SCOPUS 정보 검색 플랫폼

Volumn 84, Issue , 2014, Pages 555-565

Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors

(9) Karki, Radha a Park, Chanmi b Jun, Kyu Yeon b Jee, Jun Goo c Lee, Jun Ho d Thapa, Pritam a Kadayat, Tara Man a Kwon, Youngjoo b Lee, Eung Seok a

a Yeungnam University (South Korea)

b Ewha Womans University (South Korea)

c Kyungpook National University (South Korea)

d Daejeon University (South Korea)

Author keywords

Anticancer agents; Cytotoxicity; Docking study; Topo II inhibitory activity; Topoisomerase I; Topoisomerase II; Trihydroxylated 2,4,6 triphenyl pyridines

Indexed keywords

2 [2 (3 HYDROXYPHENYL) 6 (4 HYDROXYPHENYL)PYRIDIN 2 YL]PHENOL; 2 [4 (3 HYDROXYPHENYL) 6 (4 HYDROXYPHENYL)PYRIDIN 2 YL]PHENOL; 2 [6 (3 HYDROXYPHENYL) 4 (4 HYDROXYPHENYL)PYRIDIN 2 YL]PHENOL; 2,2' [4 (3 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 2,2' [4 (4 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 2,2' [6 (3 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 2,2' [6 (4 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 2,2',2'' (PYRIDINE 2,4 6 TRIYL)TRIPHENOL; 3,3' [4 (2 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 3,3' [4 (4 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 3,3' [6 (2 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 3,3' [6 (4 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 3,3',3'' (PYRIDINE 2,4 6 TRIYL)TRIPHENOL; 4,4' [4 (2 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 4,4' [4 (3 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 4,4' [6 (2 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 4,4' [6 (3 HYDROXYPHENYL)PYRIDINE 2,6 DIYL]DIPHENOL; 4,4',4'' (PYRIDINE 2,4 6 TRIYL)TRIPHENOL; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DOXORUBICIN; ETOPOSIDE; GYRASE INHIBITOR; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; DNA TOPOISOMERASE (ATP HYDROLYSING); PHENOL DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; EPITHELIUM TUMOR; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; MALE; MOLECULAR DOCKING; PROSTATE TUMOR; STRUCTURE ACTIVITY RELATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HEK293 CELL LINE; METABOLISM; NEOPLASMS; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HEK293 CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; NEOPLASMS; PHENOLS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84905178623 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2014.07.058 Document Type: Article

Times cited : (34)

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