MyD88 and trif signaling play distinct roles in cardiac dysfunction and mortality during endotoxin shock and polymicrobial sepsis

Anesthesiology

Volumn 115, Issue 3, 2011, Pages 555-567

  Feng, Yan ^a   Zou, Lin ^a   Zhang, Ming ^a   Li, Yan ^a   Chen, Chan ^a   Chao, Wei ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; HEART DISEASE; HEART FUNCTION; HEART LEFT VENTRICLE FUNCTION; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; PERITONITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

EID: 80052148652     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31822a22f7     Document Type: Article

References (45)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310 (Pubitemid 32641789)
2. Minino AM, Heron MP, Murphy SL, Kochanek KD: Deaths: Final data for 2004. Natl Vital Stat Rep 2007; 55:1-119
3. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124:783-801 (Pubitemid 43261452)
4. Chao W: Toll-like receptor signaling: A critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol 2009; 296:H1-12
5. Kaczorowski DJ, Mollen KP, Edmonds R, Billiar TR: Early events in the recognition of danger signals after tissue injury. J Leukoc Biol 2008; 83:546-552 (Pubitemid 351966863)
6. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S: Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11:115-122 (Pubitemid 29359962)
7. Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 2003; 301:640-643 (Pubitemid 36927946)
8. Uematsu S, Akira S: Toll-like receptors and Type I interferons. J Biol Chem 2007; 282:15319-5323
9. Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol 2001; 1:135-145 (Pubitemid 33741967)
10. Alves-Filho JC, Freitas A, Souto FO, Spiller F, Paula-Neto H, Silva JS, Gazzinelli RT, Teixeira MM, Ferreira SH, Cunha FQ: Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis. Proc Natl Acad Sci USA 2009; 106:4018-4023
11. Alves-Filho JC, de Freitas A, Russo M, Cunha FQ: Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit Care Med 2006; 34:461-470 (Pubitemid 43145627)
12. Roger T, Froidevaux C, Le Roy D, Reymond MK, Chanson AL, Mauri D, Burns K, Riederer BM, Akira S, Calandra T: Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc Natl Acad Sci USA 2009; 106:2348-2352
13. Plitas G, Burt BM, Nguyen HM, Bamboat ZM, DeMatteo RP: Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. J Exp Med 2008; 205:1277-1283 (Pubitemid 351831485)
14. Zou L, Feng Y, Chen YJ, Si R, Shen S, Zhou Q, Ichinose F, Scherrer-Crosbie M, Chao W: Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med 2010; 38:1335-1342
15. Weighardt H, Kaiser-Moore S, Vabulas RM, Kirschning CJ, Wagner H, Holzmann B: Cutting edge: Myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 2002; 169:2823-2827 (Pubitemid 35013119)
16. Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS: Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol 2008; 83:1009-1018 (Pubitemid 351959882)
17. Weighardt H, Kaiser-Moore S, Schlautkötter S, Rossmann-Bloeck T, Schleicher U, Bogdan C, Holzmann B: Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. J Immunol 2006; 177:5623-5630 (Pubitemid 44527637)
18. Kelly-Scumpia KM, Scumpia PO, Delano MJ, Weinstein JS, Cuenca AG, Wynn JL, Moldawer LL: Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med 2010; 207:319-326
19. Frantz S, Kobzik L, Kim YD, Fukazawa R, Medzhitov R, Lee RT, Kelly RA: Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J Clin Invest 1999; 104:271-280
20. Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS, Takeuchi O, Akira S, Vallejo JG: Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. Circulation 2004; 110:3693-3698 (Pubitemid 39665259)
21. Nemoto S, Vallejo JG, Knuefermann P, Misra A, Defreitas G, Carabello BA, Mann DL: Escherichia coli LPS-induced LV dysfunction: Role of toll-like receptor-4 in the adult heart. Am J Physiol Heart Circ Physiol 2002; 282:H2316-2323 (Pubitemid 34663043)
22. Zhu X, Bagchi A, Zhao H, Kirschning CJ, Hajjar RJ, Chao W, Hellman J, Schmidt U: Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction. Crit Care Med 2007; 35:886-892 (Pubitemid 46407806)
23. Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA: Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009; 4:31-6
24. Feng Y, Zhao H, Xu X, Buys ES, Raher MJ, Bopassa JC, Thibault H, Scherrer-Crosbie M, Schmidt U, Chao W: Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice. Am J Physiol Heart Circ Physiol 2008; 295:H1311-1318
25. Wang E, Feng Y, Zhang M, Zou L, Li Y, Buys ES, Huang P, Brouckaert P, Chao W: Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase-and soluble guanylate cyclase-dependent mechanisms. Anesthesiology 2011; 114:603-613
26. Feng Y, Zou L, Si R, Nagasaka Y, Chao W: Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury. Am J Physiol Cell Physiol 2010; 299:C760-769
27. Charo IF, Ransohoff RM: The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354:610-621 (Pubitemid 43209108)
28. Bozic CR, Kolakowski LF Jr, Gerard NP, Garcia-Rodriguez C, von Uexkull-Guldenband C, Conklyn MJ, Breslow R, Showell HJ, Gerard C: Expression and biologic characterization of the murine chemokine KC. J Immunol 1995; 154:6048-6057
29. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock-a review of laboratory models and a proposal. J Surg Res 1980; 29:189-201 (Pubitemid 10039498)
30. Deitch EA: Animal models of sepsis and shock: A review and lessons learned. Shock 1998; 9:1-11 (Pubitemid 128463868)
31. Schultz MJ, van der Poll T: Animal and human models for sepsis. Ann Med 2002; 34:573-581 (Pubitemid 36113816)
32. Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 1990; 49:186-196 (Pubitemid 20241651)
33. Baker CC, Chaudry IH, Gaines HO, Baue AE: Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983; 94:331-335 (Pubitemid 13043132)
34. Remick DG, Newcomb DE, Bolgos GL, Call DR: Comparison of the mortality and inflammatory response of two models of sepsis: Lipopolysaccharide vs. cecal ligation and puncture. Shock 2000; 13:110-116
35. Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE: Apoptosis in lymphoid and parenchymal cells during sepsis: Findings in normal and T-and B-cell-deficient mice. Crit Care Med 1997; 25:1298-1307 (Pubitemid 27347292)
36. Albiger B, Dahlberg S, Henriques-Normark B, Normark S: Role of the innate immune system in host defence against bacterial infections: Focus on the Toll-like receptors. J Intern Med 2007; 261:511-528 (Pubitemid 46835986)
37. Bhan U, Lukacs NW, Osterholzer JJ, Newstead MW, Zeng X, Moore TA, McMillan TR, Krieg AM, Akira S, Standiford TJ: TLR9 is required for protective innate immunity in Gramnegative bacterial pneumonia: Role of dendritic cells. J Immunol 2007; 179:3937-3946
38. Albiger B, Dahlberg S, Sandgren A, Wartha F, Beiter K, Katsuragi H, Akira S, Normark S, Henriques-Normark B: Tolllike receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol 2007; 9:633-644 (Pubitemid 46231970)
39. Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K: A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci USA 2008; 105:20446-0451
40. Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG: Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. Am J Physiol Heart Circ Physiol 2007; 292:H251-258 (Pubitemid 46105186)
41. Riad A, Westermann D, Zietsch C, Savvatis K, Becher PM, Bereswill S, Heimesaat MM, Lettau O, Lassner D, Dörner A, Poller W, Busch M, Felix SB, Schultheiss HP, Tschöpe C: TRIF Is a Critical Survival Factor in Viral Cardiomyopathy. J Immunol 2011; 186:2561-2570
42. Echtenacher B, Freudenberg MA, Jack RS, Männel DN: Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect Immun 2001; 69:7271-7276 (Pubitemid 33086548)
43. Casey LC, Balk RA, Bone RC: Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119:771-778 (Pubitemid 24012641)
44. Cohen J: The immunopathogenesis of sepsis. Nature 2002; 420:885-891 (Pubitemid 36019643)
45. Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA: The sepsis seesaw: Tilting toward immunosuppression. Nat Med 2009; 15:496-497