메뉴 건너뛰기




Volumn 26, Issue 5, 2014, Pages 467-474

Advances in understanding the role of type i interferons in systemic lupus erythematosus

Author keywords

autoimmunity; cytoplasmic sensors; interferon ; long interspersed nuclear elements; systemic lupus erythematosus; Toll like receptors; type I interferons

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON ANTIBODY; AUTOANTIBODY; BETA INTERFERON; CYTOKINE ANTIBODY; CYTOPLASMIC RECEPTOR; DNA; HYDROXYCHLOROQUINE; INTERFERON; INTERFERON REGULATORY FACTOR 5; NUCLEIC ACID; RETINOIC ACID INDUCIBLE PROTEIN I; RNA; RNA BINDING PROTEIN; SIFALIMUMAB; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; ALPHA BETA INTERFERON RECEPTOR;

EID: 84905456707     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000087     Document Type: Review
Times cited : (97)

References (72)
  • 1
    • 84876282977 scopus 로고    scopus 로고
    • Recent insights into the genetic basis of systemic lupus erythematosus
    • Rullo OJ, Tsao BP. Recent insights into the genetic basis of systemic lupus erythematosus. Ann Rheum Dis 2013; 72 (Suppl. 2):ii56-ii61.
    • (2013) Ann Rheum Dis , vol.72 , Issue.SUPPL. 2
    • Rullo, O.J.1    Tsao, B.P.2
  • 2
    • 84896991922 scopus 로고    scopus 로고
    • Genetics of the type i interferon pathway in systemic lupus erythematosus
    • Ghodke-Puranik Y, Niewold TB. Genetics of the type I interferon pathway in systemic lupus erythematosus. Int J Clin Rheumtol 2013; 8:657-669.
    • (2013) Int J Clin Rheumtol , vol.8 , pp. 657-669
    • Ghodke-Puranik, Y.1    Niewold, T.B.2
  • 3
    • 84869044634 scopus 로고    scopus 로고
    • Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus
    • Cherian TS, Kariuki SN, Franek BS, et al. Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus. Arthritis Rheum 2012; 64:3383-3387.
    • (2012) Arthritis Rheum , vol.64 , pp. 3383-3387
    • Cherian, T.S.1    Kariuki, S.N.2    Franek, B.S.3
  • 4
    • 84887607415 scopus 로고    scopus 로고
    • Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: A case-control study
    • Rice GI, Forte GM, Szynkiewicz M, et al. Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. Lancet Neurol 2013; 12:1159-1169.
    • (2013) Lancet Neurol , vol.12 , pp. 1159-1169
    • Rice, G.I.1    Forte, G.M.2    Szynkiewicz, M.3
  • 5
    • 84888858547 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome: A model disease for systemic autoimmunity
    • Lee-Kirsch MA, Wolf C, Gunther C. Aicardi-Goutieres syndrome: a model disease for systemic autoimmunity. Clin Exp Immunol 2014; 175:17-24.
    • (2014) Clin Exp Immunol , vol.175 , pp. 17-24
    • Lee-Kirsch, M.A.1    Wolf, C.2    Gunther, C.3
  • 6
    • 84868207785 scopus 로고    scopus 로고
    • Mutations in ADAR1 cause Aicardi- Goutieres syndrome associated with a type i interferon signature
    • Rice GI, Kasher PR, Forte GM, et al. Mutations in ADAR1 cause Aicardi- Goutieres syndrome associated with a type I interferon signature. Nat Genet 2012; 44:1243-1248.
    • (2012) Nat Genet , vol.44 , pp. 1243-1248
    • Rice, G.I.1    Kasher, P.R.2    Forte, G.M.3
  • 7
    • 84885095772 scopus 로고    scopus 로고
    • The TREX1 C-terminal region controls cellular localization through ubiquitination
    • Orebaugh CD, Fye JM, Harvey S, et al. The TREX1 C-terminal region controls cellular localization through ubiquitination. J Biol Chem 2013; 288:28881-28892.
