Levosimendan preserves the contractile responsiveness of hypoxic human myocardium via mitochondrial KATP channel and potential pERK 1/2 activation

European Journal of Pharmacology

Volumn 655, Issue 1-3, 2011, Pages 59-66

  Soeding, Paul F ^a,b   Crack, Peter J ^a   Wright, Christine E ^a   Angus, James A ^a   Royse, Colin F ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Apoptosis; Human right atrium levosimendan; Hypoxia reoxygenation; Prosurvival mediator

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CASPASE 3; CYTOCHROME C; ISOPRENALINE; LEVOSIMENDAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SYNAPTOPHYSIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HEART FUNCTION; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART RIGHT ATRIUM; HUMAN; HUMAN TISSUE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN SECRETION; REOXYGENATION;

ADRENERGIC BETA-AGONISTS; APOPTOSIS; CASPASE 3; CELL HYPOXIA; CYTOCHROMES C; ENZYME ACTIVATION; HEART ATRIA; HUMANS; HYDRAZONES; ISCHEMIC PRECONDITIONING, MYOCARDIAL; ISOPROTERENOL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE CONTRACTION; MYOCARDIUM; OXYGEN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; POTASSIUM CHANNELS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDAZINES;

EID: 79952491928     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.12.035     Document Type: Article

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