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Volumn 78, Issue 3, 2010, Pages 366-375

Molecular determinants for competitive inhibition of α4β2 nicotinic acetylcholine receptors

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; DIHYDRO BETA ERYTHROIDINE; ERYTHRINA ALKALOID; NICOTINIC RECEPTOR ALPHA4BETA2; ALKALOID; AZOCINE DERIVATIVE; BETA-ERYTHROIDINE; CYTISINE; ERYSODINE; NICOTINIC RECEPTOR; QUINOLIZINE DERIVATIVE;

EID: 77956246788     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.110.065490     Document Type: Article
Times cited : (42)

References (36)
  • 1
    • 34548679635 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors: A perspective on two decades of drug discovery research
    • Arneric SP, Holladay M, and Williams M (2007) Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. Biochem Pharmacol 74: 1092-1101.
    • (2007) Biochem Pharmacol , vol.74 , pp. 1092-1101
    • Arneric, S.P.1    Holladay, M.2    Williams, M.3
  • 2
    • 67649789023 scopus 로고    scopus 로고
    • Aromatic residues εTrp-55 and δTrp-57 and the activation of acetylcholine receptor channels
    • Bafna PA, Jha A, and Auerbach A (2009) Aromatic residues εTrp-55 and δTrp-57 and the activation of acetylcholine receptor channels. J Biol Chem 284:8582-8588.
    • (2009) J Biol Chem , vol.284 , pp. 8582-8588
    • Bafna, P.A.1    Jha, A.2    Auerbach, A.3
  • 3
    • 0037072311 scopus 로고    scopus 로고
    • Cation-π interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic aceylcholine receptors: The anomalous binding properties of nicotine
    • Beene DL, Brandt GS, Zhong W, Zacharias NM, Lester HA, and Dougherty DA (2002) Cation-π interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic aceylcholine receptors: the anomalous binding properties of nicotine. Biochemistry 41:10262-10269.
    • (2002) Biochemistry , vol.41 , pp. 10262-10269
    • Beene, D.L.1    Brandt, G.S.2    Zhong, W.3    Zacharias, N.M.4    Lester, H.A.5    Dougherty, D.A.6
  • 7
    • 0030941561 scopus 로고    scopus 로고
    • Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes
    • Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ, and Johnson EC (1997) Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 280:346-356.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 346-356
    • Chavez-Noriega, L.E.1    Crona, J.H.2    Washburn, M.S.3    Urrutia, A.4    Elliott, K.J.5    Johnson, E.C.6
  • 8
    • 0015861774 scopus 로고
    • Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
    • Cheng Y and Prusoff WH (1973) Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
    • (1973) Biochem Pharmacol , vol.22 , pp. 3099-3108
    • Cheng, Y.1    Prusoff, W.H.2
  • 10
    • 10744221698 scopus 로고    scopus 로고
    • Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells
    • Eaton JB, Peng JH, Schroeder KM, George AA, Fryer JD, Krishnan C, Buhlman L, Kuo YP, Steinlein O, and Lukas RJ (2003) Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Mol Pharmacol 64:1283-1294.
    • (2003) Mol Pharmacol , vol.64 , pp. 1283-1294
    • Eaton, J.B.1    Peng, J.H.2    Schroeder, K.M.3    George, A.A.4    Fryer, J.D.5    Krishnan, C.6    Buhlman, L.7    Kuo, Y.P.8    Steinlein, O.9    Lukas, R.J.10
  • 11
    • 0025985732 scopus 로고
    • Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site-directed mutagenesis
    • Galzi JL, Bertrand D, Devillers-Thiéry A, Revah F, Bertrand S, and Changeux JP (1991) Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS Lett 294:198-202.
    • (1991) FEBS Lett , vol.294 , pp. 198-202
    • Galzi, J.L.1    Bertrand, D.2    Devillers-Thiéry, A.3    Revah, F.4    Bertrand, S.5    Changeux, J.P.6
  • 12
    • 0037544107 scopus 로고    scopus 로고
    • An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism in nicotinic receptors
    • Grutter T, Prado de Carvalho L, Le Novère N, Corringer PJ, Edelstein S, and Changeux JP (2003) An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism in nicotinic receptors. EMBO J 22:1990-2003.
