HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes

Journal of Biological Chemistry

Volumn 289, Issue 31, 2014, Pages 21716-21726

  Guo, Haitao ^a   Gao, Jianmei ^a   Taxman, Debra J ^a,b   Ting, Jenny P Y ^a,b   Su, Lishan ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CHEMICAL ACTIVATION; TRANSCRIPTION; VIRUSES;

DISEASE PROGRESSION; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE ACTIVATION; INFLAMMATORY CYTOKINES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTION; TOLL-LIKE RECEPTORS; TRANSCRIPTIONAL LEVELS;

DISEASES;

CATHEPSIN B; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; CARRIER PROTEIN; NLRP3 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN; VIRUS RNA;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INNATE IMMUNITY; MONOCYTE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; BIOSYNTHESIS; GENE SILENCING; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; PHYSIOLOGY;

CARRIER PROTEINS; CATHEPSIN B; GENE KNOCKDOWN TECHNIQUES; HIV INFECTIONS; HIV-1; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; MONOCYTES; REACTIVE OXYGEN SPECIES; RNA, VIRAL; TOLL-LIKE RECEPTOR 8;

EID: 84905376910     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.566620     Document Type: Article

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