Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins

Circulation Research

Volumn 94, Issue 12, 2004, Pages 1554-1561

  Broedl, Uli C ^a   Maugeais, Cyrille ^a   Millar, John S ^a   Jin, Weijun ^a   Moore, Ryan E ^a   Fuki, Ilia V ^a   Marchadier, Dawn ^a   Glick, Jane M ^a   Rader, Daniel J ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Lipase; Lipids; Lipoproteins

Indexed keywords

APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHOLIPID; TRIACYLGLYCEROL LIPASE; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; CATABOLISM; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; HYDROLYSIS; IMMUNOPRECIPITATION; LIPID BLOOD LEVEL; LIPOLYSIS; LIPOPROTEIN METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

AMINO ACID SUBSTITUTION; ANIMALS; APOLIPOPROTEINS B; APOLIPOPROTEINS E; CATALYSIS; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; CHOLESTEROL, LDL; CHOLESTEROL, VLDL; COS CELLS; CULTURE MEDIA, CONDITIONED; DIMERIZATION; HUMANS; LIPASE; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIVER; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PHOSPHOLIPIDS; PROTEIN INTERACTION MAPPING; RECEPTORS, LDL; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3042702876     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000130657.00222.39     Document Type: Article

References (35)

1. Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ. A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet. 1999;21:424-428.
2. Hirata K, Dichek HL, Cioffi JA, Choi SY, Leeper NJ, Quintana L, Kronmal GS, Cooper AD, Quertermous T. Cloning of a unique lipase from endothelial cells extends the lipase gene family. J Biol Chem. 1999;274:14170-14175.
3. Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD, Quertermous T. Endothelial lipase is a major determinant of HDL level. J Clin Invest. 2003;111:347-355.
4. Jin W, Millar JS, Broedl U, Glick JM, Rader DJ. Inhibition of endothelial lipase causes increased HDL cholesterol levels in vivo. J Clin Invest. 2003;111:357-362.
5. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003;100:2748-2753.
6. McCoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ. Characterization of the lipolytic activity of endothelial lipase. J Lipid Res. 2002;6:921-929.
7. Fuki IV, Blanchard N, Jin W, Marchadier DH, Millar JS, Glick JM, Rader DJ. Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via HSPG-mediated pathway. J Biol Chem. 2003;278:34331-34338.
8. Broedl UC, Maugeais C, Marchadier D, Glick JM, Rader DJ. Effects of nonlipolytic ligand function of endothelial lipase on HDL metabolism in vivo. J Biol Chem. 2003;278:40688-40693.
9. Hatch FT. Practical methods for plasma lipoprotein analysis. Adv Lipid Res. 1968;6:1-68.
10. Tietge UJ, Maugeais C, Cain W, Grass D, Glick JM, de Beer FC, Rader DJ. Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I. J Biol Chem. 2000;275:10077-10084.
11. Dole VP. A relation between non-esterified fatty acids in the plasma and the metabolism of glucose. J Clin Invest. 1956;35:150-154.
12. Otvos JD, Jeyarajah EJ, Bennett DW, Krauss RM. Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement. Clin Chem. 1992;38:1632-1638.
13. Belfrage P, Vaughan M. Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. J Lipid Res. 1969;10:341-344.
14. Berneis KK, Krauss RM. Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res. 2002;43:1363-1379.
15. Campos H, Dreon DM, Krauss RM. Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses. J Lipid Res. 1995;36:462-472.
16. Barbagallo CM, Fan J, Blanche PJ, Rizzo M, Taylor JM, Krauss RM. Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions. Arterioscler Thromb Vasc Biol. 1999;19:625-632.
17. Breckenridge WC, Little JA, Alaupovic P, Wang CS, Kuksis A, Kakis G, Lindgren F, Gardiner G. Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase. Atherosclerosis. 1982;45:161-179.
18. Auwerx JH, Marzetta CA, Hokanson JE, Brunzell JD. Large buoyant LDL-like particles in hepatic lipase deficiency. Arteriosclerosis. 1989;9:319-325.
19. Brown MS, Kovanen PT, Goldstein JL. Regulation of plasma cholesterol by lipoprotein receptors. Science. 1981;212:628-635.
20. Shepherd J, Packard CJ. Receptor-independent low-density lipoprotein catabolism. Methods Enzymol. 1986;129:566-590.
21. Spady DK, Woollett LA, Dietschy JM. Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. Annu Rev Nutr. 1993;13:355-381.
22. Lund-Katz S, Laplaud PM, Phillips MC, Chapman MJ. Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction. Biochemistry. 1998;37:12867-12874.
23. Shepherd J, Caslake MJ, Lorimer AR, Vallance BD, Packard CJ. Fenofibrate reduces low density lipoprotein catabolism in hypertriglyceridemic subjects. Arteriosclerosis. 1985;5:162-168.
24. Galeano NF, Al-Haideri M, Keyserman F, Rumsey SC, Deckelbaum RJ. Small dense low density lipoprotein has increased affinity for LDL receptor-independent cell surface binding sites: a potential mechanism for increased atherogenicity. J Lipid Res. 1998;39:1263-1273.
25. Ueda Y, Royer L, Gong E, Zhang J, Cooper PN, Francone O, Rubin EM. Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic mice. J Biol Chem. 1999;274:7165-7171.
26. Rhainds D, Brodeur M, Lapointe J, Charpentier D, Falstrault L, Brissette L. The role of human and mouse hepatic scavenger receptor class B type I (SR-BI) in the selective uptake of low-density lipoprotein-cholesteryl esters. Biochemistry. 2003;42:7527-7538.
27. Merkel M, Kako Y, Radner H, Cho IS, Ramasamy R, Brunzell JD, Goldberg IJ, Breslow JL. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci U S A. 1998;95:13841-13846.
28. Merkel M, Heeren J, Dudeck W, Rinninger F, Radner H, Breslow JL, Goldberg IJ, Zechner R, Greten H. Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake. J Biol Chem. 2002;277:7405-7411.
29. Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. J Biol Chem. 1998;273:1896-1903.
30. Dichek HL, Johnson SM, Akeefe H, Lo GT, Sage E, Yap CE, Mahley RW. Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice. J Lipid Res. 2001;42:201-210.
31. Dugi KA, Amar MJ, Haudenschild CC, Shamburek RD, Bensadoun A, Hoyt RF Jr, Fruchart-Najib J, Madj Z, Brewer HB Jr, Santamarina-Fojo S. In vivo evidence for both lipolytic and nonlipolytic function of hepatic lipase in the metabolism of HDL. Arterioscler Thromb Vasc Biol. 2000;20:793-800.
32. Garfinkel AS, Kempner ES, Ben-Zeev O, Nikazy J, James SJ, Schotz MC. Lipoprotein lipase: size of the functional unit determined by radiation inactivation. J Lipid Res. 1983;24:775-780.
33. Olivecrona T, Bengtsson-Olivecrona G, Osborne JC Jr, Kempner ES. Molecular size of bovine lipoprotein lipase as determined by radiation inactivation. J Biol Chem. 1985;260:6888-6891.
34. Osborne JC Jr, Bengtsson-Olivecrona G, Lee NS, Olivecrona T. Studies on inactivation of lipoprotein lipase: role of the dimer to monomer dissociation. Biochemistry. 1985;24:5606-5611.
35. Hill JS, Davis RC, Yang D, Wen J, Philo JS, Poon PH, Phillips ML, Kempner ES, Wong H. Human hepatic lipase subunit structure determination. J Biol Chem. 1996;271:22931-22936.