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Volumn 64, Issue 3, 2014, Pages 199-208

Inotropes and inodilators for acute heart failure: Sarcomere active drugs in focus

Author keywords

Acute heart failure syndrome; Ca2+ mobilizer; Levosimendan; Omecamtiv mecarbil; Sarcomere targeted agent

Indexed keywords

CALCIUM; CALCIUM SENSITIZER; CARDIOVASCULAR AGENT; INODILATOR; INOTROPIC AGENT; LEVOSIMENDAN; MYOSIN; OMECAMTIV MECARBIL; PIMOBENDAN; UNCLASSIFIED DRUG; CARDIOTONIC AGENT; VASODILATOR AGENT;

EID: 84906070649     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000113     Document Type: Article
Times cited : (22)

References (107)
  • 1
    • 0037323582 scopus 로고    scopus 로고
    • The problem of decompensated heart failure: Nomenclature, classification, and risk stratification
    • Felker GM, Adams KF Jr, Konstam MA, et al. The problem of decompensated heart failure: nomenclature, classification, and risk stratification. Am Heart J. 2003; 145(suppl 2): S18-S25.
    • (2003) Am Heart J , vol.145 , pp. S18-S25
    • Felker, G.M.1    Adams, K.F.2    Konstam, M.A.3
  • 2
    • 33644878033 scopus 로고    scopus 로고
    • Acute heart failure syndromes: Current state and framework for future research
    • Gheorghiade M, Zannad F, Sopko G, et al. Acute heart failure syndromes: current state and framework for future research. Circulation. 2005; 112: 3958-3968.
    • (2005) Circulation , vol.112 , pp. 3958-3968
    • Gheorghiade, M.1    Zannad, F.2    Sopko, G.3
  • 3
    • 84864493727 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
    • McMurray JJ, Adamopoulos S, Anker SD, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2012; 33: 1787-1847.
    • (2012) Eur Heart J , vol.33 , pp. 1787-1847
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3
  • 4
    • 84878588169 scopus 로고    scopus 로고
    • Acute decompensated heart failure: Update on new and emerging evidence and directions for future research
    • Givertz MM, Teerlink JR, Albert NM, et al. Acute decompensated heart failure: update on new and emerging evidence and directions for future research. J Card Fail. 2013; 19: 371-389.
    • (2013) J Card Fail , vol.19 , pp. 371-389
    • Givertz, M.M.1    Teerlink, J.R.2    Albert, N.M.3
  • 5
    • 0026072848 scopus 로고
    • Effect of oral milrinone on mortality in severe chronic heart failure
    • The PROMISE Study Research Group
    • Packer M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med. 1991; 325: 1468-1475.
    • (1991) N Engl J Med , vol.325 , pp. 1468-1475
    • Packer, M.1    Carver, J.R.2    Rodeheffer, R.J.3
  • 6
    • 36849084209 scopus 로고    scopus 로고
    • The pathophysiology of acute heart failure-is it all about fluid accumulation?
    • Cotter G, Felker GM, Adams KF, et al. The pathophysiology of acute heart failure-is it all about fluid accumulation? Am Heart J. 2008; 155: 9-18.
    • (2008) Am Heart J , vol.155 , pp. 9-18
    • Cotter, G.1    Felker, G.M.2    Adams, K.F.3
  • 7
    • 0036623850 scopus 로고    scopus 로고
    • Acute heart failure: A novel approach to its pathogenesis and treatment
    • Cotter G, Moshkovitz Y, Milovanov O, et al. Acute heart failure: a novel approach to its pathogenesis and treatment. Eur J Heart Fail. 2002; 4: 227-234.
    • (2002) Eur J Heart Fail , vol.4 , pp. 227-234
    • Cotter, G.1    Moshkovitz, Y.2    Milovanov, O.3
  • 8
    • 0030690491 scopus 로고    scopus 로고
    • Calcium sensitisers: Mechanisms of action and potential usefulness as inotropes
    • Lee JA, Allen DG. Calcium sensitisers: mechanisms of action and potential usefulness as inotropes. Cardiovasc Res. 1997; 36: 10-20.
    • (1997) Cardiovasc Res , vol.36 , pp. 10-20
    • Lee, J.A.1    Allen, D.G.2
  • 9
    • 0013606550 scopus 로고
    • Potential deleterious effects of inotropic agents in the therapy of chronic heart failure
    • Katz AM. Potential deleterious effects of inotropic agents in the therapy of chronic heart failure. Circulation. 1986; 73(3 pt 2): III184-III190.
    • (1986) Circulation , vol.73 , Issue.3 , pp. III184-III190
    • Katz, A.M.1
  • 10
    • 37549032096 scopus 로고    scopus 로고
    • Inotropes in the management of acute heart failure
    • Petersen JW, Felker GM. Inotropes in the management of acute heart failure. Crit Care Med. 2008; 36(suppl 1): S106-S111.
    • (2008) Crit Care Med , vol.36 , pp. S106-S111
    • Petersen, J.W.1    Felker, G.M.2
  • 11
    • 56849111197 scopus 로고    scopus 로고
    • 2+ sensitizers
    • 2+ sensitizers. Circ J. 2008; 72: 1915-1925.
    • (2008) Circ J , vol.72 , pp. 1915-1925
    • Endoh, M.1
  • 12
    • 0020333754 scopus 로고
    • Mechanism of action of digitalis: Is the Na K-ATPase the pharmacological receptor?