    • (2013) J Biol Chem , vol.288 , pp. 28881-28892
    • Orebaugh, C.D.1    Fye, J.M.2    Harvey, S.3
  • 8
    • 84878361920 scopus 로고    scopus 로고
    • Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferonregulated genes in naive CD4+ T cells from lupus patients
    • Coit P, Jeffries M, Altorok N, et al. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferonregulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 2013; 43:78-84.
    • (2013) J Autoimmun , vol.43 , pp. 78-84
    • Coit, P.1    Jeffries, M.2    Altorok, N.3
  • 9
    • 84884634092 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations
    • Absher DM, Li X, Waite LL, et al. Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations. PLoS Genet 2013; 9:e1003678.
    • (2013) PLoS Genet , vol.9
    • Absher, D.M.1    Li, X.2    Waite, L.L.3
  • 10
    • 0344665750 scopus 로고    scopus 로고
    • Microarray analysis of interferon-regulated genes in SLE
    • Crow MK, Kirou KA, Wohlgemuth J. Microarray analysis of interferon-regulated genes in SLE. Autoimmunity 2003; 36:481-490.
    • (2003) Autoimmunity , vol.36 , pp. 481-490
    • Crow, M.K.1    Kirou, K.A.2    Wohlgemuth, J.3
  • 11
    • 66449116665 scopus 로고    scopus 로고
    • Development of potential pharmacodynamic and diagnostic markers for anti-IFN-alpha monoclonal antibody trials in systemic lupus erythematosus
    • Yao Y, Higgs BW, Morehouse C, et al. Development of potential pharmacodynamic and diagnostic markers for anti-IFN-alpha monoclonal antibody trials in systemic lupus erythematosus. Hum Genomics Proteomics 2009; 2009:1-16.
    • (2009) Hum Genomics Proteomics , vol.2009 , pp. 1-16
    • Yao, Y.1    Higgs, B.W.2    Morehouse, C.3
  • 12
    • 84881104975 scopus 로고    scopus 로고
    • Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers
    • Bloom CI, Graham CM, Berry MP, et al. Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One 2013; 8:e70630.
    • (2013) PLoS One , vol.8
    • Bloom, C.I.1    Graham, C.M.2    Berry, M.P.3
  • 13
    • 84878565142 scopus 로고    scopus 로고
    • Current perspectives on systems immunology approaches to rheumatic diseases
    • Chiche L, Jourde-Chiche N, Pascual V, Chaussabel D. Current perspectives on systems immunology approaches to rheumatic diseases. Arthritis Rheum 2013; 65:1407-1417.
    • (2013) Arthritis Rheum , vol.65 , pp. 1407-1417
    • Chiche, L.1    Jourde-Chiche, N.2    Pascual, V.3    Chaussabel, D.4
  • 14
    • 84901641596 scopus 로고    scopus 로고
    • Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type i and type II interferon signatures
    • Chiche L, Jourde-Chiche N, Whalen E, et al. Modular transcriptional repertoire analyses of adults with systemic lupus erythematosus reveal distinct type I and type II interferon signatures. Arthritis Rheumatol 2014; 66:1583-1595.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1583-1595
    • Chiche, L.1    Jourde-Chiche, N.2    Whalen, E.3
  • 15
    • 84883146392 scopus 로고    scopus 로고
    • Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1
    • De Weerd NA, Vivian JP, Nguyen TK, et al. Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1. Nat Immunol 2013; 14:901-907.
    • (2013) Nat Immunol , vol.14 , pp. 901-907
    • De Weerd, N.A.1    Vivian, J.P.2    Nguyen, T.K.3
  • 16
    • 84867907920 scopus 로고    scopus 로고
    • Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases
    • Hall JC, Casciola-Rosen L, Berger AE, et al. Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases. Proc Natl Acad Sci USA 2012; 109:17609-17614.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 17609-17614
    • Hall, J.C.1    Casciola-Rosen, L.2    Berger, A.E.3
  • 17
    • 84874229894 scopus 로고    scopus 로고
    • Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
    • Baccala R, Gonzalez-Quintial R, Blasius AL, et al. Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus. Proc Natl Acad Sci USA 2013; 110:2940-2945.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 2940-2945
    • Baccala, R.1    Gonzalez-Quintial, R.2    Blasius, A.L.3
  • 18
    • 84856301080 scopus 로고    scopus 로고
    • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    • Gall A, Treuting P, Elkon KB, et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 2012; 36:120-131.
