Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism

Experimental Neurology

Volumn 261, Issue , 2014, Pages 87-96

  Chen, Sha Sha ^a   Yang, Chun ^a   Hao, Fei ^a   Li, Chen ^a   Lu, Tao ^a   Zhao, Li Ru ^b   Duan, Wei Ming ^a,c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b State University of New York Upstate Medical University: College of Medicine   (United States)

^c BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

Dopaminergic neurons; Gene transfer; Glial cell line derived neurotrophic factor; Lentivirus vectors; Parkinson's disease; Striatum

Indexed keywords

D 9891; DEXAMPHETAMINE; DOXYCYCLINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LENTIVIRUS VECTOR; OXIDOPAMINE; SODIUM CHLORIDE; TET ON LENTIVIRUS VECTOR; UNCLASSIFIED DRUG; TETRACYCLINE; ADRENERGIC RECEPTOR STIMULATING AGENT; CULTURE MEDIUM; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG POTENTIATION; GDNF GENE; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE FIBER; NEURAL STEM CELL; NEUROPROTECTION; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; ANIMAL BEHAVIOR; CELL DIFFERENTIATION; DRUG MECHANISM; GENE; GENE CONTROL; GENE EXPRESSION; IN VIVO STUDY; INTRASTRIATAL DRUG ADMINISTRATION; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; CULTURE MEDIUM; DISEASE MODEL; DOSE RESPONSE; GENE VECTOR; GENETICS; LENTIVIRINAE; METABOLISM; NEUROBLASTOMA; NEWBORN; PARKINSONIAN DISORDERS; PATHOLOGY; PHARMACOLOGY; PHYSIOLOGY; TRANSPLANTATION;

ADRENERGIC AGENTS; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; CORPUS STRIATUM; CULTURE MEDIA, CONDITIONED; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEINS; HUMANS; LENTIVIRUS; NEURAL STEM CELLS; NEUROBLASTOMA; OXIDOPAMINE; PARKINSONIAN DISORDERS; RATS;

EID: 84905220724     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.06.022     Document Type: Article

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