    • Schwartz A, Whitmer K, Grupp G, et al. Mechanism of action of digitalis: is the Na, K-ATPase the pharmacological receptor? Ann N Y Acad Sci. 1982; 402: 253-271.
    • (1982) Ann N y Acad Sci , vol.402 , pp. 253-271
    • Schwartz, A.1    Whitmer, K.2    Grupp, G.3
  • 13
    • 0031051347 scopus 로고    scopus 로고
    • The effect of digoxin on mortality and morbidity in patients with heart failure
    • Digitalis Investigation G.
    • Digitalis Investigation G. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med. 1997; 336: 525-533.
    • (1997) N Engl J Med , vol.336 , pp. 525-533
  • 14
    • 84891625961 scopus 로고    scopus 로고
    • Digoxin use and lower 30-day all-cause readmission for medicare beneficiaries hospitalized for heart failure
    • Ahmed A, Bourge RC, Fonarow GC, et al. Digoxin use and lower 30-day all-cause readmission for medicare beneficiaries hospitalized for heart failure. Am J Med. 2014; 127: 61-70.
    • (2014) Am J Med , vol.127 , pp. 61-70
    • Ahmed, A.1    Bourge, R.C.2    Fonarow, G.C.3
  • 15
    • 0032814621 scopus 로고    scopus 로고
    • Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: Insights from the Flolan International Randomized Survival Trial (FIRST)
    • O'Connor CM, Gattis WA, Uretsky BF, et al. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST). Am Heart J. 1999; 138(1 pt 1): 78-86.
    • (1999) Am Heart J , vol.138 , Issue.1 , pp. 78-86
    • O'Connor, C.M.1    Gattis, W.A.2    Uretsky, B.F.3
  • 16
    • 73849141245 scopus 로고    scopus 로고
    • Cardiorenal syndrome in acute decompensated heart failure
    • Sarraf M, Masoumi A, Schrier RW. Cardiorenal syndrome in acute decompensated heart failure. Clin J Am Soc Nephrol. 2009; 4: 2013-2026.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 2013-2026
    • Sarraf, M.1    Masoumi, A.2    Schrier, R.W.3
  • 17
    • 55949130403 scopus 로고    scopus 로고
    • The effects of dobutamine on renal sympathetic activity in human heart failure
    • Al-Hesayen A, Parker JD. The effects of dobutamine on renal sympathetic activity in human heart failure. J Cardiovasc Pharmacol. 2008; 51: 434-436.
    • (2008) J Cardiovasc Pharmacol , vol.51 , pp. 434-436
    • Al-Hesayen, A.1    Parker, J.D.2
  • 18
    • 38949205222 scopus 로고    scopus 로고
    • Worsening renal function in patients hospitalised for acute heart failure: Clinical implications and prognostic significance
    • Metra M, Nodari S, Parrinello G, et al. Worsening renal function in patients hospitalised for acute heart failure: clinical implications and prognostic significance. Eur J Heart Fail. 2008; 10: 188-195.
    • (2008) Eur J Heart Fail , vol.10 , pp. 188-195
    • Metra, M.1    Nodari, S.2    Parrinello, G.3
  • 19
    • 0037181515 scopus 로고    scopus 로고
    • Outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure i Short-term intravenous milrinone for acute exacerbation of chronic heart failure: A randomized controlled trial
    • Cuffe MS, Califf RM, Adams KF Jr, et al, Outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure I. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 2002; 287: 1541-1547.
    • (2002) JAMA , vol.287 , pp. 1541-1547
    • Cuffe, M.S.1    Califf, R.M.2    Adams, K.F.3
  • 20
    • 84881322149 scopus 로고    scopus 로고
    • Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition
    • Ferrandi M, Barassi P, Tadini-Buoninsegni F, et al. Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition. Br J Pharmacol. 2013; 169: 1849-1861.
    • (2013) Br J Pharmacol , vol.169 , pp. 1849-1861
    • Ferrandi, M.1    Barassi, P.2    Tadini-Buoninsegni, F.3
  • 21
    • 67049100043 scopus 로고    scopus 로고
    • Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: Results from the hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: A randomized controlled trial in patients hospitalized with heart failure (HORIZON-HF) trial
    • Shah SJ, Blair JE, Filippatos GS, et al. Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure (HORIZON-HF) trial. Am Heart J. 2009; 157: 1035-1041.
    • (2009) Am Heart J , vol.157 , pp. 1035-1041
    • Shah, S.J.1    Blair, J.E.2    Filippatos, G.S.3
  • 23
    • 23644460318 scopus 로고    scopus 로고
    • Calcium sensitizer agents: A new class of inotropic agents in the treatment of decompensated heart failure
    • Perrone SV, Kaplinsky EJ. Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure. Int J Cardiol. 2005; 103: 248-255.
    • (2005) Int J Cardiol , vol.103 , pp. 248-255
    • Perrone, S.V.1    Kaplinsky, E.J.2
  • 24
    • 67650364180 scopus 로고    scopus 로고
    • Effects of levosimendan on the energy balance: Preclinical and clinical evidence
    • Nieminen MS, Pollesello P, Vajda G, et al. Effects of levosimendan on the energy balance: preclinical and clinical evidence. J Cardiovasc Pharmacol. 2009; 53: 302-310.
    • (2009) J Cardiovasc Pharmacol , vol.53 , pp. 302-310
    • Nieminen, M.S.1    Pollesello, P.2    Vajda, G.3
  • 25
    • 0019941515 scopus 로고
    • Stimulation of Ca++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent
    • Solaro RJ, Ruegg JC. Stimulation of Ca++ binding and ATPase activity of dog cardiac myofibrils by AR-L 115BS, a novel cardiotonic agent. Circ Res. 1982; 51: 290-294.
