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Volumn 46, Issue 5, 2014, Pages 304-310

HLA and rheumatoid arthritis: How do they connect?

Author keywords

Autoantibodies; Autoimmune diseases; CD4 positive T lymphocytes; Histocompatibility antigens class II; Rheumatoid arthritis

Indexed keywords

ANTICITRULLINATED PROTEIN ANTIBODY; ANTIGEN; BIOLOGICAL MARKER; EPITOPE; HLA DRB1 ANTIGEN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; HLA ANTIGEN; HLA ANTIGEN CLASS 2;

EID: 84905502621     PISSN: 07853890     EISSN: 13652060     Source Type: Journal    
DOI: 10.3109/07853890.2014.907097     Document Type: Review
Times cited : (28)

References (75)
  • 2
    • 80054806901 scopus 로고    scopus 로고
    • Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage
    • Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA, et al. Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci USA. 2011; 108: 17372-7.
    • (2011) Proc Natl Acad Sci USA. , vol.108 , pp. 17372-17377
    • Shi, J.1    Knevel, R.2    Suwannalai, P.3    Van Der Linden, M.P.4    Janssen, G.M.5    Van Veelen, P.A.6
  • 3
    • 68049104242 scopus 로고    scopus 로고
    • Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis
    • van der Linden MP, van der Woude D, Ioan-Facsinay A, Levarht EW, Stoeken-Rijsbergen G, Huizinga TW, et al. Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rheumatoid arthritis. Arthritis Rheum. 2009;60:2232-41.
    • (2009) Arthritis Rheum. , vol.60 , pp. 2232-2241
    • Van Der Linden, M.P.1    Van Der Woude, D.2    Ioan-Facsinay, A.3    Levarht, E.W.4    Stoeken-Rijsbergen, G.5    Huizinga, T.W.6
  • 4
    • 77956055481 scopus 로고    scopus 로고
    • 2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative
    • Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010; 62: 2569-81.
    • (2010) Arthritis Rheum. , vol.62 , pp. 2569-2581
    • Aletaha, D.1    Neogi, T.2    Silman, A.J.3    Funovits, J.4    Felson, D.T.5    Bingham, C.O.I.I.I.6
  • 6
    • 27744550413 scopus 로고    scopus 로고
    • Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    • Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen F A, Jawaheer D, et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum. 2005;52:3433-8.
    • (2005) Arthritis Rheum. , vol.52 , pp. 3433-3438
    • Huizinga, T.W.1    Amos, C.I.2    Van Der Helm-Van Mil, A.H.3    Chen, W.4    Van Gaalen, F.A.5    Jawaheer, D.6
  • 7
    • 52149095213 scopus 로고    scopus 로고
    • Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets
    • van der Helm-van Mil AH, Huizinga TW. Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets. Arthritis Res Ther. 2008; 10: 205.
    • (2008) Arthritis Res Ther. , vol.10 , pp. 205
    • Van Der Helm-Van Mil, A.H.1    Huizinga, T.W.2
  • 8
    • 74849107568 scopus 로고    scopus 로고
    • Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients
    • Snir O, Widhe M, Hermansson M, von Spee C, Lindberg J, Hensen S, et al. Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients. Arthritis Rheum. 2010; 62: 44-52.
    • (2010) Arthritis Rheum. , vol.62 , pp. 44-52
    • Snir, O.1    Widhe, M.2    Hermansson, M.3    Von Spee, C.4    Lindberg, J.5    Hensen, S.6
  • 9
    • 84877587255 scopus 로고    scopus 로고
    • Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
    • Amara K, Steen J, Murray F, Morbach H, Fernandez-Rodriguez BM, Joshua V, et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J Exp Med. 2013; 210: 445-55.
    • (2013) J Exp Med. , vol.210 , pp. 445-455
    • Amara, K.1    Steen, J.2    Murray, F.3    Morbach, H.4    Fernandez-Rodriguez, B.M.5    Joshua, V.6
  • 11
    • 84860561645 scopus 로고    scopus 로고
    • Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    • Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012; 122: 1791-802.
