AEG-1 regulates retinoid X receptor and inhibits retinoid signaling

Cancer Research

Volumn 74, Issue 16, 2014, Pages 4364-4377

  Srivastava, Jyoti ^a   Robertson, Chadia L ^a   Rajasekaran, Devaraja ^a   Gredler, Rachel ^a   Siddiq, Ayesha ^a   Emdad, Luni ^a   Mukhopadhyay, Nitai D ^a   Ghosh, Shobha ^b   Hylemon, Phillip B ^a   Gil, Gregorio ^a   Shah, Khalid ^c   Bhere, Deepak ^c   Subler, Mark A ^a   Windle, Jolene J ^a,d   Fisher, Paul B ^a,b,d   Sarkar, Devanand ^a,b,d  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; MTDH PROTEIN, HUMAN; RETINOIC ACID; RETINOID; RETINOID X RECEPTOR;

ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CBA MOUSE; CELL DIFFERENTIATION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; LIVER NEOPLASMS; METABOLISM; MOUSE; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROMOTER REGION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION; XENOGRAFT;

ANIMALS; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, NUDE; MICE, TRANSGENIC; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RETINOID X RECEPTORS; RETINOIDS; SIGNAL TRANSDUCTION; TRANSFECTION; TRETINOIN; UP-REGULATION;

EID: 84905991731     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0421     Document Type: Article

References (38)