    • (2003) EMBO J , vol.22 , pp. 1990-2003
    • Grutter, T.1    Prado De Carvalho, L.2    Le Novère, N.3    Corringer, P.J.4    Edelstein, S.5    Changeux, J.P.6
  • 13
    • 27144473613 scopus 로고    scopus 로고
    • Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
    • Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, and Bourne Y (2005) Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J 24:3635-3646.
    • (2005) EMBO J , vol.24 , pp. 3635-3646
    • Hansen, S.B.1    Sulzenbacher, G.2    Huxford, T.3    Marchot, P.4    Taylor, P.5    Bourne, Y.6
  • 14
    • 0029889642 scopus 로고    scopus 로고
    • Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits
    • Harvey SC and Luetje CW (1996) Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits. J Neurosci 16:3798-3806.
    • (1996) J Neurosci , vol.16 , pp. 3798-3806
    • Harvey, S.C.1    Luetje, C.W.2
  • 15
    • 34247108065 scopus 로고    scopus 로고
    • Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors
    • Horenstein NA, McCormack TJ, Stokes C, Ren K, and Papke RL (2007) Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors. J Biol Chem 282:5899-5909.
    • (2007) J Biol Chem , vol.282 , pp. 5899-5909
    • Horenstein, N.A.1    McCormack, T.J.2    Stokes, C.3    Ren, K.4    Papke, R.L.5
  • 16
    • 0034839206 scopus 로고    scopus 로고
    • Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors
    • Houlihan LM, Slater Y, Guerra DL, Peng JH, Kuo YP, Lukas RJ, Cassels BK, and Bermudez I (2001) Activity of cytisine and its brominated isosteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors. J Neurochem 78: 1029-1043.
    • (2001) J Neurochem , vol.78 , pp. 1029-1043
    • Houlihan, L.M.1    Slater, Y.2    Guerra, D.L.3    Peng, J.H.4    Kuo, Y.P.5    Lukas, R.J.6    Cassels, B.K.7    Bermudez, I.8
  • 17
    • 45749094140 scopus 로고    scopus 로고
    • Roles of accessory subunits in α4β2* nicotinic receptors
    • Kuryatov A, Onksen J, and Lindstrom J (2008) Roles of accessory subunits in α4β2* nicotinic receptors. Mol Pharmacol 74:132-143.
    • (2008) Mol Pharmacol , vol.74 , pp. 132-143
    • Kuryatov, A.1    Onksen, J.2    Lindstrom, J.3
  • 19
  • 22
    • 33746238089 scopus 로고    scopus 로고
    • α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
    • Moroni M, Zwart R, Sher E, Cassels BK, and Bermudez I (2006) α4β2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol Pharmacol 70:755-768.
    • (2006) Mol Pharmacol , vol.70 , pp. 755-768
    • Moroni, M.1    Zwart, R.2    Sher, E.3    Cassels, B.K.4    Bermudez, I.5
  • 24
    • 22244478670 scopus 로고    scopus 로고
    • Initial coupling of binding to gating mediated by conserved residues in muscle nicotinic receptor
    • Mukhtasimova N, Free C, and Sine SM (2005) Initial coupling of binding to gating mediated by conserved residues in muscle nicotinic receptor. J Gen Physiol 126: 23-39.
    • (2005) J Gen Physiol , vol.126 , pp. 23-39
    • Mukhtasimova, N.1    Free, C.2    Sine, S.M.3
  • 25
    • 67349279395 scopus 로고    scopus 로고
    • Detection and trapping of intermediate states priming nicotinic receptor channel opening
    • Mukhtasimova N, Lee WY, Wang HL, and Sine SM (2009) Detection and trapping of intermediate states priming nicotinic receptor channel opening. Nature 459:451-454.
