Levocetirizine ameliorates high fructose diet-induced insulin resistance, vascular dysfunction and hepatic steatosis in rats

European Journal of Pharmacology

Volumn 740, Issue , 2014, Pages 353-363

  Shawky, Noha M ^a   Shehatou, George S G ^a   Abdel Rahim, Mona ^b   Suddek, Ghada M ^a   Gameil, Nariman M ^a  

^a Mansoura University 35516   (Egypt)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Aortic rings; Insulin resistance; Levocetirizine; Lipid profile; Oxidative stress

Indexed keywords

C REACTIVE PROTEIN; CETIRIZINE; FRUCTOSE; GLUTATHIONE; HISTAMINE H1 RECEPTOR ANTAGONIST; INSULIN; LACTATE DEHYDROGENASE; LEVOCETIRIZINE; LIPID; PROTECTIVE AGENT; SUPEROXIDE DISMUTASE; TLR4 PROTEIN, RAT; TOLL LIKE RECEPTOR 4;

ANIMAL; BLOOD; BODY WEIGHT; DIET; DRUG EFFECTS; EATING; FATTY LIVER; GLUCOSE TOLERANCE TEST; INSULIN RESISTANCE; LIPID PEROXIDATION; LIVER; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; AORTA, THORACIC; BODY WEIGHT; C-REACTIVE PROTEIN; CETIRIZINE; DIET; EATING; ENDOTHELIUM, VASCULAR; FATTY LIVER; FRUCTOSE; GLUCOSE TOLERANCE TEST; GLUTATHIONE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; INSULIN; INSULIN RESISTANCE; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; PROTECTIVE AGENTS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TOLL-LIKE RECEPTOR 4; VASODILATION;

EID: 84906043439     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.07.021     Document Type: Article

References (76)

