Increased mitral valve regurgitation and myocardial hypertrophy in two dogs with long-term pimobendan therapy

Cardiovascular Toxicology

Volumn 5, Issue 1, 2005, Pages 43-51

  Tissier, R ^a,b   Chetboul, V ^a,b   Moraillon, R ^a   Nicolle, A ^a   Carlos, C ^a   Enriquez, B ^a,b   Pouchelon, J L ^a,b  

^a ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^b FACULTÉ DE MÉDECINE   (France)

Author keywords

Dog; Echocardiography; Inodilator; Inotrope; Mitral valve regurgitation; Pimobendan; Tissue Doppler imaging; Ventricular hypertrophy

Indexed keywords

BENAZEPRIL; PIMOBENDAN;

ARTICLE; CLINICAL FEATURE; DISEASE COURSE; DOG; DOPPLER ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART VENTRICLE HYPERTROPHY; MALE; MITRAL VALVE REGURGITATION; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; SYMPTOMATOLOGY; SYSTOLIC HEART MURMUR; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

CANIS FAMILIARIS;

EID: 18544380923     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/ct:5:1:043     Document Type: Article

References (28)

1. Follath, F., Cleland, J.G., Just, H., Papp, J.G., Scholz, H., Peuhkurinen, K., et al. (2002). Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial. Lancet 360:196-202.
2. Moiseyev, V.S., Poder, P., Andrejevs, N., Ruda, M.Y., Golikov, A.P., Lazebnik, L.B., et al. (2002). Safety and efficacy of a novel calcium sensitizer, levosimendan, in patients with left ventricular failure due to an acute myocardial infarction. A randomized, placebo-controlled, double-blind study (RUSSLAN). Eur. Heart J. 23:1422-1432.
3. Remme, W.J., Krayenbuhl, H.P., Baumann, G., Frick, M.H., Haehl, M., Nehmiz, G., et al. (1994). Long-term efficacy and safety of pimobendan in moderate heart failure. A double-blind parallel 6-month comparison with enalapril. The Pimobendan-Enalapril Study Group. Eur. Heart J. 15:947-956.
4. Fuentes, V.L., Corcoran, B., Rench, A., Schober, K.E., Kleemann, R., and Justus, C. (2002). A double-blind, randomized, placebo-controlled study of pimobendan in dogs with dilated cardiomyopathy. J. Vet. Intern. Med. 16:255-261.
5. Schneider, P., Guttner, J., Eckenfels, A., Heinzel, G., Von Nicolai, H., Trieb, G., et al. (1997). Comparative cardiac toxicity of the i.v. administered benzimidazole pyridazon derivative Pimobendan and its enantiomers in female Beagle dogs. Exp. Toxicol. Pathol. 49:217-224.
6. Boswood, A., McEwans, J.D., French, A., Little, C., Swift, S., Smith, S., et al. (2003). Investigation of pimobendan versus benazepril in canine myxomatous valvular disease. Vet. Rec. 153:439-440.
7. Sahn, D.J., DeMaria, A., Kisslo, J., and Weyman, A. (1978). Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation 58:1072-1083.
8. Hansson, K., Häggström, J., Kvart, C., and Lord, P. (2002). Left atrial to aortic root indices using two-dimensional and M-mode echocardiography in Cavalier King Charles spaniels with and without left atrial enlargement. Vet. Radiol. Ultrasound 43:568-575.
9. Chetboul, V., Athanassiadis, N., Concordet, D., Nicolle, A., Tessier, D., Pouchelon, J.-L., et al. (2004) Observer-dependent variability of quantitative clinical endpoints: the example of canine echocardiography. J. Vet. Pharmacol. Ther. 27:49-56.
10. Muzzi, R.A., De Araújo, R.B., Muzzi, L.A., Pena, J.L., and Fraga Silva, E. (2003). Regurgitant jet area by Doppler color flow mapping: quantitative assessment of mitral regurgitation severity in dogs. J. Vet. Cardiol. 2:33-38.
