Determination of carryover and contamination for mass spectrometry-based chromatographic assays

AAPS Journal

Volumn 9, Issue 3, 2007, Pages

  Hughes, Nicola C ^a   Wong, Ernest Y K ^a   Fan, Juan ^a   Bajaj, Navgeet ^a  

^a Biovail Contract Research   (Canada)

Author keywords

Accuracy; Bioanalysis; Carryover; Chromatography; Contamination; Detection; Extraction; Memory effect; Precision

Indexed keywords

TRIETHYLAMINE;

ACCURACY; ARTIFACT; AUTOMATION; BIOASSAY; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; CONFERENCE PAPER; ELECTROSPRAY MASS SPECTROMETRY; FOOD AND DRUG ADMINISTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; MASS SPECTROMETRY; MEDICAL INSTRUMENTATION; QUADRUPOLE MASS SPECTROMETRY; STANDARD; VALIDATION STUDY; WORKSHOP; METHODOLOGY; REPRODUCIBILITY; REVIEW; TANDEM MASS SPECTROMETRY;

ARTIFACTS; AUTOMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 38849144761     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj0903042     Document Type: Conference Paper

References (21)

1. Viswanathan CT, Bansal S, Booth B, et al. Workshop/conference report - quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. AAPS J [serial online]. 2007;9:E30-E42.
2. Zeng W, Musson DG, Fisher AL, et al. Determination of MK-0431 in human plasma using high turbulence liquid chromatography online extraction and tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20:1169-1175.
3. Dethy JM, Ackermann BL, Delatour C, et al. Demonstration of direct bioanalysis of drugs in plasma using nanoelectrospray infusion from a silicon chip coupled with tandem mass spectrometry. Anal Chem. 2003;75:805-811.
4. Chang MS, Kim EJ, El-Shourbagy TA. Anovel approach for in-process monitoring and managing cross-contamination in a high-throughput high-performance liquid chromatography assay with tandem mass spectrometric detection. Rapid Commun Mass Spectrom. 2006;20:2190-2200.
5. Chang MS, Kim EJ, El-Shourbagy TA. Managing bioanalytical cross-contamination. Available at: http://www.americanpharmaceuticalreview.com/ articleDetail.asp?SID-02F0ABB61C2C47B6BAC99C9C6A00A84D&ArticleID=483. Accessed October 16, 2007.
6. Mannonen S, Syrja, K. Liquid handling application notes. Available at: http://www.biohit.com/pdf/app11.pdf. Accessed October 16, 2007.
7. Chang MS, Kim EJ, El-Shourbagy TA. Evaluation of 384-well formatted sample preparation technologies for regulated bioanalysis. Rapid Commun Mass Spectrom. 2007;21:64-72.
8. Lambert W. Analytical Pitfalls and Trends in Clinical and Forensic Toxicology. Joint GTFCh/TIAFT Symposium of the Analytical Conference; May 12, 2004; Munich, Germany. 2004; Available at: http:/www.gtfch.org/ tk/tk71_2/Lambert.pdf. Accessed November 1, 2007.
9. Hedgepeth W, Steinike S. High Sensitivity MS Determination of Carryover in a New Autosampler Design. Application Note. Available at: http://www.ssi.shimadzu.com/products/pdfs/hplc/ Shimadzu-ABI_Carryove_PC2006.pdf. Accessed November 1, 2007.
10. Elmashni D. HPLC Carryover - Decreased Sample Carryover Using the Finnigan Surveyor Autosampler. Application Note 330. Thermo Electron Corporation.
11. Dolan JW. Autosampler Carryover. 2006; Available at: http://www.lcgceurope.com/lcgceurope/LC+Troubleshooting/ Autosampler-Carryover/ArticleStandard/Article/detail/377221. Accessed October 31, 2007.
12. Tobien T, Bethem R. Problems and Solutions for Carry-Over on High-Throughput LC Autosamplers. Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics; June 2-6, 2002; Orlando, Florida. Available at: http://www.asms.org/asms02pdf/1891.pdf Accessed November 1, 2007.
13. Watanabe J, Hike H, Koura Y, Cueni H, Bando Y. Method Development of Minimizing Carry Over in LC/MS/MS-Novel Cleaning Technique and Device. Paper presented at: Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics; May 28-June 1, 2006; Seattle, Washington. 2006: Poster TP0118.
14. Dolan JW. Autosampler Carryover. 2001; Available at: http://www.lcgceurope.com/lcgceurope/data/articlestandard//lcgceurope/ 042002/7657/article.pdf. Accessed October 31, 2007.
15. Yamagishi Y. Utility of H-SRM to Reduce Matrix Interference in Food Residue Analysis of Pesticides by LC/MS/MS Using the Finnigan TSQ Quantum Discovery. Application Note 355. Thermo Scientific. 2005; Available at: http://www.thermo.com/eThermo/CMA/PDFs/Articles/ articlesFile_28817.pdf. Accessed November 1, 2007.
16. A Simple and Rapid LC-MS/MS Method for the Simultaneous Determination of Nine Antiretroviral Drugs Commonly Used in Europe (Protease Inhibitors and Non-Nucleoside Reverse Transcriptase Inhibitors). Application Note. Applied Biosystems. 2005; Available at: http://www3.appliedbiosystems.com/cms/groups/psmr̄keting/documents/ generaldocuments/cms_042226.pdf. Accessed November 1, 2007.
17. Organ A. Mux for Parallel LC-MS. CPSA Digest. New Technologies and Approaches for Increasing Drug Candidate Survivability: Lead Identification to Lead Optimization. October, 2001. Available at: http://www.milestonedevelopment.com/CPSA/2001/dayloc3.html. Accessed October 31, 2007.
18. Yang L, Mann TD, Little D, et al. Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes. Anal Chem. 2001;73: 1740-1747.
19. Thurmond M, Hodgin JC. Chromatographic factors affecting sample carry-over in the LC/MS analyses of small molecules pharmaceuticals. Available at: http://www.nocarryover.com/Chromatographic-Tabloid.pdf Accessed October 15, 2007.
20. Rutters H, Mohring T, Rullkotter J, et al. The persistent memory effect of triethylamine in the analysis of phospholipids by liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2000;14:122-123.
21. Wickremsinhe ER, Ackermann BL, Chadhary AK. Validating regulatory-compliant wide dynamic range bioanalytical assays using chip-based nanoelectrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19:47-56.