The absolute quantification of endogenous levels of brain neuropeptides in vivo using LC-MS/MS

Bioanalysis

Volumn 3, Issue 11, 2011, Pages 1271-1285

  Van Eeckhaut, Ann ^a   Maes, Katrien ^a   Aourz, Najat ^a   Smolders, Ilse ^a   Michotte, Yvette ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ENDORPHIN; ANGIOTENSIN II [3-8]; BETA ENDORPHIN; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; DYNORPHIN A; DYNORPHIN[1-8]; GAMMA ENDORPHIN; LEUCINE ENKEPHALIN; METENKEPHALIN; NEUROKININ A; NEUROPEPTIDE; NEUROTENSIN; NEUROTENSIN[8-13]; SUBSTANCE P;

CALCIUM CELL LEVEL; CEREBROSPINAL FLUID; DIALYSATE; ELECTROSPRAY MASS SPECTROMETRY; EXTRACELLULAR SPACE; HOMOGENATE; HUMAN; IMMUNOPRECIPITATION; IONIZATION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICRODIALYSIS; NANOANALYSIS; NONHUMAN; PRECIPITATION; PROCESS OPTIMIZATION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION;

ANIMALS; BRAIN; CHROMATOGRAPHY, LIQUID; HUMANS; MICRODIALYSIS; MINIATURIZATION; NEUROPEPTIDES; TANDEM MASS SPECTROMETRY;

EID: 79958751966     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.11.91     Document Type: Review

References (81)

1. Bergquist F, Ludwig M. Neuropeptide Release. In: Encyclopedia of Neuroscience (Volume 6). Squire LR (Ed.). Academic Press, Oxford, UK, 811-816 (2009).
2. Hökfelt T, Bartfai T, Bloom F. Neuropeptides: opportunities for drug discovery. Lancet Neurol. 2(8), 463-472 (2003). (Pubitemid 36876103)
3. Hökfelt T, Broberger C, Xu ZQ, Sergeyev V, Ubink R, Diez M. Neuropeptides - an overview. Neuropharmacology 39(8), 1337-1356 (2000). (Pubitemid 30249197)
4. Nusbaum MP, Blitz DM, Swensen AM, Wood D, Marder E. The roles of co-transmission in neural network modulation. Trends Neurosci. 24(3), 146-154 (2001). (Pubitemid 32166819)
5. Wotjak CT, Landgraf R, Engelmann M. Listening to neuropeptides by microdialysis: echoes and new sounds? Pharmacol. Biochem. Behav. 90(2), 125-134 (2008).
6. Schwarzer C, Sperk G, Samanin R, Rizzi M, Gariboldi M, Vezzani A. Neuropeptides- immunoreactivity and their mRNA expression in kindling: functional implications for limbic epileptogenesis. Brain Res. Rev. 22(1), 27-50 (1996). (Pubitemid 26280896)
7. Baulac M, Pitkänen A. Research priorities in epilepsy for the next decade - a representative view of the european scientific community. Epilepsia 50(3), 571-578 (2009).
8. Mazarati A. Neuropeptides: epilepsy. In: Encyclopedia of Neuroscience. Squire LR (Ed.). Elsevier, Amsterdam, The Netherlands 6, 907-914 (2009).
9. Hökfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultzberg M. Peptidergic neurones. Nature 284(5756), 515-521 (1980).
10. Lanckmans K, Stragier B, Sarre S, Smolders I, Michotte Y. Nano-LC-MS/MS for the monitoring of angiotensin IV in rat brain microdialysates: limitations and possibilities. J. Sep. Sci. 30(14), 2217-2224 (2007). (Pubitemid 47497022)
11. Nyberg F. Neuropeptides in CNS tissue and body fluids: functional aspects and strategies for their identification, purification, and characterization. In: Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research. Silberring J, Ekman R (Eds). John Wiley and Sons Inc., NY, USA, 11-45 (2002).
