Fcγ receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins

Annals of the Rheumatic Diseases

Volumn 70, Issue 6, 2011, Pages 1052-1059

  Laurent, Lætitia ^a   Clavel, Cyril ^a   Lemaire, Olivia ^b   Anquetil, Florence ^a   Cornillet, Martin ^a   Zabraniecki, Laurent ^b   Nogueira, Leonor ^a   Fournié, Bernard ^b   Serre, Guy ^a   Sebbag, Mireille ^a  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b CHU PURPAN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; AUTOANTIBODY; C REACTIVE PROTEIN; CD14 ANTIGEN; CD16 ANTIGEN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; CYCLOPHOSPHAMIDE; ETANERCEPT; FC RECEPTOR; INFLIXIMAB; LEFLUNOMIDE; METHOTREXATE; PENICILLAMINE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE DURATION; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MACROPHAGE; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SUPERNATANT; SYNOVIAL FLUID;

ADULT; AGED; AGED, 80 AND OVER; ANTIGEN-ANTIBODY COMPLEX; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HUMANS; MACROPHAGES; MALE; MIDDLE AGED; MONOCYTES; PEPTIDES, CYCLIC; RECEPTORS, IGG; SYNOVIAL FLUID; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 79955824880     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.142091     Document Type: Article

References (51)

