A metabolic strategy to enhance long-term survival by Phx1 through stationary phase-specific pyruvate decarboxylases in fission yeast

Aging

Volumn 6, Issue 7, 2014, Pages 587-601

  Kim, Ji Yoon ^a   Kim, Eun Jung ^a   Lopez Maury, Luis ^b,c   Bähler, Jürg ^b   Roe, Jung Hye ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Ethanol; Long term survival; Metabolic flux; Phx1; Pyruvate decarboxylases; Stationary phase

Indexed keywords

FUNGAL PROTEIN; PYRUVATE DECARBOXYLASE; REACTIVE OXYGEN METABOLITE; THIAMINE; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; OXYGEN CONSUMPTION; PHYLOGENY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SCHIZOSACCHAROMYCES; TIME;

FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; MITOCHONDRIA; MUTATION; OXYGEN CONSUMPTION; PHYLOGENY; PYRUVATE DECARBOXYLASE; REACTIVE OXYGEN SPECIES; SCHIZOSACCHAROMYCES; STRESS, PHYSIOLOGICAL; THIAMINE; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTOME;

EID: 84905715993     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100682     Document Type: Article

References (41)

1. Gray JV, Petsko GA, Johnston GC, Ringe D, Singer RA and Werner-Washburne M. "Sleeping beauty": quiescence in Saccharomyces cerevisiae. Microbiology and molecular biology reviews: MMBR. 2004; 68:187-206.
2. Longo VD, Shadel GS, Kaeberlein M and Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell metabolism. 2012; 16:18-31.
3. Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L and Longo VD. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 2008; 4:e13.
4. Roux AE, Quissac A, Chartrand P, Ferbeyre G and Rokeach LA. Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell. 2006; 5:345-357.
5. Fontana L, Partridge L and Longo VD. Extending healthy life span--from yeast to humans. Science. 2010; 328:321-326.
6. Zuin A, Carmona M, Morales-Ivorra I, Gabrielli N, Vivancos AP, Ayte J and Hidalgo E. Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J. 2010; 29:981-991.
7. Harris N, Bachler M, Costa V, Mollapour M, Moradas-Ferreira P and Piper PW. Overexpressed Sod1p acts either to reduce or to increase the lifespans and stress resistance of yeast, depending on whether it is Cu(2+)-deficient or an active Cu,Znsuperoxide dismutase. Aging Cell. 2005; 4:41-52.
8. Shama S, Lai CY, Antoniazzi JM, Jiang JC and Jazwinski SM. Heat stress-induced life span extension in yeast. Experimental cell research. 1998; 245:379-388.
9. Zuin A, Castellano-Esteve D, Ayte J and Hidalgo E. Living on the edge: stress and activation of stress responses promote lifespan extension. Aging. 2010; 2:231-237.
10. Rallis C, Lopez-Maury L, Georgescu T, Pancaldi V and Bahler J. Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth. Biology open. 2014; 3:1-11.
11. Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, Fink GR and Guarente L. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature. 2002; 418:344-348.
12. Rallis C, Codlin S and Bahler J. TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast. Aging Cell. 2013; 12:563- 573.
13. Ohtsuka H, Mita S, Ogawa Y, Azuma K, Ito H and Aiba H. A novel gene, ecl1(+), extends the chronological lifespan in fission yeast. FEMS yeast research. 2008; 8:520-530.
14. Hao Z, Furunobu A, Nagata A and Okayama H. A zinc finger protein required for stationary phase viability in fission yeast. J Cell Sci. 1997; 110:2557-2566.
15. Kim JY, Kwon ES and Roe JH. A homeobox protein Phx1 regulates long-term survival and meiotic sporulation in Schizosaccharomyces pombe. BMC microbiology. 2012; 12:86.
16. Kwon ES, Jeong JH and Roe JH. Inactivation of homocitrate synthase causes lysine auxotrophy in copper/zinc-containing superoxide dismutase-deficient yeast Schizosaccharomyces pombe. The Journal of biological chemistry. 2006; 281:1345- 1351.
17. Schweingruber AM, Dlugonski J, Edenharter E and Schweingruber ME. Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport. Curr Genet. 1991; 19:249-254.
