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Volumn 288, Issue 10, 2013, Pages 6991-6997

Binding interactions with the complementary subunit of nicotinic receptors

Author keywords

[No Author keywords available]

Indexed keywords

BINDING INTERACTION; DRUG DISCOVERY; DRUG-RECEPTOR INTERACTIONS; FUNCTIONAL RECEPTORS; FUNCTIONAL VALIDATION; HYDROGEN BONDING INTERACTIONS; NICOTINIC RECEPTOR; STRUCTURAL MODELS;

EID: 84874859868     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.439968     Document Type: Article
Times cited : (21)

References (30)
  • 2
    • 0035424008 scopus 로고    scopus 로고
    • Nicotinic receptors in wonderland
    • DOI 10.1016/S0968-0004(01)01921-1, PII S0968000401019211
    • Grutter, T., and Changeux, J. P. (2001) Nicotinic receptors in wonderland. Trends Biochem. Sci. 26, 459-463 (Pubitemid 32735440)
    • (2001) Trends in Biochemical Sciences , vol.26 , Issue.8 , pp. 459-463
    • Grutter, T.1    Changeux, J.-P.2
  • 3
    • 0036480194 scopus 로고    scopus 로고
    • Emerging structure of the nicotinic acetylcholine receptors
    • DOI 10.1038/nrn731
    • Karlin, A. (2002) Emerging structure of the nicotinic acetylcholine receptors. Nat. Rev. Neurosci. 3, 102-114 (Pubitemid 135706579)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.2 , pp. 102-114
    • Karlin, A.1
  • 6
    • 44849128243 scopus 로고    scopus 로고
    • Cys-loop neuroreceptors: Structure to the rescue?
    • DOI 10.1021/cr078207z
    • Dougherty, D. A. (2008) Cys-loop neuroreceptors: Structure to the rescue? Chem. Rev. 108, 1642-1653 (Pubitemid 351796402)
    • (2008) Chemical Reviews , vol.108 , Issue.5 , pp. 1642-1653
    • Dougherty, D.A.1
  • 7
    • 22844432580 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors: Structural revelations, target identifications, and therapeutic inspirations
    • DOI 10.1021/jm040219e
    • Jensen, A. A., Frølund, B., Liljefors, T., and Krogsgaard-Larsen, P. (2005) Neuronal nicotinic acetylcholine receptors: Structural revelations, target identifications, and therapeutic inspirations. J. Med. Chem. 48, 4705-4745 (Pubitemid 41038456)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.15 , pp. 4705-4745
    • Jensen, A.A.1    Frolund, B.2    Liljefors, T.3    Krogsgaard-Larsen, P.4
  • 8
    • 0035902009 scopus 로고    scopus 로고
    • Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
    • DOI 10.1038/35077011
    • Brejc, K., van Dijk, W. J., Klaassen, R. V., Schuurmans, M., van Der Oost, J., Smit, A. B., and Sixma, T. K. (2001) Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature 411, 269-276 (Pubitemid 32467026)
    • (2001) Nature , vol.411 , Issue.6835 , pp. 269-276
    • Brejc, K.1    Van Dijk, W.J.2    Klaassen, R.V.3    Schuurmans, M.4    Van Der Oost, J.5    Smit, A.B.6    Sixma, T.K.7
  • 9
    • 1842475289 scopus 로고    scopus 로고
    • Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures
    • DOI 10.1016/S0896-6273(04)00115-1, PII S0896627304001151
    • Celie, P. H., van Rossum-Fikkert, S. E., van Dijk, W. J., Brejc, K., Smit, A. B., and Sixma, T. K. (2004) Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron 41, 907-914 (Pubitemid 38429734)
    • (2004) Neuron , vol.41 , Issue.6 , pp. 907-914
    • Celie, P.H.N.1    Van Rossum-Fikkert, S.E.2    Van Dijk, W.J.3    Brejc, K.4    Smit, A.B.5    Sixma, T.K.6
  • 10
    • 0041352143 scopus 로고    scopus 로고
    • Acetylcholine binding protein (AChBP): A secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels
    • DOI 10.1146/annurev.biophys.32.110601.142536
    • Sixma, T. K., and Smit, A. B. (2003) Acetylcholine-binding protein (AChBP): A secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels. Annu. Rev. Biophys. Biomol. Struct. 32, 311-334 (Pubitemid 37056232)
