Digoxin use and lower 30-day all-cause readmission for medicare beneficiaries hospitalized for heart failure

American Journal of Medicine

Volumn 127, Issue 1, 2014, Pages 61-70

  Ahmed, Ali ^a,b   Bourge, Robert C ^a   Fonarow, Gregg C ^c   Patel, Kanan ^a   Morgan, Charity J ^a   Fleg, Jerome L ^d   Aban, Inmaculada B ^a   Love, Thomas E ^e   Yancy, Clyde W ^f   Deedwania, Prakash ^g   Van Veldhuisen, Dirk J ^h   Filippatos, Gerasimos S ⁱ   Anker, Stefan D ^j   Allman, Richard M ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e CASE WESTERN RESERVE UNIVERSITY   (United States)

^f NORTHWESTERN UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF GRONINGEN   (Netherlands)

ⁱ NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^j CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

more..

Author keywords

Digoxin; Heart failure; Hospital readmission

Indexed keywords

DIGOXIN;

AGED; ARTICLE; CARDIOVASCULAR MORTALITY; DRUG USE; FEMALE; HEART EJECTION FRACTION; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICARE; PRESCRIPTION; PRIORITY JOURNAL; SYSTOLIC HEART FAILURE;

EID: 84891625961     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2013.08.027     Document Type: Article

References (51)

