Exploration of the SAR of anti-invasive chalcones: Synthesis and biological evaluation of conformationally restricted analogues

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 15, 2012, Pages 4812-4819

  Roman, Bart I ^a   Ryck, Tine De ^b   Dierickx, Laura ^a   Vanhoecke, Barbara W A ^b   Katritzky, Alan R ^c,d   Bracke, Marc ^b   Stevens, Christian V ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c University of Florida   (United States)

^d KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Cancer; Chalcone; Invasion; Isoxazole; SAR

Indexed keywords

1 (4 FLUOROPHENYL) 2 (3,4,5 TRIMETHOXYPHENYL)ETHANONE; 1 TRIMETHYLSILYLMETHYL 1H BENZOTRIAZOLE; 1,3 DIARYLPROPENONE DERIVATIVE; 2 (4 FLUOROPHENYL) 1 (3,4,5 TRIMETHOXYPHENYL)ETHANONE; 2 BENZOTRIAZOL 1 YL 1 (3,4,5 TRIMETHOXYPHENYL)THANONE; 2 BENZOTRIAZOL 1 YL 1 (4 FLUOROPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL)PROPENONE; 2 BENZOTRIAZOL 1 YL 1 ARYLETHANONE; 3 (4 FLUOROPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOLE; 3,5 DIARYL 4,5 DIHYDROISOXAZOLE DERIVATIVE; 3,5 DIARYLISOXAZOLE DERIVATIVE; 3,5 ISOXAZOLE DERIVATIVE; 4 (4 FLUOROPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOLE; 4,5 DIARYLISOXAZOLE DERIVATIVE; 4,5 ISOXAZOLE DERIVATIVE; 5 (4 CHLOROPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOLE; 5 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE; 5 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL)ISOXAZOLE; 5 (4 FLUOROPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDROISOXAZOLE; 5 (4 FLUOROPHENYL) 3 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOLE; 5 (4 FLUOROPHENYL) 4 (3,4,5 TRIMETHOXYPHENYL)ISOXAZOLE; ANTINEOPLASTIC AGENT; CHALCONE DERIVATIVE; DIMETHYL [(4 FLUOROPHENYL)HYDROXYMETHYL]PHOSPHONATE; DIMETHYL[HYDROXY (3,4,5 TRIMETHOXYPHENYL)METHYL]PHOSPHONATE; ISOXAZOLE DERIVATIVE; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CANCER INVASION; CHICK; DRUG CONFORMATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; GEOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHALCONES; CHICK EMBRYO; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HEART; HUMANS; ISOXAZOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASM INVASIVENESS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863981893     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.05.069     Document Type: Article

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