MyD88-, but not Nod1- And/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Sônego, Fabiane ^a,b   Castanheira, Fernanda V S ^a   Czaikoski, Paula G ^a   Kanashiro, Alexandre ^a   Souto, Fabricio O ^a   França, Rafael O ^a   Nascimento, Daniele C ^a   Freitas, Andressa ^a   Spiller, Fernando ^a   Cunha, Larissa D ^a   Zamboni, Dario S ^a   Alves Filho, José C ^a   Cunha, Fernando Q ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CXCL14 CHEMOKINE; CXCL2 CHEMOKINE; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; TUMOR NECROSIS FACTOR ALPHA; CARD15 PROTEIN, MOUSE; CARD4 PROTEIN, MOUSE; MYD88 PROTEIN, MOUSE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL LOAD; BACTERIAL PERITONITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; INFLAMMATION; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEAL CAVITY; POLYMICROBIAL SEPSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPSIS; WILD TYPE; ANIMAL; C57BL MOUSE; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SEPSIS;

EID: 84905457851     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103734     Document Type: Article

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