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Volumn 1840, Issue 10, 2014, Pages 3079-3087

Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB

Author keywords

HuR; NF B; SASP; Senescence

Indexed keywords

HUR; NF-ΚB; SASP; SENESCENCE;

EID: 84905837082     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.07.005     Document Type: Article
Times cited : (20)

References (45)
  • 1
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • DOI 10.1038/nrm2233, PII NRM2233
    • J. Campisi, and d.F. d'Adda Cellular senescence: when bad things happen to good cells Nat. Rev. Mol. Cell Biol. 8 2007 729 740 (Pubitemid 47312822)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 2
    • 34447543913 scopus 로고    scopus 로고
    • Cellular Senescence in Cancer and Aging
    • DOI 10.1016/j.cell.2007.07.003, PII S0092867407008902
    • M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233 (Pubitemid 47081143)
    • (2007) Cell , vol.130 , Issue.2 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 3
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: Cellular senescence as a DNA-damage response
    • d.F. d'Adda Living on a break: cellular senescence as a DNA-damage response Nat. Rev. Cancer 8 2008 512 522
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 512-522
    • D'Adda, D.F.1
  • 5
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • DOI 10.1038/35096061
    • C.J. Sherr The INK4a/ARF network in tumour suppression Nat. Rev. Mol. Cell Biol. 2 2001 731 737 (Pubitemid 33679835)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.10 , pp. 731-737
    • Sherr, C.J.1
  • 8
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • J.P. Coppe, C.K. Patil, F. Rodier, Y. Sun, D.P. Munoz, J. Goldstein, P.S. Nelson, P.Y. Desprez, and J. Campisi Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor PLoS Biol. 6 2008 2853 2868
    • (2008) PLoS Biol. , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.P.5    Goldstein, J.6    Nelson, P.S.7    Desprez, P.Y.8    Campisi, J.9
  • 10
  • 11
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
    • DOI 10.1016/j.cell.2007.12.032, PII S0092867408000536
    • N. Wajapeyee, R.W. Serra, X. Zhu, M. Mahalingam, and M.R. Green Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7 Cell 132 2008 363 374 (Pubitemid 351191995)
    • (2008) Cell , vol.132 , Issue.3 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 12
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • DOI 10.1038/nature05529, PII NATURE05529
    • W. Xue, L. Zender, C. Miething, R.A. Dickins, E. Hernando, V. Krizhanovsky, C. Cordon-Cardo, and S.W. Lowe Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas Nature 445 2007 656 660 (Pubitemid 46232886)
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8
  • 13
    • 33749549246 scopus 로고    scopus 로고
    • Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
    • DOI 10.1074/jbc.M603307200
    • J.P. Coppe, K. Kauser, J. Campisi, and C.M. Beausejour Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence J. Biol. Chem. 281 2006 29568 29574 (Pubitemid 44536964)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.40 , pp. 29568-29574
    • Coppe, J.-P.1    Kauser, K.2    Campisi, J.3    Beausejour, C.M.4
  • 14
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: The dark side of tumor suppression
    • J.P. Coppe, P.Y. Desprez, A. Krtolica, and J. Campisi The senescence-associated secretory phenotype: the dark side of tumor suppression Annu. Rev. Pathol. 5 2010 99 118
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 15
    • 31544479046 scopus 로고    scopus 로고
    • The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
    • DOI 10.1158/0008-5472.CAN-05-1716
    • C. Bavik, I. Coleman, J.P. Dean, B. Knudsen, S. Plymate, and P.S. Nelson The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms Cancer Res. 66 2006 794 802 (Pubitemid 43165944)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 794-802