    • (1982) Circ Res , vol.51 , pp. 290-294
    • Solaro, R.J.1    Ruegg, J.C.2
  • 26
    • 0023944537 scopus 로고
    • The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator Gi
    • Parsons WJ, Ramkumar V, Stiles GL. The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi. Mol Pharmacol. 1988; 33: 441-448.
    • (1988) Mol Pharmacol , vol.33 , pp. 441-448
    • Parsons, W.J.1    Ramkumar, V.2    Stiles, G.L.3
  • 27
    • 33644997173 scopus 로고    scopus 로고
    • Mechanisms and use of calcium-sensitizing agents in the failing heart
    • Kass DA, Solaro RJ. Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation. 2006; 113: 305-315.
    • (2006) Circulation , vol.113 , pp. 305-315
    • Kass, D.A.1    Solaro, R.J.2
  • 28
    • 84885063647 scopus 로고    scopus 로고
    • PKCalpha-specific phosphorylation of the troponin complex in human myocardium: A functional and proteomics analysis
    • Kooij V, Zhang P, Piersma SR, et al. PKCalpha-specific phosphorylation of the troponin complex in human myocardium: a functional and proteomics analysis. PLoS One. 2013; 8: e74847.
    • (2013) PLoS One , vol.8 , pp. e74847
    • Kooij, V.1    Zhang, P.2    Piersma, S.R.3
  • 29
    • 0029613261 scopus 로고
    • Mechanisms of action of calcium-sensitizing drugs
    • Haikala H, Linden IB. Mechanisms of action of calcium-sensitizing drugs. J Cardiovasc Pharmacol. 1995; 26 (suppl 1): S10-S19.
    • (1995) J Cardiovasc Pharmacol , vol.26 , pp. S10-S19
    • Haikala, H.1    Linden, I.B.2
  • 30
    • 0027453927 scopus 로고
    • Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments
    • Solaro RJ, Gambassi G, Warshaw DM, et al. Stereoselective actions of thiadiazinones on canine cardiac myocytes and myofilaments. Circ Res. 1993; 73: 981-990.
    • (1993) Circ Res , vol.73 , pp. 981-990
    • Solaro, R.J.1    Gambassi, G.2    Warshaw, D.M.3
  • 31
    • 16644369017 scopus 로고    scopus 로고
    • 2+ -sensitizers in permeabilized cardiac myocytes from donor and end-stage failing human hearts
    • 2+ -sensitizers in permeabilized cardiac myocytes from donor and end-stage failing human hearts. J Muscle Res Cell Motil. 2004; 25: 219-224.
    • (2004) J Muscle Res Cell Motil , vol.25 , pp. 219-224
    • Papp, Z.1    Van Der Velden, J.2    Borbely, A.3
  • 32
    • 84864990939 scopus 로고    scopus 로고
    • Levosimendan: Molecular mechanisms and clinical implications: Consensus of experts on the mechanisms of action of levosimendan
    • Papp Z, Edes I, Fruhwald S, et al. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012; 159: 82-87.
    • (2012) Int J Cardiol , vol.159 , pp. 82-87
    • Papp, Z.1    Edes, I.2    Fruhwald, S.3
  • 34
    • 0026039109 scopus 로고
    • Structure, function, and regulation of troponin C
    • Parmacek MS, Leiden JM. Structure, function, and regulation of troponin C. Circulation. 1991; 84: 991-1003.
    • (1991) Circulation , vol.84 , pp. 991-1003
    • Parmacek, M.S.1    Leiden, J.M.2
  • 35
    • 9444292903 scopus 로고    scopus 로고
    • The contractile apparatus as a target for drugs against heart failure: Interaction of levosimendan, a calcium sensitiser, with cardiac troponin c
    • Sorsa T, Pollesello P, Solaro RJ. The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. Mol Cell Biochem. 2004; 266: 87-107.
    • (2004) Mol Cell Biochem , vol.266 , pp. 87-107
    • Sorsa, T.1    Pollesello, P.2    Solaro, R.J.3
  • 36
  • 38
    • 0031578459 scopus 로고    scopus 로고
    • 2+]i in Guinea-pig isolated ventricular myocytes
    • 2+]i in guinea-pig isolated ventricular myocytes. Eur J Pharmacol. 1997; 339: 97-100.
    • (1997) Eur J Pharmacol , vol.339 , pp. 97-100
    • Lancaster, M.K.1    Cook, S.J.2
  • 39
    • 0030999763 scopus 로고    scopus 로고
    • Ca++ sensitizers impair cardiac relaxation in failing human myocardium
    • Hajjar RJ, Schmidt U, Helm P, et al. Ca++ sensitizers impair cardiac relaxation in failing human myocardium. J Pharmacol Exp Ther. 1997; 280: 247-254.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 247-254
    • Hajjar, R.J.1    Schmidt, U.2    Helm, P.3
  • 40
    • 0029098682 scopus 로고
    • Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan
    • Haikala H, Kaivola J, Nissinen E, et al. Cardiac troponin C as a target protein for a novel calcium sensitizing drug, levosimendan. J Mol Cell Cardiol. 1995; 27: 1859-1866.
    • (1995) J Mol Cell Cardiol , vol.27 , pp. 1859-1866
    • Haikala, H.1    Kaivola, J.2    Nissinen, E.3
  • 41
    • 0034666682 scopus 로고    scopus 로고
    • Levosimendan improves diastolic and systolic function in failing human myocardium
    • Janssen PM, Datz N, Zeitz O, et al. Levosimendan improves diastolic and systolic function in failing human myocardium. Eur J Pharmacol. 2000; 404: 191-199.