    • (2012) J Clin Invest. , vol.122 , pp. 1791-1802
    • Harre, U.1    Georgess, D.2    Bang, H.3    Bozec, A.4    Axmann, R.5    Ossipova, E.6
  • 12
    • 84898013615 scopus 로고    scopus 로고
    • Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies
    • Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, et al. Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis. 2014; 73: 854-60.
    • (2014) Ann Rheum Dis. , vol.73 , pp. 854-860
    • Kleyer, A.1    Finzel, S.2    Rech, J.3    Manger, B.4    Krieter, M.5    Faustini, F.6
  • 13
    • 33645511657 scopus 로고    scopus 로고
    • Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
    • Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest. 2006; 116: 961-73.
    • (2006) J Clin Invest. , vol.116 , pp. 961-973
    • Kuhn, K.A.1    Kulik, L.2    Tomooka, B.3    Braschler, K.J.4    Arend, W.P.5    Robinson, W.H.6
  • 14
    • 79955824880 scopus 로고    scopus 로고
    • Fcgamma receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins
    • Laurent L, Clavel C, Lemaire O, Anquetil F, Cornillet M, Zabraniecki L, et al. Fcgamma receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins. Ann Rheum Dis. 2011; 70: 1052-9.
    • (2011) Ann Rheum Dis. , vol.70 , pp. 1052-1059
    • Laurent, L.1    Clavel, C.2    Lemaire, O.3    Anquetil, F.4    Cornillet, M.5    Zabraniecki, L.6
  • 15
    • 78651426965 scopus 로고    scopus 로고
    • Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins
    • van Steendam K, Tilleman K, de Ceuleneer M, de Keyser F, Elewaut D, Deforce D. Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins. Arthritis Res Ther. 2010; 12: R132.
    • (2010) Arthritis Res Ther. , vol.12
    • Van Steendam, K.1    Tilleman, K.2    De Ceuleneer, M.3    De Keyser, F.4    Elewaut, D.5    Deforce, D.6
  • 17
    • 84889635694 scopus 로고    scopus 로고
    • Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis
    • Suwannalai P, Britsemmer K, Knevel R, Scherer HU, Levarht EW, van der Helm-van Mil AH, et al. Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis. Ann Rheum Dis. 2014; 73: 270-6.
    • (2014) Ann Rheum Dis. , vol.73 , pp. 270-276
    • Suwannalai, P.1    Britsemmer, K.2    Knevel, R.3    Scherer, H.U.4    Levarht, E.W.5    Van Der Helm-Van Mil, A.H.6
  • 18
    • 67650065027 scopus 로고    scopus 로고
    • Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways
    • Trouw LA, Haisma EM, Levarht EW, van der Woude D, Ioan-Facsinay A, Daha MR, et al. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum. 2009;60:1923-31.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1923-1931
    • Trouw, L.A.1    Haisma, E.M.2    Levarht, E.W.3    Van Der Woude, D.4    Ioan-Facsinay, A.5    Daha, M.R.6
  • 20
    • 75949145891 scopus 로고
    • A new serum factor in patients with rheumatoid arthritis; The antiperinuclear factor
    • Nienhuis RL, Mandema E. A new serum factor in patients with rheumatoid arthritis; the antiperinuclear factor. Ann Rheum Dis. 1964;23:302-5.
    • (1964) Ann Rheum Dis. , vol.23 , pp. 302-305
    • Nienhuis, R.L.1    Mandema, E.2
  • 21
    • 0029017016 scopus 로고
    • The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies
    • Sebbag M, Simon M, Vincent C, Masson-Bessiere C, Girbal E, Durieux J J, et al. The antiperinuclear factor and the so-called antikeratin antibodies are the same rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1995;95:2672-9.
    • (1995) J Clin Invest. , vol.95 , pp. 2672-2679
    • Sebbag, M.1    Simon, M.2    Vincent, C.3    Masson-Bessiere, C.4    Girbal, E.5    Durieux, J.J.6
  • 22
    • 0035869593 scopus 로고    scopus 로고
    • The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha-and beta-chains of fibrin
    • Masson-Bessiere C, Sebbag M, Girbal-Neuhauser E, Nogueira L, Vincent C, Senshu T, et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha-and beta-chains of fibrin. J Immunol. 2001;166:4177-84.
