Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-onesas potential anticancer agents starting from cytotoxic spiromamakone A

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 180-184

  Fuse, Shinichiro ^a   Inaba, Kennichi ^b   Takagi, Motoki ^b   Tanaka, Masahiro ^b   Hirokawa, Takatsugu ^c   Johmoto, Kohei ^a   Uekusa, Hidehiro ^a   Shin ya, Kazuo ^c   Takahashi, Takashi ^a   Doi, Takayuki ^d  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b Japan Biological Informatics Consortium   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Anticancer agent; Spiroacetal; Spirocycle; Spiromamakone A; Spiropreussione B

Indexed keywords

2 (3 BROMOPHENYL) 7 CHLORO 1,4 DIOXA SPIRO[4.5]DECA 6,9 DIEN 8 ONE; 2 (4 BROMOPHENYL) 1,4 DIOXA SPIRO[4.5]DECA 6,9 DIEN 8 ONE; 2 (4 BROMOPHENYL) 7 CHLORO 1,4 DIOXA SPIRO[4.5]DECA 6,9 DIEN 8 ONE; 2 (4 CHLOROPHENYL) 7 CHLORO 1,4 DIOXA SPIRO[4.5]DECA 6,9 DIEN 8 ONE; 2 (4 IODOPHENYL) 7 CHLORO 1,4 DIOXA SPIRO[4.5]DECA 6,9 DIEN 8 ONE; 2 PHENYL 1,4 DIOXA SPIRO[4.5]DECA 6,9 DIEN 8 ONE; ANTINEOPLASTIC AGENT; NATURAL PRODUCT; SPIRO COMPOUND; SPIROMAMAKONE A; UNCLASSIFIED DRUG; BENZENE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DIASTEREOISOMER; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MURINE LEUKEMIA; NONHUMAN; OVARY CARCINOMA; STEREOCHEMISTRY; UTERINE CERVIX CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; FEMALE; HELA CELL LINE;

EID: 84879211315     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.030     Document Type: Article

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