1. F. Abbasi, N.K. Lima, and G.M. Reaven Relationship between changes in insulin sensitivity and associated cardiovascular disease risk factors in thiazolidinedione-treated, insulin-resistant, nondiabetic individuals: pioglitazone versus rosiglitazone Metabolism 58 2009 373 378
2. S.M. Ammar, S.A. Said, G.M. Suddek, and S.L. El-Damarawy Amelioration of doxorubicin-induced cardiotoxicity by deferiprone in rats Can. J. Physiol. Pharmacol. 89 2011 269 276
3. C. Babacanoglu, N. Yildirim, G. Sadi, M.B. Pektas, and F. Akar Resveratrol prevents high-fructose corn syrup-induced vascular insulin resistance and dysfunction in rats Food Chem. Toxicol. 60 2013 160 167
4. P.J. Barter, S. Nicholls, K.A. Rye, G.M. Anantharamaiah, M. Navab, and A.M. Fogelman Antiinflammatory properties of HDL Circ. Res. 95 2004 764 772 (Pubitemid 39390578)
5. A.P. Bautista, C.P. Eisenlohr, and M.J. Lanz Nasal nitric oxide and nasal eosinophils decrease with levocetirizine in subjects with perennial allergic rhinitis Am. J. Rhinol. Allergy 25 2011 383 387
6. M.E. Bocarsly, E.S. Powell, N.M. Avena, and B.G. Hoebel High-fructose corn syrup causes characteristics of obesity in rats: increased body weight, body fat and triglyceride levels Pharmacol. Biochem. Behav. 97 2010 101 106
7. J.Y. Cha, H.Y. Ahn, Y.S. Cho, and J.Y. Je Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague-Dawley rats Food Chem. Toxicol. 60 2013 52 57
8. M. Ciebiada, M. Barylski, and C.M. Gorska Nasal eosinophilia and serum soluble intercellular adhesion molecule 1 in patients with allergic rhinitis treated with montelukast alone or in combination with desloratadine or levocetirizine Am. J. Rhinol. Allergy 27 2013 e58 e62
9. S. Dai, and J.H. McNeill Fructose-induced hypertension in rats is concentration- and duration-dependent J. Pharmacol. Toxicol. Methods 33 1995 101 107
10. M. Davidson, P.M. Meyer, S. Haffner, S. Feinstein, R. D'Agostino Sr., G.T. Kondos, A. Perez, Z. Chen, and T. Mazzone Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus Circulation 117 2008 2123 2130 (Pubitemid 351572171)
11. M.A. Deeg, J.B. Buse, R.B. Goldberg, D.M. Kendall, A.J. Zagar, S.J. Jacober, M.A. Khan, A.T. Perez, and M.H. Tan Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia Diabetes Care 30 2007 2458 2464 (Pubitemid 47547772)
12. R.A. DeFronzo, and E. Ferrannini Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease Diabetes Care 14 1991 173 194
13. J.L. Devalia, V.C. De, F. Hanotte, and E. Baltes A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers Allergy 56 2001 50 57 (Pubitemid 32099072)
14. G.L. Ellman Tissue sulfhydryl groups Arch. Biochem. Biophys. 82 1959 70 77
15. M.M. Elmazar, H.S. El-Abhar, M.F. Schaalan, and N.A. Farag Phytol/Phytanic acid and insulin resistance: potential role of phytanic acid proven by docking simulation and modulation of biochemical alterations PLoS.One 8 2013 e45638
16. W.T. Friedewald, R.I. Levy, and D.S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin. Chem. 18 1972 499 502
17. A.K. Fulop, A. Foldes, E. Buzas, K. Hegyi, I.H. Miklos, L. Romics, M. Kleiber, A. Nagy, A. Falus, and K.J. Kovacs Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene Endocrinology 144 2003 4306 4314 (Pubitemid 37204829)
18. D. Galipeau, E. Arikawa, I. Sekirov, and J.H. McNeill Chronic thromboxane synthase inhibition prevents fructose-induced hypertension Hypertension 38 2001 872 876 (Pubitemid 34258685)
19. D. Galipeau, S. Verma, and J.H. McNeill Female rats are protected against fructose-induced changes in metabolism and blood pressure Am. J. Physiol. Heart Circ. Physiol. 283 2002 H2478 H2484
20. J.M. Gandon, and H. Allain Lack of effect of single and repeated doses of levocetirizine, a new antihistamine drug, on cognitive and psychomotor functions in healthy volunteers Br. J. Clin. Pharmacol. 54 2002 51 58 (Pubitemid 36124754)
21. R.B. Goldberg, D.M. Kendall, M.A. Deeg, J.B. Buse, A.J. Zagar, J.A. Pinaire, M.H. Tan, M.A. Khan, A.T. Perez, and S.J. Jacober A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia Diabetes Care 28 2005 1547 1554 (Pubitemid 40923063)
22. J.M. Guilemany, A. Garcia-Pinero, I. Alobid, S. Centellas, F.S. Marino, A. Valero, M. Bernal-Sprekelsen, C. Picado, and J. Mullol The loss of smell in persistent allergic rhinitis is improved by levocetirizine due to reduction of nasal inflammation but not nasal congestion (the CIRANO study) Int. Arch. Allergy Immunol. 158 2012 184 190
23. A. Gupta, M. Gillard, B. Christophe, P. Chatelain, R. Massingham, and M. Hammarlund-Udenaes Peripheral and central H1 histamine receptor occupancy by levocetirizine, a non-sedating antihistamine; a time course study in the guinea pig Br. J Pharmacol. 151 2007 1129 1136 (Pubitemid 47195533)