    • (2001) J Immunol. , vol.166 , pp. 4177-4184
    • Masson-Bessiere, C.1    Sebbag, M.2    Girbal-Neuhauser, E.3    Nogueira, L.4    Vincent, C.5    Senshu, T.6
  • 23
    • 0028275351 scopus 로고
    • The Sasystem: A novel antigen-antibody system specific for rheumatoid arthritis
    • Despres N, Boire G, Lopez-Longo FJ, Menard HA. The Sasystem: a novel antigen-antibody system specific for rheumatoid arthritis. J Rheumatol. 1994;21:1027-33.
    • (1994) J Rheumatol. , vol.21 , pp. 1027-1033
    • Despres, N.1    Boire, G.2    Lopez-Longo, F.J.3    Menard, H.A.4
  • 24
    • 0031974911 scopus 로고    scopus 로고
    • Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoanti-bodies
    • Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoanti-bodies. J Clin Invest. 1998; 101: 273-81.
    • (1998) J Clin Invest. , vol.101 , pp. 273-281
    • Schellekens, G.A.1    De Jong, B.A.2    Van Den Hoogen, F.H.3    Van De Putte, L.B.4    Van Venrooij, W.J.5
  • 25
    • 0032960781 scopus 로고    scopus 로고
    • The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues
    • Girbal-Neuhauser E, Durieux JJ, Arnaud M, Dalbon P, Sebbag M, Vincent C, et al. The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues. J Immunol. 1999;162:585-94.
    • (1999) J Immunol. , vol.162 , pp. 585-594
    • Girbal-Neuhauser, E.1    Durieux, J.J.2    Arnaud, M.3    Dalbon, P.4    Sebbag, M.5    Vincent, C.6
  • 27
    • 72149084899 scopus 로고    scopus 로고
    • Peptidylarginine deiminase 4 and citrullination in health and disease
    • Anzilotti C, Pratesi F, Tommasi C, Migliorini P. Peptidylarginine deiminase 4 and citrullination in health and disease. Autoimmun Rev. 2010;9:158-60.
    • (2010) Autoimmun Rev. , vol.9 , pp. 158-160
    • Anzilotti, C.1    Pratesi, F.2    Tommasi, C.3    Migliorini, P.4
  • 28
    • 37149029370 scopus 로고    scopus 로고
    • Calcium signaling
    • Clapham DE. Calcium signaling. Cell. 2007;131:1047-58.
    • (2007) Cell. , vol.131 , pp. 1047-1058
    • Clapham, D.E.1
  • 29
    • 0042667153 scopus 로고    scopus 로고
    • Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
    • Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, et al. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat Genet. 2003; 34: 395-402.
    • (2003) Nat Genet. , vol.34 , pp. 395-402
    • Suzuki, A.1    Yamada, R.2    Chang, X.3    Tokuhiro, S.4    Sawada, T.5    Suzuki, M.6
  • 30
    • 53149103590 scopus 로고    scopus 로고
    • Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
    • Makrygiannakis D, Hermansson M, Ulfgren AK, Nicholas AP, Zendman AJ, Eklund A, et al. Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells. Ann Rheum Dis. 2008; 67: 1488-92.
    • (2008) Ann Rheum Dis. , vol.67 , pp. 1488-1492
    • Makrygiannakis, D.1    Hermansson, M.2    Ulfgren, A.K.3    Nicholas, A.P.4    Zendman, A.J.5    Eklund, A.6
  • 31
    • 84878321478 scopus 로고    scopus 로고
    • Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity
    • 186r a65
    • Darrah E, Giles JT, Ols ML, Bull HG, Andrade F, Rosen A. Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity. Sci Transl Med. 2013; 5:186r a65.
    • (2013) Sci Transl Med. , vol.5
    • Darrah, E.1    Giles, J.T.2    Ols, M.L.3    Bull, H.G.4    Andrade, F.5    Rosen, A.6
  • 33
    • 78650632503 scopus 로고    scopus 로고
    • Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities
    • Ioan-Facsinay A, el-Bannoudi H, Scherer HU, van der Woude D, Menard HA, Lora M, et al. Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities. Ann Rheum Dis. 2011;70:188-93.
