Hepatic overexpression of the prodomain of furin lessens progression of atherosclerosis and reduces vascular remodeling in response to injury

Atherosclerosis

Volumn 236, Issue 1, 2014, Pages

  Lei, Xia ^a   Basu, Debapriya ^a   Li, Zhiqiang ^a   Zhang, Maoxiang ^b   Rudic, R Dan ^b   Jiang, Xian Cheng ^a   Jin, Weijun ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b AUGUSTA UNIVERSITY   (United States)

Author keywords

ApoB; Atherosclerosis; Furin; HDL; Prodomain; Typical proprotein convertase; Vascular remodeling; VLDL

Indexed keywords

ADENOVIRUS VECTOR; APOLIPOPROTEIN B; APOLIPOPROTEIN B100; FURIN; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PROFURIN; PROTEASOME; PROTECTIVE AGENT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; FURIN PROTEIN, HUMAN; HYBRID PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROTEIN PRECURSOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKENING; ARTERY LIGATION; ARTICLE; ATHEROSCLEROSIS; BIOACCUMULATION; BLOOD VESSEL WALL; CELL MIGRATION; CELL PROLIFERATION; CHOLESTEROL BLOOD LEVEL; COMMON CAROTID ARTERY; CONTROLLED STUDY; DISEASE COURSE; ENZYME DEGRADATION; FEMALE; FEMORAL ARTERY; GENE OVEREXPRESSION; IN VITRO STUDY; LIPID LIVER LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REDUCTION; SMOOTH MUSCLE FIBER; VASCULAR DISEASE; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE; WILD TYPE; ADENOVIRIDAE; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; BLOOD; BLOOD RHEOLOGY; C57BL MOUSE; CAROTID ARTERY INJURY; DEFICIENCY; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; INJURIES; KNOCKOUT MOUSE; LIGATION; LIVER; LIVER CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; THERAPEUTIC USE; VASCULAR ENDOTHELIUM; WESTERN DIET;

ADENOVIRIDAE; ANIMALS; APOLIPOPROTEINS B; ATHEROSCLEROSIS; CAROTID ARTERY INJURIES; CAROTID ARTERY, COMMON; CHOLESTEROL, LDL; DIET, WESTERN; ENDOTHELIUM, VASCULAR; FEMORAL ARTERY; FURIN; GENETIC THERAPY; GENETIC VECTORS; HEMORHEOLOGY; HEPATOCYTES; HUMANS; LIGATION; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LDL; RECOMBINANT FUSION PROTEINS;

EID: 84905819404     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.06.015     Document Type: Article

References (31)

1. Seidah N.G., Chretien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 1999, 848:45-62.
2. Seidah N.G., Sadr M.S., Chretien M., Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary and opposite functions. JBiol Chem 2013, 288:21473-21481.
3. Seidah N.G., Khatib A.M., Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem 2006, 387:871-877.
4. Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 2002, 3:753-766.
5. Zhong M., Munzer J.S., Basak A., et al. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. Invitro and exvivo assessment of their efficacy and selectivity. JBiol Chem 1999, 274:33913-33920.
6. Jin W., Wang X., Millar J.S., et al. Hepatic proprotein convertases modulate HDL metabolism. Cell Metab 2007, 6:129-136.
7. Stawowy P., Kallisch H., Borges Pereira Stawowy N., et al. Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Virchows Arch 2005, 446:351-359.
8. Lei X., Shi F., Basu D., et al. Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity. JBiol Chem 2011, 286:15747-15756.
9. Liu J., Huan C., Chakraborty M., et al. Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice. Circ Res 2009, 105:295-303.
10. Folch J., Lees M., Sloane Stanley G.H. Asimple method for the isolation and purification of total lipides from animal tissues. JBiol Chem 1957, 226:497-509.
11. Yazdanyar A., Jiang X.C. Liver phospholipid transfer protein (PLTP) expression with a PLTP-null background promotes very low-density lipoprotein production in mice. Hepatology 2012, 56:576-584.
12. Chakraborty M., Lou C., Huan C., et al. Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis. JClin Invest 2013, 123:1784-1797.
13. Anea C.B., Zhang M., Stepp D.W., et al. Vascular disease in mice with a dysfunctional circadian clock. Circulation 2009, 119:1510-1517.
14. Jin W., Fuki I.V., Seidah N.G., Benjannet S., Glick J.M., Rader D.J. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. JBiol Chem 2005, 280:36551-36559.
15. Anea C.B., Ali M.I., Osmond J.M., et al. Matrix metalloproteinase 2 and 9 dysfunction underlie vascular stiffness in circadian clock mutant mice. Arterioscler Thromb Vasc Biol 2010, 30:2535-2543.
16. Wolfrum C., Poy M.N., Stoffel M. Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med 2005, 11:418-422.
17. Broedl U.C., Jin W., Fuki I.V., Glick J.M., Rader D.J. Structural basis of endothelial lipase tropism for HDL. FASEB J 2004, 18:1891-1893.
18. Millar J.S., Cromley D.A., McCoy M.G., Rader D.A., Billheimer J.T. Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with triton WR-1339. JLipid Res 2005, 46:2023-2028.
19. Raabe M., Flynn L.M., Zlot C.H., et al. Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes. Proc Natl Acad Sci U S A 1998, 95:8686-8691.
20. Nakajima K., Yamashita T., Kita T., et al. Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 2011, 31:1963-1972.
21. Parathath S., Grauer L., Huang L.S., et al. Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes 2011, 60:1759-1769.
22. Van Craeyveld E., Gordts S.C., Nefyodova E., Jacobs F., De Geest B. Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies. JMol Med Berl 2011, 89:555-567.
23. Broedl U.C., Maugeais C., Millar J.S., et al. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 2004, 94:1554-1561.
24. Denis M., Marcinkiewicz J., Zaid A., et al. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation 2012, 125:894-901.
25. Benjannet S., Rhainds D., Hamelin J., Nassoury N., Seidah N.G. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications. JBiol Chem 2006, 281:30561-30572.
26. Essalmani R., Susan-Resiga D., Chamberland A., et al. Invivo evidence that furin from hepatocytes inactivates PCSK9. JBiol Chem 2011, 286:4257-4263.
27. Klugherz B.D., Song C., DeFelice S., et al. Gene delivery to pig coronary arteries from stents carrying antibody-tethered adenovirus. Hum Gene Ther 2002, 13:443-454.
28. Oguchi S., Dimayuga P., Zhu J., et al. Monoclonal antibody against vascular cell adhesion molecule-1 inhibits neointimal formation after periadventitial carotid artery injury in genetically hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 2000, 20:1729-1736.
29. Reis E.D., Roque M., Dansky H., et al. Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice. Proc Natl Acad Sci U.S A 2000, 97:12764-12769.
30. Tacken P.J., Delsing D.J., Gijbels M.J., et al. VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area. Atherosclerosis 2002, 162:103-110.
31. Zhu B., Kuhel D.G., Witte D.P., Hui D.Y. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice. Am J Pathol 2000, 157:1839-1848.