Structure and activity relationship in the (S)-N-chroman-3-ylcarboxamide series of voltage-gated sodium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 17, 2012, Pages 5618-5624

  Kers, Inger ^a   Csjernyik, Gabor ^a   MacSari, Istvan ^a   Nylöf, Martin ^a   Sandberg, Lars ^a   Skogholm, Karin ^a   Bueters, Tjerk ^a   Eriksson, Anders B ^a   Oerther, Sandra ^a   Lund, Per Eric ^a   Venyike, Elisabet ^a   Nyström, Jan Erik ^a   Besidski, Yevgeni ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

(S) N Chroman 3 ylcarboxamide; Nav1.7 blocker; Neuropathic pain; Sodium channel blockers; Voltage gated channel

Indexed keywords

AMIDE; ANALGESIC AGENT; CHROMAN DERIVATIVE; N CHROMAN 3 YLCARBOXAMIDE; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.7; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MUTATION; NOCICEPTION; NOCICEPTIVE PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; CHROMANS; FORMALDEHYDE; HUMANS; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NOCICEPTIVE PAIN; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VOLTAGE-GATED SODIUM CHANNEL BLOCKERS;

RATTUS;

EID: 84865108666     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.105     Document Type: Article

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