    • (2011) Ann Rheum Dis. , vol.70 , pp. 188-193
    • Ioan-Facsinay, A.1    El-Bannoudi, H.2    Scherer, H.U.3    Van Der Woude, D.4    Menard, H.A.5    Lora, M.6
  • 34
    • 84875614928 scopus 로고    scopus 로고
    • Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns
    • van de Stadt LA, van Schouwenburg PA, Bryde S, Kruithof S, van Schaardenburg D, Hamann D, et al. Monoclonal anti-citrullinated protein antibodies selected on citrullinated fibrinogen have distinct targets with different cross-reactivity patterns. Rheumatology (Oxford). 2013; 52: 631-5.
    • (2013) Rheumatology (Oxford). , vol.52 , pp. 631-635
    • Van De Stadt, L.A.1    Van Schouwenburg, P.A.2    Bryde, S.3    Kruithof, S.4    Van Schaardenburg, D.5    Hamann, D.6
  • 35
    • 84871798688 scopus 로고    scopus 로고
    • The rheumatoid arthritis synovial fluid citrul linome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and beta-actin
    • van Beers JJ, Schwarte CM, Stammen-Vogelzangs J, Oosterink E, Bozic B, Pruijn GJ. The rheumatoid arthritis synovial fluid citrul linome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and beta-actin. Arthritis Rheum. 2013;65:69-80.
    • (2013) Arthritis Rheum. , vol.65 , pp. 69-80
    • Van Beers, J.J.1    Schwarte, C.M.2    Stammen-Vogelzangs, J.3    Oosterink, E.4    Bozic, B.5    Pruijn, G.J.6
  • 36
    • 33644667809 scopus 로고    scopus 로고
    • Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis
    • Kinloch A, Tatzer V, Wait R, Peston D, Lundberg K, Donatien P, et al. Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis. Arthritis Res Ther. 2005; 7: R1421-9.
    • (2005) Arthritis Res Ther. , vol.7
    • Kinloch, A.1    Tatzer, V.2    Wait, R.3    Peston, D.4    Lundberg, K.5    Donatien, P.6
  • 37
    • 47749141839 scopus 로고    scopus 로고
    • Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis
    • Tabushi Y, Nakanishi T, Takeuchi T, Nakajima M, Ueda K, Kotani T, et al. Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis. Ann Clin Biochem. 2008; 45(Pt 4): 413-17.
    • (2008) Ann Clin Biochem. , vol.45 , Issue.PART 4 , pp. 413-417
    • Tabushi, Y.1    Nakanishi, T.2    Takeuchi, T.3    Nakajima, M.4    Ueda, K.5    Kotani, T.6
  • 38
    • 84901824943 scopus 로고    scopus 로고
    • Mass spectrometric analysis of citrullinated type II collagen reveals new citrulline-specific autoantibodies, which bind to human arthritic cartilage
    • Jan 27. [Epub ahead of print]
    • Haag S, Schneider N, Mason DE, Tuncel J, Andersson IE, Peters EC, et al. Mass spectrometric analysis of citrullinated type II collagen reveals new citrulline-specific autoantibodies, which bind to human arthritic cartilage. Arthritis Rheumatol. 2014 Jan 27. [Epub ahead of print]
    • (2014) Arthritis Rheumatol.
    • Haag, S.1    Schneider, N.2    Mason, D.E.3    Tuncel, J.4    Andersson, I.E.5    Peters, E.C.6
  • 40
    • 18744430797 scopus 로고    scopus 로고
    • Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    • Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003; 48: 2741-9.
    • (2003) Arthritis Rheum. , vol.48 , pp. 2741-2749
    • Rantapaa-Dahlqvist, S.1    De Jong, B.A.2    Berglin, E.3    Hallmans, G.4    Wadell, G.5    Stenlund, H.6
  • 41
    • 84857922958 scopus 로고    scopus 로고
    • The influence of ACPA status and characteristics on the course of RA
    • Willemze A, Trouw LA, Toes RE, Huizinga TW. The influence of ACPA status and characteristics on the course of RA. Nat Rev Rheumatol. 2012; 8: 144-52.
