Cell-specific type I IFN signatures in autoimmunity and viral infection: What makes the difference?

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Kyogoku, Chieko ^a,c   Smiljanovic, Biljana ^a   Grün, Joachim R ^a   Biesen, Robert ^a,b   Schulte Wrede, Ursula ^a   Häupl, Thomas ^b   Hiepe, Falk ^a,b   Alexander, Tobias ^a,b   Radbruch, Andreas ^a   Grützkau, Andreas ^a  

^a POTSDAM INSTITUTE FOR CLIMATE IMPACT RESEARCH PIK   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF TSUKUBA HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD4 ANTIGEN; DEATH RECEPTOR; FC RECEPTOR; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 9; JANUS KINASE; ND YF DAY7 VACCINE; PROTEIN KINASE R; STAT PROTEIN; UNCLASSIFIED DRUG; YELLOW FEVER VACCINE;

ADULT; ARTICLE; AUTOIMMUNITY; BIOSENSOR; CD16+ MONOCYTE; CD4+ T LYMPHOCYTE; CELL COMPOSITION; CELL DEATH; CELL GROWTH; CELL ISOLATION; CELL MOTION; CELL PROLIFERATION; CELL SPECIFICITY; CLINICAL ARTICLE; CONTROLLED STUDY; EXPOSURE; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; HUMAN CELL; INFECTION PREVENTION; INFLAMMATION; INTERFERON INDUCTION; MACROPHAGE; MOLECULAR RECOGNITION; MONOCYTE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHAGOCYTOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSCRIPTION REGULATION; UPREGULATION; VACCINATION; VIRUS INFECTION; YELLOW FEVER; YELLOW FEVER FLAVIVIRUS;

ADULT; AUTOIMMUNITY; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; GENE EXPRESSION PROFILING; HEALTHY VOLUNTEERS; HUMANS; INTERFERON TYPE I; LEUKOCYTES, MONONUCLEAR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; YELLOW FEVER; YELLOW FEVER VACCINE; YELLOW FEVER VIRUS;

EID: 84896709089     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0083776     Document Type: Article

References (46)

