Phosphorylation of the human retinoid X receptor α at serine 260 impairs coactivator(s) recruitment and induces hormone resistance to multiple ligands

Journal of Biological Chemistry

Volumn 283, Issue 8, 2008, Pages 4943-4956

  Macoritto, Michael ^a   Nguyen Yamamoto, Loan ^a   Dao, Chao Huang ^a   Samuel, Sara ^a   Xian, Fang Yang ^a   Tian, Tian Wang ^a   White, John H ^a   Kremer, Richard ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACID RESISTANCE; ACIDS; AMINO ACIDS; CHEMICAL REACTIONS; CYTOLOGY; EMPLOYMENT; PHOSPHORYLATION; PHYSIOLOGICAL MODELS; RECORDING INSTRUMENTS; TRANSCRIPTION;

CHROMATIN IMMUNOPRECIPITATION; CO ACTIVATORS; DO-MAINS; GROWTH INHIBITIONS; HETERO DIMERS; HETERODIMERIZATION; KERATINOCYTES; MULTIPLE LIGANDS; NUCLEAR RECEPTORS; OVEREXPRESSION; PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS; PHYSIOLOGICAL RESPONSES; PULLDOWN ASSAYS; RETINOIC ACID RECEPTORS; RETINOID X RECEPTORS; STRUCTURAL CHANGES; TARGET GENES; VITAMIN D RECEPTORS;

LIGANDS;

BEXAROTENE; CALCITRIOL; CYCLIN DEPENDENT KINASE INHIBITOR 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RETINOID X RECEPTOR ALPHA; SERINE; UO 126; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; HORMONE; LIGAND; MULTIPROTEIN COMPLEX; PROTEIN P21; RAF PROTEIN; THRAP1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VITAMIN;

ARTICLE; CELL GROWTH; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GROWTH INHIBITION; HORMONE RESISTANCE; HUMAN; HUMAN CELL; KERATINOCYTE; LIGAND BINDING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL LINE; DRUG EFFECT; DRUG RESISTANCE; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

CALCITRIOL; CELL LINE, TRANSFORMED; DRUG RESISTANCE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HORMONES; HUMANS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MULTIPROTEIN COMPLEXES; ONCOGENE PROTEIN P21(RAS); PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RAF KINASES; RECEPTORS, CALCITRIOL; RETINOID X RECEPTOR ALPHA; SERINE; TRANSCRIPTION FACTORS; VITAMINS;

EID: 41949117824     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707517200     Document Type: Article

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