1562-1570
-
-
Yamagishi, Y.1
Shoji, I.2
Miyagawa, S.3
Kawakami, T.4
Katoh, T.5
Goto, Y.6
Suga, H.7
-
35
-
-
0021779081
-
Turns in peptides and proteins
-
in (Anfinsen, C.B. Edsall, J. T. and Frederic, M. R. Eds.), pp, Academic Press, New York.
-
Rose, G. D., Glerasch, L. M., and Smith, J. A. (1985) Turns in peptides and proteins, in Advances in Protein Chemistry (Anfinsen, C.B., Edsall, J. T., and Frederic, M. R., Eds.), pp 1-109, Academic Press, New York.
-
(1985)
Advances in Protein Chemistry
, pp. 1-109
-
-
Rose, G.D.1
Glerasch, L.M.2
Smith, J.A.3
-
36
-
-
67650522906
-
Macrocyclic design strategies for small, stable, parallel β-sheet scaffolds
-
Freire, F. and Gellman, S. H. (2009) Macrocyclic design strategies for small, stable, parallel β-sheet scaffolds J. Am. Chem. Soc. 131, 7970-7972
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 7970-7972
-
-
Freire, F.1
Gellman, S.H.2
-
37
-
-
0001561813
-
Rules for antiparallel β-sheet design: D -Pro-Gly is superior to l -Asn-Gly for β-hairpin nucleation
-
Stanger, H. E. and Gellman, S. H. (1998) Rules for antiparallel β-sheet design: d -Pro-Gly is superior to l -Asn-Gly for β-hairpin nucleation J. Am. Chem. Soc. 120, 4236-4237
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 4236-4237
-
-
Stanger, H.E.1
Gellman, S.H.2
-
38
-
-
57349151828
-
β-Hairpin peptidomimetics: Design, structures, and biological activities
-
Robinson, J. A. (2008) β-Hairpin peptidomimetics: Design, structures, and biological activities Acc. Chem. Res. 41, 1278-1288
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 1278-1288
-
-
Robinson, J.A.1
-
39
-
-
0027987391
-
De-novo design, synthesis, and X-ray crystal-structures of pyrrolinone-based β-strand peptidomimetics
-
Smith, A. B., Guzman, M. C., Sprengeler, P. A., Keenan, T. P., Holcomb, R. C., Wood, J. L., Carroll, P. J., and Hirschmann, R. (1994) De-novo design, synthesis, and X-ray crystal-structures of pyrrolinone-based β-strand peptidomimetics J. Am. Chem. Soc. 116, 9947-9962
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 9947-9962
-
-
Smith, A.B.1
Guzman, M.C.2
Sprengeler, P.A.3
Keenan, T.P.4
Holcomb, R.C.5
Wood, J.L.6
Carroll, P.J.7
Hirschmann, R.8
-
40
-
-
0037045238
-
″@-tides″: The 1,2-dihydro-3(6H)-pyridinone unit as a β-strand mimic
-
Phillips, S. T., Rezac, M., Abel, U., Kossenjans, M., and Bartlett, P. A. (2002) ″@-tides″: The 1,2-dihydro-3(6H)-pyridinone unit as a β-strand mimic J. Am. Chem. Soc. 124, 58-66
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 58-66
-
-
Phillips, S.T.1
Rezac, M.2
Abel, U.3
Kossenjans, M.4
Bartlett, P.A.5
-
41
-
-
67949112621
-
Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended β-strand mimetics
-
Wyrembak, P. N. and Hamilton, A. D. (2009) Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended β-strand mimetics J. Am. Chem. Soc. 131, 4566-4567
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 4566-4567
-
-
Wyrembak, P.N.1
Hamilton, A.D.2
-
42
-
-
29044447377
-
Nonpeptidic foldamers from amino acids: Synthesis and characterization of 1,3-substituted triazole oligomers
-
Angelo, N. G. and Arora, P. S. (2005) Nonpeptidic foldamers from amino acids: Synthesis and characterization of 1,3-substituted triazole oligomers J. Am. Chem. Soc. 127, 17134-17135
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 17134-17135
-
-
Angelo, N.G.1
Arora, P.S.2
-
43
-
-
84897390934
-
Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation
-
Lingard, H., Han, J. T., Thompson, A. L., Leung, I. K. H., Scott, R. T. W., Thompson, S., and Hamilton, A. D. (2014) Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation Angew. Chem., Int. Ed. 53, 3650-3653
-
(2014)
Angew. Chem., Int. Ed.
