Cross-talk between signalling pathways and the multidrug resistant protein MDR-1

British Journal of Cancer

Volumn 85, Issue 8, 2001, Pages 1175-1184

  Ding, S ^a   Chamberlain, M ^a   McLaren, A ^a   Goh, L b ^a   Duncan, I ^a   Wolf, C R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Drug resistance; MAP kinase; MDR 1; Ovarian cancer; Taxol

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; UO 126; VERAPAMIL;

ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; ENZYME ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; DRUG RESISTANCE, NEOPLASM; FEMALE; FLAVONOIDS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; OVARIAN NEOPLASMS; P-GLYCOPROTEIN; PACLITAXEL; PHOSPHORYLATION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035914258     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.2044     Document Type: Article

References (43)

1. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
2. Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells
3. P-glycoprotein multidrug resistance and cancer
4. Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers
5. Specificity and mechanism of action of some commonly used protein kinase inhibitors
6. The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio-and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity
7. High levels of recombinant CYP3A4 expression in Chinese hamster ovary cells are modulated by coexpressed human P450 reductase and hemin supplementation
8. Antimitotic drugs cause increased tumorigenicity of multidrug resistant cells
9. Cellular genes analogous to retroviral one genes are transcribed in human tumour cells
10. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
11. P13K: Downstream AKTion blocks apoptosis
12. Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line
13. Constitutive activation of the 41/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
14. P-Glycoprotein protects leukaemia cells against caspase-dependent, but not caspase-independen, cell death
15. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
16. An emerging family of dual specificity MAP kinase phosphatases
17. Hwansodan protects PC12 cells against serum-deprivation-induced apoptosis via a mechanism involving Ras and mitogen-activated protein (MAP) kinase pathway
18. The pharmacology of apoptosis
19. P-glycoprotein gene (MDR-1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance
20. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
21. Paclitaxel-induced apoptosis is associated with expression and activation of c-Mos gene product in human ovarian carcinoma SKOV3 cells
22. MEK inhibition enhances paclitaxel-induced tumor apoptosis
23. Transformation of mammalian cells by constitutively active MAP kinase kinase
24. Phosphoinostide 3-kinase lipid products regulate ATP-dependent transporter by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles
25. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
26. Acquisition of Taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells
27. The phosphoinositide 3-kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines
28. PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-terminal Kinase in HT29 cells
29. Future perspectives for the development of P-glycoprotein modulators
30. Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma
31. Protein kinases: Six degrees of separation
32. Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway
33. Blockade of the MAP kinase pathway supresses growth of colon tumors in vivo
34. PIK3CA is implicated as an oncogene in ovarian cancer
35. Circumvention of P-glycoprotein-mediated multiple drug resistance by phosphorylation modulators is independent of protein kinases
36. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
37. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
38. The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
39. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor
40. Opposite effects of pressurized steady versus pulsatile perfusion on vascular endothelial cell cytosolic pH: Role of tyrosine kinase and mitogen-activated protein kinase signaling
41. Enhanced expression of c-myc and epidermal growth factor receptor (c-erbB-1) genes in primary human renal cancer
42. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
43. A genome-wide survey of RAS transformation targets