    • (2000) Eur J Pharmacol , vol.404 , pp. 191-199
    • Janssen, P.M.1    Datz, N.2    Zeitz, O.3
  • 42
    • 24344434559 scopus 로고    scopus 로고
    • Two inotropes with different mechanisms of action: Contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone
    • Szilagyi S, Pollesello P, Levijoki J, et al. Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone. J Cardiovasc Pharmacol. 2005; 46: 369-376.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 369-376
    • Szilagyi, S.1    Pollesello, P.2    Levijoki, J.3
  • 43
    • 0029061923 scopus 로고
    • 2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in Guinea pig heart
    • 2+ sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circ Res. 1995; 77: 107-113.
    • (1995) Circ Res , vol.77 , pp. 107-113
    • Edes, I.1    Kiss, E.2    Kitada, Y.3
  • 44
    • 0030955524 scopus 로고    scopus 로고
    • The role of cAMP- and cGMPdependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan
    • Haikala H, Kaheinen P, Levijoki J, et al. The role of cAMP- and cGMPdependent protein kinases in the cardiac actions of the new calcium sensitizer, levosimendan. Cardiovasc Res. 1997; 34: 536-546.
    • (1997) Cardiovasc Res , vol.34 , pp. 536-546
    • Haikala, H.1    Kaheinen, P.2    Levijoki, J.3
  • 45
    • 1642441317 scopus 로고    scopus 로고
    • The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the Guinea pig
    • Szilagyi S, Pollesello P, Levijoki J, et al. The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig. Eur J Pharmacol. 2004; 486: 67-74.
    • (2004) Eur J Pharmacol , vol.486 , pp. 67-74
    • Szilagyi, S.1    Pollesello, P.2    Levijoki, J.3
  • 46
    • 33745607928 scopus 로고    scopus 로고
    • The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles
    • Erdei N, Papp Z, Pollesello P, et al. The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles. Br J Pharmacol. 2006; 148: 696-702.
    • (2006) Br J Pharmacol , vol.148 , pp. 696-702
    • Erdei, N.1    Papp, Z.2    Pollesello, P.3
  • 47
    • 16744366479 scopus 로고    scopus 로고
    • Levosimendan interacts with potassium channel blockers in human saphenous veins
    • Hohn J, Pataricza J, Petri A, et al. Levosimendan interacts with potassium channel blockers in human saphenous veins. Basic Clin Pharmacol Toxicol. 2004; 94: 271-273.
    • (2004) Basic Clin Pharmacol Toxicol , vol.94 , pp. 271-273
    • Hohn, J.1    Pataricza, J.2    Petri, A.3
  • 48
    • 0035088001 scopus 로고    scopus 로고
    • Levosimendan increases diastolic coronary flow in isolated Guinea-pig heart by opening ATP-sensitive potassium channels
    • Kaheinen P, Pollesello P, Levijoki J, et al. Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels. J Cardiovasc Pharmacol. 2001; 37: 367-374.
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 367-374
    • Kaheinen, P.1    Pollesello, P.2    Levijoki, J.3
  • 49
    • 84879164683 scopus 로고    scopus 로고
    • Levosimendan relaxes pulmonary arteries and veins in precision-cut lung slices - The role of K-channels, cAMP and cGMP
    • Rieg AD, Rossaint R, Verjans E, et al. Levosimendan relaxes pulmonary arteries and veins in precision-cut lung slices-the role of K-channels, cAMP and cGMP. PLoS One. 2013; 8: e66195.
    • (2013) PLoS One , vol.8 , pp. e66195
    • Rieg, A.D.1    Rossaint, R.2    Verjans, E.3
  • 50
    • 34249003950 scopus 로고    scopus 로고
    • Vasodilating mechanisms of levosimendan: Involvement of K+ channels
    • Yildiz O. Vasodilating mechanisms of levosimendan: involvement of K+ channels. J Pharmacol Sci. 2007; 104: 1-5.
    • (2007) J Pharmacol Sci , vol.104 , pp. 1-5
    • Yildiz, O.1
  • 51
    • 0030608872 scopus 로고    scopus 로고
    • 2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes
    • 2+ sensitizer, activates the glibenclamide-sensitive K+ channel in rat arterial myocytes. Eur J Pharmacol. 1997; 333: 249-259.
    • (1997) Eur J Pharmacol , vol.333 , pp. 249-259
    • Yokoshiki, H.1    Katsube, Y.2    Sunagawa, M.3
  • 53
    • 84894178423 scopus 로고    scopus 로고
    • Levosimendan and its metabolite OR-1896 elicit KATP channel-dependent dilation in resistance arteries in vivo
    • Godeny I, Pollesello P, Edes I, et al. Levosimendan and its metabolite OR-1896 elicit KATP channel-dependent dilation in resistance arteries in vivo. Pharmacol Rep. 2013; 65: 1304-1310.
    • (2013) Pharmacol Rep , vol.65 , pp. 1304-1310
    • Godeny, I.1    Pollesello, P.2    Edes, I.3
  • 54
    • 0041639573 scopus 로고    scopus 로고
    • Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs
    • Leather HA, Ver Eycken K, Segers P, et al. Effects of levosimendan on right ventricular function and ventriculovascular coupling in open chest pigs. Crit Care Med. 2003; 31: 2339-2343.
