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Bioorganic and Medicinal Chemistry

Volumn 18, Issue 23, 2010, Pages 8218-8225

Synthesis, molecular modeling and biological evaluation of guanidine derivatives as novel antitubulin agents

(4) Qian, Yong a Zhang, Hong Jia a Lv, Peng Cheng a Zhu, Hai Liang a

a NANJING UNIVERSITY (China)

Author keywords

Antitubulin polymerization; Chalcone; Guanidine; Molecular modeling

Indexed keywords

2 (1 (3,4 DICHLOROPHENYL) 3 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (1 (4 BROMOPHENYL) 3 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (1 (4 CHLOROPHENYL) 3 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (1 (4 METHOXYPHENYL) 3 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (1 PHENYL 3 4 TOLYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (1,3 DIPHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (2 BROMOPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (2 CHLOROPHENYL) 1 (4 METHOXYPHENYL)ALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (2 CHLOROPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (2 FLUOROPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (2 METHOXPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (3 FLUOROPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (3 METHOXYPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (3 NITROPHENYL) 1 PHENYLALLYLIDENE) HYDRAZINECARBOXIMIDAMIDE; 2 (3 (4 (BENZYLOXY)PHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (4 BROMOPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (4 CHLOROPHENYL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (4 FLUOROPHENYL) 1 PHENYLALLYLIDENE) HYDRAZINECARBOXIMIDAMIDE; 2 (3 (4 METHOXYPHENYL) 1 PHENYLALLYLIDENE) HYDRAZINECARBOXIMIDAMIDE; 2 (3 (BIPHENYL 4 YL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 (NAPHTHALEN 2 YL) 1 PHENYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; 2 (3 PHENYL 1 4 TOLYLALLYLIDENE)HYDRAZINECARBOXIMIDAMIDE; ANTINEOPLASTIC AGENT; ANTITUBULIN AGENT; COLCHICINE; GUANIDINE DERIVATIVE; PROTEIN INHIBITOR; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; BREAST CARCINOMA; CELL STRAIN MCF 7; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; MOLECULAR DOCKING; MOLECULAR MODEL; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CHALCONE; COMPUTER SIMULATION; GUANIDINE; HUMANS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 78249240359 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/j.bmc.2010.10.008 Document Type: Article

Times cited : (37)

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