Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4014-4017

  Furet, Pascal ^a   Schoepfer, Joseph ^a   Radimerski, Thomas ^a   Chène, Patrick ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Anticancer agents; ATPase inhibitors; Structure based design; Topoisomerase II inhibitors

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; GYRASE INHIBITOR;

ARTICLE; CATALYSIS; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVE SITE; HIGH THROUGHPUT SCREENING; IC 50;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; BINDING SITES; CATALYSIS; CHEMISTRY, PHARMACEUTICAL; COMPUTATIONAL BIOLOGY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PURINES; TOPOISOMERASE II INHIBITORS;

EID: 67649959170     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.034     Document Type: Article

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