HLA class II molecules influence susceptibility versus protection in inflammatory diseases by determining the cytokine profile

Journal of Immunology

Volumn 190, Issue 2, 2013, Pages 513-518

  Mangalam, Ashutosh K ^a   Taneja, Veena ^a   David, Chella S ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DQ2 ANTIGEN; HLA DQ6 ANTIGEN; HLA DQ8 ANTIGEN; HLA DR2 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; HLA DRB1 ANTIGEN; UNCLASSIFIED DRUG;

ALLELE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE RELEASE; DISEASE EXACERBATION; DISEASE PREDISPOSITION; EPITOPE MAPPING; HAPLOTYPE; HLA SYSTEM; HUMAN; IMMUNOREGULATION; INFECTION SENSITIVITY; INFLAMMATORY DISEASE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PATHOGEN CLEARANCE; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY; T LYMPHOCYTE ACTIVATION;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE SUSCEPTIBILITY; HAPLOTYPES; HLA-D ANTIGENS; HUMANS; T-LYMPHOCYTE SUBSETS;

EID: 84872177374     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201891     Document Type: Short Survey

References (47)

1. Finch, C. E. 2010. Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc. Natl. Acad. Sci. USA 107(Suppl. 1): 1718-1724.
2. Janeway, C. A., P. Travers, M. Walport, and M. Shlomchik. 2002. Immunobiology. Garland Science, New York.
3. Klein, J. 1986. Natural History of the Major Histocompatibility Complex. John Wiley & Sons, New York.
4. Piertney, S. B., and M. K. Oliver. 2006. The evolutionary ecology of the major histocompatibility complex. Heredity (Edinb) 96: 7-21.
5. Trowsdale, J. 2011. The MHC, disease and selection. Immunol. Lett. 137: 1-8.
6. Yeager, M., and A. L. Hughes. 1999. Evolution of the mammalian MHC: natural selection, recombination, and convergent evolution. Immunol. Rev. 167: 45-58.
7. Moore, C. B., M. John, I. R. James, F. T. Christiansen, C. S.Witt, and S. A. Mallal. 2002. Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level. Science 296: 1439-1443.
8. Wills, C., and D. R. Green. 1995. A genetic herd-immunity model for the maintenance of MHC polymorphism. Immunol. Rev. 143: 263-292.
9. Stern, L. J., J. H. Brown, T. S. Jardetzky, J. C. Gorga, R. G. Urban, J. L. Strominger, and D. C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368: 215-221.
10. Apanius, V., D. Penn, P. R. Slev, L. R. Ruff, and W. K. Potts. 1997. The nature of selection on the major histocompatibility complex. Crit. Rev. Immunol. 17: 179-224.
11. Oliver, M. K., and S. B. Piertney. 2012. Selection maintains MHC diversity through a natural population bottleneck. Mol. Biol. Evol. 29: 1713-1720.
12. Abraham, R. S., L. Wen, E. V. Marietta, and C. S. David. 2001. Type 1 diabetes-predisposing MHC alleles influence the selection of glutamic acid decarboxylase (GAD) 65-specific T cells in a transgenic model. J. Immunol. 166: 1370-1379.
13. Olerup, O., M. Troye-Blomberg, G. M. Schreuder, and E. M. Riley. 1991. HLA-DR and -DQ gene polymorphism in West Africans is twice as extensive as in north European Caucasians: evolutionary implications. Proc. Natl. Acad. Sci. USA 88: 8480-8484.
14. Lawrence, D. N., J. G. Bodmer, and W. F. Bodmer. 1980. Distribution of HLA antigens in Ticuna Indians of Brazil: results of typing a leprosy-affected family. Tissue Antigens 16: 152-160.
15. Yan, Z. H., Y. Fan, X. H. Wang, Q. Mao, G. H. Deng, and Y. M. Wang. 2012. Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections: a meta-analysis. World J. Gastroenterol. 18: 3119-3128.
16. Chadwick, D., and G. Cardew. 1996. Variation in the Human Genome. Wiley, New York.
17. Tsuji, K., M. Aizawa, and T. Sasazuki. 1992. HLA 1991: Proceedings of the Eleventh International Histocompatbility Workshop and Conference. Oxford University Press, Oxford, U.K.
18. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
19. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17: 138-146.
20. + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22: 531-562.
21. Korn, T., E. Bettelli, M. Oukka, and V. K. Kuchroo. 2009. IL-17 and Th17 cells. Annu. Rev. Immunol. 27: 485-517.
22. Akdis, M. 2010. The cellular orchestra in skin allergy; are differences to lung and nose relevant? Curr. Opin. Allergy Clin. Immunol. 10: 443-451.
23. Billiau, A., and P. Matthys. 2009. Interferon-γ: a historical perspective. Cytokine Growth Factor Rev. 20: 97-113.
