The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: A double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

The Lancet

Volumn 378, Issue 9792, 2011, Pages 676-683

  Cleland, John G F ^a   Teerlink, John R ^b   Senior, Roxy ^c   Nifontov, Evgeny M ^d   McMurray, John J V ^e   Lang, Chim C ^f   Tsyrlin, Vitaly A ^g   Greenberg, Barry H ^h   Mayet, Jamil ⁱ   Francis, Darrel P ⁱ   Shaburishvili, Tamaz ^j   Monaghan, Mark ^k   Saltzberg, Mitchell ^l   Neyses, Ludwig ^m   Wasserman, Scott M ⁿ   Lee, Jacqueline H ^p   Saikali, Khalil G ^p   Clarke, Cyril P ^m   Goldman, Jonathan H ^o   Wolff, Andrew A ^p   Malik, Fady I ^p   more..

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWICK PARK HOSPITAL   (United Kingdom)

^d PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

^f UNIVERSITY OF DUNDEE   (United Kingdom)

^g ALMAZOV NATIONAL MEDICAL RESEARCH CENTRE   (Russian Federation)

^h UCSD MEDICAL CENTER   (United States)

ⁱ ST MARY S HOSPITAL   (United Kingdom)

^j Diagnostic Services Clinic   (Georgia)

^k KING S COLLEGE HOSPITAL   (United Kingdom)

^l THOMAS JEFFERSON UNIVERSITY   (United States)

^m UNIVERSITY OF MANCHESTER   (United Kingdom)

ⁿ AMGEN INC   (United States)

^o ICON Medical Imaging   (United States)

^p Cytokinetics Inc   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOOP DIURETIC AGENT; OMECAMTIV MECARBIL; PLACEBO; TROPONIN I;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIABETIC FOOT; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; FOOT ULCER; HEART BEAT; HEART FUNCTION; HEART LEFT VENTRICLE EJECTION TIME; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE ISCHEMIA; HEART RATE; HEART STROKE VOLUME; HUMAN; LOADING DRUG DOSE; MALE; MULTICENTER STUDY; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPTICEMIA; SYSTOLIC DYSFUNCTION; SYSTOLIC HEART FAILURE; TIME TO MAXIMUM PLASMA CONCENTRATION; TREATMENT DURATION; TREATMENT OUTCOME; VITAL SIGN;

EID: 80051989633     PISSN: 0140-6736     EISSN: 1474-547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(11)61126-4     Document Type: Article

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