    • (2003) Crit Care Med , vol.31 , pp. 2339-2343
    • Leather, H.A.1    Ver Eycken, K.2    Segers, P.3
  • 55
    • 2942574937 scopus 로고    scopus 로고
    • The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia
    • Sonntag S, Sundberg S, Lehtonen LA, et al. The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia. J Am Coll Cardiol. 2004; 43: 2177-2182.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2177-2182
    • Sonntag, S.1    Sundberg, S.2    Lehtonen, L.A.3
  • 56
    • 84864124308 scopus 로고    scopus 로고
    • Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs
    • Grossini E, Molinari C, Pollesello P, et al. Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs. J Pharmacol Exp Ther. 2012; 342: 376-388.
    • (2012) J Pharmacol Exp Ther , vol.342 , pp. 376-388
    • Grossini, E.1    Molinari, C.2    Pollesello, P.3
  • 57
    • 80455158136 scopus 로고    scopus 로고
    • Levosimendan decreases intracranial pressure after hypothermic circulatory arrest in a porcine model
    • Jensen H, Eija R, Tuomas M, et al. Levosimendan decreases intracranial pressure after hypothermic circulatory arrest in a porcine model. Scand Cardiovasc J. 2011; 45: 307-315.
    • (2011) Scand Cardiovasc J , vol.45 , pp. 307-315
    • Jensen, H.1    Eija, R.2    Tuomas, M.3
  • 58
    • 85039817384 scopus 로고    scopus 로고
    • Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats
    • Grossini E, Pollesello P, Bellofatto K, et al. Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats. Liver Transpl. 2013.
    • (2013) Liver Transpl
    • Grossini, E.1    Pollesello, P.2    Bellofatto, K.3
  • 59
    • 12244311885 scopus 로고    scopus 로고
    • Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs
    • Schwarte LA, Picker O, Bornstein SR, et al. Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med. 2005; 33: 135-142.
    • (2005) Crit Care Med , vol.33 , pp. 135-142
    • Schwarte, L.A.1    Picker, O.2    Bornstein, S.R.3
  • 60
    • 43249121194 scopus 로고    scopus 로고
    • Role of levosimendan in sepsis and septic shock
    • Pinto BB, Rehberg S, Ertmer C, et al. Role of levosimendan in sepsis and septic shock. Curr Opin Anaesthesiol. 2008; 21: 168-177.
    • (2008) Curr Opin Anaesthesiol , vol.21 , pp. 168-177
    • Pinto, B.B.1    Rehberg, S.2    Ertmer, C.3
  • 61
    • 57349195150 scopus 로고    scopus 로고
    • Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli
    • Sareila O, Korhonen R, Auvinen H, et al. Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli. Br J Pharmacol. 2008; 155: 884-895.
    • (2008) Br J Pharmacol , vol.155 , pp. 884-895
    • Sareila, O.1    Korhonen, R.2    Auvinen, H.3
  • 62
    • 79961025154 scopus 로고    scopus 로고
    • Levosimendan attenuates pulmonary vascular remodeling
    • Revermann M, Schloss M, Mieth A, et al. Levosimendan attenuates pulmonary vascular remodeling. Intensive Care Med. 2011; 37: 1368-1377.
    • (2011) Intensive Care Med , vol.37 , pp. 1368-1377
    • Revermann, M.1    Schloss, M.2    Mieth, A.3
  • 63
    • 79960189784 scopus 로고    scopus 로고
    • Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: A prospective observational study
    • Hasslacher J, Bijuklic K, Bertocchi C, et al. Levosimendan inhibits release of reactive oxygen species in polymorphonuclear leukocytes in vitro and in patients with acute heart failure and septic shock: a prospective observational study. Crit Care. 2011; 15: R166.
    • (2011) Crit Care , vol.15 , pp. R166
    • Hasslacher, J.1    Bijuklic, K.2    Bertocchi, C.3
  • 64
    • 41149083577 scopus 로고    scopus 로고
    • Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1 4 5, 6-tetrahydropyridazin-3-yl)phenyl) acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4, 5-dihydropyridazin- 3(2H)-one], dobutamine, and milrinone: Comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure
    • Segreti JA, Marsh KC, Polakowski JS, et al. Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1, 4, 5, 6-tetrahydropyridazin-3-yl)phenyl) acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4, 5-dihydropyridazin- 3(2H)-one], dobutamine, and milrinone: comparative effects on peripheral resistance, cardiac output, dP/dt, pulse rate, and blood pressure. J Pharmacol Exp Ther. 2008; 325: 331-340.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 331-340
    • Segreti, J.A.1    Marsh, K.C.2    Polakowski, J.S.3
  • 65
    • 3843094875 scopus 로고    scopus 로고
    • Potassium-specific effects of levosimendan on heart mitochondria
    • Kopustinskiene DM, Pollesello P, Saris NE. Potassium-specific effects of levosimendan on heart mitochondria. Biochem Pharmacol. 2004; 68: 807-812.
    • (2004) Biochem Pharmacol , vol.68 , pp. 807-812
    • Kopustinskiene, D.M.1    Pollesello, P.2    Saris, N.E.3
  • 66
    • 42949135943 scopus 로고    scopus 로고
    • A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated Guinea pig heart
    • du Toit EF, Genis A, Opie LH, et al. A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart. Br J Pharmacol. 2008; 154: 41-50.
    • (2008) Br J Pharmacol , vol.154 , pp. 41-50
    • Du Toit, E.F.1    Genis, A.2    Opie, L.H.3
  • 68
    • 1142273368 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore opening during myocardial reperfusion - A target for cardioprotection
    • Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res. 2004; 61: 372-385.