11. Chetboul, V., Athanassiadis, N., Carlos, C., Nicolle, A., Zilberstein, L., Pouchelon, J.-L., et al. (2004) Assessment of repeatability, reproducibility, and effect of anesthesia on determination of radial and longitudinal left ventricular velocities via tissue Doppler imaging in dogs. Am. J. Vet. Res. 65:909-915.
12. Boon, J.A., Wingfield, W.E., and Miller, C.W. (1983). Echocardiographic indices in the normal dog. Vet. Radiol. 24:214-221.
13. Boon, J.A. (1998). Echocardiographic reference values, in Manual of Veterinary Echocardiography. Williams & Wilkins, Baltimore.
14. Boon, J.A. (2003). Handy Reference Veterinary Echocardiography: Two-Dimensional and M-Mode Imaging. Teton Newmedia, Jackson, WY.
15. Morrison, S.A., Moise, N.S., Scarlett, J., Mohammed, H., and Yeager, A.E. (1992). Effect of breed and body weight on echocardiographic values in four breeds of dogs of differing somatotype. J. Vet. Intern. Med. 6:220-224.
16. Chetboul, V., Athanassiadis, N., Carlos, C., Nicolle, A., Zilberstein, L., Pouchelon, J.-L., et al. (2003). Quantification of radial left ventricular motion in healthy dogs using tissue Doppler imaging: intraday and interday variability. Proceedings of the 21st ACVIM Forum, Charlotte, NC.
17. Keren, G., Katz, S., Strom, J., Sonnenblick, E.H., and LeJemtel, T.H. (1989). Dynamic mitral regurgitation. An important determinant of the hemodynamic response to load alterations and inotropic therapy in severe heart failure. Circulation 80:306-313.
18. Keren, G., Laniado, S., Sonnenblick, E.H., and LeJemtel, T.H. (1989). Dynamics of functional mitral regurgitation during dobutamine therapy in patients with severe congestive heart failure: a Doppler echocardiographic study. Am. Heart J. 118:748-754.
19. Gorman, J.H., Jackson, B.M., Moainie, S.L., Enomoto, Y., and Gorman R.C. (2004). Influence of inotropy and chronotropy on the mitral valve sphincter mechanism. Ann. Thorac. Surg. 77:852-858.
20. Uehara, Y. and Takahashi, M. (1998). Hemodynamic changes during administration of drugs for mitral regurgitation in dogs. J. Vet. Med. Sci. 60:213-218.
21. Pedersen, H.D., Häggström, J., Falk, T., Mow, T., Olsen, L.H., Iversen, L., et al. (1999). Auscultation in mild mitral regurgitation in dogs: observer variation, effects of physical maneuvers, and agreement with color Doppler echocardiography and phonocardiography. J. Vet. Int. Med. 13:56-64.
22. Liu, S.K., Roberts, W.C., and Maron, B.J. (1993). Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs. Am. J. Cardiol. 72:944-951.
23. Pedersen, H.D., Lorentzen, K.A., and Kristensen, B.O. (1999). Echocardiographic mitral valve prolapse in cavalier King Charles spaniels: epidemiology and prognostic significance for regurgitation. Vet. Rec. 144:315-320.
24. Buttrick, P., Malhotra, A., Factor, S., Geenen, D., and Scheuer, J. (1988). Effects of chronic dobutamine administration on hearts of normal and hypertensive rats. Circ. Res. 63:173-181.
25. Iaccarino, G., Dolber, P.C., Lefkowitz, R.J., and Koch, W.J. (1999). Beta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Hypertension 33:396-401.
26. Geenen, D.L., Malhotra, A., Scheuer, J., and Buttrick, P.M. (1997). Repeated catecholamine surges alter cardiac isomyosin expression but not protein synthesis in the rat heart. J. Mol. Cell. Cardiol. 29:2711-2716.
27. Zimmer, H.G. (1997). Catecholamine-induced cardiac hypertrophy: significance of proto-oncogene expression. J. Mol. Med. 75:849-859.
28. Oudit, G.Y., Crackower, M.A., Eriksson, U., Sarao, R., Kozieradzki, I., Sasaki, T., et al. (2003). Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 108:2147-2152.