    • (2012) Immunity , vol.36 , pp. 120-131
    • Gall, A.1    Treuting, P.2    Elkon, K.B.3
  • 19
    • 84887557925 scopus 로고    scopus 로고
    • Role of neutrophils in systemic autoimmune diseases
    • Kaplan MJ. Role of neutrophils in systemic autoimmune diseases. Arthritis Res Ther 2013; 15:219.
    • (2013) Arthritis Res Ther , vol.15 , pp. 219
    • Kaplan, M.J.1
  • 20
    • 79952476762 scopus 로고    scopus 로고
    • Netting neutrophils are major inducers of type i IFN production in pediatric systemic lupus erythematosus
    • Garcia-Romo GS, Caielli S, Vega B, et al. Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. Sci Transl Med 2011; 3:73ra20.
    • (2011) Sci Transl Med , vol.3
    • Garcia-Romo, G.S.1    Caielli, S.2    Vega, B.3
  • 21
    • 79952468782 scopus 로고    scopus 로고
    • Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus
    • Lande R, Ganguly D, Facchinetti V, et al. Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus. Sci Transl Med 2011; 3:73ra19.
    • (2011) Sci Transl Med , vol.3
    • Lande, R.1    Ganguly, D.2    Facchinetti, V.3
  • 22
    • 84879599357 scopus 로고    scopus 로고
    • Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation
    • Ries M, Schuster P, Thomann S, et al. Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation. J Leukoc Biol 2013; 94:123-135.
    • (2013) J Leukoc Biol , vol.94 , pp. 123-135
    • Ries, M.1    Schuster, P.2    Thomann, S.3
  • 23
    • 77951935256 scopus 로고    scopus 로고
    • A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type i IFNs
    • Denny MF, Yalavarthi S, Zhao W, et al. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs. J Immunol 2010; 184:3284-3297.
    • (2010) J Immunol , vol.184 , pp. 3284-3297
    • Denny, M.F.1    Yalavarthi, S.2    Zhao, W.3
  • 24
    • 84893397971 scopus 로고    scopus 로고
    • Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus
    • Palanichamy A, Bauer JW, Yalavarthi S, et al. Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus. J Immunol 2014; 192:906-918.
    • (2014) J Immunol , vol.192 , pp. 906-918
    • Palanichamy, A.1    Bauer, J.W.2    Yalavarthi, S.3
  • 25
    • 84868020491 scopus 로고    scopus 로고
    • NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus
    • Campbell AM, Kashgarian M, Shlomchik MJ. NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus. Sci Transl Med 2012; 4:157ra141.
    • (2012) Sci Transl Med , vol.4
    • Campbell, A.M.1    Kashgarian, M.2    Shlomchik, M.J.3
  • 26
    • 84885395758 scopus 로고    scopus 로고
    • Nucleic acid sensors and type i interferon production in systemic lupus erythematosus
    • Shrivastav M, Niewold TB. Nucleic acid sensors and type I interferon production in systemic lupus erythematosus. Front Immunol 2013; 4:319.
    • (2013) Front Immunol , vol.4 , pp. 319
    • Shrivastav, M.1    Niewold, T.B.2
  • 27
    • 84899685774 scopus 로고    scopus 로고
    • Safeguard against DNA sensing: The role of TREX1 in HIV-1 infection and autoimmune diseases
    • Hasan M, Yan N. Safeguard against DNA sensing: the role of TREX1 in HIV-1 infection and autoimmune diseases. Front Microbiol 2014; 5:193.
    • (2014) Front Microbiol , vol.5 , pp. 193
    • Hasan, M.1    Yan, N.2
  • 28
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu J, Chen ZJ. Innate immune sensing and signaling of cytosolic nucleic acids. Annu Rev Immunol 2014; 32:461-488.