    • (2004) Cardiovasc Res , vol.61 , pp. 372-385
    • Halestrap, A.P.1    Clarke, S.J.2    Javadov, S.A.3
  • 69
    • 77950353079 scopus 로고    scopus 로고
    • Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition
    • Honisch A, Theuring N, Ebner B, et al. Postconditioning with levosimendan reduces the infarct size involving the PI3K pathway and KATP-channel activation but is independent of PDE-III inhibition. Basic Res Cardiol. 2010; 105: 155-167.
    • (2010) Basic Res Cardiol , vol.105 , pp. 155-167
    • Honisch, A.1    Theuring, N.2    Ebner, B.3
  • 70
    • 80052029553 scopus 로고    scopus 로고
    • Multiple signalling pathways underlie the protective effect of levosimendan in cardiac myocytes
    • Markou T, Makridou Z, Galatou E, et al. Multiple signalling pathways underlie the protective effect of levosimendan in cardiac myocytes. Eur J Pharmacol. 2011; 667: 298-305.
    • (2011) Eur J Pharmacol , vol.667 , pp. 298-305
    • Markou, T.1    Makridou, Z.2    Galatou, E.3
  • 71
    • 79952491928 scopus 로고    scopus 로고
    • Levosimendan preserves the contractile responsiveness of hypoxic human myocardium via mitochondrial K(ATP) channel and potential pERK 1/2 activation
    • Soeding PF, Crack PJ, Wright CE, et al. Levosimendan preserves the contractile responsiveness of hypoxic human myocardium via mitochondrial K(ATP) channel and potential pERK 1/2 activation. Eur J Pharmacol. 2011; 655: 59-66.
    • (2011) Eur J Pharmacol , vol.655 , pp. 59-66
    • Soeding, P.F.1    Crack, P.J.2    Wright, C.E.3
  • 72
    • 67650242870 scopus 로고    scopus 로고
    • Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: Role for mitochondrial K(ATP) channel
    • Grossini E, Molinari C, Caimmi PP, et al. Levosimendan induces NO production through p38 MAPK, ERK and Akt in porcine coronary endothelial cells: role for mitochondrial K(ATP) channel. Br J Pharmacol. 2009; 156: 250-261.
    • (2009) Br J Pharmacol , vol.156 , pp. 250-261
    • Grossini, E.1    Molinari, C.2    Caimmi, P.P.3
  • 73
    • 79952533901 scopus 로고    scopus 로고
    • Intracoronary levosimendan prevents myocardial ischemic damages and activates survival signaling through ATP-sensitive potassium channel and nitric oxide
    • Caimmi PP, Molinari C, Uberti F, et al. Intracoronary levosimendan prevents myocardial ischemic damages and activates survival signaling through ATP-sensitive potassium channel and nitric oxide. Eur J Cardiothorac Surg. 2011; 39: e59-67.
    • (2011) Eur J Cardiothorac Surg , vol.39 , pp. e59-67
    • Caimmi, P.P.1    Molinari, C.2    Uberti, F.3
  • 74
    • 0035843756 scopus 로고    scopus 로고
    • Improved survival with simendan after experimental myocardial infarction in rats
    • Levijoki J, Pollesello P, Kaheinen P, et al. Improved survival with simendan after experimental myocardial infarction in rats. Eur J Pharmacol. 2001; 419: 243-248.
    • (2001) Eur J Pharmacol , vol.419 , pp. 243-248
    • Levijoki, J.1    Pollesello, P.2    Kaheinen, P.3
  • 75
    • 33750630750 scopus 로고    scopus 로고
    • Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model
    • Lepran I, Pollesello P, Vajda S, et al. Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model. J Cardiovasc Pharmacol. 2006; 48: 148-152.
    • (2006) J Cardiovasc Pharmacol , vol.48 , pp. 148-152
    • Lepran, I.1    Pollesello, P.2    Vajda, S.3
  • 76
    • 34548725115 scopus 로고    scopus 로고
    • The cardioprotective effects of levosimendan: Preclinical and clinical evidence
    • Pollesello P, Papp Z. The cardioprotective effects of levosimendan: preclinical and clinical evidence. J Cardiovasc Pharmacol. 2007; 50: 257-263.
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 257-263
    • Pollesello, P.1    Papp, Z.2
  • 77
    • 84883557389 scopus 로고    scopus 로고
    • Pharmacology of levosimendan: Inotropic, vasodilatory and cardioprotective effects
    • Pathak A, Lebrin M, Vaccaro A, et al. Pharmacology of levosimendan: inotropic, vasodilatory and cardioprotective effects. J Clin Pharm Ther. 2013; 38: 341-349.
    • (2013) J Clin Pharm Ther , vol.38 , pp. 341-349
    • Pathak, A.1    Lebrin, M.2    Vaccaro, A.3
  • 78
    • 77950439794 scopus 로고    scopus 로고
    • Levosimendan reduces mortality in critically ill patients. A meta-analysis of randomized controlled studies
    • Landoni G, Mizzi A, Biondi-Zoccai G, et al. Levosimendan reduces mortality in critically ill patients. A meta-analysis of randomized controlled studies. Minerva Anestesiol. 2010; 76: 276-286.
    • (2010) Minerva Anestesiol , vol.76 , pp. 276-286
    • Landoni, G.1    Mizzi, A.2    Biondi-Zoccai, G.3
  • 79
    • 74449087114 scopus 로고    scopus 로고
    • Reducing mortality in cardiac surgery with levosimendan: A meta-analysis of randomized controlled trials
    • Landoni G, Mizzi A, Biondi-Zoccai G, et al. Reducing mortality in cardiac surgery with levosimendan: a meta-analysis of randomized controlled trials. J Cardiothorac Vasc Anesth. 2010; 24: 51-57.