, vol.53
, pp. 3650-3653
-
-
Lingard, H.1
Han, J.T.2
Thompson, A.L.3
Leung, I.K.H.4
Scott, R.T.W.5
Thompson, S.6
Hamilton, A.D.7
-
44
-
-
67650468079
-
Evaluating β-turn mimics as β-sheet folding nucleators
-
Fuller, A. A., Du, D., Liu, F., Davoren, J. E., Bhabha, G., Kroon, G., Case, D. A., Dyson, H. J., Powers, E. T., Wipf, P., Gruebele, M., and Kelly, J. W. (2009) Evaluating β-turn mimics as β-sheet folding nucleators Proc. Natl. Acad. Sci. U.S.A. 106, 11067-11072
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 11067-11072
-
-
Fuller, A.A.1
Du, D.2
Liu, F.3
Davoren, J.E.4
Bhabha, G.5
Kroon, G.6
Case, D.A.7
Dyson, H.J.8
Powers, E.T.9
Wipf, P.10
Gruebele, M.11
Kelly, J.W.12
-
45
-
-
84871568871
-
Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics
-
Kang, C. W., Sun, Y., and Del Valle, J. R. (2012) Substituted imidazo[1,2-a]pyridines as β-strand peptidomimetics Org. Lett. 14, 6162-6165
-
(2012)
Org. Lett.
, vol.14
, pp. 6162-6165
-
-
Kang, C.W.1
Sun, Y.2
Del Valle, J.R.3
-
46
-
-
33845499030
-
β-Strand peptidomimetics as potent PDZ domain ligands
-
Hammond, M. C., Harris, B. Z., Lim, W. A., and Bartlett, P. A. (2006) β-Strand peptidomimetics as potent PDZ domain ligands Chem. Biol. 13, 1247-1251
-
(2006)
Chem. Biol.
, vol.13
, pp. 1247-1251
-
-
Hammond, M.C.1
Harris, B.Z.2
Lim, W.A.3
Bartlett, P.A.4
-
47
-
-
4544342753
-
Using a β-hairpin to mimic an α-helix: Cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction
-
Fasan, R., Dias, R. L., Moehle, K., Zerbe, O., Vrijbloed, J. W., Obrecht, D., and Robinson, J. A. (2004) Using a β-hairpin to mimic an α-helix: Cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction Angew. Chem., Int. Ed. Engl. 43, 2109-2112
-
(2004)
Angew. Chem., Int. Ed. Engl.
, vol.43
, pp. 2109-2112
-
-
Fasan, R.1
Dias, R.L.2
Moehle, K.3
Zerbe, O.4
Vrijbloed, J.W.5
Obrecht, D.6
Robinson, J.A.7
-
48
-
-
84899953412
-
Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions
-
Huang, Z., Zhang, M., Burton, S. D., Katsakhyan, L. N., and Ji, H. (2014) Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions ACS Chem. Biol. 9, 193-201
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 193-201
-
-
Huang, Z.1
Zhang, M.2
Burton, S.D.3
Katsakhyan, L.N.4
Ji, H.5
-
49
-
-
0030969462
-
Targeting the dimerization interface of HIV-1 protease: Inhibition with cross-linked interfacial peptides
-
Zutshi, R., Franciskovich, J., Shultz, M., Schweitzer, B., Bishop, P., Wilson, M., and Chmielewski, J. (1997) Targeting the dimerization interface of HIV-1 protease: Inhibition with cross-linked interfacial peptides J. Am. Chem. Soc. 119, 4841-4845
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 4841-4845
-
-
Zutshi, R.1
Franciskovich, J.2
Shultz, M.3
Schweitzer, B.4
Bishop, P.5
Wilson, M.6
Chmielewski, J.7
-
50
-
-
0015222647
-
Interpretation of protein structures-Estimation of static accessibility
-
Lee, B. and Richards, F. M. (1971) Interpretation of protein structures-Estimation of static accessibility J. Mol. Biol. 55, 379-400
-
(1971)