    • (2014) Annu Rev Immunol , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 30
    • 84889092194 scopus 로고    scopus 로고
    • Spontaneous activation of RNA-sensing pathways in autoimmune disease
    • Crampton SP, Bolland S. Spontaneous activation of RNA-sensing pathways in autoimmune disease. Curr Opin Immunol 2013; 25:712-719.
    • (2013) Curr Opin Immunol , vol.25 , pp. 712-719
    • Crampton, S.P.1    Bolland, S.2
  • 31
    • 84887280855 scopus 로고    scopus 로고
    • DDX24 negatively regulates cytosolic RNAmediated innate immune signaling
    • Ma Z, Moore R, Xu X, Barber GN. DDX24 negatively regulates cytosolic RNAmediated innate immune signaling. PLoS Pathog 2013; 9:e1003721.
    • (2013) PLoS Pathog , vol.9
    • Ma, Z.1    Moore, R.2    Xu, X.3    Barber, G.N.4
  • 32
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
    • Sun L, Wu J, Du F, et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013; 339:786-791.
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3
  • 33
    • 84873724533 scopus 로고    scopus 로고
    • Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    • Wu J, Sun L, Chen X, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 2013; 339:826-830.
    • (2013) Science , vol.339 , pp. 826-830
    • Wu, J.1    Sun, L.2    Chen, X.3
  • 34
    • 84878572947 scopus 로고    scopus 로고
    • The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
    • Diner EJ, Burdette DL, Wilson SC, et al. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. Cell Rep 2013; 3:1355-1361.
    • (2013) Cell Rep , vol.3 , pp. 1355-1361
    • Diner, E.J.1    Burdette, D.L.2    Wilson, S.C.3
  • 35
    • 84879385334 scopus 로고    scopus 로고
    • CGAS produces a 20-50-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser A, Goldeck M, Cavlar T, et al. cGAS produces a 20-50-linked cyclic dinucleotide second messenger that activates STING. Nature 2013; 498:380-384.
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1    Goldeck, M.2    Cavlar, T.3
  • 36
    • 84879408976 scopus 로고    scopus 로고
    • Structural mechanism of cytosolic DNA sensing by cGAS
    • Civril F, Deimling T, de Oliveira Mann CC, et al. Structural mechanism of cytosolic DNA sensing by cGAS. Nature 2013; 498:332-337.
    • (2013) Nature , vol.498 , pp. 332-337
    • Civril, F.1    Deimling, T.2    De Oliveira Mann, C.C.3
  • 37
    • 84893637182 scopus 로고    scopus 로고
    • STING-dependent cytosolic DNA sensing pathways
    • Barber GN. STING-dependent cytosolic DNA sensing pathways. Trends Immunol 2013; 35:88-93.
    • (2013) Trends Immunol , vol.35 , pp. 88-93
    • Barber, G.N.1
  • 38
    • 84875065899 scopus 로고    scopus 로고
    • IRF-3, IRF-5, and IRF-7 coordinately regulate the type i IFN response in myeloid dendritic cells downstream of MAVS signaling
    • Lazear HM, Lancaster A, Wilkins C, et al. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling. PLoS Pathog 2013; 9:e1003118.
    • (2013) PLoS Pathog , vol.9
    • Lazear, H.M.1    Lancaster, A.2    Wilkins, C.3
  • 39
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson DB, Ko JS, Heidmann T, Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008; 134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 40
    • 84869862031 scopus 로고    scopus 로고
    • Endogenous retroelements and autoimmune disease
    • Stetson DB. Endogenous retroelements and autoimmune disease. Curr Opin Immunol 2012; 24:692-697.
    • (2012) Curr Opin Immunol , vol.24 , pp. 692-697
    • Stetson, D.B.1
  • 41
    • 84899112356 scopus 로고    scopus 로고
    • The enemy within: Endogenous retroelements and autoimmune disease
    • Volkman HE, Stetson DB. The enemy within: endogenous retroelements and autoimmune disease. Nat Immunol 2014; 15:415-422.