    • (2010) J Cardiothorac Vasc Anesth , vol.24 , pp. 51-57
    • Landoni, G.1    Mizzi, A.2    Biondi-Zoccai, G.3
  • 80
    • 0025982134 scopus 로고
    • Contribution of cAMPphosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium
    • Bohm M, Morano I, Pieske B, et al. Contribution of cAMPphosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ Res. 1991; 68: 689-701.
    • (1991) Circ Res , vol.68 , pp. 689-701
    • Bohm, M.1    Morano, I.2    Pieske, B.3
  • 81
    • 0034882772 scopus 로고    scopus 로고
    • Decrease in Ca(2+)-sensitizing effect of UD-CG 212 Cl, a metabolite of pimobendan, under acidotic condition in canine ventricular myocardium
    • Takahashi R, Shimazaki Y, Endoh M. Decrease in Ca(2+)-sensitizing effect of UD-CG 212 Cl, a metabolite of pimobendan, under acidotic condition in canine ventricular myocardium. J Pharmacol Exp Ther. 2001; 298: 1060-1066.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1060-1066
    • Takahashi, R.1    Shimazaki, Y.2    Endoh, M.3
  • 82
    • 0024460406 scopus 로고
    • Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction
    • Lynch JJ Jr, Uprichard AC, Frye JW, et al. Effects of the positive inotropic agents milrinone and pimobendan on the development of lethal ischemic arrhythmias in conscious dogs with recent myocardial infarction. J Cardiovasc Pharmacol. 1989; 14: 585-597.
    • (1989) J Cardiovasc Pharmacol , vol.14 , pp. 585-597
    • Lynch, J.J.1    Uprichard, A.C.2    Frye, J.W.3
  • 83
    • 18544380923 scopus 로고    scopus 로고
    • Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy
    • Tissier R, Chetboul V, Moraillon R, et al. Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy. Cardiovasc Toxicol. 2005; 5: 43-51.
    • (2005) Cardiovasc Toxicol , vol.5 , pp. 43-51
    • Tissier, R.1    Chetboul, V.2    Moraillon, R.3
  • 84
    • 0029742865 scopus 로고    scopus 로고
    • Effect of pimobendan on exercise capacity in patients with heart failure: Main results from the pimobendan in congestive heart failure (PICO) trial
    • Lubsen J, Just H, Hjalmarsson AC, et al. Effect of pimobendan on exercise capacity in patients with heart failure: main results from the pimobendan in congestive heart failure (PICO) trial. Heart. 1996; 76: 223-231.
    • (1996) Heart , vol.76 , pp. 223-231
    • Lubsen, J.1    Just, H.2    Hjalmarsson, A.C.3
  • 85
    • 79955579255 scopus 로고    scopus 로고
    • Translational medicine: To the rescue of the failing heart
    • Bers DM, Harris SP. Translational medicine: to the rescue of the failing heart. Nature. 2011; 473: 36-39.
    • (2011) Nature , vol.473 , pp. 36-39
    • Bers, D.M.1    Harris, S.P.2
  • 86
    • 80052806071 scopus 로고    scopus 로고
    • Cardiac myosin activation part 1: From concept to clinic
    • Malik FI, Morgan BP. Cardiac myosin activation part 1: from concept to clinic. J Mol Cell Cardiol. 2011; 51: 454-461.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 454-461
    • Malik, F.I.1    Morgan, B.P.2
  • 87
    • 79952781139 scopus 로고    scopus 로고
    • Cardiac myosin activation: A potential therapeutic approach for systolic heart failure
    • Malik FI, Hartman JJ, Elias KA, et al. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure. Science. 2011; 331: 1439-1443.
    • (2011) Science , vol.331 , pp. 1439-1443
    • Malik, F.I.1    Hartman, J.J.2    Elias, K.A.3
  • 88
    • 70449112931 scopus 로고    scopus 로고
    • A novel approach to improve cardiac performance: Cardiac myosin activators
    • Teerlink JR. A novel approach to improve cardiac performance: cardiac myosin activators. Heart Fail Rev. 2009; 14: 289-298.
    • (2009) Heart Fail Rev , vol.14 , pp. 289-298
    • Teerlink, J.R.1
  • 89
    • 77955506679 scopus 로고    scopus 로고
    • Improvement of cardiac function by a cardiac myosin activator in conscious dogs with systolic heart failure
    • Shen YT, Malik FI, Zhao X, et al. Improvement of cardiac function by a cardiac myosin activator in conscious dogs with systolic heart failure. Circ Heart Fail. 2010; 3: 522-527.
    • (2010) Circ Heart Fail , vol.3 , pp. 522-527
    • Shen, Y.T.1    Malik, F.I.2    Zhao, X.3
  • 90
    • 80051956025 scopus 로고    scopus 로고
    • Cardiac myosin activation: Will theory and practice coincide?
    • Dickstein K. Cardiac myosin activation: will theory and practice coincide? Lancet. 2011; 378: 639-641.
    • (2011) Lancet , vol.378 , pp. 639-641
    • Dickstein, K.1
  • 91
    • 84857551829 scopus 로고    scopus 로고
    • Omecamtiv mecarbil: A promising new drug in systolic heart failure
    • Meijs MF, Asselbergs FW, Doevendans PA. Omecamtiv mecarbil: a promising new drug in systolic heart failure. Eur J Heart Fail. 2012; 14: 232-233.
