메뉴 건너뛰기




Volumn 3, Issue 2, 2014, Pages 161-171

Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth

Author keywords

Cell growth; Chronological lifespan; Oxidative stress; Protein translation; S. Pombe; S6 kinase sck2; TOR

Indexed keywords


EID: 84979031699     PISSN: None     EISSN: 20466390     Source Type: Journal    
DOI: 10.1242/bio.20147245     Document Type: Article
Times cited : (55)

References (49)
  • 3
    • 84871235870 scopus 로고    scopus 로고
    • Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling
    • Becker, M., Müller, S., Nellen, W., Jurkowski, T. P., Jeltsch, A. and Ehrenhofer-Murray, A. E. (2012). Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Nucleic Acids Res. 40, 11648-11658.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 11648-11658
    • Becker, M.1    Müller, S.2    Nellen, W.3    Jurkowski, T.P.4    Jeltsch, A.5    Ehrenhofer-Murray, A.E.6
  • 4
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • Blagosklonny, M. V. (2008). Aging: ROS or TOR. Cell Cycle 7, 3344-3354.
    • (2008) Cell Cycle , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 6
    • 56449097008 scopus 로고    scopus 로고
    • Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast
    • Burg, J. S., Powell, D. W., Chai, R., Hughes, A. L., Link, A. J. and Espenshade, P. J. (2008). Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metab. 8, 522-531.
    • (2008) Cell Metab , vol.8 , pp. 522-531
    • Burg, J.S.1    Powell, D.W.2    Chai, R.3    Hughes, A.L.4    Link, A.J.5    Espenshade, P.J.6
  • 9
    • 67650604368 scopus 로고    scopus 로고
    • A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity
    • Chen, B. R. and Runge, K. W. (2009). A new Schizosaccharomyces pombe chronological lifespan assay reveals that caloric restriction promotes efficient cell cycle exit and extends longevity. Exp. Gerontol. 44, 493-502.
    • (2009) Exp. Gerontol , vol.44 , pp. 493-502
    • Chen, B.R.1    Runge, K.W.2
  • 10
    • 66149087761 scopus 로고    scopus 로고
    • A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    • Cristina, D., Cary, M., Lunceford, A., Clarke, C. and Kenyon, C. (2009). A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans. PLoS Genet. 5, e1000450.
    • (2009) PLoS Genet , vol.5 , pp. e1000450
    • Cristina, D.1    Cary, M.2    Lunceford, A.3    Clarke, C.4    Kenyon, C.5
  • 13
    • 57749095081 scopus 로고    scopus 로고
    • Against the oxidative damage theory of aging: Superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans
    • Doonan, R., McElwee, J. J., Matthijssens, F., Walker, G. A., Houthoofd, K., Back, P., Matscheski, A., Vanfleteren, J. R. and Gems, D. (2008). Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev. 22, 3236-3241.
    • (2008) Genes Dev , vol.22 , pp. 3236-3241
    • Doonan, R.1    McElwee, J.J.2    Matthijssens, F.3    Walker, G.A.4    Houthoofd, K.5    Back, P.6    Matscheski, A.7    Vanfleteren, J.R.8    Gems, D.9
  • 14
    • 34948846000 scopus 로고    scopus 로고
    • Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p
    • Erjavec, N., Larsson, L., Grantham, J. and Nyström, T. (2007). Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev. 21, 2410-2421.
    • (2007) Genes Dev , vol.21 , pp. 2410-2421
    • Erjavec, N.1    Larsson, L.2    Grantham, J.3    Nyström, T.4
  • 15
    • 57749089780 scopus 로고    scopus 로고
    • Selective benefits of damage partitioning in unicellular systems and its effects on aging
    • Erjavec, N., Cvijovic, M., Klipp, E. and Nyström, T. (2008). Selective benefits of damage partitioning in unicellular systems and its effects on aging. Proc. Natl. Acad. Sci. USA 105, 18764-18769.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 18764-18769
    • Erjavec, N.1    Cvijovic, M.2    Klipp, E.3    Nyström, T.4
  • 16
    • 66749126389 scopus 로고    scopus 로고
    • Antioxidant defense and aging in C. Elegans: Is the oxidative damage theory of aging wrong?
    • Gems, D. and Doonan, R. (2009). Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong? Cell Cycle 8, 1681-1687.
    • (2009) Cell Cycle , vol.8 , pp. 1681-1687
    • Gems, D.1    Doonan, R.2
  • 17
    • 44049095588 scopus 로고    scopus 로고
    • Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae
    • Georis, I., Tate, J. J., Cooper, T. G. and Dubois, E. (2008). Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae. J. Biol. Chem. 283, 8919-8929.
    • (2008) J. Biol. Chem. , vol.283 , pp. 8919-8929
    • Georis, I.1    Tate, J.J.2    Cooper, T.G.3    Dubois, E.4
