Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 29, 2010, Pages 12895-12900

  Ryana, Jeremy A ^a   Brunellea, Joslyn K ^a   Letai, Anthony ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

BCL 2; BIM; Negative selection

Indexed keywords

BH3 PROTEIN; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; AUTOIMMUNITY; CD4+ CD8+ THYMOCYTE; CELL DEATH; CELL FUNCTION; CELL POPULATION; HYPERSENSITIVITY; MITOCHONDRION; PHENOTYPE; PRIORITY JOURNAL; THYMOCYTE; WHOLE CELL;

ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL MEMBRANE PERMEABILITY; CROSS-PRIMING; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; THYMUS GLAND;

EID: 77955616572     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914878107     Document Type: Article

References (34)

1. Grillot DA, Merino R, Núñez G (1995) Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med 182:1973-1983.
2. Strasser A, Harris AW, Cory S (1991) bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889-899.
3. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD (1997) The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136.
4. Danial NN, Korsmeyer SJ (2004) Cell death: Critical control points. Cell 116:205-219.
5. Lindsten T, et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6: 1389-1399. (Pubitemid 32045931)
6. Wei MC, et al. (2001) Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292:727-730.
7. Wang X (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933.
8. Boyd JM, et al. (1995) Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene 11:1921-1928.
9. Letai A, et al. (2002) Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell 2:183-192. (Pubitemid 41043974)
10. Gavathiotis E, et al. (2008) BAX activation is initiated at a novel interaction site. Nature 455:1076-1081.
11. Lovell JF, et al. (2008) Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. Cell 135:1074-1084.
12. Wei MC, et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 14:2060-2071.
13. Certo M, et al. (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9:351-365. (Pubitemid 43668734)
14. Kuwana T, et al. (2005) BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell 17:525-535. (Pubitemid 40269117)
15. Cheng EH, Levine B, Boise LH, Thompson CB, Hardwick JM (1996) Bax-independent inhibition of apoptosis by Bcl-XL. Nature 379:554-556.
16. Cheng EH, et al. (2001) BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell 8:705-711.
17. Chen L, et al. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3- only ligands allows complementary apoptotic function. Mol Cell 17:393-403. (Pubitemid 40193310)
18. Opferman JT, et al. (2003) Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 426:671-676. (Pubitemid 38009376)
19. Deng J, et al. (2007) BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 12:171-185. (Pubitemid 47199122)
20. Del Gaizo Moore V, et al. (2007) Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. J Clin Invest 117:112-121.
21. Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A (2008) BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia. Blood 111:2300-2309. (Pubitemid 351451437)
22. Brunelle JK, Ryan J, Yecies D, Opferman JT, Letai A (2009) MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts. J Cell Biol 187:429-442.
23. Yamaguchi R, et al. (2007) Mitochondria frozen with trehalose retain a number of biological functions and preserve outer membrane integrity. Cell Death Differ 14: 616-624. (Pubitemid 46259969)
24. Punt JA, Suzuki H, Granger LG, Sharrow SO, Singer A (1996) Lineage commitment in the thymus: Only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis. J Exp Med 184:2091-2099.
25. Dzhagalov I, Dunkle A, He YW (2008) The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. J Immunol 181:521-528.
26. Bouillet P, et al. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738. (Pubitemid 129515880)
27. Bouillet P, et al. (2002) BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415:922-926. (Pubitemid 34174755)
28. Ma A, et al. (1995) Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci USA 92:4763-4767.
29. Gratiot-Deans J, Ding L, Turka LA, Nuñez G (1993) bcl-2 proto-oncogene expression during human T cell development: Evidence for biphasic regulation. J Immunol 151: 83-91. (Pubitemid 23206973)
30. Veis DJ, Sentman CL, Bach EA, Korsmeyer SJ (1993) Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. J Immunol 151: 2546-2554. (Pubitemid 23264507)
31. Zhu Y, et al. (2004) Constitutive association of the proapoptotic protein Bim with Bcl- 2-related proteins on mitochondria in T cells. Proc Natl Acad Sci USA 101:7681-7686. (Pubitemid 38658089)
32. Colell A, et al. (2007) GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation. Cell 129:983-997. (Pubitemid 46813151)
33. Ricci JE, et al. (2004) Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell 117:773-786.
34. Zamzami N, Kroemer G (2004) Methods to measure membrane potential and permeability transition in the mitochondria during apoptosis. Methods Mol Biol 282: 103-115.