    • (2014) Nat Immunol , vol.15 , pp. 415-422
    • Volkman, H.E.1    Stetson, D.B.2
  • 42
    • 75749101744 scopus 로고    scopus 로고
    • Long interspersed nuclear elements (LINE-1): Potential triggers of systemic autoimmune disease
    • Crow MK. Long interspersed nuclear elements (LINE-1): potential triggers of systemic autoimmune disease. Autoimmunity 2010; 43:7-16.
    • (2010) Autoimmunity , vol.43 , pp. 7-16
    • Crow, M.K.1
  • 43
    • 84883277795 scopus 로고    scopus 로고
    • Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    • Behrendt R, Schumann T, Gerbaulet A, et al. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep 2013; 4:689-696.
    • (2013) Cell Rep , vol.4 , pp. 689-696
    • Behrendt, R.1    Schumann, T.2    Gerbaulet, A.3
  • 44
    • 84884590112 scopus 로고    scopus 로고
    • Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1
    • Zhao K, Du J, Han X, et al. Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutieres syndrome-related SAMHD1. Cell Rep 2013; 4:1108-1115.
    • (2013) Cell Rep , vol.4 , pp. 1108-1115
    • Zhao, K.1    Du, J.2    Han, X.3
  • 45
    • 85027909901 scopus 로고    scopus 로고
    • SAMHD1 prevents autoimmunity by maintaining genome stability
    • [Epub ahead of print]
    • Kretschmer S, Wolf C, Konig N, et al. SAMHD1 prevents autoimmunity by maintaining genome stability. Ann Rheum Dis 2014. [Epub ahead of print]
    • (2014) Ann Rheum Dis
    • Kretschmer, S.1    Wolf, C.2    Konig, N.3
  • 46
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STINGdependent immune sensing
    • Gehrke N, Mertens C, Zillinger T, et al. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STINGdependent immune sensing. Immunity 2013; 39:482-495.
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1    Mertens, C.2    Zillinger, T.3
  • 47
  • 48
    • 18644384042 scopus 로고    scopus 로고
    • Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease
    • Kirou KA, Lee C, George S, et al. Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease. Arthritis Rheum 2005; 52:1491-1503.
    • (2005) Arthritis Rheum , vol.52 , pp. 1491-1503
    • Kirou, K.A.1    Lee, C.2    George, S.3
  • 49
    • 84870861513 scopus 로고    scopus 로고
    • Noncanonical autophagy is required for type i interferon secretion in response to DNA-immune complexes
    • Henault J, Martinez J, Riggs JM, et al. Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity 2012; 37:986-997.
    • (2012) Immunity , vol.37 , pp. 986-997
    • Henault, J.1    Martinez, J.2    Riggs, J.M.3
  • 50
    • 84890840281 scopus 로고    scopus 로고
    • RNA recognition by human TLR8 can lead to autoimmune inflammation
    • Guiducci C, Gong M, Cepika AM, et al. RNA recognition by human TLR8 can lead to autoimmune inflammation. J Exp Med 2013; 210:2903-2919.
    • (2013) J Exp Med , vol.210 , pp. 2903-2919
    • Guiducci, C.1    Gong, M.2    Cepika, A.M.3
  • 51
    • 84896709089 scopus 로고    scopus 로고
    • Cell-specific type i IFN signatures in autoimmunity and viral infection: What makes the difference?
    • Kyogoku C, Smiljanovic B, Grun JR, et al. Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference? PLoS One 2013; 8:e83776.
    • (2013) PLoS One , vol.8
    • Kyogoku, C.1    Smiljanovic, B.2    Grun, J.R.3
  • 52
    • 84876299371 scopus 로고    scopus 로고
    • Blockade of chronic type i interferon signaling to control persistent LCMV infection
    • Wilson EB, Yamada DH, Elsaesser H, et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 2013; 340:202-207.
    • (2013) Science , vol.340 , pp. 202-207
    • Wilson, E.B.1    Yamada, D.H.2    Elsaesser, H.3
  • 53
    • 84876311772 scopus 로고    scopus 로고
    • Persistent LCMV infection is controlled by blockade of type i interferon signaling
    • Teijaro JR, Ng C, Lee AM, et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 2013; 340:207-211.
