Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function

Circulation Research

Volumn 111, Issue 8, 2012, Pages 1002-1011

  Gao, Wei Dong ^a   Murray, Christopher I ^a   Tian, Ye ^a,b   Zhong, Xin ^a,b   Dumond, Jenna F ^c   Shen, Xiaoxu ^a   Stanley, Brian A ^a   Brian Foster, D ^a   Wink, David A ^d   Bruce King, S ^c   Van Eyk, Jennifer E ^a   Paolocci, Nazareno ^a,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c WAKE FOREST UNIVERSITY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY OF PERUGIA   (Italy)

Author keywords

calcium; contractility; nitroxyl; oxidant signaling; oxidation; redox; redox switch

Indexed keywords

1 NITROSOCYCLOHEXYL ACETATE; ACTIN; BIOTIN; CALCIUM; CARDIAC MYOFILAMENT PROTEIN; CYSTEINE; MYOSIN HEAVY CHAIN; MYOSIN LIGHT CHAIN; TEMPOL; TROPOMYOSIN; UNCLASSIFIED DRUG;

ACUTE HEART FAILURE; ARTICLE; CALCIUM CELL LEVEL; DISULFIDE BOND; HEART MUSCLE CONTRACTILE FORCE; MASS SPECTROMETRY; OXIDATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MODIFICATION; SKELETAL MUSCLE;

ACETATES; ACTINS; ANIMALS; CALCIUM; CYSTEINE; DIMERIZATION; DISULFIDES; HEART FAILURE; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; MYOFIBRILS; MYOSIN LIGHT CHAINS; NITRIC OXIDE; NITROGEN OXIDES; NITROSO COMPOUNDS; OXIDATION-REDUCTION; RATS;

EID: 84866990581     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.270827     Document Type: Article

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