1. Klareskog L, Rönnelid J, Lundberg K, et al. Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 2008 ; 26 : 651-75. (Pubitemid 351600388) (Pubitemid 351600388)
2. Sebbag M, Clavel C, Nogueira L, et al. Autoimmune response to posttranslationally modified (citrullinated) proteins: prime suspect in the pathophysiology of rheumatoid arthritis. In: Zouali M, ed. The epigenetics of autoimmune diseases. Chichester: John Wiley and Sons, 2009:279-308.
3. Nielen MM, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004 ; 50 : 380-6. (Pubitemid 38198821) (Pubitemid 38198821)
4. Avouac J, Gossec L, Dougados M. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis 2006 ; 65 : 845-51.
5. Szodoray P, Szabó Z, Kapitány A, et al. Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis. Autoimmun Rev 2010 ; 9 : 140-3.
6. Masson-Bessière C, Sebbag M, Durieux JJ, et al. In the rheumatoid pannus, antifilaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum. Clin Exp Immunol 2000; 119 : 544-52. (Pubitemid 30146353) (Pubitemid 30146353)
7. Iwaki-Egawa S, Matsuno H, Ogawa Y, et al. Production of anti-CCP antibodies and matrix metalloproteinase-3 by human rheumatoid arthritis synovial tissues using SCID mice. Ann Rheum Dis 2005 ; 64 : 1094-5. (Pubitemid 40909535) (Pubitemid 40909535)
8. Humby F, Bombardieri M, Manzo A, et al. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 2009 ; 6 : e1.
9. Masson-Bessière C, Sebbag M, Girbal-Neuhauser E, et al. The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin. J Immunol 2001 ; 166 : 4177-84. (Pubitemid 32224951) (Pubitemid 32224951)
10. Tak PP, Smeets TJ, Daha MR, et al. Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 1997 ; 40 : 217-25. (Pubitemid 27114085) (Pubitemid 27114085)
11. Mulherin D, Fitzgerald O, Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 1996 ; 39 : 115-24. (Pubitemid 26036386) (Pubitemid 26036386)
12. Haringman JJ, Gerlag DM, Zwinderman AH, et al. Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2005 ; 64 : 834-8. (Pubitemid 40733904) (Pubitemid 40733904)
13. Chu CQ, Field M, Feldmann M, et al. Localization of tumor necrosis factor alpha in synovial tissues and at the cartilage-pannus junction in patients with rheumatoid arthritis. Arthritis Rheum 1991 ; 34 : 1125-32.
14. Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996 ; 14 : 397-440. (Pubitemid 26130190) (Pubitemid 26130190)
15. McInnes IB, Leung BP, Liew FY. Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells. Arthritis Res 2000 ; 2 : 374-8. (Pubitemid 32223767) (Pubitemid 32223767)
16. Lubberts E, Koenders MI, van den Berg WB. The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. Arthritis Res Ther 2005 ; 7 : 29-37. (Pubitemid 40214525) (Pubitemid 40214525)
17. Sacre SM, Lo A, Gregory B, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol 2008 ; 181 : 8002-9.
18. Midwood K, Sacre S, Piccinini AM, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 2009 ; 15 : 774-80.
19. Chapuy-Regaud S, Nogueira L, Clavel C, et al. IgG subclass distribution of the rheumatoid arthritis-specific autoantibodies to citrullinated fibrin. Clin Exp Immunol 2005 ; 139 : 542-50. (Pubitemid 40333267) (Pubitemid 40333267)
20. Clavel C, Nogueira L, Laurent L, et al. Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum 2008 ; 58 : 678-88. (Pubitemid 351364865) (Pubitemid 351364865)
21. Belge KU, Dayyani F, Horelt A, et al. The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF. J Immunol 2002 ; 168 : 3536-42. (Pubitemid 34250422) (Pubitemid 34250422)
22. Frankenberger M, Sternsdorf T, Pechumer H, et al. Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis. Blood 1996 ; 87 : 373-7. (Pubitemid 26011852) (Pubitemid 26011852)
23. Hamilton JA, Tak PP. The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases. Arthritis Rheum 2009 ; 60 : 1210-21.
24. Baeten D, Boots AM, Steenbakkers PG, et al. Human cartilage gp-39+,CD16+ monocytes in peripheral blood and synovium: correlation with joint destruction in rheumatoid arthritis. Arthritis Rheum 2000 ; 43 : 1233-43. (Pubitemid 30416308) (Pubitemid 30416308)
25. Katayama K, Matsubara T, Fujiwara M, et al. CD14+CD16+ monocyte subpopulation in Kawasaki disease. Clin Exp Immunol 2000 ; 121 : 566-70.
26. Okamoto H, Mizuno K, Horio T. Circulating CD14+ CD16+ monocytes are expanded in sarcoidosis patients. J Dermatol 2003 ; 30 : 503-9. (Pubitemid 36950762) (Pubitemid 36950762)
27. Hahn G, Stuhlmüller B, Hain N, et al. Modulation of monocyte activation in patients with rheumatoid arthritis by leukapheresis therapy. J Clin Invest 1993 ; 91 : 862-70. (Pubitemid 23095260) (Pubitemid 23095260)
28. Steven MM, Lennie SE, Sturrock RD, et al. Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis. Ann Rheum Dis 1984 ; 43 : 435-9. (Pubitemid 14117919) (Pubitemid 14117919)
29. Bunescu A, Seideman P, Lenkei R, et al. Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: interaction with platelets. J Rheumatol 2004 ; 31 : 2347-55. (Pubitemid 39603080) (Pubitemid 39603080)
30. Stuhlmüller B, Ungethüm U, Scholze S, et al. Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum 2000 ; 43 : 775-90.
31. Blom AB, Radstake TR, Holthuysen AE, et al. Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase. Arthritis Rheum 2003 ; 48 : 1002-14. (Pubitemid 36418242) (Pubitemid 36418242)
32. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988 ; 31 : 315-24. (Pubitemid 18091653) (Pubitemid 18091653)
33. Highton J, Carlisle B, Palmer DG. Changes in the phenotype of monocytes/macrophages and expression of cytokine mRNA in peripheral blood and synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 1995 ; 102 : 541-6. (Pubitemid 26013218) (Pubitemid 26013218)
34. Wijngaarden S, van de Winkel JG, Jacobs KM, et al. A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis. Arthritis Rheum 2004 ; 50 : 3878-87. (Pubitemid 39643934) (Pubitemid 39643934)
35. Wijngaarden S, van Roon JA, Bijlsma JW, et al. Fcgamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs. Rheumatology (Oxford) 2003 ; 42 : 681-8. (Pubitemid 37220879) (Pubitemid 37220879)
36. Hepburn AL, Mason JC, Davies KA. Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis. Rheumatology (Oxford) 2004 ; 43 : 547-54. (Pubitemid 38628182) (Pubitemid 38628182)
37. Torsteinsdóttir I, Arvidson NG, Hällgren R, et al. Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids. Clin Exp Immunol 1999 ; 115 : 554-60. (Pubitemid 29130375) (Pubitemid 29130375)
38. Wijngaarden S, van de Winkel JG, Bijlsma JW, et al. Treatment of rheumatoid arthritis patients with anti-TNF-alpha monoclonal antibody is accompanied by downregulation of the activating Fcgamma receptor I on monocytes. Clin Exp Rheumatol 2008 ; 26 : 89-95. (Pubitemid 351385260) (Pubitemid 351385260)
39. Wijngaarden S, van Roon JA, van de Winkel JG, et al. Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment. Rheumatology (Oxford) 2005 ; 44 : 729-34. (Pubitemid 41487200) (Pubitemid 41487200)
40. Kawanaka N, Yamamura M, Aita T, et al. CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum 2002 ; 46 : 2578-86. (Pubitemid 36118920) (Pubitemid 36118920)
41. Schlitt A, Heine GH, Blankenberg S, et al. CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels. Thromb Haemost 2004 ; 92 : 419-24. (Pubitemid 39172323) (Pubitemid 39172323)
42. Ziegler-Heitbrock L. The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 2007 ; 81 : 584-92. (Pubitemid 46393535) (Pubitemid 46393535)
43. Hibbs ML, Selvaraj P, Carpén O, et al. Mechanisms for regulating expression of membrane isoforms of Fc gamma RIII (CD16). Science 1989 ; 246 : 1608-11. (Pubitemid 20036696) (Pubitemid 20036696)
44. van Vugt MJ, Heijnen AF, Capel PJ, et al. FcR gamma-chain is essential for both surface expression and function of human Fc gamma RI (CD64) in vivo. Blood 1996 ; 87 : 3593-9. (Pubitemid 26129586) (Pubitemid 26129586)
45. Klareskog L, Catrina AI, Paget S. Rheumatoid arthritis. Lancet 2009 ; 373 : 659-72.
46. Van Steendam K, Tilleman K, De Ceuleneer M, et al. Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins. Arthritis Res Ther 2010; 12 : R132.
47. Fossati G, Bucknall RC, Edwards SW. Insoluble and soluble immune complexes activate neutrophils by distinct activation mechanisms: changes in functional responses induced by priming with cytokines. Ann Rheum Dis 2002 ; 61 : 13-19. (Pubitemid 34074832) (Pubitemid 34074832)
48. DiMartino SJ, Yuan W, Redecha P, et al. Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a. Clin Immunol 2008 ; 127 : 56-65.
49. Trouw LA, Haisma EM, Levarht EW, et al. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum 2009 ; 60 : 1923-31.
50. Schuerwegh AJ, Ioan-Facsinay A, Dorjée AL, et al. Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. Proc Natl Acad Sci U S A 2010 ; 107 : 2586-91.
51. Vander Cruyssen B, Cantaert T, Nogueira L, et al. Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays. Arthritis Res Ther 2006 ; 8 : R122.