    • (2013) Science , vol.340 , pp. 207-211
    • Teijaro, J.R.1    Ng, C.2    Lee, A.M.3
  • 54
    • 84874280676 scopus 로고    scopus 로고
    • Interferon-alpha is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers
    • Hardy GA, Sieg S, Rodriguez B, et al. Interferon-alpha is the primary plasma type-I IFN in HIV-1 infection and correlates with immune activation and disease markers. PLoS One 2013; 8:e56527.
    • (2013) PLoS One , vol.8
    • Hardy, G.A.1    Sieg, S.2    Rodriguez, B.3
  • 55
    • 84885153163 scopus 로고    scopus 로고
    • Interferon-alpha abrogates the suppressive effect of apoptotic cells on dendritic cells in an in vitro model of systemic lupus erythematosus pathogenesis
    • Abeler-Dorner L, Rieger CC, Berger B, et al. Interferon-alpha abrogates the suppressive effect of apoptotic cells on dendritic cells in an in vitro model of systemic lupus erythematosus pathogenesis. J Rheumatol 2013; 40:1683-1696.
    • (2013) J Rheumatol , vol.40 , pp. 1683-1696
    • Abeler-Dorner, L.1    Rieger, C.C.2    Berger, B.3
  • 57
    • 84880618088 scopus 로고    scopus 로고
    • The antiviral cytokines IFN-alpha and IFN-beta modulate parietal epithelial cells and promote podocyte loss: Implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration
    • Migliorini A, Angelotti ML, Mulay SR, et al. The antiviral cytokines IFN-alpha and IFN-beta modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration. Am J Pathol 2013; 183:431-440.
    • (2013) Am J Pathol , vol.183 , pp. 431-440
    • Migliorini, A.1    Angelotti, M.L.2    Mulay, S.R.3
  • 58
    • 84881543805 scopus 로고    scopus 로고
    • Cardiovascular disease in lupus: Insights and updates
    • Knight JS, Kaplan MJ. Cardiovascular disease in lupus: insights and updates. Curr Opin Rheumatol 2013; 25:597-605.
    • (2013) Curr Opin Rheumatol , vol.25 , pp. 597-605
    • Knight, J.S.1    Kaplan, M.J.2
  • 59
    • 77956454663 scopus 로고    scopus 로고
    • Platelet CD154 potentiates interferonalpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus
    • Duffau P, Seneschal J, Nicco C, et al. Platelet CD154 potentiates interferonalpha secretion by plasmacytoid dendritic cells in systemic lupus erythematosus. Sci Transl Med 2010; 2:47ra63.
    • (2010) Sci Transl Med , vol.2
    • Duffau, P.1    Seneschal, J.2    Nicco, C.3
  • 60
    • 84860991009 scopus 로고    scopus 로고
    • Type i interferons are associated with subclinical markers of cardiovascular disease in a cohort of systemic lupus erythematosus patients
    • Somers EC, Zhao W, Lewis EE, et al. Type I interferons are associated with subclinical markers of cardiovascular disease in a cohort of systemic lupus erythematosus patients. PLoS One 2012; 7:e37000.
    • (2012) PLoS One , vol.7
    • Somers, E.C.1    Zhao, W.2    Lewis, E.E.3
  • 61
    • 84891153241 scopus 로고    scopus 로고
    • Future prospects in biologic therapy for systemic lupus erythematosus
    • Stohl W. Future prospects in biologic therapy for systemic lupus erythematosus. Nat Rev Rheumatol 2013; 9:705-720.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 705-720
    • Stohl, W.1
  • 62
    • 80053562466 scopus 로고    scopus 로고
    • Safety profile and clinical activity of sifalimumab, a fully human antiinterferon alpha monoclonal antibody, in systemic lupus erythematosus: A phase I, multicentre, double-blind randomised study
    • Merrill JT, Wallace DJ, Petri M, et al. Safety profile and clinical activity of sifalimumab, a fully human antiinterferon alpha monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis 2011; 70:1905-1913.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1905-1913
    • Merrill, J.T.1    Wallace, D.J.2    Petri, M.3
  • 63
    • 84868144947 scopus 로고    scopus 로고
    • Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: Results of a phase I, placebo-controlled, double-blind, dose-escalation study
    • McBride JM, Jiang J, Abbas AR, et al. Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study. Arthritis Rheum 2012; 64:3666-3676.