    • (2012) Nat Rev Rheumatol. , vol.8 , pp. 144-152
    • Willemze, A.1    Trouw, L.A.2    Toes, R.E.3    Huizinga, T.W.4
  • 42
    • 10344227722 scopus 로고    scopus 로고
    • An update of the HLA genomic region locus information and disease associations: 2004
    • Shiina T, Inoko H, Kulski JK. An update of the HLA genomic region, locus information and disease associations: 2004. Tissue Antigens. 2004;64:631-49.
    • (2004) Tissue Antigens. , vol.64 , pp. 631-649
    • Shiina, T.1    Inoko, H.2    Kulski, J.K.3
  • 43
    • 0017157626 scopus 로고
    • Mixed lymphocyte cultures in rheumatoid arthritis
    • Stastny P. Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest. 1976; 57: 1148-57.
    • (1976) J Clin Invest. , vol.57 , pp. 1148-1157
    • Stastny, P.1
  • 44
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregersen P K, Silver J, Winchester R J. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 1987;30:1205-13.
    • (1987) Arthritis Rheum. , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 46
    • 0023751241 scopus 로고
    • The molecular basis of susceptibility to rheumatoid arthritis: The conformational equivalence hypothesis
    • Winchester RJ, Gregersen PK. The molecular basis of susceptibility to rheumatoid arthritis: the conformational equivalence hypothesis. Springer Semin Immunopathol. 1988; 10: 119-39.
    • (1988) Springer Semin Immunopathol. , vol.10 , pp. 119-139
    • Winchester, R.J.1    Gregersen, P.K.2
  • 47
    • 84862776511 scopus 로고    scopus 로고
    • Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
    • Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet. 2012;44:291-6.
    • (2012) Nat Genet. , vol.44 , pp. 291-296
    • Raychaudhuri, S.1    Sandor, C.2    Stahl, E.A.3    Freudenberg, J.4    Lee, H.S.5    Jia, X.6
  • 48
    • 0023637868 scopus 로고
    • HLA-DQ beta-chain polymorphism in HLA-DR4 haplotypes associated with rheumatoid arthritis
    • Singal DP, D'Souza M, Reid B, Bensen WG, Kassam YB, Adachi JD. HLA-DQ beta-chain polymorphism in HLA-DR4 haplotypes associated with rheumatoid arthritis. Lancet. 1987;2:1118-20.
    • (1987) Lancet. , vol.2 , pp. 1118-1120
    • Singal, D.P.1    D'Souza, M.2    Reid, B.3    Bensen, W.G.4    Kassam, Y.B.5    Adachi, J.D.6
  • 49
    • 34249810950 scopus 로고    scopus 로고
    • The spectrum of HLA-DQ and HLA-DR alleles 2006: A listing correlating sequence and structure with function
    • Bondinas GP, Moustakas AK, Papadopoulos GK. The spectrum of HLA-DQ and HLA-DR alleles, 2006: a listing correlating sequence and structure with function. Immunogenetics. 2007; 59: 539-53.
    • (2007) Immunogenetics. , vol.59 , pp. 539-553
    • Bondinas, G.P.1    Moustakas, A.K.2    Papadopoulos, G.K.3
  • 51
    • 0028298229 scopus 로고
    • Noelle RJ. Gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory
    • Foy TM, Laman JD, Ledbetter JA, Aruffo A, Claassen E, Noelle RJ. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J Exp Med. 1994; 180: 157-63.
    • (1994) J Exp Med. , vol.180 , pp. 157-163
    • Foy, T.M.1    Laman, J.D.2    Ledbetter, J.A.3    Aruffo, A.4    Claassen, E.5
  • 53
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol. 2011;29:621-63.
    • (2011) Annu Rev Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 55
    • 50249108486 scopus 로고    scopus 로고
    • The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels
    • Bos WH, Ursum J, de Vries N, Bartelds GM, Wolbink GJ, Nurmohamed M T, et al. The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels. Ann Rheum Dis. 2008;67:1347-50.