24. Alexander, J., A. R. Satoskar, and D. G. Russell. 1999. Leishmania species: models of intracellular parasitism. J. Cell Sci. 112: 2993-3002.
25. Curtis, M. M., and S. S. Way. 2009. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 126: 177-185.
26. Pappu, R., V. Ramirez-Carrozzi, and A. Sambandam. 2011. The interleukin-17 cytokine family: critical players in host defence and inflammatory diseases. Immunology 134: 8-16.
27. Mitsdoerffer, M., Y. Lee, A. Jäger, H. J. Kim, T. Korn, J. K. Kolls, H. Cantor, E. Bettelli, and V. K. Kuchroo. 2010. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc. Natl. Acad. Sci. USA 107: 14292-14297.
28. Novelli, F., and J. L. Casanova. 2004. The role of IL-12, IL-23 and IFN-γ in immunity to viruses. Cytokine Growth Factor Rev. 15: 367-377.
29. Huang, W., L. Na, P. L. Fidel, and P. Schwarzenberger. 2004. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J. Infect. Dis. 190: 624-631.
30. Ishigame, H., S. Kakuta, T. Nagai, M. Kadoki, A. Nambu, Y. Komiyama, N. Fujikado, Y. Tanahashi, A. Akitsu, H. Kotaki, et al. 2009. Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 30: 108-119.
31. Mangalam, A. K., G. Rajagopalan, V. Taneja, and C. S. David. 2008. HLA class II transgenic mice mimic human inflammatory diseases. Adv. Immunol. 97: 65-147.
32. Taneja, V., and C. S. David. 1999. HLA class II transgenic mice as models of human diseases. Immunol. Rev. 169: 67-79.
33. Lee, K. H., K. W. Wucherpfennig, and D. C. Wiley. 2001. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2: 501-507.
34. Hovhannisyan, Z., A. Weiss, A. Martin, M. Wiesner, S. Tollefsen, K. Yoshida, C. Ciszewski, S. A. Curran, J. A. Murray, C. S. David, et al. 2008. The role of HLA-DQ8 β57 polymorphism in the anti-gluten T-cell response in coeliac disease. Nature 456: 534-538.
35. Feitsma, A. L., A. H. van der Helm-van Mil, T. W. Huizinga, R. R. de Vries, and R. E. Toes. 2008. Protection against rheumatoid arthritis by HLA: nature and nurture. Ann. Rheum. Dis. 67(Suppl. 3): iii61-iii63.
36. Mangalam, A., D. Luckey, E. Basal, M. Behrens, M. Rodriguez, and C. David. 2008. HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-γ. J. Immunol. 180: 7747-7756.
37. Gourraud, P. A., H. F. Harbo, S. L. Hauser, and S. E. Baranzini. 2012. The genetics of multiple sclerosis: an up-to-date review. Immunol. Rev. 248: 87-103.
38. Rodriguez, M., L. J. Zoecklein, C. L. Howe, K. D. Pavelko, J. D. Gamez, S. Nakane, and L. M. Papke. 2003. Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection. J. Virol. 77: 12252-12265.
39. Weaver, C. T., L. E. Harrington, P. R. Mangan, M. Gavrieli, and K. M. Murphy. 2006. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688.
40. Pierson, E., S. B. Simmons, L. Castelli, and J. M. Goverman. 2012. Mechanisms regulating regional localization of inflammation during CNS autoimmunity. Immunol. Rev. 248: 205-215.
41. Kaushansky, N., D. M. Altmann, S. Ascough, C. S. David, H. Lassmann, and A. Ben-Nun. 2009. HLA-DQB1*0602 determines disease susceptibility in a new "humanized" multiple sclerosis model in HLA-DR15 (DRB1*1501; DQB1*0602) transgenic mice. J. Immunol. 183: 3531-3541.
42. Kaushansky, N., D. M. Altmann, C. S. David, H. Lassmann, and A. Ben-Nun. 2012. DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP). J. Neuroinflammation 9: 29.
43. Graham, J., I. Kockum, C. B. Sanjeevi, M. Landin-Olsson, L. Nyström, G. Sundkvist, H. Arnqvist, G. Blohmé, F. Lithner, B. Littorin, et al Swedish Childhood Diabetes Study Group. 1999. Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset. Eur. J. Immunogenet. 26: 117-127.
44. Luckey, D., D. Bastakoty, and A. K. Mangalam. 2011. Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice. J. Autoimmun. 37: 122-128.
45. Mangalam, A., D. Luckey, E. Basal, M. Jackson, M. Smart, M. Rodriguez, and C. David. 2009. HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. J. Immunol. 182: 5131-5139.
46. Peters, A., L. A. Pitcher, J. M. Sullivan, M. Mitsdoerffer, S. E. Acton, B. Franz, K. Wucherpfennig, S. Turley, M. C. Carroll, R. A. Sobel, et al. 2011. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity 35: 986-996.
47. Behrens, M., T. Trejo, H. Luthra, M. Griffiths, C. S. David, and V. Taneja. 2010. Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice. J. Autoimmun. 35: 1-9.