  • 18
    • 29444440214 scopus 로고    scopus 로고
    • Moc3, a novel Zn finger type protein involved in sexual development, ascus formation, and stress response of Schizosaccharomyces pombe
    • Goldar, M. M., Jeong, H. T., Tanaka, K., Matsuda, H. and Kawamukai, M. (2005). Moc3, a novel Zn finger type protein involved in sexual development, ascus formation, and stress response of Schizosaccharomyces pombe. Curr. Genet. 48, 345-355.
    • (2005) Curr. Genet , vol.48 , pp. 345-355
    • Goldar, M.M.1    Jeong, H.T.2    Tanaka, K.3    Matsuda, H.4    Kawamukai, M.5
  • 20
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman, J., Movva, N. R. and Hall, M. N. (1991). Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253, 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 21
    • 69249240179 scopus 로고    scopus 로고
    • Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
    • Huber, A., Bodenmiller, B., Uotila, A., Stahl, M., Wanka, S., Gerrits, B., Aebersold, R. and Loewith, R. (2009). Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev. 23, 1929-1943.
    • (2009) Genes Dev , vol.23 , pp. 1929-1943
    • Huber, A.1    Bodenmiller, B.2    Uotila, A.3    Stahl, M.4    Wanka, S.5    Gerrits, B.6    Aebersold, R.7    Loewith, R.8
  • 22
    • 81055140318 scopus 로고    scopus 로고
    • The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe
    • Ikai, N., Nakazawa, N., Hayashi, T. and Yanagida, M. (2011). The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe. Open Biology 1, 110007.
    • (2011) Open Biology , vol.1 , pp. 110007
    • Ikai, N.1    Nakazawa, N.2    Hayashi, T.3    Yanagida, M.4
  • 23
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K. et al. (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-968.
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1    Ouyang, H.2    Zhu, T.3    Lindvall, C.4    Wang, Y.5    Zhang, X.6    Yang, Q.7    Bennett, C.8    Harada, Y.9    Stankunas, K.10
  • 24
    • 77950214581 scopus 로고    scopus 로고
    • Lessons on longevity from budding yeast
    • Kaeberlein, M. (2010). Lessons on longevity from budding yeast. Nature 464, 513-519.
    • (2010) Nature , vol.464 , pp. 513-519
    • Kaeberlein, M.1
  • 26
    • 0026092585 scopus 로고
    • Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein
    • Koltin, Y., Faucette, L., Bergsma, D. J., Levy, M. A., Cafferkey, R., Koser, P. L., Johnson, R. K. and Livi, G. P. (1991). Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol. Cell. Biol. 11, 1718-1723.
    • (1991) Mol. Cell. Biol , vol.11 , pp. 1718-1723
    • Koltin, Y.1    Faucette, L.2    Bergsma, D.J.3    Levy, M.A.4    Cafferkey, R.5    Koser, P.L.6    Johnson, R.K.7    Livi, G.P.8
  • 28
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante, M. and Sabatini, D. M. (2012). mTOR signaling in growth control and disease. Cell 149, 274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 29
    • 34147207884 scopus 로고    scopus 로고
    • Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast
    • Matsuo, T., Otsubo, Y., Urano, J., Tamanoi, F. and Yamamoto, M. (2007). Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast. Mol. Cell. Biol. 27, 3154-3164.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 3154-3164
    • Matsuo, T.1    Otsubo, Y.2    Urano, J.3    Tamanoi, F.4    Yamamoto, M.5
  • 31
    • 0028957971 scopus 로고
    • Bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily
    • Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K. and Yamasaki, M. (1995). bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily. J. Bacteriol. 177, 1536-1543.
    • (1995) J. Bacteriol , vol.177 , pp. 1536-1543
    • Nagao, K.1    Taguchi, Y.2    Arioka, M.3    Kadokura, H.4    Takatsuki, A.5    Yoda, K.6    Yamasaki, M.7
  • 32
    • 77149141403 scopus 로고    scopus 로고
    • Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin
    • Nakashima, A., Sato, T. and Tamanoi, F. (2010). Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin. J. Cell Sci. 123, 777-786.
    • (2010) J. Cell Sci. , vol.123 , pp. 777-786
    • Nakashima, A.1    Sato, T.2    Tamanoi, F.3
  • 33
    • 84874675231 scopus 로고    scopus 로고
    • Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase
    • Nakashima, A., Otsubo, Y., Yamashita, A., Sato, T., Yamamoto, M. and Tamanoi, F. (2012). Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase. J. Cell Sci. 125, 5840-5849.
    • (2012) J. Cell Sci , vol.125 , pp. 5840-5849