    • (2008) Ann Rheum Dis. , vol.67 , pp. 1347-1350
    • Bos, W.H.1    Ursum, J.2    De Vries, N.3    Bartelds, G.M.4    Wolbink, G.J.5    Nurmohamed, M.T.6
  • 56
    • 84945909081 scopus 로고    scopus 로고
    • Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: An epidemiological investigation in twins
    • Nov 25. [Epub ahead of print]
    • Hensvold HA, Magnusson PK, Joshua V, Hansson M, Israelsson L, Ferreira R, et al. Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins. Ann Rheum Dis. 2013 Nov 25. [Epub ahead of print]
    • (2013) Ann Rheum Dis.
    • Hensvold, H.A.1    Magnusson, P.K.2    Joshua, V.3    Hansson, M.4    Israelsson, L.5    Ferreira, R.6
  • 57
    • 72949104779 scopus 로고    scopus 로고
    • Antigen presentation in the thymus for positive selection and central tolerance induction
    • Klein L, Hinterberger M, Wirnsberger G, Kyewski B. Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol. 2009;9:833-44.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 833-844
    • Klein, L.1    Hinterberger, M.2    Wirnsberger, G.3    Kyewski, B.4
  • 58
    • 0036360019 scopus 로고    scopus 로고
    • The enemy within: Keeping self-reactive T cells at bay in the periphery
    • Walker LS, Abbas AK. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol. 2002; 2: 11-19.
    • (2002) Nat Rev Immunol. , vol.2 , pp. 11-19
    • Walker, L.S.1    Abbas, A.K.2
  • 61
    • 73249145617 scopus 로고    scopus 로고
    • Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    • Wegner N, Lundberg K, Kinloch A, Fisher B, Malmstrom V, Feldmann M, et al. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev. 2010;233:34-54.
    • (2010) Immunol Rev. , vol.233 , pp. 34-54
    • Wegner, N.1    Lundberg, K.2    Kinloch, A.3    Fisher, B.4    Malmstrom, V.5    Feldmann, M.6
  • 62
    • 26844469416 scopus 로고    scopus 로고
    • Celiac disease: Caught between a rock and a hard place
    • Koning F. Celiac disease: caught between a rock and a hard place. Gastroenterology. 2005; 129:1294-301.
    • (2005) Gastroenterology. , vol.129 , pp. 1294-1301
    • Koning, F.1
  • 63
    • 54949091137 scopus 로고    scopus 로고
    • Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase
    • Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, et al. Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum. 2008; 58: 3009-19.
    • (2008) Arthritis Rheum. , vol.58 , pp. 3009-3019
    • Lundberg, K.1    Kinloch, A.2    Fisher, B.A.3    Wegner, N.4    Wait, R.5    Charles, P.6
  • 64
    • 33644926954 scopus 로고    scopus 로고
    • Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anticitrullinated protein antibodies in rheumatoid arthritis
    • Pratesi F, Tommasi C, Anzilotti C, Chimenti D, Migliorini P. Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anticitrullinated protein antibodies in rheumatoid arthritis. Arthritis Rheum. 2006; 54: 733-41.
    • (2006) Arthritis Rheum. , vol.54 , pp. 733-741
    • Pratesi, F.1    Tommasi, C.2    Anzilotti, C.3    Chimenti, D.4    Migliorini, P.5
  • 65
    • 0037546559 scopus 로고    scopus 로고
    • Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1
    • Munz C, Bickham KL, Subklewe M, Tsang ML, Chahroudi A, Kurilla MG, et al. Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1. J Exp Med. 2000; 191: 1649-60.
    • (2000) J Exp Med. , vol.191 , pp. 1649-1660
    • Munz, C.1    Bickham, K.L.2    Subklewe, M.3    Tsang, M.L.4    Chahroudi, A.5    Kurilla, M.G.6
  • 66
    • 49049095134 scopus 로고    scopus 로고
    • Increased frequency of EBV-specific effector memory CD8 + T cells correlates with higher viral load in rheumatoid arthritis
    • Lunemann JD, Frey O, Eidner T, Baier M, Roberts S, Sashihara J, et al. Increased frequency of EBV-specific effector memory CD8 + T cells correlates with higher viral load in rheumatoid arthritis. J Immunol. 2008;181:991-1000.
