Strategies to reduce aspecific adsorption of peptides and proteins in liquid chromatography-mass spectrometry based bioanalyses: An overview

Journal of Chromatography A

Volumn 1358, Issue , 2014, Pages 1-13

  Maes, Katrien ^a   Smolders, Ilse ^a   Michotte, Yvette ^a   Van Eeckhaut, Ann ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Aspecific adsorption; Carryover; Liquid chromatography mass spectrometry; Peptides; Proteins; Sticking

Indexed keywords

ASSAYS; CHROMATOGRAPHY; PEPTIDES; PROTEINS;

BIOANALYTICAL METHODS; CARRYOVER; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PHARMACEUTICAL INDUSTRY; PHYSICOCHEMICAL PROPERTY; QUANTIFICATION ASSAYS; REGULATORY GUIDELINES; STICKING;

ADSORPTION;

ORGANIC SOLVENT; PEPTIDE DERIVATIVE; PROTEIN DERIVATIVE; SURFACTANT;

ADSORPTION; ASPECIFIC ADSORPTION; AUTOSAMPLER; BINDING AFFINITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROFLUIDICS; MOLECULAR SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN ISOLATION; QUANTITATIVE ANALYSIS; REVIEW; SAMPLER; SOLUBILIZATION; SURFACE CHARGE; TEMPERATURE SENSITIVITY;

ASPECIFIC ADSORPTION; CARRYOVER; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PEPTIDES; PROTEINS; STICKING;

ADSORPTION; ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; HUMANS; MASS SPECTROMETRY; PEPTIDES; PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84905743996     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.06.072     Document Type: Review

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