F-box only protein 31 (FBXO31) negatively regulates p38 Mitogen-activated Protein Kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of Mitogen-activated Protein Kinase Kinase 6 (MKK6)

Journal of Biological Chemistry

Volumn 289, Issue 31, 2014, Pages 21508-21518

  Liu, Jia ^a   Han, Liang ^a   Li, Bin ^a   Yang, Jie ^a   Huen, Michael S Y ^a   Pan, Xin ^b   Tsao, Sai Wah ^a   Cheung, Annie L M ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIOPHAGES; CELL DEATH; CELL SIGNALING; CHEMICAL ACTIVATION; ENZYMES; MACHINERY; SIGNAL TRANSDUCTION;

GENOTOXIC STRESS; MITOGEN-ACTIVATED PROTEIN KINASE KINASE; NEGATIVE REGULATORS; P38 MITOGEN-ACTIVATED PROTEIN KINASE; POLYUBIQUITINATION; PROTEASOMAL DEGRADATION; SCAFFOLD PROTEIN; SIGNAL TRANSDUCTION PATHWAYS;

SCAFFOLDS (BIOLOGY);

F BOX ONLY PROTEIN 31; LIGASE; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; UNCLASSIFIED DRUG; F BOX PROTEIN; FBXO31 PROTEIN, HUMAN; MAP2K6 PROTEIN, HUMAN; OLIGODEOXYRIBONUCLEOTIDE; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; BIOACCUMULATION; CANCER CELL; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INACTIVATION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; GENETICS; HEK293 CELL LINE; METABOLISM; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHYSIOLOGY; PROTEIN DEGRADATION; SITE DIRECTED MUTAGENESIS; TUMOR CELL LINE;

APOPTOSIS; BASE SEQUENCE; CELL LINE, TUMOR; F-BOX PROTEINS; HEK293 CELLS; HUMANS; LYSINE; MAP KINASE KINASE 6; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEOLYSIS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

EID: 84905390264     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.560342     Document Type: Article

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