    • Bavik, C.1    Coleman, I.2    Dean, J.P.3    Knudsen, B.4    Plymate, S.5    Nelson, P.S.6
  • 17
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: Causes and consequences
    • A. Freund, A.V. Orjalo, P.Y. Desprez, and J. Campisi Inflammatory networks during cellular senescence: causes and consequences Trends Mol. Med. 16 2010 238 246
    • (2010) Trends Mol. Med. , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3    Campisi, J.4
  • 18
    • 0029015816 scopus 로고
    • A conserved family of elav-like genes in vertebrates
    • P.J. Good A conserved family of elav-like genes in vertebrates Proc. Natl. Acad. Sci. U.S.A. 92 1995 4557 4561
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 4557-4561
    • Good, P.J.1
  • 19
    • 0029873536 scopus 로고    scopus 로고
    • Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
    • DOI 10.1074/jbc.271.14.8144
    • W.J. Ma, S. Cheng, C. Campbell, A. Wright, and H. Furneaux Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein J. Biol. Chem. 271 1996 8144 8151 (Pubitemid 26108641)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.14 , pp. 8144-8151
    • Ma, W.-J.1    Cheng, S.2    Campbell, C.3    Wright, A.4    Furneaux, H.5
  • 21
    • 55049088775 scopus 로고    scopus 로고
    • Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR
    • A. Doller, J. Pfeilschifter, and W. Eberhardt Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR Cell Signal. 20 2008 2165 2173
    • (2008) Cell Signal. , vol.20 , pp. 2165-2173
    • Doller, A.1    Pfeilschifter, J.2    Eberhardt, W.3
  • 22
    • 0034908634 scopus 로고    scopus 로고
    • Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence
    • DOI 10.1128/MCB.21.17.5889-5898.2001
    • W. Wang, X. Yang, V.J. Cristofalo, N.J. Holbrook, and M. Gorospe Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence Mol. Cell Biol. 21 2001 5889 5898 (Pubitemid 32737806)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.17 , pp. 5889-5898
    • Wang, W.1    Yang, X.2    Cristofalo, V.J.3    Holbrook, N.J.4    Gorospe, M.5
  • 24
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19(ARF)
    • T. Kamijo, F. Zindy, M.F. Roussel, D.E. Quelle, J.R. Downing, R.A. Ashmun, G. Grosveld, and C.J. Sherr Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF Cell 91 1997 649 659 (Pubitemid 27513656)
    • (1997) Cell , vol.91 , Issue.5 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3    Quelle, D.E.4    Downing, J.R.5    Ashmun, R.A.6    Grosveld, G.7    Sherr, C.J.8
  • 28
    • 0024157116 scopus 로고
    • Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human
    • O. Tanabe, S. Akira, T. Kamiya, G.G. Wong, T. Hirano, and T. Kishimoto Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human J. Immunol. 141 1988 3875 3881
    • (1988) J. Immunol. , vol.141 , pp. 3875-3881
    • Tanabe, O.1    Akira, S.2    Kamiya, T.3    Wong, G.G.4    Hirano, T.5    Kishimoto, T.6
  • 29
    • 34547651351 scopus 로고    scopus 로고
    • Posttranscriptional orchestration of an anti-apoptotic program by HuR
    • K. Abdelmohsen, A. Lal, H.H. Kim, and M. Gorospe Posttranscriptional orchestration of an anti-apoptotic program by HuR Cell Cycle 6 2007 1288 1292 (Pubitemid 47327958)
    • (2007) Cell Cycle , vol.6 , Issue.11 , pp. 1288-1292
    • Abdelmohsen, K.1    Lal, A.2    Hyeon, H.K.3    Gorospe, M.4
  • 30
    • 10644277849 scopus 로고    scopus 로고
    • Posttranscriptional suppression of interleukin-6 production by human cytomegalovirus
    • DOI 10.1128/JVI.79.1.472-485.2005
    • C. Gealy, M. Denson, C. Humphreys, B. McSharry, G. Wilkinson, and R. Caswell Posttranscriptional suppression of interleukin-6 production by human cytomegalovirus J. Virol. 79 2005 472 485 (Pubitemid 39648400)
    • (2005) Journal of Virology , vol.79 , Issue.1 , pp. 472-485
    • Gealy, C.1    Denson, M.2    Humphreys, C.3    McSharry, B.4    Wilkinson, G.5    Caswell, R.6
  • 31
    • 0035266295 scopus 로고    scopus 로고
    • HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3′ untranslated regions of cytokine and angiogenic factor mRNAs