18. Vogl C, Klein CM, Batke AF, Schweingruber ME and Stolz J. Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. The Journal of biological chemistry. 2008; 283:7379-7389.
19. Chen D, Toone WM, Mata J, Lyne R, Burns G, Kivinen K, Brazma A, Jones N and Bahler J. Global transcriptional responses of fission yeast to environmental stress. Molecular biology of the cell. 2003; 14:214-229.
20. Mata J, Lyne R, Burns G and Bahler J. The transcriptional program of meiosis and sporulation in fission yeast. Nat Genet. 2002; 32:143-147.
21. Mata J, Wilbrey A and Bahler J. Transcriptional regulatory network for sexual differentiation in fission yeast. Genome Biol. 2007; 8:R217.
22. Fankhauser H, Zurlinden A, Schweingruber AM, Edenharter E and Schweingruber ME. Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth. The Journal of biological chemistry. 1995; 270:28457- 28462.
23. Costelloe SJ, Ward JM and Dalby PA. Evolutionary analysis of the TPP-dependent enzyme family. Journal of molecular evolution. 2008; 66:36-49.
24. Wang CY, Chen WL and Wang SW. Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe. Mol Cell Biol. 2013; 33:1244-1253.
25. Pronk JT, Yde Steensma H and Van Dijken JP. Pyruvate metabolism in Saccharomyces cerevisiae. Yeast. 1996; 12:1607- 1633.
26. Vuralhan Z, Morais MA, Tai SL, Piper MD and Pronk JT. Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae. Applied and environmental microbiology. 2003; 69:4534-4541.
27. Kim DU, Hayles J, Kim D, Wood V, Park HO, Won M, Yoo HS, Duhig T, Nam M, Palmer G, Han S, Jeffery L, Baek ST, et al. Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol. 2010; 28:617-623.
28. Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J and Bahler J. Dynamic repertoire of a eukaryotic transcriptome surveyed at singlenucleotide resolution. Nature. 2008; 453:1239-1243.
29. Marguerat S, Schmidt A, Codlin S, Chen W, Aebersold R and Bahler J. Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells. Cell. 2012; 151:671-683.
30. Rhind N, Chen Z, Yassour M, Thompson DA, Haas BJ, Habib N, Wapinski I, Roy S, Lin MF, Heiman DI, Young SK, Furuya K, Guo Y, et al. Comparative functional genomics of the fission yeasts. Science. 2011; 332:930-936.
31. Flores CL, Rodriguez C, Petit T and Gancedo C. Carbohydrate and energy-yielding metabolism in non-conventional yeasts. FEMS microbiology reviews. 2000; 24:507-529.
32. Van Urk H, Voll WS, Scheffers WA and Van Dijken JP. Transient-state analysis of metabolic fluxes in crabtree-positive and crabtree-negative yeasts. Applied and environmental microbiology. 1990; 56:281-287.
33. Ralser M, Wamelink MM, Latkolik S, Jansen EE, Lehrach H and Jakobs C. Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response. Nat Biotechnol. 2009; 27:604-605.
34. Finkel T and Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000; 408:239-247.
35. Reverter-Branchat G, Cabiscol E, Tamarit J, Sorolla MA, Angeles de la Torre M and Ros J. Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1. Microbiology. 2007; 153:3667-3676.
36. Roux AE, Arseneault G, Chartrand P, Ferbeyre G and Rokeach LA. A screen for genes involved in respiration control and longevity in Schizosaccharomyces pombe. Annals of the New York Academy of Sciences. 2010; 1197:19-27.
37. Longo VD and Kennedy BK. Sirtuins in aging and age-related disease. Cell. 2006; 126:257-268.
38. Manning BD and Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007; 129:1261-1274.
39. Lyne R, Burns G, Mata J, Penkett CJ, Rustici G, Chen D, Langford C, Vetrie D and Bähler J. Whole-genome microarrays of fission yeast: characteristics, accuracy, reproducibility, and processing of array data. BMC Genomics. 2003; 4:27.
40. Schmittgen TD and Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nature protocols. 2008; 3:1101- 1108.
41. Tylicki A, Ziolkowska G, Bolkun A, Siemieniuk M, Czerniecki J and Nowakiewicz A. Comparative study of the activity and kinetic properties of malate dehydrogenase and pyruvate decarboxylase from Candida albicans, Malassezia pachydermatis, and Saccharomyces cerevisiae. Canadian journal of microbiology. 2008; 54:734-741.