    • (2012) Eur J Heart Fail , vol.14 , pp. 232-233
    • Meijs, M.F.1    Asselbergs, F.W.2    Doevendans, P.A.3
  • 92
    • 80051967502 scopus 로고    scopus 로고
    • Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: A first-in-man study
    • Teerlink JR, Clarke CP, Saikali KG, et al. Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study. Lancet. 2011; 378: 667-675.
    • (2011) Lancet , vol.378 , pp. 667-675
    • Teerlink, J.R.1    Clarke, C.P.2    Saikali, K.G.3
  • 93
    • 80051989633 scopus 로고    scopus 로고
    • The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: A double-blind, placebo-controlled, crossover, doseranging phase 2 trial
    • Cleland JG, Teerlink JR, Senior R, et al. The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, doseranging phase 2 trial. Lancet. 2011; 378: 676-683.
    • (2011) Lancet , vol.378 , pp. 676-683
    • Cleland, J.G.1    Teerlink, J.R.2    Senior, R.3
  • 95
    • 84896113843 scopus 로고    scopus 로고
    • An overview of recent developments in the treatment of heart failure: Update from the ESC congress 2013
    • Valentova M, von Haehling S. An overview of recent developments in the treatment of heart failure: update from the ESC congress 2013. Expert Opin Investig Drugs. 2014; 23: 573-578.
    • (2014) Expert Opin Investig Drugs. , vol.23 , pp. 573-578
    • Valentova, M.1    Von Haehling, S.2
  • 96
    • 84876408911 scopus 로고    scopus 로고
    • A new approach to inotropic therapy in the treatment of heart failure: Cardiac myosin activators in treatment of HF
    • Garg V, Frishman WH. A new approach to inotropic therapy in the treatment of heart failure: cardiac myosin activators in treatment of HF. Cardiol Rev. 2013; 21: 155-159.
    • (2013) Cardiol Rev , vol.21 , pp. 155-159
    • Garg, V.1    Frishman, W.H.2
  • 97
    • 79960759579 scopus 로고    scopus 로고
    • Searching for the ideal inotropic agent to rescue a failing heart
    • Howlett SE. Searching for the ideal inotropic agent to rescue a failing heart. Cardiovasc Res. 2011; 91: 371-372.
    • (2011) Cardiovasc Res , vol.91 , pp. 371-372
    • Howlett, S.E.1
  • 99
    • 46149117254 scopus 로고    scopus 로고
    • Slow contractions characterize failing rat hearts
    • Bokenes J, Aronsen JM, Birkeland JA, et al. Slow contractions characterize failing rat hearts. Basic Res Cardiol. 2008; 103: 328-344.
    • (2008) Basic Res Cardiol , vol.103 , pp. 328-344
    • Bokenes, J.1    Aronsen, J.M.2    Birkeland, J.A.3
  • 100
    • 79960819821 scopus 로고    scopus 로고
    • Beneficial effects of SR33805 in failing myocardium
    • Ait Mou Y, Toth A, Cassan C, et al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011; 91: 412-419.
    • (2011) Cardiovasc Res , vol.91 , pp. 412-419
    • Ait Mou, Y.1    Toth, A.2    Cassan, C.3
  • 102
    • 0037884933 scopus 로고    scopus 로고
    • Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: Independence from betaadrenergic signaling
    • Paolocci N, Katori T, Champion HC, et al. Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from betaadrenergic signaling. Proc Natl Acad Sci U S A. 2003; 100: 5537-5542.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 5537-5542
    • Paolocci, N.1    Katori, T.2    Champion, H.C.3
  • 103
    • 84892653976 scopus 로고    scopus 로고
    • Nitroxyl (HNO): A novel approach for the acute treatment of heart failure
    • Sabbah HN, Tocchetti CG, Wang M, et al. Nitroxyl (HNO): a novel approach for the acute treatment of heart failure. Circ Heart Fail. 2013; 6: 1250-1258.
    • (2013) Circ Heart Fail , vol.6 , pp. 1250-1258
    • Sabbah, H.N.1    Tocchetti, C.G.2    Wang, M.3
  • 104
    • 34249853701 scopus 로고    scopus 로고
    • Nitroxyl increases force development in rat cardiac muscle
    • Dai T, Tian Y, Tocchetti CG, et al. Nitroxyl increases force development in rat cardiac muscle. J Physiol. 2007; 580(pt 3): 951-960.
    • (2007) J Physiol , vol.580 , pp. 951-960
    • Dai, T.1    Tian, Y.2    Tocchetti, C.G.3
  • 105
    • 84866990581 scopus 로고    scopus 로고
    • Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function
    • Gao WD, Murray CI, Tian Y, et al. Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res. 2012; 111: 1002-1011.
    • (2012) Circ Res , vol.111 , pp. 1002-1011
    • Gao, W.D.1    Murray, C.I.2    Tian, Y.3
  • 106
    • 84884776664 scopus 로고    scopus 로고
    • HNO enhances SERCA2a activity and cardiomyocyte function by promoting redoxdependent phospholamban oligomerization
    • Sivakumaran V, Stanley BA, Tocchetti CG, et al. HNO enhances SERCA2a activity and cardiomyocyte function by promoting redoxdependent phospholamban oligomerization. Antioxid Redox Signal. 2013; 19: 1185-1197.
    • (2013) Antioxid Redox Signal , vol.19 , pp. 1185-1197
    • Sivakumaran, V.1    Stanley, B.A.2    Tocchetti, C.G.3


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