    • L.B. Nabors, G.Y. Gillespie, L. Harkins, and P.H. King HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within the 3′ untranslated regions of cytokine and angiogenic factor mRNAs Cancer Res. 61 2001 2154 2161 (Pubitemid 32692041)
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 2154-2161
    • Nabors, L.B.1    Gillespie, G.Y.2    Harkins, L.3    King, P.H.4
  • 32
    • 4143122397 scopus 로고    scopus 로고
    • Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
    • DOI 10.1038/sj.emboj.7600305
    • A. Lal, K. Mazan-Mamczarz, T. Kawai, X. Yang, J.L. Martindale, and M. Gorospe Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs EMBO J. 23 2004 3092 3102 (Pubitemid 39093603)
    • (2004) EMBO Journal , vol.23 , Issue.15 , pp. 3092-3102
    • Lal, A.1    Mazan-Mamczarz, K.2    Kawai, T.3    Yang, X.4    Martindale, J.L.5    Gorospe, M.6
  • 35
    • 21644479921 scopus 로고    scopus 로고
    • An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein β (C/EBPβ) mRNA by HuR and its translocation to the cytosol
    • DOI 10.1074/jbc.M502011200
    • K. Gantt, J. Cherry, R. Tenney, V. Karschner, and P.H. Pekala An early event in adipogenesis, the nuclear selection of the CCAAT enhancer-binding protein {beta} (C/EBP{beta}) mRNA by HuR and its translocation to the cytosol J. Biol. Chem. 280 2005 24768 24774 (Pubitemid 40934567)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.26 , pp. 24768-24774
    • Gantt, K.1    Cherry, J.2    Tenney, R.3    Karschner, V.4    Pekala, P.H.5
  • 36
    • 0037443478 scopus 로고    scopus 로고
    • CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: Involvement of NF-κB, AP-1, and C/EBP
    • M. Baccam, S.Y. Woo, C. Vinson, and G.A. Bishop CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP J. Immunol. 170 2003 3099 3108 (Pubitemid 36302185)
    • (2003) Journal of Immunology , vol.170 , Issue.6 , pp. 3099-3108
    • Baccam, M.1    Woo, S.-Y.2    Vinson, C.3    Bishop, G.A.4
  • 37
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • DOI 10.1146/annurev.biochem.73.011303.073723
    • A. Sancar, L.A. Lindsey-Boltz, K. Unsal-Kacmaz, and S. Linn Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints Annu. Rev. Biochem. 73 2004 39 85 (Pubitemid 39050363)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 38
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    • Z.H. Wu, Y. Shi, R.S. Tibbetts, and S. Miyamoto Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli Science 311 2006 1141 1146
    • (2006) Science , vol.311 , pp. 1141-1146
    • Wu, Z.H.1    Shi, Y.2    Tibbetts, R.S.3    Miyamoto, S.4
  • 42
    • 84863992349 scopus 로고    scopus 로고
    • The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype
    • G. Kim, A.B. Meriin, V.L. Gabai, E. Christians, I. Benjamin, A. Wilson, B. Wolozin, and M.Y. Sherman The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype Aging Cell 11 2012 617 627
    • (2012) Aging Cell , vol.11 , pp. 617-627
    • Kim, G.1    Meriin, A.B.2    Gabai, V.L.3    Christians, E.4    Benjamin, I.5    Wilson, A.6    Wolozin, B.7    Sherman, M.Y.8
  • 44
    • 84855982133 scopus 로고    scopus 로고
    • The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage
    • M. Gajjar, M.M. Candeias, L. Malbert-Colas, A. Mazars, J. Fujita, V. Olivares-Illana, and R. Fahraeus The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage Cancer Cell 21 2012 25 35
    • (2012) Cancer Cell , vol.21 , pp. 25-35
    • Gajjar, M.1    Candeias, M.M.2    Malbert-Colas, L.3    Mazars, A.4    Fujita, J.5    Olivares-Illana, V.6    Fahraeus, R.7
  • 45
    • 79952759375 scopus 로고    scopus 로고
    • Posttranscriptional regulation of cancer traits by HuR
    • K. Abdelmohsen, and M. Gorospe Posttranscriptional regulation of cancer traits by HuR Wiley. Interdiscip. Rev. RNA 1 2010 214 229
    • (2010) Wiley. Interdiscip. Rev. RNA , vol.1 , pp. 214-229
    • Abdelmohsen, K.1    Gorospe, M.2


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