Critical role of toll-like receptors and nucleotide oligomerisation domain in the regulation of health and disease

Journal of Endocrinology

Volumn 193, Issue 3, 2007, Pages 323-330

  Mitchell, Jane A ^a   Paul Clark, Mark J ^a   Clarke, Graham W ^a   McMaster, Shaun K ^a   Cartwright, Neil ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; BINDING PROTEIN; CARBOHYDRATE BINDING PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CD14 ANTIGEN; CYCLOOXYGENASE 2; ENDOTHELIN 1; IMIQUIMOD; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOTEICHOIC ACID; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; PATTERN RECOGNITION RECEPTOR; PROTEIN MD 2; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ASTHMA; ATHEROSCLEROSIS; BACTERIAL IMMUNITY; CONDYLOMA; DRUG TARGETING; GENE INDUCTION; GENE MUTATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HOST PATHOGEN INTERACTION; HUMAN; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SEPSIS; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; BACTERIAL INFECTIONS; HUMANS; LIPOPOLYSACCHARIDES; MICE; NOD SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; VIRAL PROTEINS; VIRUS DISEASES;

EID: 34447107898     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/JOE-07-0067     Document Type: Review

References (75)

1. Abreu MT, Fukata M & Arditi M 2005 TLR signaling in the gut in health and disease. Journal of Immunology 174 4453-4460.
2. Ajuebor MN, Das AM, Virag L, Flower PJ, Szabo C & Perretti M 1999 Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10. Journal of Immunology 162 1685-1691.
3. Akira S & Takeda K 2004 Toll-like receptor signalling. Nature Reviews. Immunology 4 499-511.
4. Alexopoulou L, Holt AC, Medzhitov R & Flavell RA 2001 Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 732-738.
5. Anderson KV, Bokla L & Nusslein-Volhard C 1985 Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42 791-798.
6. Belvin MP & Anderson KV 1996 A conserved signaling pathway: the Drosophila Toll-dorsal pathway. Annual Review of Cell and Developmental Biology 12 393-416.
7. Bishop-Bailey D, Larkin SW, Warner TD, Chen G & Mitchell JA 1997 Characterization of the induction of nitric oxide synthase and cyclooxygenase in rat aorta in organ culture. British Journal of Pharmacology 121 125-133.
8. Bjorkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT et al. 2004 Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nature Medicine 10 416-421.
9. Bornstein SR, Zacharowski P, Schumann RR, Barthel A, Tran N, Papewalis C, Retton V, McCann SM, Schulze-Osthoff K, Scherbaum WA et al. 2004 Impaired adrenal stress response in Toll-like receptor 2-deficient mice. PNAS 101 16695-16700.
10. Bornstein SR, Ziegler CG, Krug AW, Kanczkowski W, Rettori V, McCann SM, Wirth M & Zacharowski K 2006 The role of Toll-like receptors in the inumme-adrenal crosstalk. Annals of the New York Academy of Sciences 1088 307-318.
11. Buckingham JC, John CD, Solito E, Tierney T, Flower RJ, Christian H & Morris J 2006 Annexin 1, glucocorticoids, and the neuroendocrine-immune interface. Annals of the New York Academy of Sciences 1088 396-409.
12. Cartwright N, Murch O, McMaster SK, Paul-Clark MJ, van Heel DA, Ryffel B, Quesmaux VF, Evans TW, Thiemermann C & Mitchell JA 2007 Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo. American Journal of Respiratory and Critical Care Medicine 175 595-603.
13. Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S et al. 2003 An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nature Immunology 4 702-707.
14. Chaudhuri N, Dower SK, Whyte MK & Sabroe I 2005 Toll-like receptors and chronic lung disease. Clinical Science 109 125-133.
15. Cunha JM, Cunha FQ, Poole S & Ferreira SH 2000 Cytokine-mediated inflammatory hyperalgesia limited by interleukin-1 receptor antagonist. British Journal of Pharmacology 130 1418-1424.
16. Diebold SS, Kaisho T, Henuni H, Akira S & Reis e Sousa C 2004 Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303 1529-1531.
17. Elmali N, Baysal O, Harma A, Esenkaya I & Mizrak B 2007 Effects of resveratrol in inflammatory arthritis. Inflammation 30 1-6.
18. Feleszko W, Jaworska J & Hamelmann E 2006 Toll-like receptors-novel targets in allergic airway disease (probiotics, friends and relatives). European Journal of Pharmacology 533 308-318.
19. Fitzgerald KA, Rowe DC & Golenbock DT 2004 Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes and Infection 6 1361-1367.
20. Gay NJ & Keith FJ 1991 Drosophila Toll and IL-1 receptor. Nature 351 355-356.
21. Gewirtz AT, Navas TA, Lyons S, Godowski PJ & Madara JL 2001 Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. Journal of Immunology 167 1882-1885.