J. Mol. Biol.
, vol.55
, pp. 379-400
-
-
Lee, B.1
Richards, F.M.2
-
51
-
-
0003187567
-
The atomic structure of protein-protein recognition sites
-
Lo Conte, L., Chothia, C., and Janin, J. (1999) The atomic structure of protein-protein recognition sites J. Mol. Biol. 285, 2177-2198
-
(1999)
J. Mol. Biol.
, vol.285
, pp. 2177-2198
-
-
Lo Conte, L.1
Chothia, C.2
Janin, J.3
-
52
-
-
31344434387
-
Assessing methods for identifying pair-wise atomic contacts across binding interfaces
-
Fischer, T. B., Holmes, J. B., Miller, I. R., Parsons, J. R., Tung, L., Hu, J. C., and Tsai, J. (2006) Assessing methods for identifying pair-wise atomic contacts across binding interfaces J. Struct. Biol. 153, 103-112
-
(2006)
J. Struct. Biol.
, vol.153
, pp. 103-112
-
-
Fischer, T.B.1
Holmes, J.B.2
Miller, I.R.3
Parsons, J.R.4
Tung, L.5
Hu, J.C.6
Tsai, J.7
-
53
-
-
0032479179
-
Anatomy of hot spots in protein interfaces
-
Bogan, A. A. and Thorn, K. S. (1998) Anatomy of hot spots in protein interfaces J. Mol. Biol. 280, 1-9
-
(1998)
J. Mol. Biol.
, vol.280
, pp. 1-9
-
-
Bogan, A.A.1
Thorn, K.S.2
-
54
-
-
84864133078
-
Small-molecule inhibitor starting points learned from protein-protein interaction inhibitor structure
-
Koes, D. R. and Camacho, C. J. (2012) Small-molecule inhibitor starting points learned from protein-protein interaction inhibitor structure Bioinformatics 28, 784-791
-
(2012)
Bioinformatics
, vol.28
, pp. 784-791
-
-
Koes, D.R.1
Camacho, C.J.2
-
55
-
-
0033954256
-
The Protein Data Bank
-
Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., and Bourne, P. E. (2000) The Protein Data Bank Nucleic Acids Res. 28, 235-242
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
Weissig, H.6
Shindyalov, I.N.7
Bourne, P.E.8
-
56
-
-
79959615159
-
RosettaScripts: A scripting language interface to the Rosetta macromolecular modeling suite
-
Fleishman, S. J., Leaver-Fay, A., Corn, J. E., Strauch, E. M., Khare, S. D., Koga, N., Ashworth, J., Murphy, P., Richter, F., Lemmon, G., Meiler, J., and Baker, D. (2011) RosettaScripts: A scripting language interface to the Rosetta macromolecular modeling suite PLoS One 6, e20161
-
(2011)
PLoS One
, vol.6
, pp. 20161
-
-
Fleishman, S.J.1
Leaver-Fay, A.2
Corn, J.E.3
Strauch, E.M.4
Khare, S.D.5
Koga, N.6
Ashworth, J.7
Murphy, P.8
Richter, F.9
Lemmon, G.10
Meiler, J.11
Baker, D.12
-
57
-
-
0004014257
-
-
Department of Biochemistry and Molecular Biology, University College, London.
-
Hubbard, S. J. and Thornton, J. M. (1993) NACCESS; Department of Biochemistry and Molecular Biology, University College, London.