    • (2012) Arthritis Rheum , vol.64 , pp. 3666-3676
    • McBride, J.M.1    Jiang, J.2    Abbas, A.R.3
  • 64
    • 66449097622 scopus 로고    scopus 로고
    • Neutralization of interferon-alpha/betainducible genes and downstream effect in a phase i trial of an antiinterferonalpha monoclonal antibody in systemic lupus erythematosus
    • Yao Y, Richman L, Higgs BW, et al. Neutralization of interferon-alpha/ betainducible genes and downstream effect in a phase I trial of an antiinterferonalpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum 2009; 60:1785-1796.
    • (2009) Arthritis Rheum , vol.60 , pp. 1785-1796
    • Yao, Y.1    Richman, L.2    Higgs, B.W.3
  • 65
    • 84878228166 scopus 로고    scopus 로고
    • Pharmacogenomics and translational simulations to bridge indications for an antiinterferon-alpha receptor antibody
    • Wang B, Higgs BW, Chang L, et al. Pharmacogenomics and translational simulations to bridge indications for an antiinterferon-alpha receptor antibody. Clin Pharmacol Ther 2013; 93:483-492.
    • (2013) Clin Pharmacol Ther , vol.93 , pp. 483-492
    • Wang, B.1    Higgs, B.W.2    Chang, L.3
  • 66
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • Barrat FJ, Coffman RL. Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol Rev 2008; 223:271-283.
    • (2008) Immunol Rev , vol.223 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 67
    • 84876067752 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
    • Kandimalla ER, Bhagat L, Wang D, et al. Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9. Nucleic Acids Res 2013; 41:3947-3961.
    • (2013) Nucleic Acids Res , vol.41 , pp. 3947-3961
    • Kandimalla, E.R.1    Bhagat, L.2    Wang, D.3
  • 68
    • 84873870755 scopus 로고    scopus 로고
    • Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon alpha-kinoid
    • Lauwerys BR, Hachulla E, Spertini F, et al. Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon alpha-kinoid. Arthritis Rheum 2013; 65:447-456.
    • (2013) Arthritis Rheum , vol.65 , pp. 447-456
    • Lauwerys, B.R.1    Hachulla, E.2    Spertini, F.3
  • 69
    • 84874853444 scopus 로고    scopus 로고
    • Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice
    • Sun X, Wiedeman A, Agrawal N, et al. Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice. J Immunol 2013; 190:2536-2543.
    • (2013) J Immunol , vol.190 , pp. 2536-2543
    • Sun, X.1    Wiedeman, A.2    Agrawal, N.3
  • 70
    • 84862752020 scopus 로고    scopus 로고
    • Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus
    • Sacre K, Criswell LA, McCune JM. Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus. Arthritis Res Ther 2012; 14:R155.
    • (2012) Arthritis Res Ther , vol.14
    • Sacre, K.1    Criswell, L.A.2    McCune, J.M.3
  • 71
    • 84881097754 scopus 로고    scopus 로고
    • Antiinterferon alpha treatment in SLE
    • Kirou KA, Gkrouzman E. Antiinterferon alpha treatment in SLE. Clin Immunol 2013; 148:303-312.
    • (2013) Clin Immunol , vol.148 , pp. 303-312
    • Kirou, K.A.1    Gkrouzman, E.2
  • 72
    • 84903188015 scopus 로고    scopus 로고
    • A type i interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes
    • [Epub ahead of print]
    • Ferreira RC, Guo H, Coulson RM, et al. A type I interferon transcriptional signature precedes autoimmunity in children genetically at-risk of type 1 diabetes. Diabetes 2014. [Epub ahead of print]
    • (2014) Diabetes
    • Ferreira, R.C.1    Guo, H.2    Coulson, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.