22. Haddad E, McCluskie K, Birrell MA, Dabrowski D, Pecoraro M, Underwood S, Chen B, De Sanctis GT, Webber SE, Foster ML et al. 2002 Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation. Journal of Immunology 169 974-982.
23. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM & Aderem A 2001 The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 1099-1103.
24. van Heel DA, Ghosh S, Butler M, Hunt K, Foxwell BM, Mengin-Lecreulx D & Playford RJ 2005 Synergistic enhancement of Toll-like receptor responses by NOD1 activation. European Journal of Immunology 35 2471-2476.
25. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H & Bauer S 2004 Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303 1526-1529.
26. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K et al. 2000 A Toll-like receptor recognizes bacterial DNA. Nature 408 740-745.
27. Hoebe K, Georgel P, Rutschmann S, Du X, Mudd S, Crozat K, Sovath S, Shamel L, Hartung T, Zahringer U et al. 2005 CD36 is a sensor of diacylglycerides. Nature 433 523-527.
28. Hoshino, K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K & Akira S 1999 Cutting edge: Toll-like receptor 4 (TLR4)-deficieot mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. Journal of Immunology 162 3749-3752.
29. Imler JL & Hoffmann JA 2001 Toll receptors in innate immunity. Trends in Cell Biology 11 304-311.
30. Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M et al. 2003 Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. Journal of Biological Chemistry 278 5509-5512.
31. Inohara N, Chamaillard M, McDonald C & Nunez G 2005 NOD-LRR proteins: role in host-nucrobial interactions and inflammatory disease. Annual Review of Biochemistry 74 355-383.
32. Kengatharan KM, De Kimpe SJ & Thiemermann C 1996a Role of nitric oxide in the circulatory failure and organ injury in a rodent model of Gram-positive shock. British Journal of Pharmacology 119 1411-1421.
33. Kengatharan M, De Kimpe SJ & Thiemermann C 1996b Analysis ofthe signal transduction in the induction of nitric oxide synthase by lipoteichoic acid in macrophages. British Journal of Pharmacology 117 1163-1170.
34. Lemaitre B, Nicolas E, Michaut L, Reichhart JM & Hoffmann JA 1996 The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86 973-983.
35. Lonchampt MO, Auguet M, Delaflotte S, Gouhn-Schulz J, Chabrier PE & Braquet P 1992 Lipoteichoic acid: a new inducer of nitric oxide synthase. Journal of Cardiovascular Pharmacology 20 (Suppl 12) S145-S147.
36. Maclean LD & Weil MH 1956 Hypotension (shock) in dogs produced by Escherichia coli endotoxin. Circulation Research 4 546-556.
37. Mansell A, Brint E, Gould JA, O'Neill LA & Hertzog PJ 2004 Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by Toll-like receptor (TLR)-2 and TLR4. Journal of Biological Chemistry 279 37227-37230.
38. Marchalant Y, Rosi S & Wenk GL 2007 Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation. Neuroscience 144 1516-1522.
39. Mariathasan S & Monack DM 2007 Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nature Reviews. Immunology 7 31-40.
40. Masumoto J, Yang K, Varambally S, Hasegawa M, Tomlins SA, Qiu S, Fujimoto Y, Kawasaki A, Foster SJ, Horie Y et al. 2006 Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. Journal of Experimental Medicine 203 203-213.
41. Medzhitov R, Preston-Hurlburt P & Janeway CA Jr 1997 A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 394-397.
42. Michelsen KS, Doherty TM, Shah PK & Arditi M 2004 TLR signaling: an emerging bridge from innate immunity to atherogenesis. Journal of Immunology 173 5901-5907.
43. Mitchell JA, Fitzgerald KA, Coyle A, Silverman N & Cartwrigbt N 2006 TOLLing away in Brazil. Nature Immunology 7 675-679.
44. Mullick AE, Tobias PS & Curtiss LK 2005 Modulation of atherosclerosis in mice by Toll-like receptor 2. Journal of Clinical Investigation 115 3149-3156.
45. Murillo LS, Morre SA & Pena AS 2003 Role of the CARD15 gene in the pathogenesis of Crohn disease: phenotypic classification and prognostic implications. Scandinavian Journal of Gastroenterology 38 1107-1114.
46. Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L & Aderem A 2000 The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. PNAS 97 13766-13771.
47. Paul-Clark MJ, McMaster SK, Belcher E, Sorrentino R, Anandarajah J, Fleet M, Sriskandan S & Mitchell JA 2006 Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFalpha in macrophages: role of TLRs in synergy between the two. British Journal of Pharmacology 148 1067-1075.
48. Poltorak A, He X, Smimova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C et al. 1998 Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 2095-2088.
