Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels

Journal of Medicinal Chemistry

Volumn 57, Issue 15, 2014, Pages 6623-6631

  Park, Jae H ^a   Carlin, Kevin P ^a   Wu, Gang ^a   Ilyin, Victor I ^a   Musza, Laszlo L ^a   Blake, Paul R ^a   Kyle, Donald J ^a  

^a Purdue Pharma Discovery Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; PHRIXOTOXIN I; POTASSIUM CHANNEL; PROTOXIN; PROTOXIN II; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.7; SPIDER VENOM; UNCLASSIFIED DRUG; PEPTIDE; PHRIXOTOXIN I, PHRIXOTRICHUS AURATUS; PROTOXIN II, THRIXOPELMA PRURIENS; SCN9A PROTEIN, HUMAN; SCN9A PROTEIN, RAT; VOLTAGE GATED SODIUM CHANNEL BLOCKING AGENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING KINETICS; BIOLOGICAL ACTIVITY; CHIMERA; CONTROLLED STUDY; DRUG CONFORMATION; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; IC 50; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POINT MUTATION; RAT; SEQUENCE HOMOLOGY; SODIUM CURRENT; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; WHOLE CELL PATCH CLAMP; ANIMAL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; HEK293 CELL LINE; PHYSIOLOGY; SYNTHESIS;

ANIMALS; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; PEPTIDES; RATS; SPIDER VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

EID: 84906075173     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500687u     Document Type: Article

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