12. Landgraf R, Neumann ID. Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol. 25(3-4), 150-176 (2004). (Pubitemid 39642188)
13. Haskins WE, Wang Z, Watson CJ et al. Capillary LC-MS2 at the attomole level for monitoring and discovering endogenous peptides in microdialysis samples collected in vivo. Anal. Chem. 73(21). 5005-5014 (2001). (Pubitemid 33032211)
14. Nilsson CL, Karlsson G, Bergquist J, Westman A, Ekman R. Mass spectrometry of peptides in neuroscience. Peptides 19(4), 781-789 (1998). (Pubitemid 28255017)
15. Saz JM, Marina ML. Application of micro- and nano-HPLC to the determination and characterization of bioactive and biomarker peptides. J. Sep. Sci. 31(3), 446-458 (2008). (Pubitemid 351351177)
16. Li Q, Zubieta JK, Kennedy RT. Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS. Anal. Chem. 81(6), 2242-2250 (2009).
17. Tamvakopoulos C. Mass spectrometry for the quantification of bioactive peptides in biological fluids. Mass Spectrom. Rev. 26(3), 389-402 (2007). (Pubitemid 46750376)
18. Perry M, Li Q, Kennedy RT. Review of recent advances in analytical techniques for the determination of neurotransmitters. Anal. Chim. Acta 653(1), 1-22 (2009).
19. Haskins WE, Watson CJ, Cellar NA, Powell DH, Kennedy RT. Discovery and neurochemical screening of peptides in brain extracellular fluid by chemical analysis of in vivo microdialysis samples. Anal. Chem. 76(18), 5523-5533 (2004). (Pubitemid 39249440)
20. Wei H, Nolkrantz K, Parkin MC, Chisolm CN, O'Callaghan JP, Kennedy RT. Identification and quantification of neuropeptides in brain tissue by capillary liquid chromatography coupled off-line to MALDI-TOF and MALDI-TOF/TOF-MS. Anal. Chem. 78(13), 4342-4351 (2006).
21. Nilsson C. Analysis of neuropeptides in cerebrospinal fluid and neural and neuroendocrine tissues by MALDI-TOFMS. In: Mass Spectrometry and Hyphenated Techniques in Neuropeptide Research. Silberring J, Ekman R (Eds). John Wiley and Sons Inc., NY, USA, 467-482 (2002).
22. Chefer VI, Thompson AC, Zapata A, Shippenberg TS. Overview of brain microdialysis. Curr. Protoc. Neurosci. Chapter 7, Unit 7.1 (2009).
23. Horn TF, Engelmann M. In vivo microdialysis for nonapeptides in rat brain - a practical guide. Methods 23(1), 41-53 (2001). (Pubitemid 32846015)
24. Westerinck B, Cremers T. Handbook of Microdialysis. Westerinck B, Cremers T (Eds). Elsevier, Amsterdam, The Netherlands (2007).
25. Plock N, Kloft C. Microdialysis-theoretical background and recent implementation in applied life-sciences. Eur. J. Pharm. Sci. 25(1), 1-24 (2005). (Pubitemid 40602191)
26. Emmett MR, Andrén PE, Caprioli RM. Specific molecular mass detection of endogenously released neuropeptides using in vivo microdialysis/mass spectrometry. J. Neurosci. Methods 62(1-2), 141-147 (1995).
27. John H, Walden M, Schafer S, Genz S, Forssmann W. Analytical procedures for quantification of peptides in pharmaceutical research by liquid chromatography-mass spectrometry. Anal. Bioanal. Chem. 378(4), 883-897 (2004). (Pubitemid 40890201)
28. Schmidt A, Karas M, D'lcks T. Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI? J. Am. Soc. Mass Spectrom. 14(5), 492-500 (2003). (Pubitemid 36871630)
29. Meiring H, van der Heeft E, ten Hove G, de Jong A. Nanoscale LC-MS(n): technical design and applications to peptide and protein analysis. J. Sep. Sci. 557-568 (2002).
30. Chervet J, Ursem M, Salzmann J. Instrumental requirements for nanoscale liquid chromatography. Anal. Chem. 1507-1512 (1996).