    • (2009) Nature , vol.459 , pp. 451-454
    • Mukhtasimova, N.1    Lee, W.Y.2    Wang, H.L.3    Sine, S.M.4
  • 26
    • 44149122567 scopus 로고    scopus 로고
    • Extending the analysis of nicotinic receptor antagonists with the study of α6 nicotinic receptor subunit chimeras
    • Papke RL, Dwoskin LP, Crooks PA, Zheng G, Zhang Z, McIntosh JM, and Stokes C (2008) Extending the analysis of nicotinic receptor antagonists with the study of α6 nicotinic receptor subunit chimeras. Neuropharmacology 54:1189-1200.
    • (2008) Neuropharmacology , vol.54 , pp. 1189-1200
    • Papke, R.L.1    Dwoskin, L.P.2    Crooks, P.A.3    Zheng, G.4    Zhang, Z.5    McIntosh, J.M.6    Stokes, C.7
  • 29
    • 0027136282 scopus 로고
    • Comparative protein modelling by satisfaction of spatial restraints
    • Sali A and Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779-815.
    • (1993) J Mol Biol , vol.234 , pp. 779-815
    • Sali, A.1    Blundell, T.L.2
  • 30
    • 69949159308 scopus 로고    scopus 로고
    • Nicotinic receptors: Allosteric transitions and therapeutic targets in the nervous system
    • Taly A, Corringer PJ, Guedin D, Lestage P, and Changeux JP (2009) Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 8:733-750.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 733-750
    • Taly, A.1    Corringer, P.J.2    Guedin, D.3    Lestage, P.4    Changeux, J.P.5
  • 31
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
    • Thompson JD, Higgins DG, and Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680.
    • (1994) Nucleic Acids Res , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 32
    • 0034744270 scopus 로고    scopus 로고
    • Agonists at the α4β2 nicotinic acetylcholine receptors: Structure-activity relationships and molecular modelling
    • Tønder JE and Olesen PH (2001) Agonists at the α4β2 nicotinic acetylcholine receptors: structure-activity relationships and molecular modelling. Curr Med Chem 8:651-674.
    • (2001) Curr Med Chem , vol.8 , pp. 651-674
    • Tønder, J.E.1    Olesen, P.H.2
  • 33
    • 13444271681 scopus 로고    scopus 로고
    • Refined structure of the nicotinic acetylcholine receptor at 4Å resolution
    • Unwin N (2005) Refined structure of the nicotinic acetylcholine receptor at 4Å resolution. J Mol Biol 346:967-989.
    • (2005) J Mol Biol , vol.346 , pp. 967-989
    • Unwin, N.1
  • 34
    • 67649873076 scopus 로고    scopus 로고
    • Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site
    • Williams DK, Stokes C, Horenstein NA, and Papke RL (2009) Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site. J Pharmacol Exp Ther 330:40-53.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 40-53
    • Williams, D.K.1    Stokes, C.2    Horenstein, N.A.3    Papke, R.L.4
  • 35
    • 63649149427 scopus 로고    scopus 로고
    • Nicotine binding to brain receptors requires a strong cation-π interaction
    • Xiu X, Puskar NL, Shanata JA, Lester HA, and Dougherty DA (2009) Nicotine binding to brain receptors requires a strong cation-π interaction. Nature 458:534-537.
    • (2009) Nature , vol.458 , pp. 534-537
    • Xiu, X.1    Puskar, N.L.2    Shanata, J.A.3    Lester, H.A.4    Dougherty, D.A.5
  • 36
    • 0032514762 scopus 로고    scopus 로고
    • From ab initio quantum mechanics to molecular neurobiology: A cation-π binding site in the nicotinic receptor
    • Zhong W, Gallivan JP, Zhang Y, Li L, Lester HA, and Dougherty DA (1998) From ab initio quantum mechanics to molecular neurobiology: a cation-π binding site in the nicotinic receptor. Proc Natl Acad Sci USA 95:12088-12093.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12088-12093
    • Zhong, W.1    Gallivan, J.P.2    Zhang, Y.3    Li, L.4    Lester, H.A.5    Dougherty, D.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.