-
(1993)
NACCESS
-
-
Hubbard, S.J.1
Thornton, J.M.2
-
58
-
-
0020997912
-
Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
-
Kabsch, W. and Sander, C. (1983) Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features Biopolymers 22, 2577-2637
-
(1983)
Biopolymers
, vol.22
, pp. 2577-2637
-
-
Kabsch, W.1
Sander, C.2
-
59
-
-
84899680229
-
Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations
-
Pedersen, S. W., Pedersen, S. B., Anker, L., Hultqvist, G., Kristensen, A. S., Jemth, P., and Stromgaard, K. (2014) Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations Nat. Commun. 5, 3215
-
(2014)
Nat. Commun.
, vol.5
, pp. 3215
-
-
Pedersen, S.W.1
Pedersen, S.B.2
Anker, L.3
Hultqvist, G.4
Kristensen, A.S.5
Jemth, P.6
Stromgaard, K.7
-
60
-
-
0028792105
-
Guidelines for protein design-The Energetics of β-sheet side-chain interactions
-
Smith, C. K. and Regan, L. (1995) Guidelines for protein design-The Energetics of β-sheet side-chain interactions Science 270, 980-982
-
(1995)
Science
, vol.270
, pp. 980-982
-
-
Smith, C.K.1
Regan, L.2
-
61
-
-
0030920194
-
Electrostatic interactions across a β-sheet
-
Blasie, C. A. and Berg, J. M. (1997) Electrostatic interactions across a β-sheet Biochemistry 36, 6218-6222
-
(1997)
Biochemistry
, vol.36
, pp. 6218-6222
-
-
Blasie, C.A.1
Berg, J.M.2
-
62
-
-
33947204210
-
-
5 th ed. W.H. Freeman, New York.
-
Nelson, D. L., Lehninger, A. L., and Cox, M. M. (2008) Principles of Biochemistry, 5 th ed., W.H. Freeman, New York.
-
(2008)
Principles of Biochemistry
-
-
Nelson, D.L.1
Lehninger, A.L.2
Cox, M.M.3
-
63
-
-
0029109468
-
Protein-protein interactions-A review of protein dimer structures
-
Jones, S. and Thornton, J. M. (1995) Protein-protein interactions-A review of protein dimer structures Prog. Biophys. Mol. Biol. 63, 31-65
-
(1995)
Prog. Biophys. Mol. Biol.
, vol.63
, pp. 31-65
-
-
Jones, S.1
Thornton, J.M.2
-
64
-
-
34548141882
-
Secondary structure based analysis and classification of biological interfaces: Identification of binding motifs in protein-protein interactions
-
Guharoy, M. and Chakrabarti, P. (2007) Secondary structure based analysis and classification of biological interfaces: Identification of binding motifs in protein-protein interactions Bioinformatics 23, 1909-1918
-
(2007)
Bioinformatics
, vol.23
, pp. 1909-1918
-
-
Guharoy, M.1
Chakrabarti, P.2
-
65
-
-
84868204295
-
Sequence criteria for the anti-parallel character of protein β-strands
-
Caudron, B. and Jestin, J. L. (2012) Sequence criteria for the anti-parallel character of protein β-strands J. Theor. Biol. 315, 146-149
-
(2012)
J. Theor. Biol.
, vol.315
, pp. 146-149
-
-
Caudron, B.1
Jestin, J.L.2
-
66
-
-
0037181045
-
A theoretical study of β-sheet models: Is the formation of hydrogen-bond networks cooperative?
-
Zhao, Y. L. and Wu, Y. D. (2002) A theoretical study of β-sheet models: Is the formation of hydrogen-bond networks cooperative? J. Am. Chem. Soc. 124, 1570-1571
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 1570-1571
-
-
Zhao, Y.L.1
Wu, Y.D.2
-
67
-
-
36048964831
-
Accurate ab initio study on the hydrogen-bond pairs in protein secondary structures
-
Wang, Z. X., Wu, C., Lei, H. X., and Duan, Y. (2007) Accurate ab initio study on the hydrogen-bond pairs in protein secondary structures J. Chem. Theory Comput. 3, 1527-1537
-
(2007)
J. Chem. Theory Comput.
, vol.3
, pp. 1527-1537
-
-
Wang, Z.X.1
Wu, C.2
Lei, H.X.3
Duan, Y.4
|