31. Abian J, Oosterkamp A, Gelpi E. Comparison of conventional, narrow-bore and capillary liquid chromatography mass spectrometry for electrospray ionization mass spectrometry: Practical considerations. J. Mass Spectrom. 244-254 (1999). (Pubitemid 29182475)
32. Lanckmans K, Van Eeckhaut A, Sarre S, Smolders I, Michotte Y. Capillary and nano-liquid chromatography-tandem mass spectrometry for the quantification of small molecules in microdialysis samples: comparison with microbore dimensions. J. Chromatogr. A 1131(1-2), 166-175 (2006). (Pubitemid 44485675)
33. Gobom J, Kraeuter KO, Persson R, Steen H, Roepstorff P, Ekman R. Detection and quantification of neurotensin in human brain tissue by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal. Chem. 72(14), 3320-3326 (2000). (Pubitemid 30482510)
34. Juraschek R, D'lcks T, Karas M. Nanoelectrospray - more than just a minimized-flow electrospray ionization source. J. Am. Soc. Mass Spectrom. 10(4), 300-308 (1999). (Pubitemid 34467738)
35. van den Broek I, Sparidans RW, Schellens JH, Beijnen JH. Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry. J. Chromatogr. B 872(1-2), 1-22 (2008).
36. Gibson GT, Mugo SM, Oleschuk RD. Nanoelectrospray emitters: trends and perspective. Mass Spectrom. Rev. 28(6), 918-936 (2009).
37. Chen Y, Qiao S, Wang C. Fragmentation of peptides with intra-chain disulfide bonds in triple quadrupole mass spectrometry and its quantitative application to biological samples. Internat. J. Mass Spectrom. 288(1-3) 68-74 (2009).
38. Wei BY, Juang YM, Lai CC. A novel approach for quantitative peptides analysis by selected electron transfer reaction monitoring. J Chromatogr. A 1217(44), 6927-6931 (2010).
39. Vatansever B, Lahrichi SL, Thiocone A et al. Comparison between a linear ion trap and a triple quadruple MS in the sensitive detection of large peptides at femtomole amounts on column. J. Sep. Sci. 33(16), 2478-2488 (2010).
40. Baseski HM, Watson CJ, Cellar NA, Shackman JG, Kennedy RT. Capillary liquid chromatography with MS3 for the determination of enkephalins in microdialysis samples from the striatum of anesthetized and freely-moving rats. J. Mass Spectrom. 40(2), 146-153 (2005). (Pubitemid 40327254)
41. Lanckmans K, Sarre S, Smolders I, Michotte Y. Quantitative liquid chromatography/mass spectrometry for the analysis of microdialysates. Talanta 74(4), 458-469 (2008).
42. Lönnroth P, Jansson PA, Smith U. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol. 253(2 Pt 1), 228-231 (1987).
43. Maidment NT, Brumbaugh DR, Rudolph VD, Erdelyi E, Evans CJ. Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo. Neuroscience. 33(3), 549-557 (1989).
44. Kennedy R. In vivo peptidomics: discovery and monitoring of neuropeptides using microdialysis and liquid chromatography with mass spectrometry. In: Handbook of microdialysis. Westerinck B, Cremers T (Eds). Elsevier, Amsterdam, The Netherlands, 279-295 (2007).
45. Pettersson A, Amirkhani A, Arvidsson B, Markides K, Bergquist J. A feasibility study of solid supported enhanced microdialysis. Anal. Chem. 76(6), 1678-1682 (2004). (Pubitemid 38338413)
46. Roy MC, Ikimura K, Nishino H, Naito T. A high recovery microsampling device based on a microdialysis probe for peptide sampling. Anal. Biochem. 399(2), 305-307 (2010).
47. Kennedy RT, Watson CJ, Haskins WE, Powell DH, Strecker RE. In vivo neurochemical monitoring by microdialysis and capillary separations. Curr. Opin. Chem. Biol. 6(5), 659-665 (2002). (Pubitemid 35284198)
48. Guihen E, O'Connor WT. Current separation and detection methods in microdialysis the drive towards sensitivity and speed. Electrophoresis. 30(12), 2062-2075 (2009).