24. M. Hahn, A. Chintoh, A. Giacca, L. Xu, L. Lam, S. Mann, P. Fletcher, M. Guenette, T. Cohn, T. Wolever, T. Arenovich, and G. Remington Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: an animal model Schizophr. Res. 131 2011 90 95
25. P.J. Havel Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism Nutr. Rev. 63 2005 133 157
26. M.P. Hermans, J.C. Levy, R.J. Morris, and R.C. Turner Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes Diabetologia 42 1999 678 687 (Pubitemid 29265585)
27. M. Herz, D. Johns, J. Reviriego, L.D. Grossman, C. Godin, S. Duran, F. Hawkins, H. Lochnan, F. Escobar-Jimenez, P.A. Hardin, C.S. Konkoy, and M.H. Tan A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus Clin. Ther. 25 2003 1074 1095 (Pubitemid 36532579)
28. T. Hidaka, K. Nakagawa, C. Goto, J. Soga, Y. Fujii, T. Hata, N. Idei, N. Fujimura, K. Chayama, Y. Kihara, and Y. Higashi Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress Atherosclerosis 210 2010 521 524
29. T.J. Horton, E.C. Gayles, P.A. Prach, T.A. Koppenhafer, and M.J. Pagliassotti Female rats do not develop sucrose-induced insulin resistance Am. J. Physiol. 272 1997 R1571 R1576
30. I.S. Hwang, H. Ho, B.B. Hoffman, and G.M. Reaven Fructose-induced insulin resistance and hypertension in rats Hypertension 10 1987 512 516 (Pubitemid 18011228)
31. T. Ishimoto, M.A. Lanaspa, M.T. Le, G.E. Garcia, C.P. Diggle, P.S. Maclean, M.R. Jackman, A. Asipu, C.A. Roncal-Jimenez, T. Kosugi, C.J. Rivard, S. Maruyama, B. Rodriguez-Iturbe, L.G. Sanchez-Lozada, D.T. Bonthron, Y.Y. Sautin, and R.J. Johnson Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice Proc. Natl. Acad. Sci. U. S. A. 109 2012 4320 4325
32. S.N. Iyer, and M.J. Katovich Effect of chronic losartan potassium treatment on fructose-induced hypertension Life Sci. 55 1994 L139 L144
33. P.V. Katakam, M.R. Ujhelyi, M.E. Hoenig, and A.W. Miller Endothelial dysfunction precedes hypertension in diet-induced insulin resistance Am. J. Physiol. 275 1998 R788 R792
34. J.J. Kim, and D.D. Sears TLR4 and insulin resistance Gastroenterol. Res. Pract. 2010 2010
35. K.A. Le, and L. Tappy Metabolic effects of fructose Curr. Opin. Clin. Nutr. Metab. Care 9 2006 469 475 (Pubitemid 44097820)
36. H.R. Light, E. Tsanzi, J. Gigliotti, K. Morgan, and J.C. Tou The type of caloric sweetener added to water influences weight gain, fat mass, and reproduction in growing Sprague-Dawley female rats Exp. Biol. Med. (Maywood) 234 2009 651 661
37. D. MacGlashan Jr. Histamine: a mediator of inflammation J. Allergy Clin. Immunol. 112 2003 S53 S59
38. J.B. Majithiya, A.N. Paramar, and R. Balaraman Pioglitazone, a PPARgamma agonist, restores endothelial function in aorta of streptozotocin-induced diabetic rats Cardiovasc. Res. 66 2005 150 161 (Pubitemid 40357878)
39. S.L. Marklund Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB/c mice Mutat. Res. 148 1985 129 134 (Pubitemid 15151671)
40. T. Masaki, H. Yoshimatsu, S. Chiba, T. Watanabe, and T. Sakata Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice Diabetes 50 2001 376 384 (Pubitemid 32127295)
41. T. Masaki, H. Yoshimatsu, S. Chiba, T. Watanabe, and T. Sakata Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice Diabetes 50 2001 385 391 (Pubitemid 32127296)
42. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419 (Pubitemid 15018832)
43. R. Miatello, N. Risler, C. Castro, S. Gonzalez, M. Ruttler, and M. Cruzado Aortic smooth muscle cell proliferation and endothelial nitric oxide synthase activity in fructose-fed rats Am. J. Hypertens. 14 2001 1135 1141 (Pubitemid 33033114)
44. Y. Miyazaki, and R.A. DeFronzo Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients Diabetes Obes. Metab. 10 2008 1204 1211
45. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358 (Pubitemid 9194347)
46. T. Omae, T. Nagaoka, I. Tanano, and A. Yoshida Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels Investig. Ophthalmol. Vis. Sci. 52 2011 6749 6756
47. A. Pechova, J. Illek, and R. Hallouzka Diagnosis and control of the development of hepatic steatosis in dairy cows in the postparturient period Acta Vet. Brno 66 1997 235 243 (Pubitemid 127531441)
48. K.F. Petersen, and G.I. Shulman Etiology of insulin resistance Am. J. Med. 119 2006 S10 S16
49. J.R. Petrie, S. Ueda, D.J. Webb, H.L. Elliott, and J.M. Connell Endothelial nitric oxide production and insulin sensitivity. A physiological link with implications for pathogenesis of cardiovascular disease Circulation 93 1996 1331 1333 (Pubitemid 26099342)
50. Y. Rayssiguier, E. Gueux, W. Nowacki, E. Rock, and A. Mazur High fructose consumption combined with low dietary magnesium intake may increase the incidence of the metabolic syndrome by inducing inflammation Magnes. Res. 19 2006 237 243 (Pubitemid 46361325)