1. S.F. Jencks, M.V. Williams, and E.A. Coleman Rehospitalizations among patients in the Medicare fee-for-service program N Engl J Med 360 2009 1418 1428
2. J. Rau Hospitals face pressure to avert readmissions The New York Times November 26, 2012 Available at: http://www.nytimes.com/2012/11/27/health/ hospitals-face-pressure-from-medicare-to-avert-readmissions.html?-r=0 Accessed December 2, 2012
3. J. Stone, and G.J. Hoffman Medicare Hospital Readmissions: Issues, Policy Options and PPACA 2010 Congressional Research Service Report for Congress: Prepared for Members and Committees of Congress Washington, DC Available at: http://www.ncsl.org/documents/health/Medicare-Hospital-Readmissions-and-PPACA. pdf Accessed September 7, 2012
4. Sommers C, Cunningham PJ. Physician visits after hospital discharge: implications for reducing readmissions. The National Institute for Health Care Reform. Washington, DC; 2011. Available at: http://www.nihcr.org/Reducing- Readmissions.pdf. Accessed May 9, 2012.
5. M.A. Konstam Heart failure in the lifetime of Musca domestica (the common housefly) JACC Heart Fail 1 2013 178 180
6. J. Butler, and A. Kalogeropoulos Hospital strategies to reduce heart failure readmissions: where is the evidence? J Am Coll Cardiol 60 2012 615 617
7. L.O. Hansen, R.S. Young, K. Hinami, A. Leung, and M.V. Williams Interventions to reduce 30-day rehospitalization: a systematic review Ann Intern Med 155 2011 520 528
8. A. Ahmed A propensity matched study of New York Heart Association class and natural history end points in heart failure Am J Cardiol 99 2007 549 553
9. P. Meyer, O.J. Ekundayo, and C. Adamopoulos et al. A propensity-matched study of elevated jugular venous pressure and outcomes in chronic heart failure Am J Cardiol 103 2009 839 844
10. M. Gheorghiade, V. Hall, J.B. Lakier, and S. Goldstein Comparative hemodynamic and neurohormonal effects of intravenous captopril and digoxin and their combinations in patients with severe heart failure J Am Coll Cardiol 13 1989 134 142
11. D.J. van Veldhuisen, A.J. Man in 't Veld, and P.H. Dunselman et al. Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial (DIMT) J Am Coll Cardiol 22 1993 1564 1573
12. G.E. Newton, J.H. Tong, A.M. Schofield, A.D. Baines, J.S. Floras, and J.D. Parker Digoxin reduces cardiac sympathetic activity in severe congestive heart failure J Am Coll Cardiol 28 1996 155 161
13. M. Packer, M. Gheorghiade, and J.B. Young et al. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting- enzyme inhibitors. RADIANCE Study N Engl J Med 329 1993 1 7
14. B.F. Uretsky, J.B. Young, F.E. Shahidi, L.G. Yellen, M.C. Harrison, and M.K. Jolly Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. PROVED Investigative Group J Am Coll Cardiol 22 1993 955 962
15. The Digitalis Investigation Group Investigators The effect of digoxin on mortality and morbidity in patients with heart failure N Engl J Med 336 1997 525 533
16. A. Ahmed, M.W. Rich, and J.L. Fleg et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial Circulation 114 2006 397 403
17. R.C. Bourge, J.L. Fleg, and G.C. Fonarow et al. Digoxin reduces 30-day all-cause hospital admission in older patients with chronic systolic heart failure Am J Med 126 2013 701 708
18. M. Gheorghiade, K. Patel, and G. Filippatos et al. Effect of oral digoxin in high-risk heart failure patients: a pre-specified subgroup analysis of the DIG trial Eur J Heart Fail 15 2013 551 559
19. G. Hess, R. Preblick, J. Hill, C.A. Plauschinat, and J. Yaskin Effects of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker therapy after hospital discharge on subsequent rehospitalization for acute myocardial infarction and heart failure Congest Heart Fail 15 2009 170 175
20. A.F. Hernandez, B.G. Hammill, C.M. O'Connor, K.A. Schulman, L.H. Curtis, and G.C. Fonarow Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry J Am Coll Cardiol 53 2009 184 192
21. A. Ahmed, G.C. Fonarow, and Y. Zhang et al. Renin-angiotensin inhibition in systolic heart failure and chronic kidney disease Am J Med 125 2012 399 410
22. A. Ahmed, M.W. Rich, and M. Zile et al. Renin-angiotensin inhibition in diastolic heart failure and chronic kidney disease Am J Med 126 2013 150 161
23. M.A. Feller, M. Mujib, and Y. Zhang et al. Baseline characteristics, quality of care, and outcomes of younger and older Medicare beneficiaries hospitalized with heart failure: findings from the Alabama Heart Failure Project Int J Cardiol 162 2012 39 44
24. G. Danaei, M. Tavakkoli, and M.A. Hernan Bias in observational studies of prevalent users: lessons for comparative effectiveness research from a meta-analysis of statins Am J Epidemiol 175 2012 250 262
25. K. Patel, G.C. Fonarow, and D.W. Kitzman et al. Angiotensin receptor blockers and outcomes in real-world older patients with heart failure and preserved ejection fraction: a propensity-matched inception cohort clinical effectiveness study Eur J Heart Fail 14 2012 1179 1188
26. P.R. Rosenbaum, and D.B. Rubin The central role of propensity score in observational studies for causal effects Biometrika 70 1983 41 55
27. D.B. Rubin Using propensity score to help design observational studies: application to the tobacco litigation Health Serv Outcomes Res Methodol 2 2001 169 188
28. A. Ahmed, A. Husain, and T.E. Love et al. Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods Eur Heart J 27 2006 1431 1439
29. A. Ahmed, M.W. Rich, and T.E. Love et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial Eur Heart J 27 2006 178 186
30. P.C. Austin Primer on statistical interpretation or methods report card on propensity-score matching in the cardiology literature from 2004 to 2006: a systematic review Circ Cardiovasc Qual Outcomes 1 2008 62 67
31. M. Mujib, K. Patel, and G.C. Fonarow et al. Angiotensin-converting enzyme inhibitors and outcomes in heart failure and preserved ejection fraction Am J Med 126 2013 401 410
32. C. Wahle, C. Adamopoulos, O.J. Ekundayo, M. Mujib, W.S. Aronow, and A. Ahmed A propensity-matched study of outcomes of chronic heart failure (HF) in younger and older adults Arch Gerontol Geriatr 49 2009 165 171
33. D.Y. Lin, L.J. Wei, and Z. Ying Checking the Cox model with cumulative sums of Martingale-based residuals Biometrika 80 1993 557 572
34. P.R. Rosenbaum Sensitivity to hidden bias P.R. Rosenbaum, Observational Studies Vol 1 2002 Springer-Verlag New York 105 170
35. S.S. Rathore, Y. Wang, and H.M. Krumholz Sex-based differences in the effect of digoxin for the treatment of heart failure N Engl J Med 347 2002 1403 1411
36. K.F. Adams Jr., J.H. Patterson, and W.A. Gattis et al. Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis J Am Coll Cardiol 46 2005 497 504
37. Krumholz HM. DIGging in: three reasons why the recent digoxin study is not relevant to readmission. CardioExchange: An NEJM Practice Community. Available at: http://www.cardioexchange.org/voices/digging-in-three-reasons-why- the-recent-digoxin-study-is-not-relevant-to-readmission/. 2013. Accessed July 27, 2013.
38. The Centers for Medicare & Medicaid Services. Chronic Conditions Among Medicare Beneficiaries, Chart Book. Baltimore, MD; 2011. Available at: http://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and- Reports/Chronic-Conditions/Downloads/2011Chartbook.pdf. Accessed August 28, 2012.
39. A. Ahmed Chronic heart failure in older adults Med Clin North Am 95 2011 439 461 ix
40. T. Hashim, S. Elbaz, and K. Patel et al. Digoxin and 30-day all-cause hospital admission in older patients with chronic diastolic heart failure Am J Med 2013 pii: S0002-9343(13)00711-0 doi:10.1016/j.amjmed.2013.08.006 [Epub ahead of print]
41. A. Ahmed Digoxin and reduction in mortality and hospitalization in geriatric heart failure: importance of low doses and low serum concentrations J Gerontol A Biol Sci Med Sci 62 2007 323 329
42. S.S. Rathore, J.P. Curtis, Y. Wang, M.R. Bristow, and H.M. Krumholz Association of serum digoxin concentration and outcomes in patients with heart failure JAMA 289 2003 871 878
43. M.R. Zile, W.H. Gaasch, and I.S. Anand et al. Mode of death in patients with heart failure and a preserved ejection fraction: results from the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-Preserve) trial Circulation 121 2010 1393 1405
44. A. Ahmed, F. Waagstein, and B. Pitt et al. Effectiveness of digoxin in reducing one-year mortality in chronic heart failure in the Digitalis Investigation Group trial Am J Cardiol 103 2009 82 87
45. S.A. Hunt, W.T. Abraham, and M.H. Chin et al. 2009 focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation Circulation 119 2009 e391 e479
46. K. Dickstein, A. Cohen-Solal, and G. Filippatos et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM) Eur Heart J 29 2008 2388 2442
47. G.C. Fonarow, W.G. Stough, and W.T. Abraham et al. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry J Am Coll Cardiol 50 2007 768 777
48. D. Castagno, M.C. Petrie, B. Claggett, and J. McMurray Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure Eur Heart J 33 2012 1137 1141
49. J. Butler, P.G. Arbogast, J. Daugherty, M.K. Jain, W.A. Ray, and M.R. Griffin Outpatient utilization of angiotensin-converting enzyme inhibitors among heart failure patients after hospital discharge J Am Coll Cardiol 43 2004 2036 2043
50. L.H. Curtis, X. Mi, and L.G. Qualls et al. Transitional adherence and persistence in the use of aldosterone antagonist therapy in patients with heart failure Am Heart J 165 2013 979 986
51. R. Clarke, M. Shipley, and S. Lewington et al. Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies Am J Epidemiol 150 1999 341 353