49. Issaq HJ, Chan KC, Blonder J, Ye X, Veenstra TD. Separation, detection and quantitation of peptides by liquid chromatography and capillary electrochromatography. J. Chromatogr. A. 1216(10), 1825-1837 (2009).
50. Jakubowski JA, Hatcher NG, Sweedler JV. Online microdialysis-dynamic nanoelectrospray ionization-mass spectrometry for monitoring neuropeptide secretion. J. Mass. Spectrom. 40(7), 924-931 (2005). (Pubitemid 41098079)
51. Van Eeckhaut A, Lanckmans K, Sarre S, Smolders I, Michotte Y. Validation of bioanalytical LC-MS/MS assays: evaluation of matrix effects. J. Chromatogr. B. 877(23), 2198-2207 (2009).
52. Lanckmans K, Sarre S, Smolders I, Michotte Y. Use of a structural analogue versus a stable isotope labeled internal standard for the quantification of angiotensin IV in rat brain dialysates using nano-liquid chromatography/tandem mass spectrometry. Rapid Commun. Mass Spectrom. 21(7), 1187-1195 (2007). (Pubitemid 46506572)
53. Fanciulli G, Azara E, Wood TD, Dettori A, Delitala G, Marchetti M. Quantification of Gluten Exorphin A5 in cerebrospinal fluid by liquid chromatography-mass spectrometry. J. Chromatogr. B. 833(2), 204-209 (2006).
54. Fanciulli G, Azara E, Wood TD, Delitala G, Marchetti M. Liquid chromatography-mass spectrometry assay for quantification of Gluten exorphin B5 in cerebrospinal fluid. J. Chromatogr. B. 852(1-2), 485-490 (2007). (Pubitemid 46830147)
55. van Midwoud PM, Rieux L, Bischoff R, Verpoorte E, Niederländer HA. Improvement of recovery and repeatability in liquid chromatography-mass spectrometry analysis of peptides. J. Proteome Res. 6(2), 781-791 (2007). (Pubitemid 46340181)
56. Bark SJ, Hook V. Differential recovery of peptides from sample tubes and the reproducibility of quantitative proteomic data. J. Proteome Res. 6(11), 4511-4516 (2007). (Pubitemid 350158526)
57. Grohganz H, Rischer M, Brandl M. Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface. Eur. J. Pharm. Sci. 21(2-3), 191-196 (2004). (Pubitemid 38156156)
58. Duncan M, Lee J, Warchol M. Influence of surfactants upon protein peptide adsorption to glass and polypropylene. Internat. J. Pharmaceutics. 120(2), 179-188 (1995).
59. Choi YS, Wood TD. Silanization of inner surfaces of nanoelectrospray ionization emitters for reduced analyte adsorption. Rapid Commun. Mass Spectrom. 22(8), 1265-1274 (2008). (Pubitemid 351600777)
60. Mituloví G, Stingl C, Steinmacher I et al. Preventing carryover of peptides and proteins in nano LC-MS separations. Anal. Chem. 81(14), 5955-5960 (2009).
61. Hughes NC, Wong EY, Fan J, Bajaj N. Determination of carryover and contamination for mass spectrometry-based chromatographic assays. AAPS J. 9(3), E353-E360 (2007). (Pubitemid 351801761)
62. Vallano PT, Shugarts SB, Woolf EJ, Matuszewski BK. Elimination of autosampler carryover in a bioanalytical HPLC-MS/MS method: a case study. J. Pharm. Biomed. Anal. 36(5), 1073-1078 (2005). (Pubitemid 40037828)
63. Wilson SR, Boix F, Holm A, Molander P, Lundanes E, Greibrokk T. Determination of bradykinin and arg-bradykinin in rat muscle tissue by microdialysis and capillary column-switching liquid chromatography with mass spectrometric detection. J. Sep. Sci. 28(14), 1751-1758 (2005). (Pubitemid 43055020)
64. Choi YS, Wood TD. Polyaniline-coated nanoelectrospray emitters treated with hydrophobic polymers at the tip. Rapid Commun. Mass Spectrom. 21(13), 2101-2108 (2007). (Pubitemid 46999264)
65. Shui W, Yu Y, Xu X, Huang Z, Xu G, Yang P. Micro-electrospray with stainless steel emitters. Rapid Commun. Mass Spectrom. 17(14), 1541-1547 (2003). (Pubitemid 36841334)
66. Tojo H. Properties of an electrospray emitter coated with material of low surface energy. J. Chromatogr. A. 1056(1-2), 223-228 (2004). (Pubitemid 39505127)
67. Emmett MR, White FM, Hendrickson CL, Shi SD, Marshall AG. Application of micro-electrospray liquid chromatography techniques to FT-ICR MS to enable high-sensitivity biological analysis. J Am Soc Mass Spectrom. 9(4), 333-340 (1998).