    • (2003) Annual Review of Biophysics and Biomolecular Structure , vol.32 , pp. 311-334
    • Sixma, T.K.1    Smit, A.B.2
  • 11
    • 11844286949 scopus 로고    scopus 로고
    • Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor
    • DOI 10.1021/ja0461771
    • Cashin, A. L., Petersson, E. J., Lester, H. A., and Dougherty, D. A. (2005) Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor. J. Am. Chem. Soc. 127, 350-356 (Pubitemid 40094396)
    • (2005) Journal of the American Chemical Society , vol.127 , Issue.1 , pp. 350-356
    • Cashin, A.L.1    James Petersson, E.2    Lester, H.A.3    Dougherty, D.A.4
  • 12
    • 63649149427 scopus 로고    scopus 로고
    • Nicotine binding to brain receptors requires a strong cation-π interaction
    • Xiu, X., Puskar, N. L., Shanata, J. A., Lester, H. A., and Dougherty, D. A. (2009) Nicotine binding to brain receptors requires a strong cation-π interaction. Nature 458, 534-537
    • (2009) Nature , vol.458 , pp. 534-537
    • Xiu, X.1    Puskar, N.L.2    Shanata, J.A.3    Lester, H.A.4    Dougherty, D.A.5
  • 14
    • 33845941611 scopus 로고    scopus 로고
    • Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica
    • DOI 10.1385/JMN:30:1:101, PII JMN301101
    • Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Bourne, Y., and Taylor, P. (2006) Structural characterization of agonist-and antagonistbound acetylcholine-binding protein from Aplysia californica. J. Mol. Neurosci. 30, 101-102 (Pubitemid 46035339)
    • (2006) Journal of Molecular Neuroscience , vol.30 , Issue.1-2 , pp. 101-102
    • Hansen, S.B.1    Sulzenbacher, G.2    Huxford, T.3    Marchot, P.4    Bourne, Y.5    Taylor, P.6
  • 15
    • 27144473613 scopus 로고    scopus 로고
    • Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations
    • DOI 10.1038/sj.emboj.7600828, PII 7600828
    • Hansen, S. B., Sulzenbacher, G., Huxford, T., Marchot, P., Taylor, P., and Bourne, Y. (2005) Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J. 24, 3635-3646 (Pubitemid 41509370)
    • (2005) EMBO Journal , vol.24 , Issue.20 , pp. 3635-3646
    • Hansen, S.B.1    Sulzenbacher, G.2    Huxford, T.3    Marchot, P.4    Taylor, P.5    Bourne, Y.6
  • 16
    • 77955805594 scopus 로고    scopus 로고
    • Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH
    • Blum, A. P., Lester, H. A., and Dougherty, D. A. (2010) Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proc. Natl. Acad. Sci. U.S.A. 107, 13206-13211
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 13206-13211
    • Blum, A.P.1    Lester, H.A.2    Dougherty, D.A.3
  • 17
    • 11244304395 scopus 로고    scopus 로고
    • Toward assessing the position-dependent contributions of backbone hydrogen bonding to β-sheet folding thermodynamics employing amide-to-ester perturbations
    • DOI 10.1021/ja045934s
    • Deechongkit, S., Dawson, P. E., and Kelly, J. W. (2004) Toward assessing the position-dependent contributions of backbone hydrogen bonding to β-sheet folding thermodynamics employing amide-to-ester perturbations. J. Am. Chem. Soc. 126, 16762-16771 (Pubitemid 40069494)
    • (2004) Journal of the American Chemical Society , vol.126 , Issue.51 , pp. 16762-16771
    • Deechongkit, S.1    Dawson, P.E.2    Kelly, J.W.3
  • 18
    • 3042848873 scopus 로고    scopus 로고
    • Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics
    • DOI 10.1038/nature02611
    • Deechongkit, S., Nguyen, H., Powers, E. T., Dawson, P. E., Gruebele, M., and Kelly, J. W. (2004) Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics. Nature 430, 101-105 (Pubitemid 38915233)
    • (2004) Nature , vol.430 , Issue.6995 , pp. 101-105
    • Deechongkit, S.1    Nguyen, H.2    Powers, E.T.3    Dawson, P.E.4    Gruebele, M.5    Kelly, J.W.6
  • 19
    • 0033534674 scopus 로고    scopus 로고