    • Nakashima, A.1    Otsubo, Y.2    Yamashita, A.3    Sato, T.4    Yamamoto, M.5    Tamanoi, F.6
  • 34
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • Powers, R. W., 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K. and Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20, 174-184.
    • (2006) Genes Dev. , vol.20 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 35
    • 84880513351 scopus 로고    scopus 로고
    • TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
    • Rallis, C., Codlin, S. and Bähler, J. (2013). TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast. Aging Cell 12, 563-573.
    • (2013) Aging Cell , vol.12 , pp. 563-573
    • Rallis, C.1    Codlin, S.2    Bähler, J.3
  • 36
    • 33746269894 scopus 로고    scopus 로고
    • Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2
    • Roux, A. E., Quissac, A., Chartrand, P., Ferbeyre, G. and Rokeach, L. A. (2006).Regulation of chronological aging in Schizosaccharomyces pombe by the protein kinases Pka1 and Sck2. Aging Cell5, 345-357
    • (2006) Aging Cell , vol.5 , pp. 345-357
    • Roux, A.E.1    Quissac, A.2    Chartrand, P.3    Ferbeyre, G.4    Rokeach, L.A.5
  • 37
    • 62149091061 scopus 로고    scopus 로고
    • Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast
    • Roux, A. E., Leroux, A., Alaamery, M. A., Hoffman, C. S., Chartrand, P., Ferbeyre, G. and Rokeach, L. A. (2009). Pro-aging effects of glucose signaling through a G protein-coupled glucose receptor in fission yeast. PLoS Genet. 5, e1000408.
    • (2009) PLoS Genet , vol.5 , pp. e1000408
    • Roux, A.E.1    Leroux, A.2    Alaamery, M.A.3    Hoffman, C.S.4    Chartrand, P.5    Ferbeyre, G.6    Rokeach, L.A.7
  • 39
    • 6344237317 scopus 로고    scopus 로고
    • PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p
    • Santhanam, A., Hartley, A., Düvel, K., Broach, J. R. and Garrett, S. (2004). PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p. Eukaryot. Cell 3, 1261-1271.
    • (2004) Eukaryot. Cell , vol.3 , pp. 1261-1271
    • Santhanam, A.1    Hartley, A.2    Düvel, K.3    Broach, J.R.4    Garrett, S.5
  • 40
    • 84864292157 scopus 로고    scopus 로고
    • TORC1 of fission yeast is rapamycin-sensitive
    • Takahara, T. and Maeda, T. (2012). TORC1 of fission yeast is rapamycin-sensitive. Genes Cells 17, 698-708.
    • (2012) Genes Cells , vol.17 , pp. 698-708
    • Takahara, T.1    Maeda, T.2
  • 41
    • 84856439546 scopus 로고    scopus 로고
    • Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. Elegans
    • Troulinaki, K. and Tavernarakis, N. (2012). Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 31, 654-666.
    • (2012) EMBO J , vol.31 , pp. 654-666
    • Troulinaki, K.1    Tavernarakis, N.2
  • 42
    • 84860879231 scopus 로고    scopus 로고
    • Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway
    • Umekawa, M. and Klionsky, D. J. (2012). Ksp1 kinase regulates autophagy via the target of rapamycin complex 1 (TORC1) pathway. J. Biol. Chem. 287, 16300-16310.
    • (2012) J. Biol. Chem. , vol.287 , pp. 16300-16310
    • Umekawa, M.1    Klionsky, D.J.2
  • 45
    • 77954920645 scopus 로고    scopus 로고
    • Fission yeast TOR and rapamycin
    • ed. M. Hall and F. Tamanoi Burlington, VT: Academic Press; Elsevier Inc
    • Weisman, R. (2010). Fission yeast TOR and rapamycin. In The Enzymes, Vol. 27 (ed. M. Hall and F. Tamanoi), pp. 251-269. Burlington, VT: Academic Press; Elsevier Inc.
    • (2010) The Enzymes , vol.27 , pp. 251-269
    • Weisman, R.1
  • 46
    • 0035831446 scopus 로고    scopus 로고
    • The fission yeast TOR homolog, tor1+, is required for the response to starvation and other stresses via a conserved serine
    • Weisman, R. and Choder, M. (2001). The fission yeast TOR homolog, tor1+ , is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem. 276, 7027-7032.
    • (2001) J. Biol. Chem , vol.276 , pp. 7027-7032
    • Weisman, R.1    Choder, M.2
  • 47
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R. and Hall, M. N. (2006). TOR signaling in growth and metabolism. Cell 124, 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 48
    • 77951245218 scopus 로고    scopus 로고
    • Identifying gene interaction enrichment for gene expression data
    • Zhang, J., Li, J. and Deng, H. W. (2009). Identifying gene interaction enrichment for gene expression data. PLoS One 4, e8064.
    • (2009) PLoS One , vol.4 , pp. e8064
    • Zhang, J.1    Li, J.2    Deng, H.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.