68. Liu J, Ro KW, Busman M, Knapp DR. Electrospray ionization with a pointed carbon fiber emitter. Anal. Chem. 76(13), 3599-3606 (2004). (Pubitemid 38868820)
69. Kheterpal I, Kastin AJ, Mollah S, Yu C, Hsuchou H, Pan W. Mass spectrometric quantification of MIF-1 in mouse brain by multiple reaction monitoring. Peptides. 30(7), 1276-1281 (2009).
70. Rubakhin SS, Sweedler JV. Quantitative measurements of cell-cell signaling peptides with single-cell MALDI MS. Anal. Chem. 80(18), 7128-7136 (2008).
71. Beaudry F, Ferland CE, Vachon P. Identification, characterization and quantification of specific neuropeptides in rat spinal cord by liquid chromatography electrospray quadrupole ion trap mass spectrometry. Biomed. Chromatogr. 23(9), 940-950 (2009).
72. Lisi TL, Sluka KA. A new electrochemical HPLC method for analysis of enkephalins and endomorphins. J. Neurosci. Methods. 150(1), 74-79 (2006). (Pubitemid 41770800)
73. Kosanam H, Ramagiri S, Dass C. Quantification of endogenous a- and g-endorphins in rat brain by liquid chromatography-tandem mass spectrometry. Anal. Biochem. 392(1), 83-89 (2009).
74. Desiderio DM, Zhu X. Quantitative analysis of methionine enkephalin and b-endorphin in the pituitary by liquid secondary ion mass spectrometry and tandem mass spectrometry. J. Chromatogr. A. 794(1-2), 85-96 (1998). (Pubitemid 28083603)
75. Shen H, Lada MW, Kennedy RT. Monitoring of met-enkephalin in vivo with 5-min temporal resolution using microdialysis sampling and capillary liquid chromatography with electrochemical detection. J. Chromatogr. B. 704(1-2), 43-52 (1997). (Pubitemid 28021887)
76. Chen Y, Xu L, Lin J, Chen G. Assay of bradykinin-related peptides in human body fluids using capillary electrophoresis with laser-induced fluorescence detection. Electrophoresis 29(6), 1302-1307 (2008). (Pubitemid 351461083)
77. Andrén PE, Caprioli RM. Determination of extracellular release of neurotensin in discrete rat brain regions utilizing in vivo microdialysis/ electrospray mass spectrometry. Brain Res. 845(2), 123-129 (1999). (Pubitemid 29486451)
78. Chen Y, Xu L, Zhang L, Chen G. Separation and determination of peptide hormones by capillary electrophoresis with laser-induced fluorescence coupled with transient pseudo-isotachophoresis preconcentration. Anal. Biochem. 380(2), 297-302 (2008).
79. Beaudry F, Vachon P. Determination of substance P in rat spinal cord by high-performance liquid chromatography electrospray quadrupole ion trap mass spectrometry. Biomed. Chromatogr. 20(12), 1344-1350 (2006). (Pubitemid 46099742)
80. Food and Drug Administration US Department of Health and Human Services. Guidance for Industry. Bioanalytical Method Validation (2001). www.fda.gov/cder/guidance/index.htm
81. EMA. Committee for medicinal products for human use. Guideline on Validation of Bioanalytical Methods. (2009). www.ema.europa.eu/docs/en-GB/ document-library/Scientific-guideline/2009/12/WC500018062.pdf