Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 31, 2014, Pages

  Goñi, Guillermina M ^a   Epifano, Carolina ^b   Boskovic, Jasminka ^a   Camacho Artacho, Marta ^a   Zhou, Jing ^c   Bronowska, Agnieszka ^c   Martín, M Teresa ^d   Eck, Michael J ^e,f   Kremer, Leonor ^d   Gräter, Frauke ^c   Gervasio, Francesco Luigi ^g   Perez Moreno, Mirna ^b   Lietha, Daniel ^a  

^a Structural Biology and Biocomputing Programme   (Spain)

^b BBVA University Institute for Economic and Social Analysis University of Alcalá   (Spain)

^c HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES   (Germany)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^e HARVARD MEDICAL SCHOOL   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cell signaling; Phosphoinositides

Indexed keywords

EZRIN; FOCAL ADHESION KINASE; INTEGRIN; MOESIN; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 5 KINASE TYPE 1GAMMA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; RADIXIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; BIOCATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INDUCTION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; FOCAL ADHESION; LIPID BILAYER; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN;

CELL SIGNALING; PHOSPHOINOSITIDES;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACIDS; BIOCATALYSIS; CELL ADHESION; CLUSTER ANALYSIS; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 84905666209     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1317022111     Document Type: Article

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