    • (2008) J Immunol. , vol.181 , pp. 991-1000
    • Lunemann, J.D.1    Frey, O.2    Eidner, T.3    Baier, M.4    Roberts, S.5    Sashihara, J.6
  • 67
    • 0031458442 scopus 로고    scopus 로고
    • The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells
    • Kimachi K, Crof M, Grey HM. The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells. Eur J Immunol. 1997;27:3310-17.
    • (1997) Eur J Immunol. , vol.27 , pp. 3310-3317
    • Kimachi, K.1    Crof, M.2    Grey, H.M.3
  • 68
    • 0022375427 scopus 로고
    • Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
    • Fujinami RS, Oldstone MB. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science. 1985;230:1043-5.
    • (1985) Science. , vol.230 , pp. 1043-1045
    • Fujinami, R.S.1    Oldstone, M.B.2
  • 69
    • 84870280593 scopus 로고    scopus 로고
    • Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection
    • Enouz S, Carrie L, Merkler D, Bevan MJ, Zehn D. Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med. 2012;209:1769-79.
    • (2012) J Exp Med. , vol.209 , pp. 1769-1779
    • Enouz, S.1    Carrie, L.2    Merkler, D.3    Bevan, M.J.4    Zehn, D.5
  • 70
    • 79958799270 scopus 로고    scopus 로고
    • Infection and rheumatoid arthritis: Still an open question
    • Hitchon CA, El-Gabalawy HS. Infection and rheumatoid arthritis: still an open question. Curr Opin Rheumatol. 2011;23:352-7.
    • (2011) Curr Opin Rheumatol. , vol.23 , pp. 352-357
    • Hitchon, C.A.1    El-Gabalawy, H.S.2
  • 71
    • 0038107566 scopus 로고    scopus 로고
    • Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1 0401 MHC class II molecule
    • Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1 0401 MHC class II molecule. J Immunol. 2003;171: 538-41.
    • (2003) J Immunol. , vol.171 , pp. 538-541
    • Hill, J.A.1    Southwood, S.2    Sette, A.3    Jevnikar, A.M.4    Bell, D.A.5    Cairns, E.6
  • 72
    • 80053494012 scopus 로고    scopus 로고
    • Identif cation and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1 0401-positive humanized mice and rheumatoid arthritis patients
    • Snir O, Rieck M, Gebe JA, Yue BB, Rawlings CA, Nepom G, et al. Identif cation and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1 0401-positive humanized mice and rheumatoid arthritis patients. Arthritis Rheum. 2011;63:2873-83.
    • (2011) Arthritis Rheum. , vol.63 , pp. 2873-2883
    • Snir, O.1    Rieck, M.2    Gebe, J.A.3    Yue, B.B.4    Rawlings, C.A.5    Nepom, G.6
  • 73
    • 84888116736 scopus 로고    scopus 로고
    • A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
    • Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL, et al. A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J Exp Med. 2013; 210: 2569-82.
    • (2013) J Exp Med. , vol.210 , pp. 2569-2582
    • Scally, S.W.1    Petersen, J.2    Law, S.C.3    Dudek, N.L.4    Nel, H.J.5    Loh, K.L.6
  • 74
    • 74849112402 scopus 로고    scopus 로고
    • Response of T 17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis
    • von Delwig A, Locke J, Robinson JH, Ng WF. Response of T 17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis. Arthritis Rheum. 2010;62:143-9.
    • (2010) Arthritis Rheum. , vol.62 , pp. 143-149
    • Von Delwig, A.1    Locke, J.2    Robinson, J.H.3    Ng, W.F.4
  • 75
    • 84861060158 scopus 로고    scopus 로고
    • T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles
    • Law SC, Street S, Yu CH, Capini C, Ramnoruth S, Nel HJ, et al. T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles. Arthritis Res Ther. 2012; 14: R118.
    • (2012) Arthritis Res Ther. , vol.14
    • Law, S.C.1    Street, S.2    Yu, C.H.3    Capini, C.4    Ramnoruth, S.5    Nel, H.J.6


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