    • Backbone mutations in transmembrane domains of a ligand-gated ion channel: Implications for the mechanism of gating
    • DOI 10.1016/S0092-8674(00)80962-9
    • England, P. M., Zhang, Y., Dougherty, D. A., and Lester, H. A. (1999) Backbone mutations in transmembrane domains of a ligand-gated ion channel: Implications for the mechanism of gating. Cell 96, 89-98 (Pubitemid 29044156)
    • (1999) Cell , vol.96 , Issue.1 , pp. 89-98
    • England, P.M.1    Zhang, Y.2    Dougherty, D.A.3    Lester, H.A.4
  • 20
    • 58149093958 scopus 로고    scopus 로고
    • An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating
    • Gleitsman, K. R., Kedrowski, S. M. A., Lester, H. A., and Dougherty, D. A. (2008) An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating. J. Biol. Chem. 283, 35638-35643
    • (2008) J. Biol. Chem. , vol.283 , pp. 35638-35643
    • Gleitsman, K.R.1    Kedrowski, S.M.A.2    Lester, H.A.3    Dougherty, D.A.4
  • 21
    • 0030922940 scopus 로고    scopus 로고
    • An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis
    • DOI 10.1021/bi9707685
    • Koh, J. T., Cornish, V. W., and Schultz, P. G. (1997) An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis. Biochemistry 36, 11314-11322 (Pubitemid 27408613)
    • (1997) Biochemistry , vol.36 , Issue.38 , pp. 11314-11322
    • Koh, J.T.1    Cornish, V.W.2    Schultz, P.G.3
  • 22
    • 0032311418 scopus 로고    scopus 로고
    • In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system
    • DOI 10.1016/S0076-6879(98)93031-2
    • Nowak, M. W., Gallivan, J. P., Silverman, S. K., Labarca, C. G., Dougherty, D. A., and Lester, H. A. (1998) In vivo incorporation of unnatural amino acids into ion channels in a Xenopus oocyte expression system. Methods Enzymol. 293, 504-529 (Pubitemid 29342505)
    • (1998) Methods in Enzymology , vol.293 , pp. 504-529
    • Nowak, M.W.1    Gallivan, J.P.2    Silverman, S.K.3    Labarca, C.G.4    Dougherty, D.A.5    Lester, H.A.6
  • 24
    • 0029163027 scopus 로고
    • Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
    • Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., and Lester, H. A. (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. Nature 376, 514-516
    • (1995) Nature , vol.376 , pp. 514-516
    • Labarca, C.1    Nowak, M.W.2    Zhang, H.3    Tang, L.4    Deshpande, P.5    Lester, H.A.6
  • 25
    • 0029123899 scopus 로고
    • The role of conserved leucines in theM2domain of the acetylcholine receptor in channel gating
    • Filatov, G. N., and White, M. M. (1995) The role of conserved leucines in theM2domain of the acetylcholine receptor in channel gating. Mol. Pharmacol. 48, 379-384
    • (1995) Mol. Pharmacol. , vol.48 , pp. 379-384
    • Filatov, G.N.1    White, M.M.2
  • 26
    • 67649400916 scopus 로고    scopus 로고
    • Long-range coupling in an allosteric receptor revealed by mutant cycle analysis
    • Gleitsman, K. R., Shanata, J. A. P., Frazier, S. J., Lester, H. A., and Dougherty, D. A. (2009) Long-range coupling in an allosteric receptor revealed by mutant cycle analysis. Biophys. J. 96, 3168-3178
    • (2009) Biophys. J. , vol.96 , pp. 3168-3178
    • Gleitsman, K.R.1    Shanata, J.A.P.2    Frazier, S.J.3    Lester, H.A.4    Dougherty, D.A.5
  • 28
    • 0014934202 scopus 로고
    • Structure and activity of acetylcholine
    • Beers, W. H., and Reich, E. (1970) Structure and activity of acetylcholine. Nature 228, 917-922
    • (1970) Nature , vol.228 , pp. 917-922
    • Beers, W.H.1    Reich, E.2
  • 29
    • 0141547115 scopus 로고
    • Dissociation constants of 2-substituted pyridines
    • Linnell, R. H. (1960) Dissociation constants of 2-substituted pyridines. J. Org. Chem. 25, 290
    • (1960) J. Org. Chem. , vol.25 , pp. 290
    • Linnell, R.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.