1. Kyogoku C, Tsuchiya N (2007) A compass that points to lupus: genetic studies on type I interferon pathway. Genes Immun 8: 445-455. (Pubitemid 47365611)
2. Hooks JJ, Moutsopoulos HM, Geis SA, Stahl NI, Decker JL, et al. (1979) Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med 301: 5-8. (Pubitemid 9226519)
3. Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, et al. (2003) Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A 100: 2610-2615. (Pubitemid 36297546)
4. Rose T, Grutzkau A, Hirseland H, Huscher D, Dahnrich C, et al. (2013) IFNalpha and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus. Ann Rheum Dis: 72:1639-1645.
5. Kong KO, Tan AW, Thong BY, Lian TY, Cheng YK, et al. (2009) Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus. Clin Exp Immunol 156: 134-140.
6. Bauer JW, Petri M, Batliwalla FM, Koeuth T, Wilson J, et al. (2009) Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study. Arthritis Rheum 60: 3098-3107.
7. van Baarsen LG, Bos CL, van der Pouw Kraan TC, Verweij CL (2009) Transcription profiling of rheumatic diseases. Arthritis Res Ther 11: 207.
8. Deng YJ, Huang ZX, Zhou CJ, Wang JW, You Y, et al. (2006) Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus. Mol Immunol 43: 1497-1507. (Pubitemid 43356391)
9. Luo N, Wu Y, Chen Y, Yang Z, Guo S, et al. (2009) Upregulated BclG(L) expression enhances apoptosis of peripheral blood CD4+ T lymphocytes in patients with systemic lupus erythematosus. Clin Immunol 132: 349-361.
10. Lyons PA, McKinney EF, Rayner TF, Hatton A, Woffendin HB, et al. (2010) Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis. Ann Rheum Dis 69: 1208-1213.
11. Smiljanovic B, Grun JR, Biesen R, Schulte-Wrede U, Baumgrass R, et al. (2012) The multifaceted balance of TNF-alpha and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. J Mol Med (Berl) 90: 1295-1309.
12. Trinchieri G (2010) Type I interferon: friend or foe? J Exp Med 207: 2053-2063.
13. Gaucher D, Therrien R, Kettaf N, Angermann BR, Boucher G, et al. (2008) Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med 205: 3119-3131.
14. Maas K, Chan S, Parker J, Slater A, Moore J, et al. (2002) Cutting edge: molecular portrait of human autoimmune disease. J Immunol 169: 5-9. (Pubitemid 34686112)
15. Aune TM, Maas K, Parker J, Moore JH, Olsen NJ (2004) Profiles of gene expression in human autoimmune disease. Cell Biochem Biophys 40: 81-96. (Pubitemid 41270781)
16. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, et al. (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466: 973-977.
17. Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, et al. (2011) Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum 63: 2049-2057.
18. Menssen A, Edinger G, Grun JR, Haase U, Baumgrass R, et al. (2009) SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data. BMC Genomics 10: 98.
19. Biesen R, Demir C, Barkhudarova F, Grun JR, Steinbrich-Zollner M, et al. (2008) Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. Arthritis Rheum 58: 1136-1145. (Pubitemid 351564017)
20. Wong LH, Hatzinisiriou I, Devenish RJ, Ralph SJ (1998) IFN-gamma priming up-regulates IFN-stimulated gene factor 3 (ISGF3) components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs. J Immunol 160: 5475-5484. (Pubitemid 28267839)
21. de Saint-Vis B, Vincent J, Vandenabeele S, Vanbervliet B, Pin JJ, et al. (1998) A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 9: 325-336. (Pubitemid 28462753)
22. Geissmann F, Jung S, Littman DR (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19: 71-82. (Pubitemid 36859902)
23. Caligaris-Cappio F (2011) Inflammation, the microenvironment and chronic lymphocytic leukemia. Haematologica 96: 353-355.
24. Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, et al. (2012) CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120: 613-625.
25. Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, et al. (2011) CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475: 222-225.
26. Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140: 805-820.
27. Glocker EO, Kotlarz D, Klein C, Shah N, Grimbacher B (2011) IL-10 and IL-10 receptor defects in humans. Ann N Y Acad Sci 1246: 102-107.
28. Ramgolam VS, Markovic-Plese S (2011) Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis. J Signal Transduct 2011: 635721.
29. Tsao JT, Kuo CC, Lin SC (2008) The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Clin Exp Med 8: 179-185.
30. Tamiya T, Kashiwagi I, Takahashi R, Yasukawa H, Yoshimura A (2011) Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: regulation of T-cell inflammation by SOCS1 and SOCS3. Arterioscler Thromb Vasc Biol 31: 980-985.
31. Moriwaki A, Inoue H, Nakano T, Matsunaga Y, Matsuno Y, et al. (2011) T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma. Am J Respir Cell Mol Biol 44: 448-455.
32. Scherberich JE (2003) Proinflammatory blood monocytes: main effector and target cells in systemic and renal disease; background and therapeutic implications. Int J Clin Pharmacol Ther 41: 459-464.
33. Ziegler-Heitbrock L (2007) The CD14+ CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 81: 584-592.
34. Ancuta P, Liu KY, Misra V, Wacleche VS, Gosselin A, et al. (2009) Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets. BMC Genomics 10: 403.
35. Frankenberger M, Hofer TP, Marei A, Dayyani F, Schewe S, et al. (2012) Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprint. Eur J Immunol 42: 957-974.
36. Ivashkiv LB (2003) Type I interferon modulation of cellular responses to cytokines and infectious pathogens: potential role in SLE pathogenesis. Autoimmunity 36: 473-479.
37. Di Sabatino A, Calarota SA, Vidali F, Macdonald TT, Corazza GR (2011) Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev 22: 19-33.
38. Baranda L, de la Fuente H, Layseca-Espinosa E, Portales-Perez D, Nino-Moreno P, et al. (2005) IL-15 and IL-15R in leucocytes from patients with systemic lupus erythematosus. Rheumatology (Oxford) 44: 1507-1513. (Pubitemid 41742466)
39. Meazza R, Azzarone B, Orengo AM, Ferrini S (2011) Role of common-gamma chain cytokines in NK cell development and function: perspectives for immunotherapy. J Biomed Biotechnol 2011: 861920.
40. Barrett AD, Teuwen DE (2009) Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? Curr Opin Immunol 21: 308-313.
41. Steinbrich-Zollner M, Grun JR, Kaiser T, Biesen R, Raba K, et al. (2008) From transcriptome to cytome: integrating cytometric profiling, multivariate cluster, and prediction analyses for a phenotypical classification of inflammatory diseases. Cytometry A 73: 333-340. (Pubitemid 351522116)
42. Haupl T, Stuhlmuller B, Grutzkau A, Radbruch A, Burmester GR (2010) Does gene expression analysis inform us in rheumatoid arthritis? Ann Rheum Dis 69 Suppl 1: i37-42.
43. Smiljanovic B, Grun JR, Steinbrich-Zollner M, Stuhlmuller B, Haupl T, et al. (2010) Defining TNF-alpha- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease. J Mol Med (Berl) 88: 1065-1079.
44. Becker AM, Dao KH, Kwanghoon Han B, Kornu R, Lakhanpal S, et al. (2013) SLE Peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One 8:e67003.
45. Allantaz F, Chaussabel D, Stichweh D, Bennett L, et al. (2007) Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med 3;204(9):2131-44.
46. Querec TD, Akondy RS, Lee EK, Cao W, et al. (2009) Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat Immunol 10(1):116-25.