49. Rock FL, Hardiman G, Timans JC, Kastelein RA & Bazan JF 1998 A family of human receptors structurally related to Drosophila Toll. PNAS 95 588-593.
50. Schronim AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K et al. 2001 Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endoto3dn-induced signaling. Journal of Experimental Medicine 194 79-88.
51. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, Tobias PS & Ulevitch RJ 1990 Structure and function of lipopolysaccharide binding protein. Science 249 1429-1431.
52. Schwandner R, Dziarski R, Wesche H, Rothe M & Kirschning CJ 1999 Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2. Journal of Biological Chemistry 274 17406-17409.
53. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K & Kimoto M 1999 MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. Journal of Experimental Medicine 189 1777-1782.
54. Skidmore BJ, Chiller JM, Morrison DC & Weigle WO 1975 Immunologic properties of bacterial lipopolysaccharide (LPS): correlation between the mitogenic, adjuvant, and immunogenic activities. Journal of Immunology 114 770-775.
55. Stockfleth E, Trefzer U, Garcia-Bartels C, Wegner T, Schmook T & Sterry W 2003 The use of Tolt-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview. British Journal of Dermatology 149 (Suppl 66) 53-56.
56. Strober W, Murray PJ, Kitani A & Watanabe T 2006 Signalling pathways and molecular interactions of NOD1 and NOD2. Nature Reviews. Immunology 6 9-20.
57. Szabo C, Mitchell JA, Thiemermann C & Vane JR 1993 Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. British Journal of Pharmacology 108 786-792.
58. Szabo C, Thiemermann C, Wu CC, Perretti M & Vane JR 1994 Attenuation of the induction of nitric oxide synthase by enclogenous glucocorticoids accounts for endotoxin tolerance in vivo. PNAS 91 271-275.
59. Taguchi T, Mitcham JL, Dower SK, Sinis JE & Testa JR 1996 Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14. Genomics 32 486-488.
60. Takada H & Uehara A 2006 Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling. Current Pharmaceutical Design 12 4163-4172.
61. Takeuchi O, Hoshino K, Kawai T, Sarjo H, Takada H, Ogawa T, Takeda K & Akira S 1999a Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11 443-451.
62. Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K & Akira S 1999b TLR6: a novel member of an expanding Toll-like receptor family. Gene 231 59-65.
63. Takeuchi O, Kawai T, Muhlradt PF, Mort M, Radolf JD, Zychhnsky A, Takeda K & Akira S 2001 Discrimination of bacterial lipoproteins by Toll-like receptor 6. International Immunology 13 933-940.
64. Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, Modlin RL & Akira S 2002 Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. Journal of Immunology 169 10-14.
65. Tobias P & Curtiss LK 2005 Thematic review series: the immune system and atherogenesis. Paying the price for pathogen protection: Toll receptors in atherogenesis. Journal of Lipid Research 46 404-411.
66. Tobias PS, Soldau K & Ulevitch RJ 1986 Isolation of a lipopolysaccharide binding acute phase reactant from rabbit serum. Journal of Experimental Medicine 164 773-793.
67. Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, Williams BR, Major J, Hamilton TA, Fenton MJ et al. 2002 TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nature Immunology 3 392-398.
68. Travassos LH, Girardin SE, Philpott DJ, Blanot D, Nahori MA, Werts C & Boneca IG 2004 Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Reports 5 1000-1006.
69. Triantafilou M, Gamper FG, Haston RM, Mouratis MA, Morath S, Hartung T & Triantafilou K 2006 Membrane sorting of Toll-like receptor (TLR)-2/ 6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intraceflular targeting. Journal of Biological Chemistry 281 31002-31011.
70. Visintin A, Mazzoni A, Spitzer JA & Segal DM 2001 Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4. PNAS 98 12156-12161.
71. Vogel SN, Fitzgerald KA & Fenton MJ 2003 TLRs: differential adapter utilization by Toll-like receptors mediates TLR-specific patterns of gene expression. Molecular Interventions 3 466-477.
72. West AP, Koblansky AA & Ghosh S 2006 Recognition and signaling by Toll-like receptors. Annual Review of Cell and Developmental Biology 22 409-437.
73. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ & Mathison JC 1990 CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 1431-1433.
74. Zacharowski K, Zacharowski PA, Koch A, Baban A, Tran N, Berkels R, Papewalis C, Schulze-Osthoff K, Knuefermann P, Zahringer U et al. 2006 Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. PNAS 103 6392-6397.
75. Zweigner J, Schumann RR & Weber JR 2006 The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes and Infection 8 946-952.