51. M. Razavizade, R. Jamali, A. Arj, S.M. Matini, A. Moraveji, and E. Taherkhani The effect of pioglitazone and metformin on liver function tests, insulin resistance, and liver fat content in nonalcoholic Fatty liver disease: a randomized double blinded clinical trial Hepat. Mon. 13 2013 e9270
52. G.M. Reaven Pathophysiology of insulin resistance in human disease Physiol. Rev. 75 1995 473 486
53. S.M. Reyna, S. Ghosh, P. Tantiwong, C.S.R. Meka, P. Eagan, C.P. Jenkinson, E. Cersosimo, R.A. DeFronzo, D.K. Coletta, A. Sriwijitkamol, and N. Musi Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects Diabetes 57 2008 2595 2602
54. P.M. Ridker, J.E. Buring, N.R. Cook, and N. Rifai C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women Circulation 107 2003 391 397
55. F. Rubino, and J. Marescaux Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease Ann. Surg. 239 2004 1 11 (Pubitemid 38176365)
56. A.C. Rutledge, and K. Adeli Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms Nutr. Rev. 65 2007 S13 S23
57. J.K. Ryu, and S.D. Yoo Simultaneous determination of levocetirizine and pseudoephedrine in dog plasma by liquid chromatography-mass spectrometry in the presence of dextrocetirizine J. Pharm. Pharm. Sci. 15 2012 519 527
58. F. Salvemini, A. Franze, A. Iervolino, S. Filosa, S. Salzano, and M.V. Ursini Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expression J. Biol. Chem. 274 1999 2750 2757 (Pubitemid 29075355)
59. I. Shimoda, M. Koizumi, T. Shimosegawa, T. Shishido, T. Ono, K. Sato, J. Ishizuka, and T. Toyota Physiological characteristics of spontaneously developed diabetes in male WBN/Kob rat and prevention of development of diabetes by chronic oral administration of synthetic trypsin inhibitor (FOY-305) Pancreas 8 1993 196 203 (Pubitemid 23062071)
60. J.L. Sievenpiper, R.J. de Souza, A. Mirrahimi, M.E. Yu, A.J. Carleton, J. Beyene, L. Chiavaroli, B.M. Di, A.L. Jenkins, L.A. Leiter, T.M. Wolever, C.W. Kendall, and D.J. Jenkins Effect of fructose on body weight in controlled feeding trials: a systematic review and meta-analysis Ann. Intern. Med. 156 2012 291 304
61. M.J. Song, K.H. Kim, J.M. Yoon, and J.B. Kim Activation of toll-like receptor 4 is associated with insulin resistance in adipocytes Biochem. Biophys. Res. Commun. 346 2006 739 745
62. A.H. Stark, B. Timar, and Z. Madar Adaptation of Sprague Dawley rats to long-term feeding of high fat or high fructose diets Eur. J. Nutr. 39 2000 229 234
63. C.D. Stehouwer, M.A. Gall, J.W. Twisk, E. Knudsen, J.J. Emeis, and H.H. Parving Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death Diabetes 51 2002 1157 1165 (Pubitemid 34438363)
64. H.O. Steinberg, G. Brechtel, A. Johnson, N. Fineberg, and A.D. Baron Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release J. Clin. Investig. 94 1994 1172 1179
65. M. Suzuki, I. Takamisawa, Y. Yoshimasa, and Y. Harano Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone Diabetes Res. Clin. Pract. 76 2007 12 17 (Pubitemid 46240368)
66. Y. Takagawa, M.E. Berger, M.T. Hori, M.L. Tuck, and M.S. Golub Long-term fructose feeding impairs vascular relaxation in rat mesenteric arteries Am. J. Hypertens. 14 2001 811 817 (Pubitemid 32682250)
67. A.W. Thorburn, L.H. Storlien, A.B. Jenkins, S. Khouri, and E.W. Kraegen Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats Am. J. Clin. Nutr. 49 1989 1155 1163 (Pubitemid 19169675)
68. T.A. Tobey, C.E. Mondon, I. Zavaroni, and G.M. Reaven Mechanism of insulin resistance in fructose-fed rats Metabolism 31 1982 608 612 (Pubitemid 12112253)
69. D. Tomasian, J.F. Keaney, and J.A. Vita Antioxidants and the bioactivity of endothelium-derived nitric oxide Cardiovasc. Res. 47 2000 426 435 (Pubitemid 30646065)
70. L.T. Tran, V.G. Yuen, and J.H. McNeill The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension Mol. Cell. Biochem. 332 2009 145 159
71. K. Tsuchiya, I. Akaza, T. Yoshimoto, and Y. Hirata Pioglitazone improves endothelial function with increased adiponectin and high-density lipoprotein cholesterol levels in type 2 diabetes Endocr. J. 56 2009 691 698
72. S. Verma, S. Bhanot, L. Yao, and J.H. McNeill Defective endothelium-dependent relaxation in fructose-hypertensive rats Am. J. Hypertens. 9 1996 370 376 (Pubitemid 26129025)
73. S. Wagnerberger, A. Spruss, G. Kanuri, C. Stahl, M. Schroder, W. Vetter, S.C. Bischoff, and I. Bergheim Lactobacillus casei Shirota protects from fructose-induced liver steatosis: a mouse model J. Nutr. Biochem. 24 2013 531 538
74. T.M. Wallace, J.C. Levy, and D.R. Matthews Use and abuse of HOMA modeling Diabetes Care 27 2004 1487 1495 (Pubitemid 38680001)
75. J. Wang, and G.P. Shi Mast cell stabilization: novel medication for obesity and diabetes Diabetes Metab. Res. Rev 27 2011 919 924
76. K.Y. Wang, A. Tanimoto, S. Yamada, X. Guo, Y. Ding, T. Watanabe, T. Watanabe, K. Kohno, K. Hirano, H. Tsukada, and Y. Sasaguri Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice Am. J. Pathol. 177 2010 713 723