1. Mangelsdorf DJ, Ong ES, Dyck JA, Evans RM. Nuclear receptor that identifies a novel retinoic acid response pathway. Nature 1990;345:224-229.
2. De Luca LM. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J 1991;5:2924-2933. (Pubitemid 21905833)
3. Lefebvre P, Benomar Y, Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metab 2010;21:676-683.
4. Matsushima-Nishiwaki R, Shidoji Y, Nishiwaki S, Yamada T, Moriwaki H, Muto Y. Aberrant metabolism of retinoid X receptor proteins in human hepatocellular carcinoma. Mol Cell Endocrinol 1996;121:179-190. (Pubitemid 26394727)
5. Takiyama Y, Miyokawa N, Sugawara A, Kato S, Ito K, Sato K, Oikawa K, et al. Decreased expression of retinoid X receptor isoforms in human thyroid carcinomas. J Clin Endocrinol Metab 2004;89:5851-5861. (Pubitemid 39518481)
6. Zhong C, Yang S, Huang J, Cohen MB, Roy-Burman P. Aberration in the expression of the retinoid receptor, RXRalpha, in prostate cancer. Cancer Biol Ther 2003;2:179-184.
7. Picard E, Seguin C, Monhoven N, Rochette-Egly C, Siat J, Borrelly J, Martinet Y, et al. Expression of retinoid receptor genes and proteins in non-small cell lung cancer. J Natl Cancer Inst 1999;91:1059-1066. (Pubitemid 29293045)
8. Altucci L, Leibowitz MD, Ogilvie KM, de Lera AR, Gronemeyer H. RAR and RXR modulation in cancer and metabolic disease. Nature Rev Drug Discov 2007;6:793-810. (Pubitemid 47504871)
9. Yanagitani A, Yamada S, Yasui S, Shimomura T, Murai R, Murawaki Y, Hashiguchi K, et al. Retinoic acid receptor alpha dominant negative form causes steatohepatitis and liver tumors in transgenic mice. Hepatology 2004;40:366-375. (Pubitemid 39062854)
10. Yoo BK, Emdad L, Lee SG, Su ZZ, Santhekadur P, Chen D, Gredler R, et al. Astrocyte elevated gene-1 (AEG-1): a multifunctional regulator of normal and abnormal physiology. Pharmacol Ther 2011;130:1-8.
11. Hu G, Wei Y, Kang Y. The multifaceted role of MTDH/AEG-1 in cancer progression. Clin Cancer Res 2009;15:5615-5620.
12. Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND, Mills AS, et al. Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 2009;119:465-477.
13. Srivastava J, Siddiq A, Emdad L, Santhekadur PK, Chen D, Gredler R, Shen XN, et al. Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology 2012;56:1782-1791.
14. Yoo BK, Santhekadur PK, Gredler R, Chen D, Emdad L, Bhutia S, Pannell L, et al. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology 2011;53:1538-1548.
15. Yoo BK, Chen D, Su ZZ, Gredler R, Yoo J, Shah K, Fisher PB, et al. Molecular mechanism of chemoresistance by astrocyte elevated gene-1. Cancer Res 2010;70:3249-3258.
16. Sarkar D, Lebedeva IV, Su ZZ, Park ES, Chatman L, Vozhilla N, Dent P, et al. Eradication of therapy-resistant human prostate tumors using a cancer terminator virus. Cancer Res 2007;67:5434-5442. (Pubitemid 46997284)
17. Sarkar D, Park ES, Emdad L, Lee SG, Su ZZ, Fisher PB. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008;68:1478-1484. (Pubitemid 351346856)
18. Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS Jr, et al. Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor kappaB and miR-221. J Biol Chem 2012;287:13952-13958.
19. Heery DM, Kalkhoven E, Hoare S, Parker MG. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 1997;387:733-736. (Pubitemid 27270617)
20. Thirkettle HJ, Girling J, Warren AY, Mills IG, Sahadevan K, Leung H, Hamdy F, et al. LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res 2009;15:3003-3013.
21. Mascanfroni ID, Montesinos Mdel M, Alamino VA, Susperreguy S, Nicola JP, Ilarregui JM, Masini-Repiso AM, et al. Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling. J Biol Chem 2010;285:9569-9582.
22. Harish S, Ashok MS, Khanam T, Rangarajan PN. Serine 27, a human retinoid X receptor alpha residue, phosphorylated by protein kinase A is essential for cyclicAMP-mediated downregulation of RXRalpha function. Biochem Biophys Res Comm 2000;279:853-857. (Pubitemid 32042866)
23. Adam-Stitah S, Penna L, Chambon P, Rochette-Egly C. Hyperphosphorylation of the retinoid X receptor alpha by activated c-Jun NH2-terminal kinases. J Biol Chem 1999;274:18932-18941.
24. Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, et al. Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci U S A 2009;106:12938-12943.
25. Macoritto M, Nguyen-Yamamoto L, Huang DC, Samuel S, Yang XF, Wang TT, White JH, et al. Phosphorylation of the human retinoid X receptor alpha at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands. J Biol Chem 2008;283:4943-4956.
26. Matsushima-Nishiwaki R, Okuno M, Adachi S, Sano T, Akita K, Moriwaki H, Friedman SL, et al. Phosphorylation of retinoid X receptor alpha at serine 260 impairs its metabolism and function in human hepatocellular carcinoma. Cancer Res 2001;61:7675-7682. (Pubitemid 32995065)
27. Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell 2010;17:560-573.
28. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 2008;27:1114-1121. (Pubitemid 351253177)
29. Fukunaka K, Saito T, Wataba K, Ashihara K, Ito E, Kudo R. Changes in expression and subcellular localization of nuclear retinoic acid receptors in human endometrial epithelium during the menstrual cycle. Mol Hum Reprod 2001;7:437-446. (Pubitemid 32447769)
30. Ghose R, Zimmerman TL, Thevananther S, Karpen SJ. Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: a novel mechanism for reduced hepatic gene expression in inflammation. Nuclear Recep 2004;2:4.
31. Tanaka T, Dancheck BL, Trifiletti LC, Birnkrant RE, Taylor BJ, Garfield SH, Thorgeirsson U, et al. Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells. Mol Cell Biol 2004;24:3972-3982. (Pubitemid 38496174)
32. Cao X, Liu W, Lin F, Li H, Kolluri SK, Lin B, Han YH, et al. Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting. Mol Cell Biol 2004;24:9705-9725. (Pubitemid 39458800)
33. Altucci L, Gronemeyer H. The promise of retinoids to fight against cancer. Nature Rev Cancer 2001;1:181-193. (Pubitemid 33741893)
34. Tanaka T, De Luca LM. Therapeutic potential of "rexinoids" in cancer prevention and treatment. Cancer Res 2009;69:4945-4947.
35. Xu XC. Tumor-suppressive activity of retinoic acid receptor-beta in cancer. Cancer Lett 2007;253:14-24.
36. Farias EF, Arapshian A, Bleiweiss IJ, Waxman S, Zelent A, Mira YLR. Retinoic acid receptor alpha2 is a growth suppressor epigenetically silenced in MCF-7 human breast cancer cells. Cell Growth Diff 2002;13:335-341.
37. Tang XH, Gudas LJ. Retinoids, retinoic acid receptors, and cancer. Ann Rev Pathol 2011;6:345-364.
38. Johansson HJ, Sanchez BC, Mundt F, Forshed J, Kovacs A, Panizza E, Hultin-Rosenberg L, et al. Retinoic acid receptor alpha is associated with tamoxifen resistance in breast cancer. Nat Comm 2013;4:2175.